CS248731B2 - Production method of the phenyl dihydropyridazinon derivatives - Google Patents
Production method of the phenyl dihydropyridazinon derivatives Download PDFInfo
- Publication number
- CS248731B2 CS248731B2 CS85202A CS20285A CS248731B2 CS 248731 B2 CS248731 B2 CS 248731B2 CS 85202 A CS85202 A CS 85202A CS 20285 A CS20285 A CS 20285A CS 248731 B2 CS248731 B2 CS 248731B2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- methyl
- compounds
- formula
- phenyl
- dihydro
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/28—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/04—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having less than three double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Saccharide Compounds (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB848400863A GB8400863D0 (en) | 1984-01-13 | 1984-01-13 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CS248731B2 true CS248731B2 (en) | 1987-02-12 |
Family
ID=10554924
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS85202A CS248731B2 (en) | 1984-01-13 | 1985-01-10 | Production method of the phenyl dihydropyridazinon derivatives |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US4654342A (pt) |
| EP (1) | EP0150937B1 (pt) |
| JP (3) | JPS60158181A (pt) |
| KR (1) | KR920006781B1 (pt) |
| CN (1) | CN85101722A (pt) |
| AT (1) | ATE37179T1 (pt) |
| AU (1) | AU572252B2 (pt) |
| CA (2) | CA1251209A (pt) |
| CS (1) | CS248731B2 (pt) |
| DD (1) | DD231350A5 (pt) |
| DE (1) | DE3564941D1 (pt) |
| DK (1) | DK162519C (pt) |
| ES (3) | ES8607949A1 (pt) |
| FI (1) | FI850140A7 (pt) |
| GB (1) | GB8400863D0 (pt) |
| GR (1) | GR850068B (pt) |
| HU (1) | HU193591B (pt) |
| IE (1) | IE57969B1 (pt) |
| IL (1) | IL74031A (pt) |
| JO (1) | JO1351B1 (pt) |
| MY (1) | MY100124A (pt) |
| NO (1) | NO850129L (pt) |
| NZ (1) | NZ210816A (pt) |
| PH (1) | PH22136A (pt) |
| PL (1) | PL147123B1 (pt) |
| PT (1) | PT79819B (pt) |
| RO (1) | RO92607A (pt) |
| SU (1) | SU1396963A3 (pt) |
| WO (1) | WO1985003076A1 (pt) |
| ZA (1) | ZA85251B (pt) |
| ZW (1) | ZW385A1 (pt) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1251448A (en) * | 1985-03-27 | 1989-03-21 | William J. Coates | Pyridazinone derivatives |
| AU581324B2 (en) * | 1985-07-05 | 1989-02-16 | Smith Kline & French Laboratories Limited | Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones |
| GB8603780D0 (en) * | 1986-02-15 | 1986-03-19 | Smith Kline French Lab | Chemical compounds |
| GB8722776D0 (en) * | 1987-09-28 | 1987-11-04 | Smith Kline French Lab | Chemical compounds |
| US5011837A (en) * | 1988-08-09 | 1991-04-30 | E. R. Squibb & Sons, Inc. | Aryl cyanoguanidines: potassium channel activators and method of making same |
| NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
| US6562821B2 (en) | 2001-02-27 | 2003-05-13 | Mitokor | Aryl-N-cyanoguanidines and methods related thereto |
| BR0213683A (pt) * | 2001-11-05 | 2004-10-26 | Merck Patent Gmbh | Hidrazono-malonitrilas |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| DE102004011512B4 (de) | 2004-03-08 | 2022-01-13 | Boehringer Ingelheim Vetmedica Gmbh | Pharmazeutische Zubereitung enthaltend Pimobendan |
| US8980894B2 (en) * | 2004-03-25 | 2015-03-17 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the treatment of asymptomatic (occult) heart failure |
| EP1579862A1 (en) * | 2004-03-25 | 2005-09-28 | Boehringer Ingelheim Vetmedica Gmbh | Use of PDE III inhibitors for the reduction of heart size in mammals suffering from heart failure |
| BRPI0618643A2 (pt) | 2005-11-09 | 2011-09-06 | Combinatorx Inc | composição compreendendo um par de fármacos, composição compreendendo um corticosteróide e um imunossupressor dependente de imunofilina não-esteróide, kits e uso |
| EP1951227B1 (en) * | 2005-11-14 | 2017-04-12 | Boehringer Ingelheim Vetmedica GmbH | Use of pimobendan for the treatment of asymptomatic (occult) heart failure |
| EP1920785A1 (en) * | 2006-11-07 | 2008-05-14 | Boehringer Ingelheim Vetmedica Gmbh | Liquid preparation comprising a complex of pimobendan and cyclodextrin |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US7879802B2 (en) | 2007-06-04 | 2011-02-01 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| AU2009256157B2 (en) | 2008-06-04 | 2014-12-18 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| JP2011528375A (ja) | 2008-07-16 | 2011-11-17 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
| DK2370070T3 (da) | 2008-11-25 | 2013-12-02 | Boehringer Ingelheim Vetmed | Pimobendan til anvendelse i behandling af hypertrofisk cardiomyopati hos katte |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CA3100941C (en) | 2011-03-01 | 2024-03-05 | Synergy Pharmaceuticals Inc. | Process of preparing guanylate cyclase c agonists |
| US20150119399A1 (en) | 2012-01-10 | 2015-04-30 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| EP2825159B1 (en) | 2012-03-15 | 2022-06-22 | Boehringer Ingelheim Vetmedica GmbH | Pharmaceutical tablet formulation for the veterinary medical sector, method of production and use thereof |
| JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
| AU2014274812B2 (en) | 2013-06-05 | 2018-09-27 | Bausch Health Ireland Limited | Ultra-pure agonists of guanylate cyclase C, method of making and using same |
| SI3865120T1 (sl) | 2013-07-19 | 2025-12-31 | Boehringer Ingelheim Vetmedica Gmbh | Konzervirani eterificirani derivati ciklodekstrina, ki vsebujejo tekoč vodni farmacevtski sestavek |
| AU2014305843B2 (en) | 2013-08-09 | 2019-08-29 | Ardelyx, Inc. | Compounds and methods for inhibiting phosphate transport |
| BR112016011111B1 (pt) | 2013-12-04 | 2022-11-16 | Boehringer Ingelheim Vetmedica Gmbh | Composições farmacêuticas aprimoradas de pimobendan |
| CN104987310A (zh) * | 2015-06-03 | 2015-10-21 | 青岛农业大学 | 左西孟旦的合成工艺 |
| US10537570B2 (en) | 2016-04-06 | 2020-01-21 | Boehringer Ingelheim Vetmedica Gmbh | Use of pimobendan for the reduction of heart size and/or the delay of onset of clinical symptoms in patients with asymptomatic heart failure due to mitral valve disease |
| CN110117257B (zh) * | 2018-02-05 | 2022-12-06 | 安徽省新星药物开发有限责任公司 | 一种含胍基的p2y12受体拮抗剂、制备方法及其用途 |
| CN114340631A (zh) | 2019-05-21 | 2022-04-12 | 阿德利克斯股份有限公司 | 用于降低患者的血清磷酸盐的组合 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3822260A (en) * | 1970-10-09 | 1974-07-02 | American Cyanamid Co | 6-(cyanophenyl)-4,5-dihydro-3(2h)-pyridazinones |
| BE791539A (fr) * | 1971-11-19 | 1973-05-17 | Basf Ag | Dihydropyridazones, leur preparation et leurs utilisations therapeutiques |
| EP0030835B1 (en) * | 1979-12-05 | 1983-05-11 | Morishita Pharmaceutical Co. Ltd. | Derivatives of 2-substituted-6-phenyl-3(2h)pyridazinone, their production and pharmaceutical compositions containing them |
| FI72718C (fi) * | 1981-03-04 | 1987-07-10 | Ciba Geigy Ag | Foerfarande foer framstaellning av terapeutiskt verkande, substituerade 6-(4-morfolino-fenyl)-4,5-dihydro- 3(2h)-pyridazinoner och deras syraadditionssalter. |
| JPS58113180A (ja) * | 1981-12-28 | 1983-07-05 | Mitsui Toatsu Chem Inc | ピリダジノン誘導体 |
| DE3204375C2 (de) * | 1982-02-09 | 1983-12-01 | J. Rettenmaier & Söhne GmbH + Co, 7091 Holzmühle | Verfahren zur Herabsetzung der Saugfähigkeit von Holz |
| JPS58140076A (ja) * | 1982-02-09 | 1983-08-19 | Mitsubishi Chem Ind Ltd | ピリダジノン誘導体又はその塩類 |
| DE3302021A1 (de) * | 1983-01-22 | 1984-07-26 | Basf Ag, 6700 Ludwigshafen | 6-aryl-4,5-dihydro-3(2h)-pyridazinone, ihre herstellung und verwendung |
| AU581324B2 (en) * | 1985-07-05 | 1989-02-16 | Smith Kline & French Laboratories Limited | Substituted 6-phenyl-4,5-dihydro pyradazin-3-ones |
-
1984
- 1984-01-13 GB GB848400863A patent/GB8400863D0/en active Pending
-
1985
- 1985-01-02 JO JO19851351A patent/JO1351B1/en active
- 1985-01-07 ZW ZW3/85A patent/ZW385A1/xx unknown
- 1985-01-07 CA CA000471594A patent/CA1251209A/en not_active Expired
- 1985-01-08 DK DK009185A patent/DK162519C/da not_active IP Right Cessation
- 1985-01-09 PH PH31697A patent/PH22136A/en unknown
- 1985-01-10 IL IL74031A patent/IL74031A/xx unknown
- 1985-01-10 GR GR850068A patent/GR850068B/el unknown
- 1985-01-10 DD DD85272500A patent/DD231350A5/de not_active IP Right Cessation
- 1985-01-10 ES ES539446A patent/ES8607949A1/es not_active Expired
- 1985-01-10 PT PT79819A patent/PT79819B/pt not_active IP Right Cessation
- 1985-01-10 CS CS85202A patent/CS248731B2/cs unknown
- 1985-01-11 WO PCT/GB1985/000014 patent/WO1985003076A1/en not_active Ceased
- 1985-01-11 IE IE69/85A patent/IE57969B1/en not_active IP Right Cessation
- 1985-01-11 FI FI850140A patent/FI850140A7/fi not_active Application Discontinuation
- 1985-01-11 NO NO850129A patent/NO850129L/no unknown
- 1985-01-11 NZ NZ210816A patent/NZ210816A/en unknown
- 1985-01-11 HU HU85109A patent/HU193591B/hu not_active IP Right Cessation
- 1985-01-11 AU AU37611/85A patent/AU572252B2/en not_active Ceased
- 1985-01-11 AT AT85300196T patent/ATE37179T1/de active
- 1985-01-11 DE DE8585300196T patent/DE3564941D1/de not_active Expired
- 1985-01-11 PL PL1985251516A patent/PL147123B1/pl unknown
- 1985-01-11 JP JP60003912A patent/JPS60158181A/ja active Pending
- 1985-01-11 EP EP85300196A patent/EP0150937B1/en not_active Expired
- 1985-01-11 ZA ZA85251A patent/ZA85251B/xx unknown
- 1985-01-12 KR KR1019850000179A patent/KR920006781B1/ko not_active Expired
- 1985-01-14 US US06/690,911 patent/US4654342A/en not_active Expired - Fee Related
- 1985-04-01 CN CN198585101722A patent/CN85101722A/zh active Pending
- 1985-09-12 SU SU853958649A patent/SU1396963A3/ru active
- 1985-09-12 RO RO85120090A patent/RO92607A/ro unknown
- 1985-12-05 ES ES549629A patent/ES8703846A1/es not_active Expired
-
1986
- 1986-05-14 ES ES554965A patent/ES8706645A1/es not_active Expired
-
1987
- 1987-06-02 MY MYPI87000758A patent/MY100124A/en unknown
-
1988
- 1988-05-09 JP JP63113411A patent/JPS63313776A/ja active Pending
- 1988-05-09 JP JP63113410A patent/JPS63313775A/ja active Pending
- 1988-10-21 CA CA000581012A patent/CA1260471A/en not_active Expired
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CS248731B2 (en) | Production method of the phenyl dihydropyridazinon derivatives | |
| RU2068844C1 (ru) | Производные азотсодержащих гетероциклических соединений или их фармацевтически приемлемые соли с щелочными или щелочно-земельными металлами | |
| DE69030206T2 (de) | Pyrazolopyridinverbindungen und Verfahren zu ihrer Herstellung | |
| CZ277698B6 (en) | Racemic or optically active bis-aza-bicyclic compounds, process for preparing thereof, intermediates and use thereof | |
| EP0123402A2 (en) | Pyrimidine derivatives, preparation thereof and use thereof | |
| EP0208518B1 (en) | 6-phenyl-pyridazinyl compounds | |
| LU82728A1 (fr) | 6-(pyridinyl)-3(2h)pyridazinones,leur preparation et leur utilisation therapeutique | |
| EP0201988B1 (en) | Dihydropyridazinone derivatives | |
| US4766122A (en) | Cyanoamidine compounds and derivatives thereof | |
| US4766123A (en) | Methylamidine compounds | |
| US4962110A (en) | Pyridazinone derivatives | |
| JPS61212583A (ja) | ２‐アミノピリミジノン誘導体 | |
| US4632924A (en) | 5-(4-substituted)phenyl-2-pyrazinones | |
| LU83251A1 (fr) | Derives d'imidazo(4,5-b)pyridine,leur preparation et leur utilisation comme agents cardiotoniques | |
| EP0197664A2 (en) | 2-Aminopyrimidinone derivatives | |
| JPS61212582A (ja) | ジヒドロピリダジノン誘導体 | |
| JPS61221177A (ja) | シアノアルカンイミドアミド化合物 | |
| HUT66083A (en) | [1,2,5,]oxadiazolo[3,4-d]pyrimidin-1-oxid derivatives, pharmaceutical preparations containing them and process for producing them | |
| JPS6212764A (ja) | ジヒドロピリダジノン誘導体 | |
| LU83320A1 (fr) | 4,5-dihydro-6-(pyridinyl)-3(2h)-pyridazinones,leur preparation et leur utilisation comme agents cardiotoniques | |
| CZ215992A3 (cs) | Nové acylaminohetrazepinové deriváty, způsob výroby a farmaceutické prostředky sjejích obsahem | |
| JPH07316162A (ja) | 三環式化合物 |