CS207399B2 - Method of making the derivates of the benzodiazepine - Google Patents

Method of making the derivates of the benzodiazepine Download PDF

Info

Publication number
CS207399B2
CS207399B2 CS772937A CS63380A CS207399B2 CS 207399 B2 CS207399 B2 CS 207399B2 CS 772937 A CS772937 A CS 772937A CS 63380 A CS63380 A CS 63380A CS 207399 B2 CS207399 B2 CS 207399B2
Authority
CS
Czechoslovakia
Prior art keywords
formula
test
benzodiazepine
dose
compounds
Prior art date
Application number
CS772937A
Other languages
Czech (cs)
English (en)
Inventor
Henri Demarne
Andre Hallot
Original Assignee
Clin Midy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clin Midy filed Critical Clin Midy
Publication of CS207399B2 publication Critical patent/CS207399B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
CS772937A 1976-05-05 1977-05-04 Method of making the derivates of the benzodiazepine CS207399B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB18492/76A GB1538164A (en) 1976-05-05 1976-05-05 Benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
CS207399B2 true CS207399B2 (en) 1981-07-31

Family

ID=10113358

Family Applications (3)

Application Number Title Priority Date Filing Date
CS772937A CS207398B2 (en) 1976-05-05 1977-05-04 Method of making the derivates of the benzodiazepine
CS772937A CS207400B2 (en) 1976-05-05 1977-05-04 Method of making the derivates of the benzodiazepine
CS772937A CS207399B2 (en) 1976-05-05 1977-05-04 Method of making the derivates of the benzodiazepine

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CS772937A CS207398B2 (en) 1976-05-05 1977-05-04 Method of making the derivates of the benzodiazepine
CS772937A CS207400B2 (en) 1976-05-05 1977-05-04 Method of making the derivates of the benzodiazepine

Country Status (31)

Country Link
US (2) US4235897A (es)
JP (3) JPS52156882A (es)
AR (1) AR219924A1 (es)
AT (1) AT356655B (es)
AU (1) AU509147B2 (es)
BE (1) BE854249A (es)
CA (1) CA1083146A (es)
CH (2) CH620912A5 (es)
CS (3) CS207398B2 (es)
DD (1) DD129446A5 (es)
DE (2) DE2719608A1 (es)
DK (2) DK195177A (es)
EG (1) EG12724A (es)
ES (1) ES458481A1 (es)
FI (1) FI771413A (es)
FR (2) FR2350345A1 (es)
GB (1) GB1538164A (es)
GR (1) GR63203B (es)
HU (1) HU177573B (es)
IE (1) IE44830B1 (es)
IL (2) IL51998A (es)
MX (1) MX4720E (es)
NL (2) NL7704912A (es)
NO (2) NO771560L (es)
NZ (1) NZ184012A (es)
PH (1) PH12641A (es)
PT (1) PT66500B (es)
SE (2) SE431543B (es)
SU (1) SU888820A3 (es)
YU (1) YU41818B (es)
ZA (1) ZA772628B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2900017A1 (de) * 1978-01-10 1979-07-12 Clin Midy 3-alkoxycarbonyl-benzodiazepin- derivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
FR2460938A1 (fr) * 1979-07-12 1981-01-30 Cm Ind Procede d'obtention de benzodiazepines-1,4
DE3021107A1 (de) * 1980-06-04 1981-12-17 Hoechst Ag, 6000 Frankfurt Carbamoyloxyamino-1,4-benzodiazepine, verfahren zu irer herstellung und diese enthaltende arzneimittel
JPS6038380A (ja) * 1983-08-11 1985-02-27 Shionogi & Co Ltd １−ピペリジニル−１，４−ベンゾジアゼピン類の改良合成法
JPH04200396A (ja) * 1990-11-30 1992-07-21 Sanwa Kagaku Kenkyusho Co Ltd 過酸化水素の酵素学的高感度測定法及びそのための試薬
AU678503B2 (en) * 1993-09-24 1997-05-29 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds and their use as squalene synthetase inhibitors
KR100668045B1 (ko) * 2005-08-17 2007-01-16 한국과학기술연구원 ω-[2-(폴리알킬렌옥시)에틸티오]알킬알콕시실레인유도체와 이의 제조방법

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US28315A (en) * 1860-05-15 Improvement in method of decomposing fats into fatty acids and glycerine
US3136815A (en) * 1959-12-10 1964-06-09 Hoffmann La Roche Amino substituted benzophenone oximes and derivatives thereof
US3236838A (en) * 1964-06-09 1966-02-22 Hoffmann La Roche Certain 1-substituted-benzodiazepin-2-one compounds
FR1497456A (fr) * 1964-06-15 1967-10-13 Clin Byla Ets Ortho-amino aryl cétimines, composés hétérocycliques qui s'y rattachent et prépaation de ces divers corps
USRE28315E (en) 1964-06-15 1975-01-21 Cooc.hi
US3812103A (en) * 1967-04-11 1974-05-21 Hoffmann La Roche 2,3-dihydro-1,4-benzodiazepines
CH500997A (de) * 1967-08-09 1970-12-31 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
CH498846A (de) * 1967-08-09 1970-11-15 Hoffmann La Roche Verfahren zur Herstellung von Benzodiazepin-Derivaten
US3657223A (en) * 1969-01-17 1972-04-18 Hoffmann La Roche Process for the preparation of benzodiazepin-2-one derivatives
DE2008612A1 (de) * 1969-03-13 1970-10-01 F. Hoffmann-La Roche & Co Ag, Basel (Schweiz) Benzodiazepin-Derivate
US3718646A (en) * 1970-10-05 1973-02-27 Upjohn Co N-lower alkenyl-2,3-dihydro-2-oxo-5-phenyl-1h-1,4-benzodiazepine-1-carboxamides
IT1044223B (it) * 1972-08-09 1980-03-20 Zambeletti Spa L I propargil 1 4 benzodiazepine

Also Published As

Publication number Publication date
FR2350345B1 (es) 1980-07-18
FR2350345A1 (fr) 1977-12-02
CH620912A5 (es) 1980-12-31
US4235897A (en) 1980-11-25
FR2350346A1 (fr) 1977-12-02
IL58648A0 (en) 1980-02-29
DE2719607C2 (es) 1987-07-16
YU41818B (en) 1988-02-29
GB1538164A (en) 1979-01-10
FI771413A (es) 1977-11-06
PT66500A (fr) 1977-06-01
PH12641A (en) 1979-07-11
CS207398B2 (en) 1981-07-31
FR2350346B1 (es) 1980-11-21
SE7705182L (sv) 1977-11-06
JPS5711317B2 (es) 1982-03-03
IE44830L (en) 1977-11-05
IE44830B1 (en) 1982-04-07
IL51998A0 (en) 1977-07-31
CS207400B2 (en) 1981-07-31
DE2719608A1 (de) 1977-11-24
CH620686A5 (es) 1980-12-15
AU2481377A (en) 1978-11-09
GR63203B (en) 1979-10-08
SE432099B (sv) 1984-03-19
DK195177A (da) 1977-11-06
NO813180L (no) 1977-11-08
BE854249A (fr) 1977-11-04
SE7705183L (sv) 1977-11-06
NO149208C (no) 1984-03-07
AU509147B2 (en) 1980-04-24
CA1083146A (en) 1980-08-05
NL7704911A (nl) 1977-11-08
AR219924A1 (es) 1980-09-30
DE2719607A1 (de) 1977-11-17
DK195077A (da) 1977-11-06
SE431543B (sv) 1984-02-13
AT356655B (de) 1980-05-12
ATA320177A (de) 1979-10-15
ES458481A1 (es) 1978-04-01
NZ184012A (en) 1981-11-19
US4587245A (en) 1986-05-06
HU177573B (en) 1981-11-28
JPS52156882A (en) 1977-12-27
IL51998A (en) 1981-05-20
JPS5781472A (en) 1982-05-21
NO149208B (no) 1983-11-28
JPS6137249B2 (es) 1986-08-22
NL7704912A (nl) 1977-11-08
ZA772628B (en) 1978-03-29
PT66500B (fr) 1978-10-13
DD129446A5 (de) 1978-01-18
YU113977A (en) 1982-08-31
NO771560L (no) 1977-11-08
SU888820A3 (ru) 1981-12-07
EG12724A (en) 1979-12-31
MX4720E (es) 1982-08-13
JPS52156883A (en) 1977-12-27

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