MX2019008592A - Compuestos químicos como inhibidores de la actividad de la interleuquina-1. - Google Patents
Compuestos químicos como inhibidores de la actividad de la interleuquina-1.Info
- Publication number
- MX2019008592A MX2019008592A MX2019008592A MX2019008592A MX2019008592A MX 2019008592 A MX2019008592 A MX 2019008592A MX 2019008592 A MX2019008592 A MX 2019008592A MX 2019008592 A MX2019008592 A MX 2019008592A MX 2019008592 A MX2019008592 A MX 2019008592A
- Authority
- MX
- Mexico
- Prior art keywords
- interleukin
- inhibitors
- activity
- chemical compounds
- nlrp3
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 102000000589 Interleukin-1 Human genes 0.000 title 1
- 108010002352 Interleukin-1 Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000000874 Pyrin Domain-Containing 3 Protein NLR Family Human genes 0.000 abstract 2
- 108010001946 Pyrin Domain-Containing 3 Protein NLR Family Proteins 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 229940100389 Sulfonylurea Drugs 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- KWGFMMAPDMTJHX-UHFFFAOYSA-N sulfonylthiourea Chemical class SC(=N)N=S(=O)=O KWGFMMAPDMTJHX-UHFFFAOYSA-N 0.000 abstract 1
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical class OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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| US11840543B2 (en) | 2017-05-24 | 2023-12-12 | The University Of Queensland | Compounds and uses |
| HRP20220195T1 (hr) | 2017-07-07 | 2022-04-15 | Inflazome Limited | Novi spojevi sulfonamid karboksamida |
| CN117209447A (zh) | 2017-07-24 | 2023-12-12 | 诺华股份有限公司 | 用于治疗与nlrp活性相关的病症的化合物和组合物 |
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| PE20211333A1 (es) | 2018-08-15 | 2021-07-22 | Inflazome Ltd | Compuestos de sulfonamidaurea novedosos |
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| JP2022505525A (ja) * | 2018-10-24 | 2022-01-14 | ノバルティス アーゲー | Nlrp活性に関連する状態を治療するための化合物及び組成物 |
| EP3870168A1 (en) * | 2018-10-24 | 2021-09-01 | Novartis AG | Compounds and compositions for treating conditions associated with nlrp activity |
| ES2974842T3 (es) | 2018-11-13 | 2024-07-01 | Novartis Ag | Compuestos y composiciones para el tratamiento de afecciones asociadas a la actividad de nlrp |
| US12134611B2 (en) | 2018-11-13 | 2024-11-05 | Novartis Ag | Compounds and compositions for treating conditions associated with NLRP activity |
| GB201819083D0 (en) * | 2018-11-23 | 2019-01-09 | Inflazome Ltd | Novel compounds |
| CN113474333B (zh) * | 2019-01-14 | 2025-06-13 | 载度思生命科学有限公司 | 新的经取代的磺酰脲类衍生物 |
| WO2020168927A1 (zh) * | 2019-02-19 | 2020-08-27 | 四川科伦博泰生物医药股份有限公司 | 含氮并环化合物、其制备方法及用途 |
| GB201905265D0 (en) | 2019-04-12 | 2019-05-29 | Inflazome Ltd | Inflammasome inhibition |
| US20220378801A1 (en) | 2019-06-21 | 2022-12-01 | Ac Immune Sa | Novel compounds |
| JP7595642B2 (ja) * | 2019-07-17 | 2024-12-06 | ズーマゲン バイオサイエンシーズ エルティーディー | Nlrp3モジュレーター |
| CA3151865A1 (en) * | 2019-07-17 | 2021-01-21 | Zomagen Biosciences Ltd | N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)-4,5,6,7-tetrahydrobenzofuran -2-sulfonamide derivatives and related compounds as nlpr3 modulators for the treatment of multiple sclerosis (ms) |
| JP2022545400A (ja) | 2019-08-16 | 2022-10-27 | インフレイゾーム リミテッド | Nlrp3阻害剤として有用な大環状スルホニル尿素誘導体 |
| JP2022547882A (ja) | 2019-09-06 | 2022-11-16 | インフレイゾーム リミテッド | Nlrp3阻害剤 |
| JP7392169B2 (ja) * | 2019-11-12 | 2023-12-05 | 成都百裕制薬股▲ふん▼有限公司 | アミド誘導体及びその調製方法並びに医薬における応用 |
| WO2021150574A1 (en) * | 2020-01-22 | 2021-07-29 | Genentech, Inc. | Sulfonimidamide compounds as nlrp3 modulators |
| JP2023513935A (ja) | 2020-02-18 | 2023-04-04 | インフレイゾーム リミテッド | 化合物 |
| JP2023518044A (ja) * | 2020-03-16 | 2023-04-27 | ズーマゲン バイオサイエンシーズ エルティーディー | Nlrp3モジュレーター |
| JP7732999B2 (ja) | 2020-04-03 | 2025-09-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | アルファ1-アンチトリプシンのモジュレーター |
| KR20230005320A (ko) * | 2020-04-30 | 2023-01-09 | 얀센 파마슈티카 엔.브이. | 신규 트리아지노인돌 화합물 |
| CA3178361A1 (en) | 2020-06-19 | 2021-12-23 | Emanuele Gabellieri | Dihydrooxazole and thiourea derivatives modulating the nlrp3 inflammasome pathway |
| CN114539256B (zh) * | 2020-11-20 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
| CN114516878B (zh) * | 2020-11-20 | 2024-02-02 | 上海拓界生物医药科技有限公司 | 三环化合物及其医药用途 |
| CN115894478B (zh) * | 2021-09-30 | 2025-04-04 | 杭州民生药物研究院有限公司 | 一种新型吡啶并吡唑类杂环化合物及其应用 |
| US20250109126A1 (en) | 2021-12-22 | 2025-04-03 | Ac Immune Sa | Dihydro-oxazol derivative compounds |
| WO2023116812A1 (zh) * | 2021-12-22 | 2023-06-29 | 瑞石生物医药有限公司 | 一种磺酰脲类化合物 |
| US20250283896A1 (en) * | 2022-04-25 | 2025-09-11 | Vanderbilt University | Probes and methods for targeted visualization of nlrp3 inflammasomes |
| CN117247393A (zh) * | 2022-06-17 | 2023-12-19 | 成都百裕制药股份有限公司 | 酰胺衍生物及其制备方法和在医药上的应用 |
| JP2025524640A (ja) | 2022-07-14 | 2025-07-30 | エーシー・イミューン・エス・アー | Nlrp3インフラマソーム経路の調節剤としてのピロロトリアジン及びイミダゾトリアジン誘導体 |
| CN119998284A (zh) | 2022-07-28 | 2025-05-13 | Ac免疫有限公司 | 新化合物 |
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| TW202545527A (zh) | 2024-01-16 | 2025-12-01 | 英商諾得瑟拉公司 | Nlrp3及glp-1a組合療法 |
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| WO2025163069A1 (en) | 2024-01-31 | 2025-08-07 | Ac Immune Sa | Novel compounds |
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| PE20211811A1 (es) | 2018-07-20 | 2021-09-14 | Hoffmann La Roche | Compuestos de sulfonimidamida como inhibidores de la actividad de interleucina-1 |
| PE20211333A1 (es) | 2018-08-15 | 2021-07-22 | Inflazome Ltd | Compuestos de sulfonamidaurea novedosos |
| GB201902327D0 (en) | 2019-02-20 | 2019-04-03 | Inflazome Ltd | Novel compounds |
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