NO984380L - Nye piperazin og piperidinforbindelser - Google Patents

Nye piperazin og piperidinforbindelser

Info

Publication number
NO984380L
NO984380L NO984380A NO984380A NO984380L NO 984380 L NO984380 L NO 984380L NO 984380 A NO984380 A NO 984380A NO 984380 A NO984380 A NO 984380A NO 984380 L NO984380 L NO 984380L
Authority
NO
Norway
Prior art keywords
piperidine compounds
new piperazine
piperazine
new
piperidine
Prior art date
Application number
NO984380A
Other languages
English (en)
Other versions
NO984380D0 (no
NO312835B1 (no
Inventor
Roelof W Feenstra
Jacobus A J Den Hartog
Cornelis G Kruse
Martinus T M Tulp
Stephen K Long
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Publication of NO984380D0 publication Critical patent/NO984380D0/no
Publication of NO984380L publication Critical patent/NO984380L/no
Publication of NO312835B1 publication Critical patent/NO312835B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
NO19984380A 1997-09-24 1998-09-21 Nye piperizin- og piperidinforbindelser, fremgangsmåte for fremstilling derav, anvendelse derav, farmasöytisk sammensetningog fremstilling av denne NO312835B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97202950 1997-09-24

Publications (3)

Publication Number Publication Date
NO984380D0 NO984380D0 (no) 1998-09-21
NO984380L true NO984380L (no) 1999-03-25
NO312835B1 NO312835B1 (no) 2002-07-08

Family

ID=8228755

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19984380A NO312835B1 (no) 1997-09-24 1998-09-21 Nye piperizin- og piperidinforbindelser, fremgangsmåte for fremstilling derav, anvendelse derav, farmasöytisk sammensetningog fremstilling av denne

Country Status (31)

Country Link
US (2) US6090812A (no)
EP (1) EP0908458B1 (no)
JP (1) JP4191826B2 (no)
KR (1) KR100632188B1 (no)
CN (1) CN1093857C (no)
AR (1) AR017127A1 (no)
AT (1) ATE316529T1 (no)
AU (1) AU733526B2 (no)
BR (1) BR9803497A (no)
CA (1) CA2247734C (no)
CY (1) CY1107494T1 (no)
CZ (1) CZ296741B6 (no)
DE (1) DE69833297T2 (no)
DK (1) DK0908458T3 (no)
DZ (1) DZ2613A1 (no)
ES (1) ES2255127T3 (no)
HK (1) HK1018272A1 (no)
HU (1) HU227422B1 (no)
ID (1) ID20895A (no)
IL (1) IL126295A (no)
NO (1) NO312835B1 (no)
NZ (1) NZ331984A (no)
PL (1) PL190622B1 (no)
PT (1) PT908458E (no)
RU (1) RU2197488C2 (no)
SI (1) SI0908458T1 (no)
SK (1) SK285205B6 (no)
TR (1) TR199801866A1 (no)
TW (1) TW530054B (no)
UA (1) UA66756C2 (no)
ZA (1) ZA988749B (no)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002534426A (ja) * 1999-01-07 2002-10-15 ワイス 鬱病の処置のための新規な1,4−二基置換されたシクロヘキサン誘導体
US6200994B1 (en) 1999-01-07 2001-03-13 American Home Products Corp 1,4-Disubstituted cyclohexane derivatives for the treatment of depression
DE10005150A1 (de) 2000-02-07 2001-08-09 Merck Patent Gmbh Verfahren zur Herstellung von 5-Arylnicotinaldehyden
DE10115922A1 (de) * 2001-03-30 2002-10-10 Bayer Ag Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
EP1408976B3 (en) 2001-07-20 2010-08-25 Psychogenics Inc. Treatment for attention-deficit hyperactivity disorder
US7435738B2 (en) 2003-08-18 2008-10-14 Solvay Pharmaceuticals, Inc. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7405216B2 (en) 2004-08-18 2008-07-29 Solvay Pharmaceuticals, B.V. Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
US7964604B2 (en) 2005-02-18 2011-06-21 Solvay Pharmaceuticals B.V. Bifeprunox mesylate maintenance dose compositions and methods for using the same
US7423040B2 (en) 2005-02-18 2008-09-09 Irene Eijgendaal Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same
US20070275977A1 (en) * 2006-05-02 2007-11-29 Van Aar Marcel P N-oxides of pyridylmethyl -piperazine and -piperidine derivatives
MX2008013887A (es) 2006-05-02 2009-01-29 Solvay Pharm Bv N-oxidos de derivados de piridilmetilpiperazina y piridilmetilpiperdina.
US7786126B2 (en) 2006-06-16 2010-08-31 Solvay Pharmaceuticals B.V. Combination preparations comprising SLV308 and a dopamine agonist
US8106056B2 (en) 2006-06-16 2012-01-31 Solvay Pharmaceuticals B.V. Combination preparations comprising bifeprunox and a dopamine agonist
WO2011088838A1 (en) 2010-01-25 2011-07-28 H. Lundbeck A/S Novel 6,6a,7,8,9,10-hexahydro-4h-4,8,10a-triaza-acephenanthrylene derivatives as dopamine d2 ligands
US8877778B2 (en) * 2010-12-15 2014-11-04 Hoffmann-La Roche Inc. Benzofurane compounds
US8921397B2 (en) 2011-05-04 2014-12-30 Hoffmann-La Roche Inc. Benzofurane-piperidine compounds
DK3487851T3 (da) 2016-07-20 2021-12-20 Novartis Ag Aminopyridinderivater og deres anvendelse som selektive alk-2-inhibitorer
KR101665971B1 (ko) 2016-08-10 2016-10-13 (주)글로벌 로보틱스 차량용 발포패드 부착장치
WO2021102258A1 (en) 2019-11-22 2021-05-27 Incyte Corporation Combination therapy comprising an alk2 inhibitor and a jak2 inhibitor
AU2021292484A1 (en) 2020-06-16 2023-01-19 Incyte Corporation ALK2 inhibitors for the treatment of anemia

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3586794T2 (de) 1984-12-21 1993-05-27 Duphar Int Res Arzneimittel mit psychotroper wirkung.
EP0185429A1 (en) * 1984-12-21 1986-06-25 Duphar International Research B.V New bicyclic heteroaryl piperazines
EP0241053B1 (en) * 1986-02-27 1992-11-11 Duphar International Research B.V Aryl-substituted (n-piperidinyl)-methyl- and (n-piperazinyl) methylazoles having antipsychotic properties
EP0508347A1 (en) 1991-04-10 1992-10-14 Hoechst Aktiengesellschaft 5,7-Dihydroxy-2-methyl-8-[4-(3-hydroxy-1-(1-propyl)) piperidinyl]-4H-1-benzopyran-4-one, its preparation and its use
NZ240863A (en) * 1991-09-11 1995-04-27 Mcneilab Inc Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof
JPH05262765A (ja) 1992-03-18 1993-10-12 Sumitomo Chem Co Ltd ベンゾフラン誘導体およびそれを有効成分とする除草剤
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
US5332732A (en) * 1992-09-11 1994-07-26 Mcneilab, Inc. Thiophene and pyridine antipsychotic agents
US5436246A (en) * 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
RU2118322C1 (ru) * 1993-07-05 1998-08-27 Дюфар Интернэшнл Рисерч Б.В. 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
GB9314758D0 (en) * 1993-07-16 1993-08-25 Wyeth John & Brother Ltd Heterocyclic derivatives
EP0650964A1 (en) 1993-11-02 1995-05-03 Duphar International Research B.V 1 2H-1-benzopyran-2-one-8-yl -piperazine derivatives
DE4425146A1 (de) 1994-07-15 1996-01-18 Basf Ag Verwendung heterocyclischer Verbindungen
US5607936A (en) * 1994-09-30 1997-03-04 Merck & Co., Inc. Substituted aryl piperazines as neurokinin antagonists
DE69615376T2 (de) * 1995-07-13 2002-09-05 Knoll Gmbh Piperazin-derivate als heilmittel
PT889889E (pt) * 1996-03-29 2007-01-31 Duphar Int Res Composto de piperazina e piperidina
DE19637237A1 (de) * 1996-09-13 1998-03-19 Merck Patent Gmbh Piperazin-Derivate

Also Published As

Publication number Publication date
NZ331984A (en) 2000-02-28
HU9802129D0 (en) 1998-11-30
USRE41425E1 (en) 2010-07-06
PL190622B1 (pl) 2005-12-30
CA2247734C (en) 2007-08-07
TW530054B (en) 2003-05-01
EP0908458B1 (en) 2006-01-25
CZ303098A3 (cs) 1999-04-14
DZ2613A1 (fr) 2003-03-01
KR100632188B1 (ko) 2007-04-25
US6090812A (en) 2000-07-18
PL328754A1 (en) 1999-03-29
SI0908458T1 (sl) 2006-06-30
JP4191826B2 (ja) 2008-12-03
UA66756C2 (uk) 2004-06-15
ATE316529T1 (de) 2006-02-15
CA2247734A1 (en) 1999-03-24
EP0908458A1 (en) 1999-04-14
HU227422B1 (en) 2011-05-30
RU2197488C2 (ru) 2003-01-27
DE69833297D1 (de) 2006-04-13
HK1018272A1 (en) 1999-12-17
BR9803497A (pt) 2000-05-02
TR199801866A1 (xx) 1999-04-21
ID20895A (id) 1999-03-25
PT908458E (pt) 2006-05-31
ZA988749B (en) 1999-03-26
ES2255127T3 (es) 2006-06-16
NO984380D0 (no) 1998-09-21
CN1220265A (zh) 1999-06-23
AU733526B2 (en) 2001-05-17
DE69833297T2 (de) 2006-07-20
AR017127A1 (es) 2001-08-22
DK0908458T3 (da) 2006-06-06
IL126295A (en) 2003-02-12
CY1107494T1 (el) 2013-03-13
HUP9802129A1 (hu) 2000-03-28
SK285205B6 (sk) 2006-08-03
NO312835B1 (no) 2002-07-08
AU8607998A (en) 1999-04-15
SK129498A3 (en) 1999-04-13
KR19990029982A (ko) 1999-04-26
CN1093857C (zh) 2002-11-06
JPH11302279A (ja) 1999-11-02
IL126295A0 (en) 1999-05-09
CZ296741B6 (cs) 2006-06-14

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