EA200101194A1 - Производные 4,5,6,7-тетрагидроиндазола в качестве противоопухолевых средств - Google Patents
Производные 4,5,6,7-тетрагидроиндазола в качестве противоопухолевых средствInfo
- Publication number
- EA200101194A1 EA200101194A1 EA200101194A EA200101194A EA200101194A1 EA 200101194 A1 EA200101194 A1 EA 200101194A1 EA 200101194 A EA200101194 A EA 200101194A EA 200101194 A EA200101194 A EA 200101194A EA 200101194 A1 EA200101194 A1 EA 200101194A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- description
- values indicated
- tetrahydroindazol
- funds
- tumor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Соединения, являющиеся производным 4,5,6,7-тетрагидроиндазола, формулы (I), где пунктирная линия (х) означает простую или двойную химическую связь; n означает 0 или 1; R, Rи Rпринимают указанные в описании значения; Ra, R'a, Rb, R'b, Rc, R'с принимают указанные в описании значения, включая также случай, когда Ra и Rb вместе и/или Ra и Rc вместе образуют N-алкилпиперидинильный цикл с 1-6 атомами углерода в алкильной цепи или фенильный цикл; или их фармацевтически приемлемые соли, применяемые для лечения клеточных пролиферативных нарушений и болезни Альцгеймера.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9911053.8A GB9911053D0 (en) | 1999-05-12 | 1999-05-12 | 4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents |
PCT/EP2000/004208 WO2000069846A1 (en) | 1999-05-12 | 2000-05-04 | 4,5,6,7-tetrahydroindazole derivatives as antitumor agents |
Publications (1)
Publication Number | Publication Date |
---|---|
EA200101194A1 true EA200101194A1 (ru) | 2002-06-27 |
Family
ID=10853343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200101194A EA200101194A1 (ru) | 1999-05-12 | 2000-05-04 | Производные 4,5,6,7-тетрагидроиндазола в качестве противоопухолевых средств |
Country Status (26)
Country | Link |
---|---|
US (1) | US6716856B1 (ru) |
EP (1) | EP1177185B1 (ru) |
JP (1) | JP2002544271A (ru) |
KR (1) | KR20010113926A (ru) |
CN (1) | CN1350528A (ru) |
AR (1) | AR023971A1 (ru) |
AT (1) | ATE293618T1 (ru) |
AU (1) | AU4564500A (ru) |
BR (1) | BR0010476A (ru) |
CA (1) | CA2372429A1 (ru) |
CZ (1) | CZ20013970A3 (ru) |
DE (1) | DE60019577T2 (ru) |
EA (1) | EA200101194A1 (ru) |
ES (1) | ES2239595T3 (ru) |
GB (1) | GB9911053D0 (ru) |
HK (1) | HK1045687A1 (ru) |
HU (1) | HUP0201225A3 (ru) |
IL (1) | IL146100A0 (ru) |
MX (1) | MXPA01011441A (ru) |
NO (1) | NO20015477L (ru) |
NZ (1) | NZ514873A (ru) |
PL (1) | PL351611A1 (ru) |
PT (1) | PT1177185E (ru) |
SK (1) | SK15712001A3 (ru) |
WO (1) | WO2000069846A1 (ru) |
ZA (1) | ZA200108530B (ru) |
Families Citing this family (41)
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ES2236217T3 (es) | 2000-04-25 | 2005-07-16 | Bristol-Myers Squibb Company | Uso de 5.tio.,sulfinil- y sulfonilpirazolo 3,4-b)-piridinas como inhibidores de la quinasa dependiente de la ciclina. |
US20040019046A1 (en) * | 2000-11-27 | 2004-01-29 | Paolo Pevarello | Phenylacetamido-pyrazole derivatives and their use as antitumor agents |
DE10148618B4 (de) * | 2001-09-25 | 2007-05-03 | Schering Ag | Substituierte N-(1,4,5,6-Tetrahydro-cyclopentapyrazol-3-yl)-Derivate, deren Herstellung und Verwendung als Arzneimittel |
DE10148617A1 (de) * | 2001-09-25 | 2003-04-24 | Schering Ag | Substituierte N-(1,4,5,6-Tetrahydro-cyclopentapyrazol-3-yl)-Derivate, deren Herstellung und Verwendung als Arzneimittel |
UA81790C2 (ru) | 2002-12-19 | 2008-02-11 | Фармация Италия С.П.А. | Замещенные пиролопиразольные производные как ингибиторы киназы |
OA13170A (en) | 2003-05-22 | 2006-12-13 | Pharmacia Italia Spa | Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors. |
US7141568B2 (en) | 2003-07-09 | 2006-11-28 | Pfizer Italia S.R.L. | Pyrrolo[3,4-c]pyrazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
TW200526204A (en) | 2004-02-03 | 2005-08-16 | Pharmacia Italia Spa | 1h-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors |
CA2558899C (en) * | 2004-03-09 | 2013-02-05 | Corcept Therapeutics, Inc. | Fused ring azadecalin glucocorticoid receptor modulators |
ES2527770T3 (es) | 2005-02-25 | 2015-01-29 | Serenex, Inc. | Derivados de tetrahidroindolona y tetrahidroindazolona |
WO2006133634A1 (fr) * | 2005-06-14 | 2006-12-21 | Beijing Gylongly Biodemtech Co., Ltd | Dérivés tétrahydroindole et dérivés tétrahydroindazole et leur utilisation |
US7943654B2 (en) | 2005-07-19 | 2011-05-17 | Nerviano Medical Sciences S.R.L. | 1H-thieno[2,3-c]pyrazole compounds useful as kinase inhibitors |
MX2008003202A (es) * | 2005-09-16 | 2008-03-25 | Serenex Inc | Derivados de carbazol. |
US7618982B2 (en) | 2005-12-19 | 2009-11-17 | Nerviano Medical Sciences S.R.L. | Heteroarylpyrrolopyridinones active as kinase inhibitors |
GB0602178D0 (en) * | 2006-02-03 | 2006-03-15 | Merck Sharp & Dohme | Therapeutic treatment |
WO2007101156A1 (en) * | 2006-02-27 | 2007-09-07 | Serenex, Inc. | Cyclohexylamino, benzene, pyridine, and pyridazine derivatives |
JP5250432B2 (ja) | 2006-03-03 | 2013-07-31 | ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ | キナーゼ阻害剤として活性なビシクロピラゾール |
WO2008024980A2 (en) * | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Pyrrole, thiophene, furan, imidazole, oxazole, and thiazole derivatives |
WO2008024981A1 (en) * | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Piperazine-substituted benzothiophenes for treatment of mental disorders |
US20080070930A1 (en) * | 2006-08-24 | 2008-03-20 | Huang Kenneth H | Pyrimidine and Pyrazine Derivatives |
WO2008024978A2 (en) * | 2006-08-24 | 2008-02-28 | Serenex, Inc. | Tetrahydroindolone and tetrahydroindazolone derivatives |
US20080076813A1 (en) * | 2006-08-24 | 2008-03-27 | Huang Kenneth H | Benzene, Pyridine, and Pyridazine Derivatives |
DE102006060598A1 (de) * | 2006-12-21 | 2008-06-26 | Merck Patent Gmbh | Tetrahydrobenzoisoxazole |
US8293762B2 (en) | 2007-02-27 | 2012-10-23 | Nerviano Medical Sciences S.R.L. | Isoquinolinopyrrolopyridinones active as kinase inhibitors |
EP2003129B1 (en) | 2007-06-11 | 2017-08-09 | Nerviano Medical Sciences S.r.l. | 1H-Pyrido[3,4-B]indol-1-one and 2,3,4,9-Tetrahydro-1H-Beta-Carbolin-1-one Derivatives |
WO2010009985A2 (en) | 2008-07-24 | 2010-01-28 | Nerviano Medical Sciences S.R.L. | Therapeutic combination comprising an aurora kinase inhibitor and antiproliferative agents |
JP6062633B2 (ja) | 2009-01-28 | 2017-01-18 | カラ セラピューティクス インコーポレイテッド | 二環式ピラゾロ複素環類 |
US7741350B1 (en) | 2009-01-28 | 2010-06-22 | Cara Therapeutics, Inc. | Bicyclic pyrazolo-heterocycles |
CN102311389A (zh) * | 2010-06-29 | 2012-01-11 | 王小龙 | 一种氮芳香取代吡唑衍生物、及其合成和抗癌应用 |
CN103298816A (zh) | 2010-12-17 | 2013-09-11 | 内尔维阿诺医学科学有限公司 | 作为激酶抑制剂的取代的吡唑并-喹唑啉衍生物 |
US8829024B2 (en) | 2011-01-07 | 2014-09-09 | Corcept Therapeutics, Inc. | Combination steroid and glucocorticoid receptor antagonist therapy |
WO2013167698A1 (en) * | 2012-05-11 | 2013-11-14 | Bayer Pharma Aktiengesellschaft | Substituted cycloalkenopyrazoles as bub1 inhibitors for the treatment of cancer |
US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
PL3074011T3 (pl) | 2013-11-25 | 2020-01-31 | Corcept Therapeutics Incorporated | Połączone fuzyjnie oktahydro związki azadekaliny jako modulatory receptora glukokortykoidowego |
WO2018183947A1 (en) | 2017-03-31 | 2018-10-04 | Corcept Therapeutics, Inc. | Glucocorticoid receptor modulators to treat cervical cancer |
SG11202105770YA (en) | 2018-12-19 | 2021-07-29 | Corcept Therapeutics Inc | Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound |
WO2020132046A1 (en) | 2018-12-19 | 2020-06-25 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
US11234971B2 (en) | 2018-12-19 | 2022-02-01 | Corcept Therapeutics Incorporated | Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent |
EP3927345A4 (en) | 2019-02-22 | 2022-12-21 | Corcept Therapeutics Incorporated | THERAPEUTIC USES OF RELACORILANT, A GLUCOCORTICOID RECEPTOR MODULATOR DERIVED FROM AZADECALIN FUSED TO A HETEROARYL KETONE |
MX2022006633A (es) | 2019-12-11 | 2022-06-24 | Corcept Therapeutics Inc | Metodos de tratamiento del aumento de peso inducido por antipsicoticos con miricorilant. |
MX2022007518A (es) | 2019-12-20 | 2022-09-19 | Pfizer | Derivados bencimidazol. |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3657438A (en) * | 1968-09-27 | 1972-04-18 | Ciba Geigy Corp | Compositions and methods for treating inflammation |
US3657270A (en) * | 1970-01-16 | 1972-04-18 | Parke Davis & Co | 1-phenyl-1h-indazole-4-acetic acids |
US3691180A (en) * | 1970-07-31 | 1972-09-12 | Ciba Geigy Corp | Cycloalkano (c)pyrazoles |
JPS60130521A (ja) | 1983-12-19 | 1985-07-12 | Morishita Seiyaku Kk | 抗癌剤 |
JPS6299361A (ja) | 1985-10-25 | 1987-05-08 | Morishita Seiyaku Kk | インデノ〔1,2−c〕ピラゾ−ル誘導体 |
KR880009024A (ko) | 1987-01-27 | 1988-09-13 | 게리 디.스트리트 | 기관지 확장제용 디피라졸 |
GB8828669D0 (en) | 1988-12-08 | 1989-01-11 | Lilly Industries Ltd | Organic compounds |
GB9718913D0 (en) | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Substituted oxindole derivatives |
JP2001518501A (ja) | 1997-10-06 | 2001-10-16 | ビーエーエスエフ アクチェンゲゼルシャフト | インデノ[1,2−c]−、ナフト[1,2−c]−およびベンゾ[6,7]シクロへプタ[1,2−c]ピラゾール誘導体 |
US6335342B1 (en) | 2000-06-19 | 2002-01-01 | Pharmacia & Upjohn S.P.A. | Azaindole derivatives, process for their preparation, and their use as antitumor agents |
-
1999
- 1999-05-12 GB GBGB9911053.8A patent/GB9911053D0/en not_active Ceased
-
2000
- 2000-05-04 US US09/926,478 patent/US6716856B1/en not_active Expired - Fee Related
- 2000-05-04 CA CA002372429A patent/CA2372429A1/en not_active Abandoned
- 2000-05-04 EP EP00927184A patent/EP1177185B1/en not_active Expired - Lifetime
- 2000-05-04 ES ES00927184T patent/ES2239595T3/es not_active Expired - Lifetime
- 2000-05-04 AU AU45645/00A patent/AU4564500A/en not_active Abandoned
- 2000-05-04 BR BR0010476-0A patent/BR0010476A/pt active Pending
- 2000-05-04 CZ CZ20013970A patent/CZ20013970A3/cs unknown
- 2000-05-04 CN CN00807465A patent/CN1350528A/zh active Pending
- 2000-05-04 MX MXPA01011441A patent/MXPA01011441A/es active IP Right Grant
- 2000-05-04 AT AT00927184T patent/ATE293618T1/de not_active IP Right Cessation
- 2000-05-04 DE DE60019577T patent/DE60019577T2/de not_active Expired - Fee Related
- 2000-05-04 KR KR1020017014383A patent/KR20010113926A/ko not_active Application Discontinuation
- 2000-05-04 NZ NZ514873A patent/NZ514873A/xx unknown
- 2000-05-04 SK SK1571-2001A patent/SK15712001A3/sk not_active Application Discontinuation
- 2000-05-04 EA EA200101194A patent/EA200101194A1/ru unknown
- 2000-05-04 JP JP2000618263A patent/JP2002544271A/ja not_active Withdrawn
- 2000-05-04 PT PT00927184T patent/PT1177185E/pt unknown
- 2000-05-04 HU HU0201225A patent/HUP0201225A3/hu unknown
- 2000-05-04 WO PCT/EP2000/004208 patent/WO2000069846A1/en not_active Application Discontinuation
- 2000-05-04 PL PL00351611A patent/PL351611A1/xx not_active Application Discontinuation
- 2000-05-04 IL IL14610000A patent/IL146100A0/xx unknown
- 2000-05-12 AR ARP000102286A patent/AR023971A1/es unknown
-
2001
- 2001-10-17 ZA ZA200108530A patent/ZA200108530B/xx unknown
- 2001-11-08 NO NO20015477A patent/NO20015477L/no not_active Application Discontinuation
-
2002
- 2002-09-26 HK HK02107036.9A patent/HK1045687A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CN1350528A (zh) | 2002-05-22 |
NO20015477D0 (no) | 2001-11-08 |
HUP0201225A2 (en) | 2002-08-28 |
MXPA01011441A (es) | 2002-10-21 |
EP1177185B1 (en) | 2005-04-20 |
KR20010113926A (ko) | 2001-12-28 |
AU4564500A (en) | 2000-12-05 |
HUP0201225A3 (en) | 2003-11-28 |
GB9911053D0 (en) | 1999-07-14 |
CA2372429A1 (en) | 2000-11-23 |
IL146100A0 (en) | 2002-07-25 |
ZA200108530B (en) | 2003-02-03 |
CZ20013970A3 (cs) | 2002-04-17 |
PT1177185E (pt) | 2005-08-31 |
DE60019577T2 (de) | 2006-03-09 |
WO2000069846A1 (en) | 2000-11-23 |
US6716856B1 (en) | 2004-04-06 |
AR023971A1 (es) | 2002-09-04 |
DE60019577D1 (de) | 2005-05-25 |
SK15712001A3 (sk) | 2002-06-04 |
NO20015477L (no) | 2002-01-11 |
ATE293618T1 (de) | 2005-05-15 |
NZ514873A (en) | 2004-05-28 |
EP1177185A1 (en) | 2002-02-06 |
ES2239595T3 (es) | 2005-10-01 |
BR0010476A (pt) | 2003-07-01 |
JP2002544271A (ja) | 2002-12-24 |
HK1045687A1 (zh) | 2002-12-06 |
PL351611A1 (en) | 2003-05-05 |
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