CS200455B2 - Method of producing derivatives of benzoxazole - Google Patents

Method of producing derivatives of benzoxazole Download PDF

Info

Publication number
CS200455B2
CS200455B2 CS733508A CS350873A CS200455B2 CS 200455 B2 CS200455 B2 CS 200455B2 CS 733508 A CS733508 A CS 733508A CS 350873 A CS350873 A CS 350873A CS 200455 B2 CS200455 B2 CS 200455B2
Authority
CS
Czechoslovakia
Prior art keywords
acid
group
propionic acid
benzoxazolyl
hydroxyphenyl
Prior art date
Application number
CS733508A
Other languages
Czech (cs)
English (en)
Inventor
Delme Evans
David W Dunwell
Terence A Hicks
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Priority to CS763951A priority Critical patent/CS200456B2/cs
Publication of CS200455B2 publication Critical patent/CS200455B2/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D263/57—Aryl or substituted aryl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CS733508A 1972-05-18 1973-05-16 Method of producing derivatives of benzoxazole CS200455B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS763951A CS200456B2 (cs) 1972-05-18 1976-06-15 Způsob výroby derivátů benzoxazolu

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2340972A GB1435721A (en) 1972-05-18 1972-05-18 Benzoxazole derivatives

Publications (1)

Publication Number Publication Date
CS200455B2 true CS200455B2 (en) 1980-09-15

Family

ID=10195157

Family Applications (1)

Application Number Title Priority Date Filing Date
CS733508A CS200455B2 (en) 1972-05-18 1973-05-16 Method of producing derivatives of benzoxazole

Country Status (31)

Country Link
US (1) US3912748A (nl)
JP (6) JPS5912672B2 (nl)
KR (1) KR780000234B1 (nl)
AR (4) AR230991A1 (nl)
AT (1) AT333752B (nl)
BE (1) BE799790A (nl)
BG (1) BG21408A3 (nl)
CA (1) CA1029019A (nl)
CH (5) CH592071A5 (nl)
CS (1) CS200455B2 (nl)
CY (1) CY1016A (nl)
DD (1) DD105229A5 (nl)
DE (1) DE2324443A1 (nl)
DK (1) DK140340B (nl)
ES (1) ES414863A1 (nl)
FR (2) FR2184966B1 (nl)
GB (1) GB1435721A (nl)
HK (1) HK72579A (nl)
HU (1) HU167933B (nl)
IE (2) IE37564B1 (nl)
IL (2) IL42102A (nl)
KE (1) KE2975A (nl)
MY (1) MY8000063A (nl)
NL (1) NL170145C (nl)
PH (3) PH9685A (nl)
PL (3) PL89247B1 (nl)
RO (2) RO66278A (nl)
SE (3) SE386174B (nl)
SU (3) SU574157A3 (nl)
YU (3) YU130473A (nl)
ZA (1) ZA732791B (nl)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3888864A (en) 1973-06-29 1975-06-10 Hoffmann La Roche Amino lower alkyl ether derivatives of opium alkaloids
GB1495488A (en) * 1976-06-23 1977-12-21 Ippco Int Pharma Patents Co Es Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids
US4087437A (en) * 1976-09-07 1978-05-02 Eli Lilly And Company 2-Phenyl-5-benzoxazolylalkanoic acid purification process
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen
IT1099589B (it) * 1978-08-04 1985-09-18 Ravizza Spa Processo per la preparazione di derivati dell'acido benzoxazolil propionico
CA1125768A (en) * 1978-10-31 1982-06-15 Hoffmann-La Roche Limited Benzoxazole derivatives
GB2058381B (en) 1979-07-18 1983-01-19 Fuji Photo Film Co Ltd Colour photographic light-sensitive material containing dye-releasing redox compound
GR75153B (nl) * 1981-03-27 1984-07-13 Lilly Co Eli
IT1157295B (it) * 1982-07-19 1987-02-11 Ravizza Spa Processo perfezionato per la preparazione di derivati dell'acido benzoxazolil propionico
DE3413875A1 (de) * 1984-04-12 1985-10-17 Ludwig Heumann & Co GmbH, 8500 Nürnberg Benzothiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltendes arzneimittel
IT1177017B (it) * 1984-10-22 1987-08-26 Ravizza Spa Processo per la preparazione dell'acido 2(4-flurofenil)alfa-metil-5-benzox azoloacetico
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
IT1233836B (it) * 1988-01-13 1992-04-21 Euroresearch Srl Sali idrosolubili dell'acido (+)2-(4 fluorofenil)-alfa-metil-5 benzoxazolo acetato.
UA83620C2 (ru) * 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
WO2004046122A2 (en) * 2002-11-16 2004-06-03 Oxford Glycosciences (Uk) Ltd Benzoxazole, benzthiazole and benzimidazole acid derivatives and their use as heparanase inhibitors
CA2516842A1 (en) * 2003-02-25 2004-09-10 Topotarget Uk Limited Hydroxamic acid compounds comprising a bicylic heteroaryl group as hdac inhibitors
DE602005013001D1 (de) * 2004-12-15 2009-04-09 Dompe Pha R Ma Spa Res & Mfg 2-arylpropionsäurederivate und pharmazeutische zusammensetzungen, die diese enthalten
EP2336117A1 (en) 2005-05-26 2011-06-22 Neuron Systems, Inc Heterocyclic compounds for treating retinal diseases
JP5369854B2 (ja) 2008-04-21 2013-12-18 住友化学株式会社 有害節足動物防除組成物および縮合複素環化合物
CA3195807A1 (en) 2013-01-23 2014-07-31 Aldeyra Therapeutics, Inc. Toxic aldehyde related diseases and treatment
WO2014116593A1 (en) 2013-01-25 2014-07-31 Aldexa Therapeutics, Inc. Novel traps in the treatment of macular degeneration
JPWO2016021706A1 (ja) * 2014-08-08 2017-05-25 カズマパートナーズ株式会社 縮合複素環化合物
CA2996183A1 (en) 2015-08-21 2017-03-02 Aldeyra Therapeutics, Inc. Deuterated compounds and uses thereof
CA3022665A1 (en) 2016-05-09 2017-11-16 Aldeyra Therapeutics, Inc. Combination treatment of ocular inflammatory disorders and diseases
JP2020511461A (ja) 2017-03-16 2020-04-16 アルデイラ セラピューティクス， インコーポレイテッド 多形化合物およびその使用
AU2018348174A1 (en) 2017-10-10 2020-04-23 Aldeyra Therapeutics, Inc. Treatment of inflammatory disorders
EP3833660A4 (en) 2018-08-06 2022-05-11 Aldeyra Therapeutics, Inc. POLYMORPHIC COMPOUNDS AND THEIR USES
CN115869258A (zh) 2018-09-25 2023-03-31 奥尔德拉医疗公司 用于治疗干眼病的调配物
WO2020198064A1 (en) 2019-03-26 2020-10-01 Aldeyra Therapeutics, Inc. Ophthalmic formulations and uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD70860A (nl) *
BE625278A (nl) * 1961-11-27
CH516339A (de) * 1969-03-03 1971-12-15 Ciba Geigy Ag Verwendung von Azolverbindungen als Antioxydantien
DE2118315C3 (de) * 1970-04-20 1975-04-03 Sumitomo Chemical Co., Ltd., Osaka (Japan) 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
IL37633A (en) * 1970-09-10 1975-08-31 Merck & Co Inc 2-(4-(2-benzoxazolyl)phenyl)alkanoic acid derivatives
DE2115926C3 (de) * 1971-04-01 1978-05-03 C.H. Boehringer Sohn, 6507 Ingelheim 1 -(4-Hydroxy-3-dimethylaminosuIfamidophenyI)-2-aminoäthanderivate, Verfahren zu ihrer Herstellung und diese enthaltende Mittel
GB1491863A (en) * 1973-10-23 1977-11-16 Lilly Industries Ltd 2,5-or 2,6-disubstituted benzoxazoles
GB1590587A (en) * 1977-06-28 1981-06-03 Lilly Industries Ltd Benoxaprofen

Also Published As

Publication number Publication date
PH10704A (en) 1977-08-24
IE37564B1 (en) 1977-08-17
JPS4954363A (nl) 1974-05-27
PH11718A (en) 1978-05-30
FR2184966B1 (nl) 1979-01-12
AR230991A1 (es) 1984-08-31
FR2184966A1 (nl) 1973-12-28
BG21408A3 (nl) 1976-05-20
DK140340C (nl) 1979-12-31
CH594643A5 (nl) 1978-01-13
JPS56167645A (en) 1981-12-23
CH595361A5 (nl) 1978-02-15
PL89247B1 (nl) 1976-11-30
SU574157A3 (ru) 1977-09-25
KR780000234B1 (en) 1978-07-01
AR207857A1 (es) 1976-11-08
NL170145C (nl) 1982-10-01
IL48711A0 (en) 1976-02-29
JPS56167675A (en) 1981-12-23
RO66800A (ro) 1982-03-24
KE2975A (en) 1979-07-20
ES414863A1 (es) 1976-02-01
SE435838B (sv) 1984-10-22
ATA432573A (de) 1976-04-15
JPS59161346A (ja) 1984-09-12
SE7509387L (sv) 1975-08-22
DE2324443A1 (de) 1973-11-29
IL42102A (en) 1977-07-31
CA1029019A (en) 1978-04-04
YU130473A (en) 1981-08-31
GB1435721A (en) 1976-05-12
JPS56167673A (en) 1981-12-23
SU580837A3 (ru) 1977-11-15
JPS56167674A (en) 1981-12-23
IE37563L (en) 1973-11-18
NL7307018A (nl) 1973-11-20
JPS5912672B2 (ja) 1984-03-24
JPS6021976B2 (ja) 1985-05-30
HK72579A (en) 1979-10-19
ZA732791B (en) 1974-12-24
IE37563B1 (en) 1977-08-17
DK140340B (da) 1979-08-06
BE799790A (fr) 1973-11-19
SE7710602L (sv) 1977-09-21
FR2284592A1 (fr) 1976-04-09
SU582762A3 (ru) 1977-11-30
NL170145B (nl) 1982-05-03
CH592071A5 (nl) 1977-10-14
AR205021A1 (es) 1976-03-31
YU117179A (en) 1981-08-31
FR2284592B1 (nl) 1979-01-05
YU36298B (en) 1982-06-18
DD105229A5 (nl) 1974-04-12
IL42102A0 (en) 1973-06-29
MY8000063A (en) 1980-12-31
AT333752B (de) 1976-12-10
SE434399B (sv) 1984-07-23
PH9685A (en) 1976-02-10
US3912748A (en) 1975-10-14
RO66278A (ro) 1981-06-26
SE386174B (sv) 1976-08-02
PL92565B1 (nl) 1977-04-30
CH595362A5 (nl) 1978-02-15
CY1016A (en) 1979-11-23
HU167933B (nl) 1976-01-28
IE37564L (en) 1973-11-18
PL94208B1 (nl) 1977-07-30
CH587834A5 (nl) 1977-05-13
AR212010A1 (es) 1978-04-28
AU5590773A (en) 1974-11-21
JPS5929185B2 (ja) 1984-07-18
YU117079A (en) 1981-08-31

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