CR20190356A - Compuestos químicos como inhibidores de la actividad de la interleuquina-1 - Google Patents

Compuestos químicos como inhibidores de la actividad de la interleuquina-1

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Publication number
CR20190356A
CR20190356A CR20190356A CR20190356A CR20190356A CR 20190356 A CR20190356 A CR 20190356A CR 20190356 A CR20190356 A CR 20190356A CR 20190356 A CR20190356 A CR 20190356A CR 20190356 A CR20190356 A CR 20190356A
Authority
CR
Costa Rica
Prior art keywords
modulation
interleukin
inhibitors
activity
nlrp3
Prior art date
Application number
CR20190356A
Other languages
English (en)
Spanish (es)
Inventor
James M Veal
Jeffrey A Stafford
Lynnie Lin Trzoss
Christopher Mcbride
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CR20190356A publication Critical patent/CR20190356A/es

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    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56Benzopyrazoles; Hydrogenated benzopyrazoles
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    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04Ortho-condensed systems
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    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/4161,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
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CR20190356A 2017-01-23 2018-01-22 Compuestos químicos como inhibidores de la actividad de la interleuquina-1 CR20190356A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762449431P 2017-01-23 2017-01-23
US201762492813P 2017-05-01 2017-05-01
PCT/US2018/014728 WO2018136890A1 (en) 2017-01-23 2018-01-22 Chemical compounds as inhibitors of interleukin-1 activity

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