DK1207166T3 - Fremgangsmåde til fremstilling af 6alpha-fluoro,9,11beta-epoxy-steroider - Google Patents

Fremgangsmåde til fremstilling af 6alpha-fluoro,9,11beta-epoxy-steroider

Info

Publication number
DK1207166T3
DK1207166T3 DK01112124T DK01112124T DK1207166T3 DK 1207166 T3 DK1207166 T3 DK 1207166T3 DK 01112124 T DK01112124 T DK 01112124T DK 01112124 T DK01112124 T DK 01112124T DK 1207166 T3 DK1207166 T3 DK 1207166T3
Authority
DK
Denmark
Prior art keywords
preparation
6alpha
11beta
fluoro
epoxy steroids
Prior art date
Application number
DK01112124T
Other languages
English (en)
Inventor
Filippo La Loggia
Marco Da Col
Original Assignee
Farmabios Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmabios Spa filed Critical Farmabios Spa
Application granted granted Critical
Publication of DK1207166T3 publication Critical patent/DK1207166T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
DK01112124T 2000-11-17 2001-05-17 Fremgangsmåde til fremstilling af 6alpha-fluoro,9,11beta-epoxy-steroider DK1207166T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI002475A IT1319663B1 (it) 2000-11-17 2000-11-17 Processo per la preparazione di fluoro-steroidi.

Publications (1)

Publication Number Publication Date
DK1207166T3 true DK1207166T3 (da) 2008-01-21

Family

ID=11446116

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01112124T DK1207166T3 (da) 2000-11-17 2001-05-17 Fremgangsmåde til fremstilling af 6alpha-fluoro,9,11beta-epoxy-steroider

Country Status (12)

Country Link
US (1) US6794503B2 (da)
EP (1) EP1207166B1 (da)
JP (1) JP4934249B2 (da)
AT (1) ATE374205T1 (da)
CA (1) CA2348223C (da)
CY (1) CY1107105T1 (da)
DE (1) DE60130615T2 (da)
DK (1) DK1207166T3 (da)
ES (1) ES2293945T3 (da)
IT (1) IT1319663B1 (da)
PT (1) PT1207166E (da)
SI (1) SI1207166T1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT102628B (pt) * 2001-06-12 2010-09-09 Hovione Farmaciencia S A Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno
ES2184628B1 (es) * 2001-07-26 2005-02-01 Ragactives, S.L. Procedimiento estereoselectivo para la produccion de 6alfa-fluorpregnanos intermedios.
CA2473471A1 (en) * 2001-11-29 2003-06-12 Taro Pharmaceuticals U.S.A., Inc. Method for the preparation of 6-alpha-fluoro corticosteroids
DE60303687D1 (de) * 2002-12-09 2006-04-27 Sicor Inc Prozess zur herstellung von 6 alpa-fluorierten pregnanen
CN100429221C (zh) * 2005-10-31 2008-10-29 浙江仙琚制药股份有限公司 皮质激素的合成方法
CN101759761B (zh) * 2008-11-28 2012-08-08 天津金耀集团有限公司 含有6α-F的甾体化合物的制备方法
US20120178124A1 (en) 2009-01-07 2012-07-12 Mitsubishi Chemical Corporation Sterol side chain-cleaving enzyme protein and use thereof
ITMI20122200A1 (it) * 2012-12-20 2014-06-21 Trifarma Spa Processo per la preparazione di 6-alfa-fluoro pregnani

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838548A (en) * 1958-02-19 1958-06-10 Upjohn Co 6 alpha-fluoro-16 alpha-hydroxy-4-pregnenes
US3207751A (en) * 1959-08-26 1965-09-21 Pfizer & Co C 6-fluoro-16beta-methyl corticosteroids
US2961441A (en) 1959-08-07 1960-11-22 Pfizer & Co C Process for producing 6beta-fluorosteroids
US3557158A (en) * 1962-01-22 1971-01-19 Upjohn Co 6alpha-fluoro-16-methyl - 4 - pregnene 3,20-diones and intermediates produced in the synthesis thereof
US3980778A (en) 1973-10-25 1976-09-14 The Upjohn Company Anti-inflammatory steroid
DE2655570A1 (de) * 1975-12-12 1977-06-16 Ciba Geigy Ag Neue polyhalogensteroide und verfahren zu ihrer herstellung
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes
JPS606700A (ja) * 1983-06-23 1985-01-14 Mitsubishi Chem Ind Ltd 含フツ素ステロイド化合物の製法
FR2701262B1 (fr) * 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.

Also Published As

Publication number Publication date
ATE374205T1 (de) 2007-10-15
EP1207166A3 (en) 2004-12-08
JP2002155098A (ja) 2002-05-28
EP1207166A2 (en) 2002-05-22
CA2348223C (en) 2009-02-17
US20020062021A1 (en) 2002-05-23
JP4934249B2 (ja) 2012-05-16
US6794503B2 (en) 2004-09-21
EP1207166B1 (en) 2007-09-26
PT1207166E (pt) 2008-01-04
SI1207166T1 (sl) 2008-04-30
DE60130615D1 (de) 2007-11-08
DE60130615T2 (de) 2008-06-19
ITMI20002475A1 (it) 2002-05-17
ES2293945T3 (es) 2008-04-01
CY1107105T1 (el) 2012-10-24
CA2348223A1 (en) 2002-05-17
IT1319663B1 (it) 2003-10-23

Similar Documents

Publication Publication Date Title
CY1107105T1 (el) Διαδικασια για την προετοιμασια των 6. αλφα.-φλουορο,9,11.βητα.-εποξυ-στεροειδων
CA2454306A1 (en) Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates their preparation and use
ES2193874A1 (es) Compuestos naturales y derivados de estos para la prevencion y el tratamiento de enfermedades cardiovasculares, hepaticas, renales y cosmeticas.
ATE548339T1 (de) Verfahren zur reduzierung des schwindens von hydraulischen bindemitteln
DE60135338D1 (de) Lösungsmittel für die chemische reinigung enthaltend biologisch abbaubaren ether
FI20011102A (fi) Menetelmä terapeuttisesti käyttökelpoisten trisyklisten bentsatsepiinien valmistamiseksi
ATE352554T1 (de) Neue picolinaminderivate und deren verwendung als fungizide
NZ331457A (en) Methoxybenzophenone compounds, a process for their preparation and a method involving them for combating fungal growth
DK1078923T3 (da) Fremgangsmåde til fremstilling af benzothiophenderivater
TW200503712A (en) (2-carboxamido)(3-amino)thiophene compounds
DK1124623T3 (da) Fremgangsmåde til den katalytiske nedbrydning af N2O
EP1304316A4 (en) PROCESSES FOR THE PRODUCTION OF FLUORINATED ORGANIC COMPOUNDS AND FLUORINATION AGENTS
DE69816731D1 (de) Benzofuranon-derivate und verfahren zu ihrer herstellung
ES2163372A1 (es) Procedimiento de oxidacion de un grupo tioeter a sulfoxido.
PL341539A1 (en) Heterocyclic toxins of topoisomerases
NZ513409A (en) 16-hydroxyestratrienes as selective estrogens
MXPA03001081A (es) Medicamento anti-inflamatorio.
BRPI0411664A (pt) composição oral antiplaca aquosa estável
DK1156058T3 (da) Fremgangsmåde til fremstilling af (E,Z) 3-(2-aminoethoxyimino)-androstan-6,17-dion og analoger deraf
EP1327626A4 (en) PRAVASTATIN PURIFICATION PROCESS
EP1114809A4 (en) METHOD FOR PRODUCING FLUOROBENZYL DERIVATIVES
CO5271703A1 (es) Compuestos quimicos
NO20062647L (no) Fremgangsmate for fremstilling av substituerte aminoalkonoler
EP1698606A4 (en) FLUORATING AGENT AND PROCESS FOR PRODUCING A FLUORINE-CONTAINING COMPOUND USING THE SAME
DK1392672T3 (da) Chlormethylering af thiopen