CS249124B2 - Method of benzimidazole's derivatives production - Google Patents

Method of benzimidazole's derivatives production Download PDF

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Publication number
CS249124B2
CS249124B2 CS826004A CS600482A CS249124B2 CS 249124 B2 CS249124 B2 CS 249124B2 CS 826004 A CS826004 A CS 826004A CS 600482 A CS600482 A CS 600482A CS 249124 B2 CS249124 B2 CS 249124B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
group
снз
och
hydrogen
Prior art date
Application number
CS826004A
Other languages
Czech (cs)
English (en)
Inventor
Enar I Carlsson
Hakan S Larsson
Wittken Sundell Gunhild Wi Von
Ulf K Junggren
Original Assignee
Haessle Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haessle Ab filed Critical Haessle Ab
Publication of CS249124B2 publication Critical patent/CS249124B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CS826004A 1981-08-13 1982-08-13 Method of benzimidazole's derivatives production CS249124B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8104811 1981-08-13

Publications (1)

Publication Number Publication Date
CS249124B2 true CS249124B2 (en) 1987-03-12

Family

ID=20344360

Family Applications (1)

Application Number Title Priority Date Filing Date
CS826004A CS249124B2 (en) 1981-08-13 1982-08-13 Method of benzimidazole's derivatives production

Country Status (27)

Country Link
US (1) US4746667A (is)
EP (1) EP0074341B1 (is)
JP (1) JPS5839622A (is)
KR (1) KR880001714B1 (is)
AT (1) ATE18765T1 (is)
AU (1) AU556736B2 (is)
CA (1) CA1226223A (is)
CS (1) CS249124B2 (is)
CY (1) CY1450A (is)
DD (1) DD202876A5 (is)
DE (1) DE3270116D1 (is)
DK (1) DK362482A (is)
ES (3) ES8401482A1 (is)
FI (1) FI822813L (is)
GR (1) GR76267B (is)
HK (1) HK2189A (is)
HU (1) HU190408B (is)
IE (1) IE54215B1 (is)
IL (1) IL66340A (is)
IS (1) IS1360B6 (is)
MY (1) MY8700139A (is)
NO (1) NO822686L (is)
NZ (1) NZ201538A (is)
OA (1) OA07182A (is)
PH (1) PH18635A (is)
PT (1) PT75420B (is)
ZA (1) ZA825106B (is)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects
DE3216843C2 (de) * 1982-05-05 1986-10-23 Ludwig Heumann & Co GmbH, 8500 Nürnberg 3-Thiomethyl-pyridin-Derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
HU195220B (en) * 1983-05-03 1988-04-28 Byk Gulden Lomberg Chem Fqb Process for production of new fluor-alkoxi-benzimidasole-derivatives and medical compositions containig them
CA1259070A (en) * 1983-07-01 1989-09-05 Upjohn Company (The) Substituted 2-¬monoannelated(3,4-,4,5-, and 5,6-)- pyridylalkylenesulfinyl|-benzimidazoles
US4575554A (en) * 1983-12-05 1986-03-11 The Upjohn Company Substituted 2-pyridylmethylthio- and sulfinyl-benzimidazoles as gastric antisecretory agents
IL75400A (en) * 1984-06-16 1988-10-31 Byk Gulden Lomberg Chem Fab Dialkoxypyridine methyl(sulfinyl or sulfonyl)benzimidazoles,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8404065D0 (sv) * 1984-08-10 1984-08-10 Haessle Ab Novel biologically active compounds
JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
JPS6150979A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
AU568441B2 (en) * 1984-09-24 1987-12-24 Upjohn Company, The 2-(pyridylalkenesulfinyl) benzimidazole derivatives
JO1406B1 (en) * 1984-11-02 1986-11-30 سميث كلاين اند فرينش لابوراتوريز ليمتد Chemical compounds
GB8526154D0 (en) * 1985-02-06 1985-11-27 Kotobuki Seiyaku Co Ltd 2-substituted cyclo-heptoimidazoles
US4738975A (en) * 1985-07-02 1988-04-19 Takeda Chemical Industries, Ltd. Pyridine derivatives, and use as anti-ulcer agents
AR243167A1 (es) * 1985-08-24 1993-07-30 Hoechst Ag Procedimiento para la preparacion de toluidinas sustituidas.
EP0786461A1 (en) * 1986-11-13 1997-07-30 Eisai Co., Ltd. Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same
FI90544C (fi) * 1986-11-13 1994-02-25 Eisai Co Ltd Menetelmä lääkeaineina käyttökelpoisten 2-pyridin-2-yyli-metyylitio- ja sulfinyyli-1H-bensimidatsolijohdannaisten valmistamiseksi
FI96860C (fi) * 1987-06-17 1996-09-10 Eisai Co Ltd Analogiamenetelmä lääkeaineena käytettävän pyridiinijohdannaisen valmistamiseksi
JP2718945B2 (ja) * 1987-06-17 1998-02-25 エーザイ株式会社 ピリジン誘導体及びそれを含有する潰瘍治療剤
US5223515A (en) * 1988-08-18 1993-06-29 Takeda Chemical Industries, Ltd. Injectable solution containing a pyridyl methylsulfinylbenzimidazole
AT394368B (de) * 1990-08-07 1992-03-25 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von 3,4-dialkoxypyridinen
WO1993024480A1 (en) * 1992-06-01 1993-12-09 Yoshitomi Pharmaceutical Industries, Ltd. Pyridine compound and medicinal use thereof
US5504082A (en) * 1992-06-01 1996-04-02 Yoshitomi Pharmaceutical Industries, Ltd. Pyridine compound and pharmaceutical compostions
US5387600A (en) * 1992-07-30 1995-02-07 Fuji Photo Film Co., Ltd. Treating arteriosclerosis using benzimidazole compositions
EP0729957A4 (en) * 1993-10-29 1996-12-27 Yoshitomi Pharmaceutical PYRIDINE COMPOUND AND ITS USE AS A REMEDY
JP3559045B2 (ja) * 1994-06-10 2004-08-25 ナウチノ−イススレドバテルスキ インスティテュト ファルマコロギイ ロスシイスコイ アカデミイ メディツィンスキフ ナウク 薬理学的活性を有する２−メルカプトベンズイミダゾール誘導体
US7230014B1 (en) 1997-10-14 2007-06-12 Eisai Co., Ltd. Pharmaceutical formulation comprising glycine as a stabilizer
US6245913B1 (en) 1999-06-30 2001-06-12 Wockhardt Europe Limited Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole
DE10140492A1 (de) 2001-08-17 2003-08-14 Gruenenthal Gmbh Hydrate von gegebenenfalls substituierten 2-(2-Pyridinyl)methylthio-1H-benzimidazolen und Verfahren zu ihrer Herstellung
EP1790647B1 (en) 2004-09-13 2013-05-08 Takeda Pharmaceutical Company Limited Method for producing oxidized compound
RU2433126C2 (ru) 2006-03-10 2011-11-10 Ариджен Фармасьютикалз, Инк. Новые производные пиридина, обладающие анти-helicobacter pylori активностью
MX2009004475A (es) 2006-10-27 2009-08-12 Univ Missouri Composiciones que comprenden agentes acido labiles que inhiben la bomba de protones, por lo menos otro agente farmaceuticamente activo y metodos de uso de las misma.
SI2103608T1 (sl) 2006-12-18 2012-12-31 Arigen Pharmaceuticals, Inc. Sredstvo za eradikacijo Helicobacterja pylori z inhibitorno aktivnostjo za izločanje želoldčne kisline
EP2252274A4 (en) 2008-02-20 2011-05-11 Univ Missouri COMPOSITION COMPRISING A COMBINATION OF OMEPRAZOLE AND LANSOPRAZOLE, AND A BUFFER AGENT, AND METHODS OF USING THE SAME
EP2420500A4 (en) * 2009-04-09 2012-09-05 Arigen Pharmaceuticals Inc PYRIDINTHIODERIVATE AND PHARMACEUTICAL COMPOSITION THEREOF AND WITH ANTI-HELIDOBACTER PYLORI EFFECT
AU2013267022B2 (en) * 2010-01-06 2016-04-21 Elc Management Llc Skin lightening compositions
US8992897B2 (en) * 2010-01-06 2015-03-31 Elc Management Llc Skin lightening compositions
US8722026B2 (en) 2010-01-06 2014-05-13 Elc Management, Llc Skin lightening compositions
IL307576A (en) * 2016-09-14 2023-12-01 Yufeng Jane Tseng Novel mutated benzimidazoles as D-amino acid oxidase (DAAO) inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7112208A (is) * 1971-09-04 1973-03-06
SE418966B (sv) * 1974-02-18 1981-07-06 Haessle Ab Analogiforfarande for framstellning av foreningar med magsyrasekretionsinhiberande verkan
SE416649B (sv) * 1974-05-16 1981-01-26 Haessle Ab Forfarande for framstellning av foreningar som paverkar magsyrasekretionen
IN148930B (is) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4359465A (en) * 1980-07-28 1982-11-16 The Upjohn Company Methods for treating gastrointestinal inflammation
CH644116A5 (de) * 1980-08-21 1984-07-13 Hoffmann La Roche Imidazolderivate.
US4472409A (en) * 1981-11-05 1984-09-18 Byk Gulden Lomberg Chemische Fabrik Gesellschaft Mit Beschrankter Haftung 2-Pyridylmethyl thio(sulfinyl)benzimidazoles with gastric acid secretion inhibiting effects

Also Published As

Publication number Publication date
ES514947A0 (es) 1983-12-16
EP0074341A1 (en) 1983-03-16
HU190408B (en) 1986-09-29
FI822813A0 (fi) 1982-08-12
ES8401482A1 (es) 1983-12-16
ES8502109A1 (es) 1984-12-16
MY8700139A (en) 1987-12-31
AU8697882A (en) 1983-02-17
IE54215B1 (en) 1989-07-19
KR880001714B1 (ko) 1988-09-08
CY1450A (en) 1989-03-10
CA1226223A (en) 1987-09-01
AU556736B2 (en) 1986-11-20
PT75420B (en) 1986-12-09
PT75420A (en) 1982-09-01
IS1360B6 (is) 1989-05-25
JPS5839622A (ja) 1983-03-08
EP0074341B1 (en) 1986-03-26
NZ201538A (en) 1985-12-13
GR76267B (is) 1984-08-04
NO822686L (no) 1983-02-14
FI822813L (fi) 1983-02-14
ES8500265A1 (es) 1984-10-01
IL66340A (en) 1986-08-31
DK362482A (da) 1983-02-14
US4746667A (en) 1988-05-24
OA07182A (fr) 1984-04-30
IE821940L (en) 1983-02-13
IS2749A7 (is) 1983-02-14
ZA825106B (en) 1983-04-27
ES523344A0 (es) 1984-10-01
DE3270116D1 (en) 1986-04-30
KR840001156A (ko) 1984-03-28
JPH0313203B2 (is) 1991-02-22
HK2189A (en) 1989-01-20
DD202876A5 (de) 1983-10-05
ES532044A0 (es) 1984-12-16
ATE18765T1 (de) 1986-04-15
PH18635A (en) 1985-08-23
IL66340A0 (en) 1982-11-30

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