CR20190356A - Compuestos químicos como inhibidores de la actividad de la interleuquina-1 - Google Patents
Compuestos químicos como inhibidores de la actividad de la interleuquina-1Info
- Publication number
- CR20190356A CR20190356A CR20190356A CR20190356A CR20190356A CR 20190356 A CR20190356 A CR 20190356A CR 20190356 A CR20190356 A CR 20190356A CR 20190356 A CR20190356 A CR 20190356A CR 20190356 A CR20190356 A CR 20190356A
- Authority
- CR
- Costa Rica
- Prior art keywords
- modulation
- interleukin
- inhibitors
- activity
- nlrp3
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 102000000589 Interleukin-1 Human genes 0.000 title 1
- 108010002352 Interleukin-1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000000874 Pyrin Domain-Containing 3 Protein NLR Family Human genes 0.000 abstract 3
- 108010001946 Pyrin Domain-Containing 3 Protein NLR Family Proteins 0.000 abstract 3
- 102000004127 Cytokines Human genes 0.000 abstract 2
- 108090000695 Cytokines Proteins 0.000 abstract 2
- 229940100389 Sulfonylurea Drugs 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- KWGFMMAPDMTJHX-UHFFFAOYSA-N sulfonylthiourea Chemical class SC(=N)N=S(=O)=O KWGFMMAPDMTJHX-UHFFFAOYSA-N 0.000 abstract 2
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 abstract 2
- 230000004913 activation Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
Classifications
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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| US11840543B2 (en) | 2017-05-24 | 2023-12-12 | The University Of Queensland | Compounds and uses |
| KR102669722B1 (ko) * | 2017-07-07 | 2024-05-29 | 인플라좀 리미티드 | 신규한 설폰아마이드 카복스아마이드 화합물 |
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| EP3668843A1 (en) | 2017-08-15 | 2020-06-24 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors |
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| FI3911631T3 (fi) * | 2019-01-14 | 2025-02-03 | Zydus Lifesciences Ltd | Uusia substituoituja sulfonyyliureajohdannaisia |
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| AU2020314186B2 (en) * | 2019-07-17 | 2026-04-23 | Zomagen Biosciences Ltd | NLRP3 modulators |
| JP7723652B2 (ja) * | 2019-07-17 | 2025-08-14 | ズーマゲン バイオサイエンシーズ エルティーディー | 多発性硬化症(MS)の治療のためのNLPR3モジュレーターとしてのN-((1,2,3,5,6,7-ヘキサヒドロ-s-インダセン-4-イル)カルバモイル)-4,5,6,7-テトラヒドロベンゾフラン-2-スルホンアミド誘導体および関連化合物 |
| EP4013761A1 (en) | 2019-08-16 | 2022-06-22 | Inflazome Limited | Macrocyclic sulfonylurea derivatives useful as nlrp3 inhibitors |
| JP2022547882A (ja) | 2019-09-06 | 2022-11-16 | インフレイゾーム リミテッド | Nlrp3阻害剤 |
| CA3158123A1 (en) * | 2019-11-12 | 2021-05-20 | Yonggang Wei | Amide derivative and preparation method therefore and use thereof in medicine |
| JP7843705B2 (ja) | 2020-01-22 | 2026-04-10 | エフ・ホフマン-ラ・ロシュ・アクチェンゲゼルシャフト | Nlrp3モジュレーターとしてのスルホンイミドアミド化合物 |
| US20230121952A1 (en) | 2020-02-18 | 2023-04-20 | Inflazome Limited | Compounds |
| EP4121059A4 (en) * | 2020-03-16 | 2023-12-13 | Zomagen Biosciences Ltd | NLRP3 MODULATORS |
| WO2021203014A1 (en) | 2020-04-03 | 2021-10-07 | Vertex Pharmaceuticals Incorporated | Pyrano[4,3-b]l ndole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd) |
| EP4126863A1 (en) | 2020-04-03 | 2023-02-08 | Vertex Pharmaceuticals Incorporated | 1 h-pyrazolo[4,3-g]isoquinoline and 1 h-pyrazolo[4,3-g]quinoline derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd) |
| JP2023523756A (ja) * | 2020-04-30 | 2023-06-07 | ヤンセン ファーマシューティカ エヌ.ベー. | 新規なトリアジノインドール化合物 |
| IL299084A (en) | 2020-06-19 | 2023-02-01 | Ac Immune Sa | History of dihydrooxazole and thiourea or urea modulating the NLRP3 inflammasome pathway |
| CN114516878B (zh) * | 2020-11-20 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
| CN114539256B (zh) * | 2020-11-20 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
| CN115894478B (zh) * | 2021-09-30 | 2025-04-04 | 杭州民生药物研究院有限公司 | 一种新型吡啶并吡唑类杂环化合物及其应用 |
| US20250109126A1 (en) | 2021-12-22 | 2025-04-03 | Ac Immune Sa | Dihydro-oxazol derivative compounds |
| TW202333678A (zh) * | 2021-12-22 | 2023-09-01 | 大陸商瑞石生物醫藥有限公司 | 一種磺醯脲類化合物 |
| US20250283896A1 (en) * | 2022-04-25 | 2025-09-11 | Vanderbilt University | Probes and methods for targeted visualization of nlrp3 inflammasomes |
| CN117247393A (zh) * | 2022-06-17 | 2023-12-19 | 成都百裕制药股份有限公司 | 酰胺衍生物及其制备方法和在医药上的应用 |
| EP4554945A1 (en) | 2022-07-14 | 2025-05-21 | AC Immune SA | Pyrrolotriazine and imidazotriazine derivatives as modulators of the nlrp3 inflammasome pathway |
| CA3261365A1 (en) | 2022-07-28 | 2024-02-01 | Ac Immune Sa | NEW COMPOUNDS |
| WO2025133307A1 (en) | 2023-12-22 | 2025-06-26 | Ac Immune Sa | Heterocyclic modulators of the nlrp3 inflammasome pathway |
| WO2025153532A1 (en) | 2024-01-16 | 2025-07-24 | NodThera Limited | Nlrp3 inhibitors and glp-1 agonists combination therapies |
| WO2025153624A1 (en) | 2024-01-17 | 2025-07-24 | Ac Immune Sa | Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway |
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| EP3668843A1 (en) | 2017-08-15 | 2020-06-24 | Inflazome Limited | Sulfonylureas and sulfonylthioureas as nlrp3 inhibitors |
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| GB201803394D0 (en) | 2018-03-02 | 2018-04-18 | Inflazome Ltd | Novel compounds |
| WO2019166619A1 (en) | 2018-03-02 | 2019-09-06 | Inflazome Limited | Novel compounds |
| GB201803393D0 (en) | 2018-03-02 | 2018-04-18 | Inflazome Ltd | Novel compounds |
| GB201806578D0 (en) | 2018-04-23 | 2018-06-06 | Inflazome Ltd | Novel compound |
| US20220267276A1 (en) | 2018-07-03 | 2022-08-25 | Novartis Ag | Nlrp modulators |
| BR112021001044A2 (pt) | 2018-07-20 | 2021-04-13 | F. Hoffmann-La Roche Ag | Compostos de sulfonimidamida como inibidores da atividade de interleucina-1 |
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| CN112672995A (zh) | 2018-08-15 | 2021-04-16 | 英夫拉索姆有限公司 | 新型磺酰胺脲化合物 |
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| GB201817038D0 (en) | 2018-10-19 | 2018-12-05 | Inflazome Ltd | Novel processes |
| CN113056451A (zh) | 2018-10-24 | 2021-06-29 | 诺华股份有限公司 | 用于治疗与nlrp活性相关的病症的化合物和组合物 |
| GB201819083D0 (en) | 2018-11-23 | 2019-01-09 | Inflazome Ltd | Novel compounds |
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