CY1107105T1 - Διαδικασια για την προετοιμασια των 6. αλφα.-φλουορο,9,11.βητα.-εποξυ-στεροειδων - Google Patents

Διαδικασια για την προετοιμασια των 6. αλφα.-φλουορο,9,11.βητα.-εποξυ-στεροειδων

Info

Publication number
CY1107105T1
CY1107105T1 CY20071101620T CY071101620T CY1107105T1 CY 1107105 T1 CY1107105 T1 CY 1107105T1 CY 20071101620 T CY20071101620 T CY 20071101620T CY 071101620 T CY071101620 T CY 071101620T CY 1107105 T1 CY1107105 T1 CY 1107105T1
Authority
CY
Cyprus
Prior art keywords
alpha
preparation
bita
steroids
fluoro
Prior art date
Application number
CY20071101620T
Other languages
English (en)
Inventor
Loggia Filippo La
Col Marco Da
Original Assignee
Farmabios S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmabios S.P.A. filed Critical Farmabios S.P.A.
Publication of CY1107105T1 publication Critical patent/CY1107105T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

Στο παρόν περιγράφεται μια διαδικασία για την παρασκευή 6 α - φλουοροστεροειδών του τύπου (Ι), όπου το R έχει επιλεχθεί από Η, ΟΗ και μια ομάδα αλκυλίου με από 1 έως 4 άτομα άνθρακα και το R' είναι μια ομάδα καρβοξυαλκυλίου με από 1 έως 4 άτομα άνθρακα στην αλυσίδα αλκυλίου, που αποτελεί την επιλεκτική φθορίωση στη θέση 6 α με επεξεργασία της ένωσης του τύπου (III), όπου το R και το R1 είναι όπως δηλώνονται πιο πάνω, με ηλεκτροφιλικό παράγοντα φθοριοποίησης.
CY20071101620T 2000-11-17 2007-12-20 Διαδικασια για την προετοιμασια των 6. αλφα.-φλουορο,9,11.βητα.-εποξυ-στεροειδων CY1107105T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI002475A IT1319663B1 (it) 2000-11-17 2000-11-17 Processo per la preparazione di fluoro-steroidi.
EP01112124A EP1207166B1 (en) 2000-11-17 2001-05-17 Process for the preparation of 6.alpha.-fluoro,9,11.beta.-epoxy-steroids

Publications (1)

Publication Number Publication Date
CY1107105T1 true CY1107105T1 (el) 2012-10-24

Family

ID=11446116

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071101620T CY1107105T1 (el) 2000-11-17 2007-12-20 Διαδικασια για την προετοιμασια των 6. αλφα.-φλουορο,9,11.βητα.-εποξυ-στεροειδων

Country Status (12)

Country Link
US (1) US6794503B2 (el)
EP (1) EP1207166B1 (el)
JP (1) JP4934249B2 (el)
AT (1) ATE374205T1 (el)
CA (1) CA2348223C (el)
CY (1) CY1107105T1 (el)
DE (1) DE60130615T2 (el)
DK (1) DK1207166T3 (el)
ES (1) ES2293945T3 (el)
IT (1) IT1319663B1 (el)
PT (1) PT1207166E (el)
SI (1) SI1207166T1 (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT102628B (pt) * 2001-06-12 2010-09-09 Hovione Farmaciencia S A Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno
ES2184628B1 (es) * 2001-07-26 2005-02-01 Ragactives, S.L. Procedimiento estereoselectivo para la produccion de 6alfa-fluorpregnanos intermedios.
CN1596241A (zh) * 2001-11-29 2005-03-16 塔罗制药美国公司 6α－氟皮质甾类的制备方法
CA2509366C (en) * 2002-12-09 2008-04-15 Sicor Inc. Process for the preparation of pregnanes
CN100429221C (zh) * 2005-10-31 2008-10-29 浙江仙琚制药股份有限公司 皮质激素的合成方法
CN101759761B (zh) * 2008-11-28 2012-08-08 天津金耀集团有限公司 含有6α-F的甾体化合物的制备方法
CN102272304B (zh) 2009-01-07 2013-10-23 三菱化学株式会社 切断固醇侧链的酶蛋白质及其应用
ITMI20122200A1 (it) 2012-12-20 2014-06-21 Trifarma Spa Processo per la preparazione di 6-alfa-fluoro pregnani

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838545A (en) * 1958-02-19 1958-06-10 Upjohn Co 6 alpha-fluoro-16 alpha-hydroxy steroids
US3207751A (en) * 1959-08-26 1965-09-21 Pfizer & Co C 6-fluoro-16beta-methyl corticosteroids
US2961441A (en) 1959-08-07 1960-11-22 Pfizer & Co C Process for producing 6beta-fluorosteroids
US3557158A (en) * 1962-01-22 1971-01-19 Upjohn Co 6alpha-fluoro-16-methyl - 4 - pregnene 3,20-diones and intermediates produced in the synthesis thereof
US3980778A (en) 1973-10-25 1976-09-14 The Upjohn Company Anti-inflammatory steroid
DE2655570A1 (de) * 1975-12-12 1977-06-16 Ciba Geigy Ag Neue polyhalogensteroide und verfahren zu ihrer herstellung
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes
JPS606700A (ja) * 1983-06-23 1985-01-14 Mitsubishi Chem Ind Ltd 含フツ素ステロイド化合物の製法
FR2701262B1 (fr) * 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.

Also Published As

Publication number Publication date
CA2348223A1 (en) 2002-05-17
EP1207166B1 (en) 2007-09-26
PT1207166E (pt) 2008-01-04
DK1207166T3 (da) 2008-01-21
US20020062021A1 (en) 2002-05-23
IT1319663B1 (it) 2003-10-23
US6794503B2 (en) 2004-09-21
ITMI20002475A1 (it) 2002-05-17
JP4934249B2 (ja) 2012-05-16
CA2348223C (en) 2009-02-17
EP1207166A3 (en) 2004-12-08
ATE374205T1 (de) 2007-10-15
DE60130615T2 (de) 2008-06-19
DE60130615D1 (de) 2007-11-08
JP2002155098A (ja) 2002-05-28
ES2293945T3 (es) 2008-04-01
SI1207166T1 (sl) 2008-04-30
EP1207166A2 (en) 2002-05-22

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