CS257276B2 - Production method substituted 3,4-diamino-1,2,5thiadiazoles - Google Patents

Production method substituted 3,4-diamino-1,2,5thiadiazoles Download PDF

Info

Publication number
CS257276B2
CS257276B2 CS854247A CS424785A CS257276B2 CS 257276 B2 CS257276 B2 CS 257276B2 CS 854247 A CS854247 A CS 854247A CS 424785 A CS424785 A CS 424785A CS 257276 B2 CS257276 B2 CS 257276B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
compound
compounds
reaction
acid
Prior art date
Application number
CS854247A
Other languages
Czech (cs)
English (en)
Other versions
CS424785A2 (en
Inventor
Aldo A Algieri
Ronnie R Crenshaw
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to CS864232A priority Critical patent/CS257287B2/cs
Publication of CS424785A2 publication Critical patent/CS424785A2/cs
Publication of CS257276B2 publication Critical patent/CS257276B2/cs

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D285/00Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01Five-membered rings
    • C07D285/02Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/101,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/44Acylated amino or imino radicals
    • C07D277/48Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CS854247A 1984-06-22 1985-06-12 Production method substituted 3,4-diamino-1,2,5thiadiazoles CS257276B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS864232A CS257287B2 (cs) 1984-06-22 1985-06-12 Způsob výroby N-/2-[2-guanidinothiazol-4-yl)mathylthioJethyl/ethandiimidamidů

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/623,588 US4644006A (en) 1984-06-22 1984-06-22 Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity

Publications (2)

Publication Number Publication Date
CS424785A2 CS424785A2 (en) 1987-09-17
CS257276B2 true CS257276B2 (en) 1988-04-15

Family

ID=24498651

Family Applications (1)

Application Number Title Priority Date Filing Date
CS854247A CS257276B2 (en) 1984-06-22 1985-06-12 Production method substituted 3,4-diamino-1,2,5thiadiazoles

Country Status (33)

Country Link
US (1) US4644006A (sh)
JP (2) JPS6118775A (sh)
KR (1) KR900004321B1 (sh)
AR (1) AR240935A1 (sh)
AT (1) AT390790B (sh)
AU (2) AU580605B2 (sh)
BE (1) BE902724A (sh)
CA (2) CA1267412A (sh)
CH (1) CH665210A5 (sh)
CS (1) CS257276B2 (sh)
DD (1) DD240889A5 (sh)
DE (1) DE3522101A1 (sh)
DK (1) DK282885A (sh)
ES (2) ES8702902A1 (sh)
FI (1) FI852405L (sh)
FR (1) FR2566406B1 (sh)
GB (2) GB2161157B (sh)
GR (1) GR851514B (sh)
HU (1) HU193992B (sh)
IE (2) IE58261B1 (sh)
IL (1) IL75567A0 (sh)
IT (1) IT1190372B (sh)
LU (1) LU85969A1 (sh)
NL (1) NL8501766A (sh)
NO (1) NO161856C (sh)
NZ (1) NZ212403A (sh)
OA (1) OA08039A (sh)
PT (1) PT80684B (sh)
SE (1) SE464305B (sh)
SU (1) SU1537136A3 (sh)
YU (2) YU45725B (sh)
ZA (1) ZA854710B (sh)
ZW (1) ZW10385A1 (sh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0535227A4 (en) * 1990-05-29 1993-08-18 Nippon Soda Co., Ltd. N-substituted heterocyclic amidine derivative
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3657237A (en) * 1968-05-22 1972-04-18 Frosst & Co Charles E Process for making 1 2 5-thiadiazoles in the sinister configuration
DK160611C (da) * 1979-09-04 1991-09-16 Bristol Myers Squibb Co Analogifremgangsmaade til fremstilling af 3,4-disubstituerede 1,2,5-thiadiazol-1-oxider og -1,1-dioxider
DE3175201D1 (en) * 1980-04-30 1986-10-02 Merck & Co Inc Aminothiadiazoles as gastric secretion inhibitors
US4394508A (en) * 1980-06-07 1983-07-19 Bristol-Myers Company Chemical compounds
EP0045155B1 (en) * 1980-07-30 1985-01-02 Imperial Chemical Industries Plc Guanidine derivatives
EP0060730A3 (en) * 1981-03-18 1982-12-08 Imperial Chemical Industries Plc Bicyclic derivatives
EP0065823A1 (en) * 1981-05-13 1982-12-01 Imperial Chemical Industries Plc Heterocyclic guanidines as histamine H-2 antagonists
US4528377A (en) * 1982-03-29 1985-07-09 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
FR2542741B1 (fr) * 1982-03-29 1989-12-08 Bristol Myers Co 3,4-diamino-1,2,5-thiadiazoles substitues possedant une activite antagoniste du recepteur-h2 de l'histamine
US4528378A (en) * 1982-03-29 1985-07-09 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4528375A (en) * 1982-03-29 1985-07-09 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4588826A (en) * 1982-03-29 1986-05-13 Bristol-Myers Company Ethanediimidamide intermediates
US4517366A (en) * 1982-03-29 1985-05-14 Bristol-Myers Company Intermediates for preparing 3,4-diamino-1,2,5-thiadiazoles
FI832519L (fi) * 1982-07-12 1984-01-13 Bristol Myers Co Farmaceutiska foerfaranden och sammansaettningar
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
JPS5978171A (ja) * 1982-10-26 1984-05-04 Ikeda Mohandou:Kk 複素環式化合物
US4440933A (en) * 1983-03-16 1984-04-03 Bristol-Myers Company Process for preparing 1,2,5-thiadiazoles

Also Published As

Publication number Publication date
SE464305B (sv) 1991-04-08
AU2977589A (en) 1989-06-01
NO852519L (no) 1985-12-23
IE58261B1 (en) 1993-08-25
ES8702902A1 (es) 1987-01-16
AR240935A1 (es) 1991-03-27
HU193992B (en) 1987-12-28
YU102587A (en) 1988-02-29
LU85969A1 (fr) 1986-01-24
GB8515749D0 (en) 1985-07-24
DD240889A5 (de) 1986-11-19
GB2192884A (en) 1988-01-27
US4644006A (en) 1987-02-17
KR900004321B1 (ko) 1990-06-22
FI852405A0 (fi) 1985-06-17
ES8702881A1 (es) 1987-01-16
ES551506A0 (es) 1987-01-16
CH665210A5 (de) 1988-04-29
IE851557L (en) 1985-12-22
SU1537136A3 (ru) 1990-01-15
HUT42087A (en) 1987-06-29
PT80684A (en) 1985-07-01
IE57937B1 (en) 1993-05-19
AU580605B2 (en) 1989-01-19
YU105185A (en) 1987-12-31
YU45822B (sh) 1992-07-20
NO161856B (no) 1989-06-26
DK282885A (da) 1985-12-23
PT80684B (en) 1987-05-08
IT1190372B (it) 1988-02-16
CA1267412A (en) 1990-04-03
AT390790B (de) 1990-06-25
SE8503110L (sv) 1985-12-23
IT8521217A0 (it) 1985-06-20
ZA854710B (en) 1986-02-26
SE8503110D0 (sv) 1985-06-20
FR2566406B1 (fr) 1988-01-29
BE902724A (fr) 1985-12-23
ZW10385A1 (en) 1986-02-05
ATA185885A (de) 1989-12-15
DK282885D0 (da) 1985-06-21
NZ212403A (en) 1989-04-26
DE3522101A1 (de) 1986-01-02
JPS61186369A (ja) 1986-08-20
CS424785A2 (en) 1987-09-17
NL8501766A (nl) 1986-01-16
NO161856C (no) 1989-10-04
KR860000275A (ko) 1986-01-27
GB2192884B (en) 1988-08-10
AR240935A2 (es) 1991-03-27
FI852405L (fi) 1985-12-23
GR851514B (sh) 1985-11-25
IL75567A0 (en) 1985-10-31
AU614331B2 (en) 1991-08-29
CA1297875C (en) 1992-03-24
GB2161157A (en) 1986-01-08
GB2161157B (en) 1988-08-10
ES544409A0 (es) 1987-01-16
GB8716149D0 (en) 1987-08-12
FR2566406A1 (fr) 1985-12-27
AU4392085A (en) 1986-01-02
JPS6118775A (ja) 1986-01-27
OA08039A (fr) 1987-01-31
YU45725B (sh) 1992-07-20

Similar Documents

Publication Publication Date Title
US4639523A (en) Aminoalkylphenoxy derivatives
FI78695B (fi) Foerfarande foer framstaellning av nya terapeutiskt anvaendbara 1,2-diaminocyklobuten-3,4-dionderivat.
SU1400508A3 (ru) Способ получени производных арилтиазолов
JPS6028819B2 (ja) 新規なるグアニジン誘導体の製造方法
JP2502343B2 (ja) 薬学的に活性な置換ベンズアミド
JPH0233031B2 (sh)
KR840001075B1 (ko) 티아졸 유도체의 제조방법
US4210658A (en) Amidinosulphonic acid derivatives
CS241072B2 (en) Method of 3-/(amino or subst,amino/)-4-/(subst.amino/)-1,2,5-thiadizoles production
HU181408B (en) Process for preparing substituted furan derivatives
US4692531A (en) Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
CS257276B2 (en) Production method substituted 3,4-diamino-1,2,5thiadiazoles
HU182645B (en) Process for preparing n-cyano-n'-2-//4-methyl-5-imidazolyl/-methyl-thio/-ethyl-n''-alkinyl-guanidine
EP0189307B1 (en) Antihistamine-h2 alkyne thiadiazole derivatives
CS244145B2 (en) Method of 4,5,6,7-tetrahydrothiazolo-(5,4-c)pyridine derivatives production
KR880002209B1 (ko) 치환된 3,4-디아미노-1,2,5-티아디아졸류 및 그의 제조방법
GB1598628A (en) Guanidine derivatives
US4200760A (en) Imidazolylalkylthioalkylamino-ethylene derivatives
US4543352A (en) Naphthalene aminoalkylene ethers and thioethers, and their pharmaceutical uses
JPH0680041B2 (ja) 2−ピリジル酢酸誘導体、その製法およびそれを含む医薬
JPH0572386B2 (sh)
CA1297107C (en) Process for the preparation of new 2-(2-thienyl)- imidazo(4,5-c)pyridine derivatives and pharmaceutically usable acid addition salts thereof
KR810000632B1 (ko) 히스타민 h₂수용기 길항제 또는 비독성인 그의 약조제 가능한 산 첨가염의 제조방법
KR880002530B1 (ko) 치환된 에탄디이미드 아미드 및 그의 제조방법
JPH034068B2 (sh)