CU23927B1 - Sal de difumarato de 4-(3-cloro-2-fluoroanilino)-7-metoxi-6-{[1-(n-metilcarbamoilmetil)piperidin-4-il]oxi}quinazolina - Google Patents

Sal de difumarato de 4-(3-cloro-2-fluoroanilino)-7-metoxi-6-{[1-(n-metilcarbamoilmetil)piperidin-4-il]oxi}quinazolina

Info

Publication number
CU23927B1
CU23927B1 CU2010000222A CU20100222A CU23927B1 CU 23927 B1 CU23927 B1 CU 23927B1 CU 2010000222 A CU2010000222 A CU 2010000222A CU 20100222 A CU20100222 A CU 20100222A CU 23927 B1 CU23927 B1 CU 23927B1
Authority
CU
Cuba
Prior art keywords
fluoroanilino
quinazoline
piperidin
chloro
metilcarbamoilmetil
Prior art date
Application number
CU2010000222A
Other languages
English (en)
Other versions
CU20100222A7 (es
Inventor
Kay Alison Boardman
Susan Elizabeth Burns
Andrew Hornby Dobson
Brian Whitlock
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40935682&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU23927(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CU20100222A7 publication Critical patent/CU20100222A7/es
Publication of CU23927B1 publication Critical patent/CU23927B1/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente solicitud se refiere a difumarato de 4-(3-cloro-2-fluoroanilino)-7-metoxi-6-{[1-(N-metilcarbamoilmetil)piperidin-4-il]oxi}quinazolina, donde el 4-(3-cloro-2-fluoroanilino)-7-metoxi-6-{[1-(N-metilcarbamoilmetil)piperidin-4-il]oxi}quinazolina posee la estructura del compuesto (I) ESPACIO PARA LA FÓRMULA la forma A cristalina de dicho difumarato que tiene un patrón de difracción de rayos X en polvo medido usando radiación CuKalfa con al menos un pico específico alrededor de 2-theta = 26.1º, 24.0º, 14.9º, 12.4º o 7.1º y un punto de fusión alrededor de 210ºC; composiciones farmacéuticas que contienen dicho difumarato y procesos para la fabricación de dichos difumaratos.
CU2010000222A 2008-05-13 2010-11-15 Sal de difumarato de 4-(3-cloro-2-fluoroanilino)-7-metoxi-6-{[1-(n-metilcarbamoilmetil)piperidin-4-il]oxi}quinazolina CU23927B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5270608P 2008-05-13 2008-05-13
US11063708P 2008-11-03 2008-11-03
PCT/GB2009/050496 WO2009138781A1 (en) 2008-05-13 2009-05-11 Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- { [1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxy}quinazoline

Publications (2)

Publication Number Publication Date
CU20100222A7 CU20100222A7 (es) 2011-11-15
CU23927B1 true CU23927B1 (es) 2013-07-31

Family

ID=40935682

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2010000222A CU23927B1 (es) 2008-05-13 2010-11-15 Sal de difumarato de 4-(3-cloro-2-fluoroanilino)-7-metoxi-6-{[1-(n-metilcarbamoilmetil)piperidin-4-il]oxi}quinazolina

Country Status (31)

Country Link
US (2) US8088782B2 (es)
EP (1) EP2303276B1 (es)
JP (1) JP5739802B2 (es)
KR (1) KR20110014192A (es)
CN (1) CN102088979B (es)
AR (1) AR071714A1 (es)
AU (1) AU2009247782C1 (es)
BR (1) BRPI0912170A2 (es)
CA (1) CA2723989C (es)
CL (1) CL2009001159A1 (es)
CO (1) CO6321256A2 (es)
CR (1) CR11791A (es)
CU (1) CU23927B1 (es)
DO (1) DOP2010000346A (es)
EA (1) EA019183B1 (es)
EC (1) ECSP10010610A (es)
ES (1) ES2444128T3 (es)
HK (1) HK1152867A1 (es)
HN (1) HN2010002408A (es)
IL (1) IL209199A0 (es)
MX (1) MX2010012442A (es)
MY (1) MY183041A (es)
NI (1) NI201000197A (es)
NZ (1) NZ589883A (es)
PE (1) PE20091970A1 (es)
SA (1) SA109300290B1 (es)
SV (1) SV2010003734A (es)
TW (1) TWI443095B (es)
UY (1) UY31820A (es)
WO (1) WO2009138781A1 (es)
ZA (1) ZA201008283B (es)

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EP2875020B1 (en) * 2012-07-19 2017-09-06 Boehringer Ingelheim International GmbH Process for the preparation of a fumaric acid salt of 9-[4-(3-chloro-2-fluoro-phenylamino)-7-methoxy- chinazolin-6-yloxy]-1,4-diaza-spiro[5.5]undecan-5-one
US10507210B2 (en) * 2014-12-03 2019-12-17 Auckland Uniservices Limited Kinase inhibitor prodrug for the treatment of cancer
WO2019196619A1 (zh) * 2018-04-08 2019-10-17 威尚（上海）生物医药有限公司 喹唑啉衍生物盐型晶型及制备方法和应用
CN109384747A (zh) * 2018-10-26 2019-02-26 苏州立新制药有限公司 吉非替尼相关物质及其制备和检测方法
WO2022170052A1 (en) * 2021-02-05 2022-08-11 Black Diamond Therapeutics, Inc. Quinazoline derivatives, pyridopyrimidine derivatives, pyrimidopyrimidine derivatives, and uses thereof

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CA2723989C (en) 2017-04-25
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