SI1207166T1 - Postopek za pripravo 6-alfa-fluoro,9,11-beta-epoksi-steroidov - Google Patents

Postopek za pripravo 6-alfa-fluoro,9,11-beta-epoksi-steroidov

Info

Publication number
SI1207166T1
SI1207166T1 SI200130793T SI200130793T SI1207166T1 SI 1207166 T1 SI1207166 T1 SI 1207166T1 SI 200130793 T SI200130793 T SI 200130793T SI 200130793 T SI200130793 T SI 200130793T SI 1207166 T1 SI1207166 T1 SI 1207166T1
Authority
SI
Slovenia
Prior art keywords
alpha
preparation
steroids
fluoro
beta
Prior art date
Application number
SI200130793T
Other languages
English (en)
Inventor
Filippo La Loggia
Marco Da Col
Original Assignee
Farmabios Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmabios Spa filed Critical Farmabios Spa
Publication of SI1207166T1 publication Critical patent/SI1207166T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
SI200130793T 2000-11-17 2001-05-17 Postopek za pripravo 6-alfa-fluoro,9,11-beta-epoksi-steroidov SI1207166T1 (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2000MI002475A IT1319663B1 (it) 2000-11-17 2000-11-17 Processo per la preparazione di fluoro-steroidi.
EP01112124A EP1207166B1 (en) 2000-11-17 2001-05-17 Process for the preparation of 6.alpha.-fluoro,9,11.beta.-epoxy-steroids

Publications (1)

Publication Number Publication Date
SI1207166T1 true SI1207166T1 (sl) 2008-04-30

Family

ID=11446116

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200130793T SI1207166T1 (sl) 2000-11-17 2001-05-17 Postopek za pripravo 6-alfa-fluoro,9,11-beta-epoksi-steroidov

Country Status (12)

Country Link
US (1) US6794503B2 (sl)
EP (1) EP1207166B1 (sl)
JP (1) JP4934249B2 (sl)
AT (1) ATE374205T1 (sl)
CA (1) CA2348223C (sl)
CY (1) CY1107105T1 (sl)
DE (1) DE60130615T2 (sl)
DK (1) DK1207166T3 (sl)
ES (1) ES2293945T3 (sl)
IT (1) IT1319663B1 (sl)
PT (1) PT1207166E (sl)
SI (1) SI1207166T1 (sl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT102628B (pt) * 2001-06-12 2010-09-09 Hovione Farmaciencia S A Novo processo de preparação de flumetasona e do seu análogo 17-carboxilo androsteno
ES2184628B1 (es) * 2001-07-26 2005-02-01 Ragactives, S.L. Procedimiento estereoselectivo para la produccion de 6alfa-fluorpregnanos intermedios.
CA2473471A1 (en) * 2001-11-29 2003-06-12 Taro Pharmaceuticals U.S.A., Inc. Method for the preparation of 6-alpha-fluoro corticosteroids
DE60303687D1 (de) * 2002-12-09 2006-04-27 Sicor Inc Prozess zur herstellung von 6 alpa-fluorierten pregnanen
CN100429221C (zh) * 2005-10-31 2008-10-29 浙江仙琚制药股份有限公司 皮质激素的合成方法
CN101759761B (zh) * 2008-11-28 2012-08-08 天津金耀集团有限公司 含有6α-F的甾体化合物的制备方法
US20120178124A1 (en) 2009-01-07 2012-07-12 Mitsubishi Chemical Corporation Sterol side chain-cleaving enzyme protein and use thereof
ITMI20122200A1 (it) * 2012-12-20 2014-06-21 Trifarma Spa Processo per la preparazione di 6-alfa-fluoro pregnani

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838548A (en) * 1958-02-19 1958-06-10 Upjohn Co 6 alpha-fluoro-16 alpha-hydroxy-4-pregnenes
US3207751A (en) * 1959-08-26 1965-09-21 Pfizer & Co C 6-fluoro-16beta-methyl corticosteroids
US2961441A (en) 1959-08-07 1960-11-22 Pfizer & Co C Process for producing 6beta-fluorosteroids
US3557158A (en) * 1962-01-22 1971-01-19 Upjohn Co 6alpha-fluoro-16-methyl - 4 - pregnene 3,20-diones and intermediates produced in the synthesis thereof
US3980778A (en) 1973-10-25 1976-09-14 The Upjohn Company Anti-inflammatory steroid
DE2655570A1 (de) * 1975-12-12 1977-06-16 Ciba Geigy Ag Neue polyhalogensteroide und verfahren zu ihrer herstellung
NL187577C (nl) * 1978-04-05 1991-11-18 Sibla Srl 3-acetoxy-9beta,11beta-epoxy-pregna-1,3,5-trienen, werkwijze voor de bereiding daarvan en werkwijze voor de bereiding van 6alfa-halogeen-pregna-1,4-dieen-3-onen.
US4188322A (en) * 1978-04-28 1980-02-12 Blasinachim S.P.A. Process for the preparation of 6-halo-pregnanes
JPS606700A (ja) * 1983-06-23 1985-01-14 Mitsubishi Chem Ind Ltd 含フツ素ステロイド化合物の製法
FR2701262B1 (fr) * 1993-02-05 1995-03-24 Roussel Uclaf Nouveau procédé de préparation de stéroïdes 6 alpa, 9 alpha-difluorés et nouveaus intermédiaires.

Also Published As

Publication number Publication date
ATE374205T1 (de) 2007-10-15
EP1207166A3 (en) 2004-12-08
JP2002155098A (ja) 2002-05-28
EP1207166A2 (en) 2002-05-22
CA2348223C (en) 2009-02-17
US20020062021A1 (en) 2002-05-23
DK1207166T3 (da) 2008-01-21
JP4934249B2 (ja) 2012-05-16
US6794503B2 (en) 2004-09-21
EP1207166B1 (en) 2007-09-26
PT1207166E (pt) 2008-01-04
DE60130615D1 (de) 2007-11-08
DE60130615T2 (de) 2008-06-19
ITMI20002475A1 (it) 2002-05-17
ES2293945T3 (es) 2008-04-01
CY1107105T1 (el) 2012-10-24
CA2348223A1 (en) 2002-05-17
IT1319663B1 (it) 2003-10-23

Similar Documents

Publication Publication Date Title
CY1107105T1 (el) Διαδικασια για την προετοιμασια των 6. αλφα.-φλουορο,9,11.βητα.-εποξυ-στεροειδων
CA2183655A1 (en) 4-polycyclic amino-substituted quinazoline derivatives
ES2193874A1 (es) Compuestos naturales y derivados de estos para la prevencion y el tratamiento de enfermedades cardiovasculares, hepaticas, renales y cosmeticas.
FI20011100A (fi) Menetelmä terapeuttisesti käyttökelpoisten trisyklisten bentsatsepiinien valmistamiseksi
ATE175676T1 (de) Propiophenon-derivate und verfahren zur ihrer herstellung
WO2002009715A3 (en) Use of an arylaldehyde 5-oxo-1, 2, 4-triazine hydrazide for the treatment of cancer
EP1304316A4 (en) PROCESSES FOR THE PRODUCTION OF FLUORINATED ORGANIC COMPOUNDS AND FLUORINATION AGENTS
PH24139A (en) Method of treating anxiety with tetrahydrobenzy(c,d)indole-6-carboxamides
CA2402635A1 (en) Method for oxidizing a thioether group into a sulfoxide group
MXPA03001081A (es) Medicamento anti-inflamatorio.
EP1114809A4 (en) METHOD FOR PRODUCING FLUOROBENZYL DERIVATIVES
NZ231649A (en) Indan-substituted imidazole derivatives; pharmaceutical compositions and preparatory processes
RU2001135821A (ru) Состав для полости рта, содержащий перлит
GB0019124D0 (en) Novel process
PT1049672E (pt) Derivados de azetidinocarboxamida para o tratamento de disturbios do snc
HU0102118D0 (en) Process for chloromethylation
EP0957088A4 (sl)
HU9203052D0 (en) Method for treatment of hypertension
ZA993528B (en) A compound for use in treating glaucoma and ischemic retinopathy.
EP1086941A4 (en) PROCESS FOR THE PREPARATION OF REDUCERS FOR UNSATURATED ORGANIC COMPOUNDS USING TROCHLOROSILANE AND REDUCING AGENTS
WO2002056869A3 (en) Method for treating sexual disorders
EP1095939A3 (en) Process for the preparation of piperidinylaminomethyl trifluoromethyl cyclic ether compounds
AU2178099A (en) Azetidinecarboxamide derivatives for treating cns disorders
HUP0105347A2 (hu) Eljárás indol-5-karbaldehidek előállítására
GR3030952T3 (en) Salmycins, a process for their preparation and their use as a pharmaceutical.