SI0908458T1 - Substituirani piridilmetilpiperazinovi in piperidinovi derivati, njihova priprava in njihova uporaba za zdravljenje motenj centralnega zivcnega sistema (cns) - Google Patents
Substituirani piridilmetilpiperazinovi in piperidinovi derivati, njihova priprava in njihova uporaba za zdravljenje motenj centralnega zivcnega sistema (cns)Info
- Publication number
- SI0908458T1 SI0908458T1 SI9830822T SI9830822T SI0908458T1 SI 0908458 T1 SI0908458 T1 SI 0908458T1 SI 9830822 T SI9830822 T SI 9830822T SI 9830822 T SI9830822 T SI 9830822T SI 0908458 T1 SI0908458 T1 SI 0908458T1
- Authority
- SI
- Slovenia
- Prior art keywords
- pyridylmethylpiperazine
- cns
- disorders
- substituted
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97202950 | 1997-09-24 | ||
EP98203154A EP0908458B1 (en) | 1997-09-24 | 1998-09-21 | Substituted pyridylmethylpiperazine and piperidine derivatives, their preparation and their use for treating central nervous system (CNS) disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
SI0908458T1 true SI0908458T1 (sl) | 2006-06-30 |
Family
ID=8228755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI9830822T SI0908458T1 (sl) | 1997-09-24 | 1998-09-21 | Substituirani piridilmetilpiperazinovi in piperidinovi derivati, njihova priprava in njihova uporaba za zdravljenje motenj centralnega zivcnega sistema (cns) |
Country Status (31)
Country | Link |
---|---|
US (2) | US6090812A (sl) |
EP (1) | EP0908458B1 (sl) |
JP (1) | JP4191826B2 (sl) |
KR (1) | KR100632188B1 (sl) |
CN (1) | CN1093857C (sl) |
AR (1) | AR017127A1 (sl) |
AT (1) | ATE316529T1 (sl) |
AU (1) | AU733526B2 (sl) |
BR (1) | BR9803497A (sl) |
CA (1) | CA2247734C (sl) |
CY (1) | CY1107494T1 (sl) |
CZ (1) | CZ296741B6 (sl) |
DE (1) | DE69833297T2 (sl) |
DK (1) | DK0908458T3 (sl) |
DZ (1) | DZ2613A1 (sl) |
ES (1) | ES2255127T3 (sl) |
HK (1) | HK1018272A1 (sl) |
HU (1) | HU227422B1 (sl) |
ID (1) | ID20895A (sl) |
IL (1) | IL126295A (sl) |
NO (1) | NO312835B1 (sl) |
NZ (1) | NZ331984A (sl) |
PL (1) | PL190622B1 (sl) |
PT (1) | PT908458E (sl) |
RU (1) | RU2197488C2 (sl) |
SI (1) | SI0908458T1 (sl) |
SK (1) | SK285205B6 (sl) |
TR (1) | TR199801866A1 (sl) |
TW (1) | TW530054B (sl) |
UA (1) | UA66756C2 (sl) |
ZA (1) | ZA988749B (sl) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6200994B1 (en) | 1999-01-07 | 2001-03-13 | American Home Products Corp | 1,4-Disubstituted cyclohexane derivatives for the treatment of depression |
ES2182775T3 (es) * | 1999-01-07 | 2003-03-16 | Wyeth Corp | Derivados de ciclohexano 1,4-disustituidos para el tratamiento de la depresion. |
DE10005150A1 (de) * | 2000-02-07 | 2001-08-09 | Merck Patent Gmbh | Verfahren zur Herstellung von 5-Arylnicotinaldehyden |
DE10115922A1 (de) * | 2001-03-30 | 2002-10-10 | Bayer Ag | Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
AU2002322539B2 (en) | 2001-07-20 | 2007-09-27 | Psychogenics Inc. | Treatment for attention-deficit hyperactivity disorder |
US7435738B2 (en) | 2003-08-18 | 2008-10-14 | Solvay Pharmaceuticals, Inc. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
US7405216B2 (en) | 2004-08-18 | 2008-07-29 | Solvay Pharmaceuticals, B.V. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
US7964604B2 (en) | 2005-02-18 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Bifeprunox mesylate maintenance dose compositions and methods for using the same |
US7423040B2 (en) | 2005-02-18 | 2008-09-09 | Irene Eijgendaal | Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same |
WO2007128694A1 (en) | 2006-05-02 | 2007-11-15 | Solvay Pharmaceuticals B.V. | N-oxides of pyridylmethylpiperazine and -piperidine derivatives |
US20070275977A1 (en) * | 2006-05-02 | 2007-11-29 | Van Aar Marcel P | N-oxides of pyridylmethyl -piperazine and -piperidine derivatives |
US8106056B2 (en) | 2006-06-16 | 2012-01-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising bifeprunox and a dopamine agonist |
US7786126B2 (en) | 2006-06-16 | 2010-08-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising SLV308 and a dopamine agonist |
WO2011088838A1 (en) | 2010-01-25 | 2011-07-28 | H. Lundbeck A/S | Novel 6,6a,7,8,9,10-hexahydro-4h-4,8,10a-triaza-acephenanthrylene derivatives as dopamine d2 ligands |
US8877778B2 (en) * | 2010-12-15 | 2014-11-04 | Hoffmann-La Roche Inc. | Benzofurane compounds |
US8921397B2 (en) | 2011-05-04 | 2014-12-30 | Hoffmann-La Roche Inc. | Benzofurane-piperidine compounds |
JP7030776B2 (ja) | 2016-07-20 | 2022-03-07 | ノバルティス アーゲー | アミノピリジン誘導体およびそれらの選択的alk-2阻害剤としての使用 |
KR101665971B1 (ko) | 2016-08-10 | 2016-10-13 | (주)글로벌 로보틱스 | 차량용 발포패드 부착장치 |
JP2023502742A (ja) | 2019-11-22 | 2023-01-25 | インサイト コーポレーション | Alk2阻害剤及びjak2阻害剤を含む併用療法 |
MX2022015900A (es) | 2020-06-16 | 2023-01-24 | Incyte Corp | Inhibidores de alk2 para el tratamiento de la anemia. |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3571436D1 (en) * | 1984-12-21 | 1989-08-17 | Duphar Int Res | New pharmaceutical compositions having anti-psychotic properties |
EP0189612B1 (en) | 1984-12-21 | 1992-11-04 | Duphar International Research B.V | New pharmaceutical compositions having a psychotropic activity |
CA1279645C (en) * | 1986-02-27 | 1991-01-29 | Ineke Van Wijngaarden | Aryl-substituted (n-piperidinyl)methyl- and (n-piperazinyl)methylazoles having antipsychotic properties |
EP0508347A1 (en) | 1991-04-10 | 1992-10-14 | Hoechst Aktiengesellschaft | 5,7-Dihydroxy-2-methyl-8-[4-(3-hydroxy-1-(1-propyl)) piperidinyl]-4H-1-benzopyran-4-one, its preparation and its use |
NZ240863A (en) * | 1991-09-11 | 1995-04-27 | Mcneilab Inc | Substituted 4-aryl piperidine and 4-aryl piperazine derivatives, preparation and pharmaceutical compositions thereof |
JPH05262765A (ja) | 1992-03-18 | 1993-10-12 | Sumitomo Chem Co Ltd | ベンゾフラン誘導体およびそれを有効成分とする除草剤 |
FR2692264B1 (fr) | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
US5332732A (en) * | 1992-09-11 | 1994-07-26 | Mcneilab, Inc. | Thiophene and pyridine antipsychotic agents |
US5436246A (en) * | 1992-09-17 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | Serotonin receptor agents |
RU2118322C1 (ru) * | 1993-07-05 | 1998-08-27 | Дюфар Интернэшнл Рисерч Б.В. | 2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли |
GB9314758D0 (en) * | 1993-07-16 | 1993-08-25 | Wyeth John & Brother Ltd | Heterocyclic derivatives |
EP0650964A1 (en) | 1993-11-02 | 1995-05-03 | Duphar International Research B.V | 1 2H-1-benzopyran-2-one-8-yl -piperazine derivatives |
DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
US5607936A (en) * | 1994-09-30 | 1997-03-04 | Merck & Co., Inc. | Substituted aryl piperazines as neurokinin antagonists |
JP4108747B2 (ja) * | 1995-07-13 | 2008-06-25 | アボット ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 治療薬としてのピペラジン誘導体 |
US6225312B1 (en) * | 1996-03-29 | 2001-05-01 | Duphar International Research B.V. | Piperazine and piperidine compounds |
DE19637237A1 (de) * | 1996-09-13 | 1998-03-19 | Merck Patent Gmbh | Piperazin-Derivate |
-
1998
- 1998-09-11 TW TW087115179A patent/TW530054B/zh not_active IP Right Cessation
- 1998-09-18 IL IL12629598A patent/IL126295A/xx not_active IP Right Cessation
- 1998-09-21 AT AT98203154T patent/ATE316529T1/de active
- 1998-09-21 PT PT98203154T patent/PT908458E/pt unknown
- 1998-09-21 AU AU86079/98A patent/AU733526B2/en not_active Ceased
- 1998-09-21 PL PL98328754A patent/PL190622B1/pl not_active IP Right Cessation
- 1998-09-21 ES ES98203154T patent/ES2255127T3/es not_active Expired - Lifetime
- 1998-09-21 BR BR9803497-9A patent/BR9803497A/pt not_active IP Right Cessation
- 1998-09-21 ID IDP981269A patent/ID20895A/id unknown
- 1998-09-21 TR TR1998/01866A patent/TR199801866A1/xx unknown
- 1998-09-21 JP JP28357898A patent/JP4191826B2/ja not_active Expired - Lifetime
- 1998-09-21 DK DK98203154T patent/DK0908458T3/da active
- 1998-09-21 EP EP98203154A patent/EP0908458B1/en not_active Expired - Lifetime
- 1998-09-21 CN CN98119652A patent/CN1093857C/zh not_active Expired - Fee Related
- 1998-09-21 RU RU98117621/04A patent/RU2197488C2/ru not_active IP Right Cessation
- 1998-09-21 SK SK1294-98A patent/SK285205B6/sk not_active IP Right Cessation
- 1998-09-21 AR ARP980104704A patent/AR017127A1/es active IP Right Grant
- 1998-09-21 DE DE69833297T patent/DE69833297T2/de not_active Expired - Lifetime
- 1998-09-21 CA CA002247734A patent/CA2247734C/en not_active Expired - Fee Related
- 1998-09-21 NO NO19984380A patent/NO312835B1/no not_active IP Right Cessation
- 1998-09-21 HU HU9802129A patent/HU227422B1/hu not_active IP Right Cessation
- 1998-09-21 KR KR1019980038929A patent/KR100632188B1/ko not_active IP Right Cessation
- 1998-09-21 CZ CZ0303098A patent/CZ296741B6/cs not_active IP Right Cessation
- 1998-09-21 SI SI9830822T patent/SI0908458T1/sl unknown
- 1998-09-21 NZ NZ331984A patent/NZ331984A/en not_active IP Right Cessation
- 1998-09-22 DZ DZ980223A patent/DZ2613A1/xx active
- 1998-09-22 US US09/158,520 patent/US6090812A/en not_active Ceased
- 1998-09-22 UA UA98094970A patent/UA66756C2/uk unknown
- 1998-09-23 ZA ZA988749A patent/ZA988749B/xx unknown
-
1999
- 1999-08-03 HK HK99103334A patent/HK1018272A1/xx not_active IP Right Cessation
-
2006
- 2006-04-07 CY CY20061100484T patent/CY1107494T1/el unknown
-
2008
- 2008-04-18 US US12/081,710 patent/USRE41425E1/en not_active Expired - Lifetime
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