CS228518B2 - Method for producing ergoline being substituted in position 8a,fa - Google Patents

Method for producing ergoline being substituted in position 8a,fa Download PDF

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Publication number
CS228518B2
CS228518B2 CS817022A CS702281A CS228518B2 CS 228518 B2 CS228518 B2 CS 228518B2 CS 817022 A CS817022 A CS 817022A CS 702281 A CS702281 A CS 702281A CS 228518 B2 CS228518 B2 CS 228518B2
Authority
CS
Czechoslovakia
Prior art keywords
ergoline
formula
substituted
proton
compound
Prior art date
Application number
CS817022A
Other languages
Czech (cs)
English (en)
Inventor
Zdenek Dr Brich
Herbert Dr Muehle
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of CS228518B2 publication Critical patent/CS228518B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/04—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 8
    • C07D457/06—Lysergic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
    • C07D457/10—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hetero atoms directly attached in position 8
    • C07D457/12—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CS817022A 1980-09-23 1981-09-23 Method for producing ergoline being substituted in position 8a,fa CS228518B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH712280A CH644606A5 (de) 1980-09-23 1980-09-23 Verfahren zur isomerisierung von 9,10-dihydrolysergsaeurederivaten.

Publications (1)

Publication Number Publication Date
CS228518B2 true CS228518B2 (en) 1984-05-14

Family

ID=4320306

Family Applications (1)

Application Number Title Priority Date Filing Date
CS817022A CS228518B2 (en) 1980-09-23 1981-09-23 Method for producing ergoline being substituted in position 8a,fa

Country Status (27)

Country Link
US (1) US4515950A (ru)
EP (1) EP0048695B1 (ru)
JP (1) JPS5785385A (ru)
KR (1) KR870001508B1 (ru)
AT (1) ATE7916T1 (ru)
AU (1) AU547647B2 (ru)
CA (1) CA1178581A (ru)
CH (1) CH644606A5 (ru)
CS (1) CS228518B2 (ru)
DD (1) DD201679A5 (ru)
DE (1) DE3164195D1 (ru)
DK (1) DK418781A (ru)
ES (1) ES8301982A1 (ru)
FI (1) FI70018C (ru)
GR (1) GR75044B (ru)
HU (1) HU185317B (ru)
IE (1) IE51593B1 (ru)
IL (1) IL63902A (ru)
MA (1) MA19281A1 (ru)
NO (1) NO155967C (ru)
NZ (1) NZ198436A (ru)
PH (1) PH19436A (ru)
PL (1) PL134179B1 (ru)
PT (1) PT73713B (ru)
SU (1) SU1152521A3 (ru)
YU (1) YU42426B (ru)
ZA (1) ZA816617B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3309493A1 (de) * 1983-03-14 1984-09-20 Schering AG, 1000 Berlin und 4709 Bergkamen Neue ergolin-derivate, verfahren zu ihrer herstellung sowie verwendung als arzneimittel
CH664568A5 (de) * 1984-01-12 1988-03-15 Sandoz Ag 8-alpha-acylaminoergoline.
DE3533672A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-substituierte ergolinderivate
DE3533675A1 (de) * 1985-09-19 1987-03-26 Schering Ag Neue 12- und 13-brom-ergolinderivate
DE3708028A1 (de) * 1987-03-10 1988-09-22 Schering Ag Verfahren zur herstellung von 2,3ss-dihydroergolinen, 2-substituierte 2,3ss-dihydroergoline und ihre verwendung als arzneimittel
US9657020B2 (en) 2015-01-20 2017-05-23 Xoc Pharmaceuticals, Inc. Ergoline compounds and uses thereof
BR112017015510A2 (pt) 2015-01-20 2018-01-30 Xoc Pharmaceuticals Inc composto de fórmula estrutural (i), método de tratamento e/ou prevenção, método de agonização do receptor d2 em um indivíduo, método de antagonização do receptor d3 em um indivíduo, método de agonização do receptor 5-ht1d em um indivíduo, método de agonização do receptor 5-ht1a em um indivíduo, método de agonização seletiva do receptor 5-ht1d em vez do receptor 5-ht1b em um indivíduo, método de agonização seletiva do re-ceptor 5-ht2c em vez do receptor 5-ht2a ou 5-ht2b em um indivíduo, método de agonização do receptor 5-ht2c em um indivíduo, método de fornecimento de atividade antagonista funcional no receptor 5-ht2b ou receptor 5-ht7, e, método de fornecimento de atividade antagonista funcional nos receptores adrenérgicos em um indivíduo
CA3064274A1 (en) 2017-06-01 2018-12-06 Xoc Pharmaceuticals, Inc. Ergoline derivatives for use in medicine

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817988A (en) * 1971-11-16 1974-06-18 Res Inst Medicine Chem PROCESS FOR 11,12-ENOLISATION OF 9a-HALO-11-KETO-STEROIDS
CH585750A5 (en) * 1973-10-12 1977-03-15 Sandoz Ag Prepn. of (8)-methyl-dihydro-lysergic acid derivs. - from (7)-ergolene-(8)-carboxylates by methylation and redn.
GB1517971A (en) * 1974-07-19 1978-07-19 Sandoz Ltd 8alpha-substituted ergoline i derivatives
US3968111A (en) * 1974-12-06 1976-07-06 Eli Lilly And Company 8,8-Disubstituted-6-methylergolines and related compounds
DE2656344A1 (de) * 1975-12-23 1977-07-07 Sandoz Ag Ergolinderivate, ihre verwendung und herstellung
EP0021206B1 (de) * 1979-06-13 1983-06-22 Schering Aktiengesellschaft Neue (Ergolin-yl)-N', N'-diäthylharnstoff-Derivate, ihre Herstellung und sie enthaltende Arzneimittel
US4246265A (en) * 1979-10-01 1981-01-20 Eli Lilly And Company 6-n-Propyl-8α-methoxymethyl or methylmercaptomethylergolines and related compounds
DE3001752A1 (de) * 1980-01-16 1981-07-30 Schering Ag Berlin Und Bergkamen, 1000 Berlin Verfahren zur herstellung von 8(alpha)-substituierten 6-methylergolinen

Also Published As

Publication number Publication date
ES505669A0 (es) 1982-12-16
NO813196L (no) 1982-03-24
HU185317B (en) 1985-01-28
GR75044B (ru) 1984-07-12
IE812201L (en) 1982-03-23
DE3164195D1 (en) 1984-07-19
CA1178581A (en) 1984-11-27
EP0048695A1 (de) 1982-03-31
KR870001508B1 (ko) 1987-08-20
IL63902A (en) 1986-07-31
IL63902A0 (en) 1981-12-31
ZA816617B (en) 1983-04-27
PH19436A (en) 1986-04-15
KR830007641A (ko) 1983-11-04
ES8301982A1 (es) 1982-12-16
AU547647B2 (en) 1985-10-31
NO155967C (no) 1987-07-01
PT73713B (en) 1983-05-11
NO155967B (no) 1987-03-23
YU227581A (en) 1983-10-31
FI70018B (fi) 1986-01-31
FI812894L (fi) 1982-03-24
MA19281A1 (fr) 1982-04-01
PT73713A (en) 1981-10-01
CH644606A5 (de) 1984-08-15
PL134179B1 (en) 1985-07-31
SU1152521A3 (en) 1985-04-23
IE51593B1 (en) 1987-01-21
NZ198436A (en) 1985-07-12
FI70018C (fi) 1986-09-12
DK418781A (da) 1982-03-24
PL233129A1 (ru) 1982-05-10
US4515950A (en) 1985-05-07
JPS5785385A (en) 1982-05-28
DD201679A5 (de) 1983-08-03
EP0048695B1 (de) 1984-06-13
ATE7916T1 (de) 1984-06-15
YU42426B (en) 1988-08-31
AU7555681A (en) 1982-04-01

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