CS207742B2 - Method of makingthe inclusion complex of the cyclodextrin and acid 1-/p-chlorbenzoyl/-5-methoxy-2-methylind-3-yl-vinegar - Google Patents

Method of makingthe inclusion complex of the cyclodextrin and acid 1-/p-chlorbenzoyl/-5-methoxy-2-methylind-3-yl-vinegar Download PDF

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Publication number
CS207742B2
CS207742B2 CS79445A CS44579A CS207742B2 CS 207742 B2 CS207742 B2 CS 207742B2 CS 79445 A CS79445 A CS 79445A CS 44579 A CS44579 A CS 44579A CS 207742 B2 CS207742 B2 CS 207742B2
Authority
CS
Czechoslovakia
Prior art keywords
indomethacin
cyclodextrin
complex
methoxy
animals
Prior art date
Application number
CS79445A
Other languages
Czech (cs)
English (en)
Inventor
Jozsef Szejtli
Lajos Szente
Aguston David
Sandor Virag
Gyula Sebestyen
Attila Mandi
Original Assignee
Chinoin Gyogyszer Es Vegyeszet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet
Publication of CS207742B2 publication Critical patent/CS207742B2/cs

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Indole Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CS79445A 1978-01-27 1979-01-19 Method of makingthe inclusion complex of the cyclodextrin and acid 1-/p-chlorbenzoyl/-5-methoxy-2-methylind-3-yl-vinegar CS207742B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU78CI1803A HU176215B (en) 1978-01-27 1978-01-27 Process for preparing a cyclodextrin-indomethacin inclusion complex with a ratio of at about 2:1

Publications (1)

Publication Number Publication Date
CS207742B2 true CS207742B2 (en) 1981-08-31

Family

ID=10994689

Family Applications (1)

Application Number Title Priority Date Filing Date
CS79445A CS207742B2 (en) 1978-01-27 1979-01-19 Method of makingthe inclusion complex of the cyclodextrin and acid 1-/p-chlorbenzoyl/-5-methoxy-2-methylind-3-yl-vinegar

Country Status (23)

Country Link
US (1) US4228160A (pl)
JP (1) JPS54117018A (pl)
AT (1) AT360554B (pl)
AU (1) AU518750B2 (pl)
BE (1) BE873725A (pl)
CA (1) CA1119115A (pl)
CH (1) CH638819A5 (pl)
CS (1) CS207742B2 (pl)
DD (1) DD141312A1 (pl)
DE (1) DE2902297A1 (pl)
DK (1) DK154977C (pl)
ES (1) ES477181A1 (pl)
FI (1) FI65441C (pl)
FR (1) FR2415631A1 (pl)
GB (1) GB2016499B (pl)
HU (1) HU176215B (pl)
IL (1) IL56309A (pl)
IT (1) IT1118282B (pl)
NL (1) NL7808792A (pl)
NO (1) NO146637C (pl)
PL (1) PL117208B1 (pl)
SE (1) SE445353B (pl)
SU (1) SU915807A3 (pl)

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HU184066B (en) * 1979-12-28 1984-06-28 Chinoin Gyogyszer Es Vegyeszet Plant growth regulating substance and process for preparing such compound
HU181733B (en) * 1980-08-07 1983-11-28 Chinoin Gyogyszer Es Vegyeszet Process for preparing sorbents containing cyclodextrin on cellulose base
HU182217B (en) * 1980-10-17 1983-12-28 Chinoin Gyogyszer Es Vegyeszet Process for producing inclusive complexes of cyclodextrines and strong inorganic oxyacids
JPS5830032B2 (ja) * 1981-02-18 1983-06-27 呉羽化学工業株式会社 ビフイダス菌の増殖剤
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JPS58177949A (ja) * 1982-04-12 1983-10-18 Takeda Chem Ind Ltd ランカシジン群抗生物質包接化合物
US4425336A (en) 1982-05-24 1984-01-10 Key Pharmaceuticals, Inc. 3,4-Dihydroxy-N-[3-(4-dihydroxyphenyl)-1-methyl-n-propyl]-beta-phenethylamine cyclodextrin complexes
JPS5920230A (ja) * 1982-07-19 1984-02-01 チバ−ガイギ−・アクチエンゲゼルシヤフト ピルプロフエン含有薬剤
HU190818B (en) * 1982-11-09 1986-11-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing complexes of piperonyl-butoxide-cyclodextrin
HU191101B (en) * 1983-02-14 1987-01-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for preparing water-soluble cyclodextrin polymers substituted with ionic groups
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US5017566A (en) * 1987-12-30 1991-05-21 University Of Florida Redox systems for brain-targeted drug delivery
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DE3809808A1 (de) * 1988-03-23 1989-10-05 Hexal Pharma Gmbh & Co Kg Feste, insbesondere festorale und rektale, etofenamat enthaltende arzneimittel
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US5321014A (en) * 1991-06-28 1994-06-14 The United States Of America As Represented By The Department Of Health And Human Services Molecular encapsulation and delivery of alkenes alkynes and long chain alkanes, to living mammalian cells
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CN107184989B (zh) * 2017-05-18 2020-09-08 宁夏蓝博思化学技术有限公司 甘草素-环糊精或环糊精衍生物包合物及组合物及制备方法及用途
CN107158403B (zh) * 2017-05-18 2020-09-08 宁夏蓝博思化学技术有限公司 异甘草素-环糊精或环糊精衍生物包合物及组合物及制备方法及用途

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Also Published As

Publication number Publication date
DD141312A1 (de) 1980-04-23
FR2415631A1 (fr) 1979-08-24
BE873725A (fr) 1979-05-16
HU176215B (en) 1981-01-28
DK35079A (da) 1979-07-28
FR2415631B1 (pl) 1981-12-24
DE2902297C2 (pl) 1989-02-09
PL117208B1 (en) 1981-07-31
US4228160A (en) 1980-10-14
ES477181A1 (es) 1979-10-16
CA1119115A (en) 1982-03-02
FI65441C (fi) 1984-05-10
GB2016499A (en) 1979-09-26
IT1118282B (it) 1986-02-24
CH638819A5 (de) 1983-10-14
ATA59179A (de) 1980-06-15
DK154977C (da) 1989-06-12
AU518750B2 (en) 1981-10-15
NO146637B (no) 1982-08-02
SE7900479L (sv) 1979-07-28
AT360554B (de) 1981-01-26
NO146637C (no) 1982-11-10
SE445353B (sv) 1986-06-16
FI65441B (fi) 1984-01-31
NL7808792A (nl) 1979-07-31
DE2902297A1 (de) 1979-08-02
IT7967050A0 (it) 1979-01-11
FI790198A (fi) 1979-07-28
AU4367179A (en) 1979-08-02
IL56309A (en) 1981-09-13
DK154977B (da) 1989-01-16
SU915807A3 (en) 1982-03-23
JPS54117018A (en) 1979-09-11
NO790261L (no) 1979-07-30
PL213015A1 (pl) 1979-12-17
GB2016499B (en) 1982-07-28

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