DE69816731D1 - Benzofuranon-derivate und verfahren zu ihrer herstellung - Google Patents

Benzofuranon-derivate und verfahren zu ihrer herstellung

Info

Publication number
DE69816731D1
DE69816731D1 DE69816731T DE69816731T DE69816731D1 DE 69816731 D1 DE69816731 D1 DE 69816731D1 DE 69816731 T DE69816731 T DE 69816731T DE 69816731 T DE69816731 T DE 69816731T DE 69816731 D1 DE69816731 D1 DE 69816731D1
Authority
DE
Germany
Prior art keywords
production
benzofuranone
derivatives
present
benzofuranone derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69816731T
Other languages
English (en)
Other versions
DE69816731T2 (de
Inventor
Makoto Yoshihama
Masamichi Nakakoshi
Junji Nakamura
Shoji Nakayama
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Publication of DE69816731D1 publication Critical patent/DE69816731D1/de
Application granted granted Critical
Publication of DE69816731T2 publication Critical patent/DE69816731T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/54—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
DE69816731T 1997-01-14 1998-01-13 Benzofuranon-derivate und verfahren zu ihrer herstellung Expired - Fee Related DE69816731T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP1599197 1997-01-14
JP1599197 1997-01-14
JP22556597 1997-08-08
JP22556597A JP3783810B2 (ja) 1997-01-14 1997-08-08 新規ベンゾフラノン誘導体及びその製造方法
PCT/JP1998/000090 WO1998030556A1 (fr) 1997-01-14 1998-01-13 Nouveaux derives de benzofuranone et procede d'elaboration

Publications (2)

Publication Number Publication Date
DE69816731D1 true DE69816731D1 (de) 2003-09-04
DE69816731T2 DE69816731T2 (de) 2004-06-03

Family

ID=26352227

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69816731T Expired - Fee Related DE69816731T2 (de) 1997-01-14 1998-01-13 Benzofuranon-derivate und verfahren zu ihrer herstellung

Country Status (18)

Country Link
US (1) US6143779A (de)
EP (1) EP0902022B1 (de)
JP (1) JP3783810B2 (de)
KR (1) KR100293907B1 (de)
CN (1) CN1173964C (de)
AT (1) ATE246180T1 (de)
AU (1) AU717159B2 (de)
CA (1) CA2248953C (de)
DE (1) DE69816731T2 (de)
DK (1) DK0902022T3 (de)
ES (1) ES2203921T3 (de)
HU (1) HUP9901616A3 (de)
IL (1) IL126137A (de)
NO (1) NO319608B1 (de)
NZ (1) NZ331857A (de)
PT (1) PT902022E (de)
RU (1) RU2152391C1 (de)
WO (1) WO1998030556A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU9001698A (en) * 1997-09-11 1999-03-29 Snow Brand Milk Products Co., Ltd. Remedies for hormone-dependent diseases
US7754709B2 (en) 2003-06-10 2010-07-13 Solvay Pharmaceuticals Bv Tetracyclic thiophenepyrimidinone compounds as inhibitors of 17β hydroxysteroid dehydrogenase compounds
US7465739B2 (en) 2003-06-10 2008-12-16 Solvay Pharmaceuticals B.V. Compounds and their use in therapy
EP1781271A1 (de) * 2004-07-14 2007-05-09 Janssen Pharmaceutica N.V. Arylidene zur behandlung von östrogenbedingten rezeptor-alpha-vermittelten erkrankungen
GB0513702D0 (en) 2005-07-04 2005-08-10 Sterix Ltd Compound
EP1990335A4 (de) * 2006-03-02 2009-11-11 Astellas Pharma Inc 17-beta-hsd-typ-5-inhibitor
US8080540B2 (en) 2006-09-19 2011-12-20 Abbott Products Gmbh Therapeutically active triazoles and their use
JPWO2009028418A1 (ja) 2007-08-24 2010-12-02 北海道公立大学法人 札幌医科大学 シクロスポリンａ結合タンパク質
GB0722779D0 (en) 2007-11-20 2008-01-02 Sterix Ltd Compound
WO2009097515A2 (en) * 2008-01-30 2009-08-06 Wyeth [a]-fused indole compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
WO2009155052A1 (en) * 2008-05-28 2009-12-23 Wyeth 3-substituted-1h-pyrrolo[2,3-b]pyridine and 3-substituted-1h-pyrrolo[3,2-b]pyridine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
JP2011521961A (ja) * 2008-05-28 2011-07-28 ワイス・エルエルシー ３−置換−１Ｈ−インドール化合物、ｍＴＯＲキナーゼおよびＰＩ３キナーゼ阻害剤としてのそれらの使用、ならびにそれらの合成
BRPI0917394A2 (pt) * 2008-08-18 2019-09-24 Univ Yale moduladores de mif
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
CN103391936B (zh) 2010-04-30 2016-04-27 国立大学法人东京大学 抗癌剂
WO2019144009A1 (en) * 2018-01-22 2019-07-25 University Of Kentucky Research Foundation Semisynthetic aurones and methods of use thereof
CN115925665B (zh) * 2022-12-09 2024-06-25 中国药科大学 一种pde4抑制剂及其应用
CN117756761B (zh) * 2023-12-14 2024-06-21 酒泉亚佳化学有限公司 一种苯并呋喃酮衍生物及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3975380A (en) * 1974-06-03 1976-08-17 Smithkline Corporation Substituted aurones
US5354861A (en) * 1992-11-04 1994-10-11 National University Of Singapore 2-(benzyl)-3-arylbenzofurans as antitumour and hypocholesterolemic agents
JP3872834B2 (ja) * 1996-03-04 2007-01-24 第一製薬株式会社 メイラード反応抑制剤

Also Published As

Publication number Publication date
RU2152391C1 (ru) 2000-07-10
CA2248953A1 (en) 1998-07-16
KR100293907B1 (ko) 2001-09-17
EP0902022A4 (de) 2002-01-23
HUP9901616A1 (hu) 2001-04-28
DK0902022T3 (da) 2003-11-24
WO1998030556A1 (fr) 1998-07-16
EP0902022B1 (de) 2003-07-30
CN1173964C (zh) 2004-11-03
JPH10259182A (ja) 1998-09-29
KR20000064582A (ko) 2000-11-06
AU717159B2 (en) 2000-03-16
NO984195D0 (no) 1998-09-11
US6143779A (en) 2000-11-07
IL126137A0 (en) 1999-05-09
ATE246180T1 (de) 2003-08-15
CA2248953C (en) 2003-09-09
PT902022E (pt) 2003-12-31
CN1217719A (zh) 1999-05-26
HUP9901616A3 (en) 2001-05-28
ES2203921T3 (es) 2004-04-16
JP3783810B2 (ja) 2006-06-07
NZ331857A (en) 2000-02-28
NO984195L (no) 1998-10-26
NO319608B1 (no) 2005-08-29
AU5343698A (en) 1998-08-03
DE69816731T2 (de) 2004-06-03
IL126137A (en) 2006-08-01
EP0902022A1 (de) 1999-03-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee