CS273610B2 - Method of silibinene's new derivatives production - Google Patents

Method of silibinene's new derivatives production Download PDF

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Publication number
CS273610B2
CS273610B2 CS837885A CS837885A CS273610B2 CS 273610 B2 CS273610 B2 CS 273610B2 CS 837885 A CS837885 A CS 837885A CS 837885 A CS837885 A CS 837885A CS 273610 B2 CS273610 B2 CS 273610B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
alk
silibinin
independently
ethyl acetate
Prior art date
Application number
CS837885A
Other languages
Czech (cs)
English (en)
Other versions
CS837885A2 (en
Inventor
Reinhard Dr Braatz
Klaus Dr Gorler
Gunter Dr Halbach
Hartwig Dr Soicke
Karlheinz Prof Dr Dr Schmidt
Original Assignee
Madaus Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Madaus Ag filed Critical Madaus Ag
Publication of CS837885A2 publication Critical patent/CS837885A2/cs
Publication of CS273610B2 publication Critical patent/CS273610B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
CS837885A 1984-11-22 1985-11-20 Method of silibinene's new derivatives production CS273610B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843442639 DE3442639A1 (de) 1984-11-22 1984-11-22 Flavolignanderivate, verfahren zu deren herstellung und arzneimittel, die diese verbindungen enthalten

Publications (2)

Publication Number Publication Date
CS837885A2 CS837885A2 (en) 1990-08-14
CS273610B2 true CS273610B2 (en) 1991-03-12

Family

ID=6250903

Family Applications (1)

Application Number Title Priority Date Filing Date
CS837885A CS273610B2 (en) 1984-11-22 1985-11-20 Method of silibinene's new derivatives production

Country Status (29)

Country Link
JP (1) JPS61143377A (hu)
KR (1) KR870001020B1 (hu)
AR (1) AR240931A1 (hu)
AT (1) AT393268B (hu)
BE (1) BE903693A (hu)
CA (1) CA1337124C (hu)
CH (1) CH659473A5 (hu)
CS (1) CS273610B2 (hu)
DD (1) DD259191A1 (hu)
DE (1) DE3442639A1 (hu)
DK (1) DK164865C (hu)
EG (1) EG19424A (hu)
ES (1) ES8609311A1 (hu)
FI (1) FI84064C (hu)
FR (1) FR2573427B1 (hu)
GB (1) GB2167414B (hu)
HU (1) HU195503B (hu)
IE (1) IE58791B1 (hu)
IT (1) IT1190426B (hu)
LU (1) LU86163A1 (hu)
MX (1) MX168415B (hu)
NL (1) NL192387C (hu)
NO (1) NO160205C (hu)
PL (1) PL146890B1 (hu)
PT (1) PT81532B (hu)
SE (1) SE465676B (hu)
SU (1) SU1436875A3 (hu)
YU (1) YU43689B (hu)
ZA (1) ZA858951B (hu)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8716918D0 (en) * 1987-07-17 1987-08-26 Inverni Della Beffa Spa Soluble derivatives of silybin
US5262439A (en) * 1992-04-30 1993-11-16 The Regents Of The University Of California Soluble analogs of probucol
EP1856085B1 (en) * 2005-03-11 2015-07-08 Howard Florey Institute Pty Ltd Flavonoid compounds and uses thereof
EP2219642B1 (en) * 2007-11-15 2011-09-21 Madaus GmbH Silibinin component for the treatment of hepatitis
RU2482844C2 (ru) * 2007-11-15 2013-05-27 Мадаус Гмбх Силибининовый компонент для лечения гепатита
EP2430017B1 (en) 2009-05-14 2016-06-29 Madaus GmbH A method for preparing AMORPHOUS SILIBININ
CN108355136B (zh) 2012-07-05 2021-12-07 纽崔玛氏科技有限责任公司 包含莱菔硫烷或莱菔硫烷前体和蕈类提取物或粉末的组合物
CN103193768B (zh) * 2013-02-22 2016-03-30 西安安健药业有限公司 治疗肝病的水飞蓟宾二偏琥珀酸酯异构体
CN103172622B (zh) * 2013-02-22 2015-11-04 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯的活性异构体
CN103113359B (zh) * 2013-02-22 2016-01-06 西安安健药业有限公司 水飞蓟宾二偏琥珀酸酯及其药用盐

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1963318A1 (de) * 1969-12-17 1971-06-24 Schwabe Willmar Gmbh & Co Silybinhalbester der Bernsteinsaeure und der Phthalsaeure,ihre Salze mit pharmakologisch vertraglichen Basen,Verfahren zu ihrer Herstellung und ihre Verwendung zur Herstellung von Arzneipraeparaten

Also Published As

Publication number Publication date
MX168415B (es) 1993-05-24
FR2573427B1 (fr) 1989-03-10
FI84064B (fi) 1991-06-28
ZA858951B (en) 1986-08-27
NL8503171A (nl) 1986-06-16
FR2573427A1 (fr) 1986-05-23
IE58791B1 (en) 1993-11-17
JPS61143377A (ja) 1986-07-01
LU86163A1 (de) 1986-03-24
AR240931A1 (es) 1991-03-27
DE3442639A1 (de) 1986-05-22
ATA337185A (de) 1991-02-15
EG19424A (en) 1995-02-28
HU195503B (en) 1988-05-30
SE8505487L (sv) 1986-05-23
YU43689B (en) 1989-10-31
PL146890B1 (en) 1989-03-31
SE465676B (sv) 1991-10-14
FI854535A (fi) 1986-05-23
NO160205B (no) 1988-12-12
PT81532B (pt) 1987-11-11
IT8522932A0 (it) 1985-11-21
DK164865C (da) 1993-01-18
PT81532A (de) 1985-12-01
NO854655L (no) 1986-05-23
DK164865B (da) 1992-08-31
YU178685A (en) 1988-02-29
NO160205C (no) 1989-03-22
FI854535A0 (fi) 1985-11-18
ES8609311A1 (es) 1986-09-01
PL256374A1 (en) 1986-12-02
DK537785D0 (da) 1985-11-21
BE903693A (fr) 1986-05-22
DK537785A (da) 1986-05-23
CS837885A2 (en) 1990-08-14
NL192387B (nl) 1997-03-03
GB8528226D0 (en) 1985-12-18
DD259191A1 (de) 1988-08-17
GB2167414B (en) 1989-01-11
SU1436875A3 (ru) 1988-11-07
IE852808L (en) 1986-05-22
CH659473A5 (de) 1987-01-30
AT393268B (de) 1991-09-25
KR860004056A (ko) 1986-06-16
GB2167414A (en) 1986-05-29
CA1337124C (en) 1995-09-26
HUT40114A (en) 1986-11-28
DE3442639C2 (hu) 1989-08-10
NL192387C (nl) 1997-07-04
SE8505487D0 (sv) 1985-11-20
ES549116A0 (es) 1986-09-01
JPH0432073B2 (hu) 1992-05-28
IT1190426B (it) 1988-02-16
FI84064C (fi) 1991-10-10
KR870001020B1 (ko) 1987-05-23
AR240931A2 (es) 1991-03-27

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