CS197300B2 - Method of producing new 1-/isoquinoline-1-one-2-yl and 1,2,3,4-tetrahydrobenzazepine-1-one-2-ylalkyl/ phenyl-et - Google Patents

Method of producing new 1-/isoquinoline-1-one-2-yl and 1,2,3,4-tetrahydrobenzazepine-1-one-2-ylalkyl/ phenyl-et Download PDF

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Publication number
CS197300B2
CS197300B2 CS775664A CS566477A CS197300B2 CS 197300 B2 CS197300 B2 CS 197300B2 CS 775664 A CS775664 A CS 775664A CS 566477 A CS566477 A CS 566477A CS 197300 B2 CS197300 B2 CS 197300B2
Authority
CS
Czechoslovakia
Prior art keywords
group
formula
isoquinolin
dimethoxy
dihydro
Prior art date
Application number
CS775664A
Other languages
Czech (cs)
English (en)
Inventor
Wolfgang Eberlein
Joachim Heider
Volkhard Austel
Juergen Daemmgen
Rudolf Kadatz
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of CS197300B2 publication Critical patent/CS197300B2/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CS775664A 1976-09-03 1977-08-30 Method of producing new 1-/isoquinoline-1-one-2-yl and 1,2,3,4-tetrahydrobenzazepine-1-one-2-ylalkyl/ phenyl-et CS197300B2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2639718A DE2639718C2 (de) 1976-09-03 1976-09-03 1-[6,7-Dimethoxy-3,4-dihydro-2H-isochinolin-1-on-2-yl]-3-[N-methyl-N-(2-(3,4-dimethoxy-phenyl)-äthyl)-amino]-propan, dessen physiologisch verträgliche Säureadditionssalze und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
CS197300B2 true CS197300B2 (en) 1980-04-30

Family

ID=5987076

Family Applications (1)

Application Number Title Priority Date Filing Date
CS775664A CS197300B2 (en) 1976-09-03 1977-08-30 Method of producing new 1-/isoquinoline-1-one-2-yl and 1,2,3,4-tetrahydrobenzazepine-1-one-2-ylalkyl/ phenyl-et

Country Status (32)

Country Link
US (1) US4137318A (no)
JP (1) JPS6026107B2 (no)
AT (1) AT357536B (no)
AU (1) AU513325B2 (no)
BE (1) BE858383A (no)
BG (1) BG31377A3 (no)
CA (1) CA1086726A (no)
CS (1) CS197300B2 (no)
DD (1) DD132585A5 (no)
DE (1) DE2639718C2 (no)
DK (1) DK392877A (no)
ES (8) ES462006A1 (no)
FI (1) FI63225C (no)
FR (1) FR2363556A1 (no)
GB (1) GB1548844A (no)
GR (1) GR63605B (no)
HK (1) HK54082A (no)
IE (1) IE45674B1 (no)
IL (1) IL52867A (no)
LU (1) LU78066A1 (no)
MY (1) MY8300244A (no)
NL (1) NL7709678A (no)
NO (1) NO147986C (no)
NZ (1) NZ185081A (no)
PH (1) PH16512A (no)
PL (3) PL112814B1 (no)
PT (1) PT66987B (no)
RO (1) RO71931A (no)
SE (1) SE437515B (no)
SG (1) SG45082G (no)
SU (3) SU659081A3 (no)
ZA (1) ZA775311B (no)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4393210A (en) * 1980-08-28 1983-07-12 Seiyaku Co., Ltd. 1(2H)-Isoquinolone compounds and acid addition salts thereof
US4473501A (en) * 1981-05-04 1984-09-25 G. D. Searle & Co. Dihydro azino isoquinolines
DE3119874A1 (de) * 1981-05-19 1982-12-09 Dr. Karl Thomae Gmbh, 7950 Biberach "benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel"
US4490369A (en) * 1981-05-19 1984-12-25 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Benzazepine derivatives, their pharmaceutical compositions and method of use
DE3242599A1 (de) * 1982-11-18 1984-05-24 Dr. Karl Thomae Gmbh, 7950 Biberach Neue benzazepinderivate, ihre herstellung und ihre verwendung als arzneimittel
DE3242345A1 (de) * 1982-11-16 1984-05-17 Dr. Karl Thomae Gmbh, 7950 Biberach Verfahren zur herstellung von benzazepinderivaten
DE3343801A1 (de) * 1983-12-03 1985-06-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue indolderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JPS61158603A (ja) * 1984-12-29 1986-07-18 株式会社小糸製作所 自動車用ランプの反射鏡
JPS6220402U (no) * 1985-07-22 1987-02-06
US5175157A (en) * 1985-11-27 1992-12-29 Boehringer Ingelheim Gmbh Cyclic amine derivatives, pharmaceutical compositions containing these compounds and methods for preparing them
DE3541811A1 (de) * 1985-11-27 1987-06-04 Thomae Gmbh Dr K Neue cyclische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3717561A1 (de) * 1987-05-25 1988-12-08 Thomae Gmbh Dr K Indol-, isochinolin- und benzazepinderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
GB8609331D0 (en) * 1986-04-16 1986-05-21 Pfizer Ltd Anti-arrythmia agents
DE3631013A1 (de) * 1986-09-12 1988-03-24 Thomae Gmbh Dr K Neue naphthylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3640641A1 (de) * 1986-11-28 1988-07-14 Thomae Gmbh Dr K Neue heteroaromatische aminderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
DE3736866A1 (de) * 1987-10-30 1989-05-11 Thomae Gmbh Dr K Mittel zur behandlung des bluthochdrucks und der herzinsuffizienz
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体
CN101250157B (zh) * 2008-03-07 2012-03-28 西安交通大学 2-取代-3,4-二氢-1-异喹啉酮类合成方法及其制备心血管药物的用途
FR2988720B1 (fr) * 2012-03-27 2014-03-14 Servier Lab Nouveau procede de synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3600394A (en) * 1968-05-17 1971-08-17 Searle & Co 2-aminoalkyl-3-arylisocarbostyrils
SE368009B (no) * 1971-09-16 1974-06-17 Kabi Ab
AT330777B (de) * 1973-09-08 1976-07-26 Thomae Gmbh Dr K Verfahren zur herstellung von neuen isochinolinderivaten und deren salzen
US4021558A (en) * 1973-09-08 1977-05-03 Boehringer Ingelheim Gmbh 1,3-Dioxo-2-[(methoxyphenethyl-amino)-alkyl]-4,4-dimethyl-isoquinolines and salts thereof useful as hypotensive agents
CH605914A5 (no) * 1974-07-31 1978-10-13 Ciba Geigy Ag

Also Published As

Publication number Publication date
CA1086726A (en) 1980-09-30
IE45674B1 (en) 1982-10-20
RO71931A (ro) 1981-11-24
NL7709678A (nl) 1978-03-07
FR2363556A1 (fr) 1978-03-31
GB1548844A (en) 1979-07-18
ES465524A1 (es) 1978-09-16
BG31377A3 (en) 1981-12-15
SU659081A3 (ru) 1979-04-25
AT357536B (de) 1980-07-10
NO147986B (no) 1983-04-11
NO147986C (no) 1983-07-20
PT66987A (de) 1977-10-01
MY8300244A (en) 1983-12-31
NZ185081A (en) 1979-11-01
SU700061A3 (ru) 1979-11-25
PL110397B1 (en) 1980-07-31
FR2363556B1 (no) 1981-09-11
IE45674L (en) 1978-03-03
PT66987B (de) 1979-09-12
PL200630A1 (pl) 1979-02-12
FI772262A (fi) 1978-03-04
ES465528A1 (es) 1978-09-16
BE858383A (fr) 1978-03-02
PL112814B1 (en) 1980-11-29
SE437515B (sv) 1985-03-04
FI63225B (fi) 1983-01-31
AU513325B2 (en) 1980-11-27
JPS5331672A (en) 1978-03-25
AU2851677A (en) 1979-03-08
JPS6026107B2 (ja) 1985-06-21
ES465526A1 (es) 1978-09-16
ATA600477A (de) 1979-12-15
LU78066A1 (no) 1978-10-17
PH16512A (en) 1983-11-08
IL52867A0 (en) 1977-11-30
FI63225C (fi) 1983-05-10
DE2639718C2 (de) 1987-03-05
PL109757B1 (en) 1980-06-30
US4137318A (en) 1979-01-30
ZA775311B (en) 1979-05-30
ES462006A1 (es) 1978-06-16
DD132585A5 (de) 1978-10-11
SG45082G (en) 1983-02-25
NO773038L (no) 1978-03-06
ES465523A1 (es) 1978-09-16
SE7709865L (sv) 1978-03-04
HK54082A (en) 1982-12-31
DE2639718A1 (de) 1978-03-16
DK392877A (da) 1978-03-04
GR63605B (en) 1979-11-26
ES465527A1 (es) 1978-09-16
SU688127A3 (ru) 1979-09-25
ES465529A1 (es) 1978-09-16
ES465525A1 (es) 1978-09-16
IL52867A (en) 1980-07-31

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