TW201837021A - 作為介白素-1活性抑制劑之化合物 - Google Patents

作為介白素-1活性抑制劑之化合物 Download PDF

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TW201837021A
TW201837021A TW107102246A TW107102246A TW201837021A TW 201837021 A TW201837021 A TW 201837021A TW 107102246 A TW107102246 A TW 107102246A TW 107102246 A TW107102246 A TW 107102246A TW 201837021 A TW201837021 A TW 201837021A
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Taiwan
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alkyl
cycloalkyl
halogen
heterocyclyl
heteroaryl
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TW107102246A
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Chinese (zh)
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傑佛瑞 艾倫 史丹福
詹姆士 馬文 畢爾
梨尼 琳 特洛斯
克里斯多福 麥克布萊德
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美商傑庫爾醫療股份有限公司
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Publication of TW201837021A publication Critical patent/TW201837021A/zh

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    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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TW107102246A 2017-01-23 2018-01-22 作為介白素-1活性抑制劑之化合物 TW201837021A (zh)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI789401B (zh) * 2017-07-07 2023-01-11 愛爾蘭商英弗雷佐姆有限公司 新穎化合物

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110366549A (zh) 2017-01-23 2019-10-22 基因泰克公司 作为白介素-1活性抑制剂的化合物
CA3059458A1 (en) 2017-05-24 2018-11-29 The University Of Queensland Novel compounds and uses
IL271259B2 (en) 2017-07-24 2024-06-01 Novartis Inflammasome Res Inc Compounds and compositions for treating conditions associated with nlrp activity
UY37848A (es) 2017-08-15 2019-03-29 Inflazome Ltd Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3
WO2019034688A1 (en) * 2017-08-15 2019-02-21 Inflazome Limited NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS
EP3668601A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Novel sulfonamide carboxamide compounds
MA49903A (fr) 2017-08-15 2020-06-24 Inflazome Ltd Sulfonylureés et sulfonylthioureés en tant qu'inhibiteurs de nlrp3
WO2019034697A1 (en) * 2017-08-15 2019-02-21 Inflazome Limited NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS
WO2019034693A1 (en) * 2017-08-15 2019-02-21 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
SG11202003984UA (en) * 2017-11-09 2020-05-28 Inflazome Ltd Novel sulfonamide carboxamide compounds
US12221434B2 (en) 2017-11-09 2025-02-11 Inflazome Limited Sulfonamide carboxamide compounds
WO2019166633A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Sulfonamide derivates as nlrp3 inhibitors
WO2019166627A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
WO2019166619A1 (en) * 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
WO2019211463A1 (en) 2018-05-04 2019-11-07 Inflazome Limited Novel compounds
WO2020018970A1 (en) * 2018-07-20 2020-01-23 Genentech, Inc. Sulfonylurea compounds as inhibitors of interleukin-1 activity
KR20210034596A (ko) 2018-07-20 2021-03-30 에프. 호프만-라 로슈 아게 인터류킨-1 활성의 저해제로서 술폰이미드아미드 화합물
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
BR112021002770A2 (pt) 2018-08-15 2021-05-04 Inflazome Limited compostos inovadores de sulfonamidaurea
GB201817038D0 (en) * 2018-10-19 2018-12-05 Inflazome Ltd Novel processes
JP2022505562A (ja) * 2018-10-24 2022-01-14 ノバルティス アーゲー Nlrp活性に関連する状態を治療するための化合物及び組成物
JP2022505525A (ja) * 2018-10-24 2022-01-14 ノバルティス アーゲー Nlrp活性に関連する状態を治療するための化合物及び組成物
JP2022506898A (ja) 2018-11-13 2022-01-17 ノバルティス アーゲー Nlrp活性に関連する状態を処置するための化合物及び組成物
CN113015730A (zh) 2018-11-13 2021-06-22 诺华股份有限公司 用于治疗与nlrp活性相关的病症的化合物和组合物
GB201819083D0 (en) * 2018-11-23 2019-01-09 Inflazome Ltd Novel compounds
FI3911631T3 (fi) * 2019-01-14 2025-02-03 Zydus Lifesciences Ltd Uusia substituoituja sulfonyyliureajohdannaisia
CN113195469B (zh) * 2019-02-19 2024-05-24 四川科伦博泰生物医药股份有限公司 含氮并环化合物、其制备方法及用途
GB201905265D0 (en) 2019-04-12 2019-05-29 Inflazome Ltd Inflammasome inhibition
WO2020254697A1 (en) 2019-06-21 2020-12-24 Ac Immune Sa Fused 1,2 thiazoles and 1,2 thiazines which act as nl3p3 modulators
KR20220064364A (ko) * 2019-07-17 2022-05-18 조마젠 바이오사이언시즈 엘티디 다발성 경화증(ms)의 치료를 위한 nlpr3 조절제로서의 n-((1,2,3,5,6,7-헥사하이드로-s-인다센-4-일)카바모일)-4,5,6,7-테트라하이드로벤조푸란-2-설폰아미드 유도체 및 관련 화합물
KR102852270B1 (ko) * 2019-07-17 2025-08-29 조마젠 바이오사이언시즈 엘티디 Nlrp3 조절제
US20220289766A1 (en) 2019-08-16 2022-09-15 Inflazome Limited Macrocyclic sulfonylurea derivatives useful as nlrp3 inhibitors
JP2022547882A (ja) 2019-09-06 2022-11-16 インフレイゾーム リミテッド Nlrp3阻害剤
AU2020383646B2 (en) * 2019-11-12 2023-10-12 Kangbaida (Sichuan) Biotechnology Co., Ltd. Amide derivative and preparation method therefore and use thereof in medicine
IL294536A (en) * 2020-01-22 2022-09-01 Hoffmann La Roche Sulfonimidamide compounds as nlrp3 modulators
WO2021165245A1 (en) 2020-02-18 2021-08-26 Inflazome Limited Compounds
CN115605209B (zh) * 2020-03-16 2024-12-17 祖玛珍生物科学有限公司 Nlrp3调节剂
WO2021203014A1 (en) 2020-04-03 2021-10-07 Vertex Pharmaceuticals Incorporated Pyrano[4,3-b]l ndole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)
US20230183249A1 (en) * 2020-04-30 2023-06-15 Janssen Pharmaceutica Nv New triazinoindole compounds
IL299084A (en) 2020-06-19 2023-02-01 Ac Immune Sa History of dihydrooxazole and thiourea or urea modulating the NLRP3 inflammasome pathway
CN114516878B (zh) * 2020-11-20 2024-02-02 上海拓界生物医药科技有限公司 三环化合物及其医药用途
CN114539256B (zh) * 2020-11-20 2024-02-02 上海拓界生物医药科技有限公司 三环化合物及其医药用途
CN115894478B (zh) * 2021-09-30 2025-04-04 杭州民生药物研究院有限公司 一种新型吡啶并吡唑类杂环化合物及其应用
TW202333678A (zh) * 2021-12-22 2023-09-01 大陸商瑞石生物醫藥有限公司 一種磺醯脲類化合物
JP2025502732A (ja) 2021-12-22 2025-01-28 エーシー・イミューン・エス・アー ジヒドロオキサゾール誘導体化合物
WO2023211929A1 (en) * 2022-04-25 2023-11-02 Vanderbilt University Probes and methods for targeted visualization of nlrp3 inflammasomes
CN117247393A (zh) * 2022-06-17 2023-12-19 成都百裕制药股份有限公司 酰胺衍生物及其制备方法和在医药上的应用
CA3261036A1 (en) 2022-07-14 2024-01-18 Ac Immune Sa Pyrrolotriazine and imidazotriazine derivatives used as NLRP3 inflammatory pathway modulators
EP4562009A1 (en) 2022-07-28 2025-06-04 AC Immune SA Novel compounds
WO2025133307A1 (en) 2023-12-22 2025-06-26 Ac Immune Sa Heterocyclic modulators of the nlrp3 inflammasome pathway
WO2025153532A1 (en) 2024-01-16 2025-07-24 NodThera Limited Nlrp3 inhibitors and glp-1 agonists combination therapies
WO2025153624A1 (en) 2024-01-17 2025-07-24 Ac Immune Sa Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway
WO2025153625A1 (en) 2024-01-17 2025-07-24 Ac Immune Sa Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway
WO2025163069A1 (en) 2024-01-31 2025-08-07 Ac Immune Sa Novel compounds
WO2025222076A1 (en) 2024-04-19 2025-10-23 Kyorin Pharmaceutical Co., Ltd. 1h-pyrrolo[2,3-b]pyridine derivatives as mrgprx2 antagonists for the treatment of inflammatory diseases

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216026A (en) 1990-07-17 1993-06-01 Eli Lilly And Company Antitumor compositions and methods of treatment
ATE242208T1 (de) 1997-01-29 2003-06-15 Pfizer Sulfonylharnstoff-derivate und ihre verwendung in der kontrolle der interleukin-1-aktivität
CA2383026A1 (en) 1999-09-14 2001-03-22 Pfizer Products Inc. Combination treatment with il-1ra and compounds that inhibit il-1 processing and release
EP1487457A1 (en) 2001-11-30 2004-12-22 Pfizer Products Inc. Combination of an il-1/18 inhibitor with a tnf inhibitor for the treatment of inflammation
ES2600355T3 (es) 2010-02-22 2017-02-08 Raqualia Pharma Inc. Uso de un antagonista del receptor EP4 en el tratamiento de dermatitis de contacto alérgica y psoriasis
KR20140075698A (ko) * 2011-09-02 2014-06-19 교와 핫꼬 기린 가부시키가이샤 케모카인 수용체 활성 조절제
EP2999691A4 (en) * 2013-05-21 2017-02-08 Virginia Commonwealth University Cryopyrin inhibitors for preventing and treating inflammation
CN113563264A (zh) 2015-02-16 2021-10-29 昆士兰大学 磺酰脲和相关化合物及其用途
FR3046933B1 (fr) 2016-01-25 2018-03-02 Galderma Research & Development Inhibiteurs nlrp3 pour le traitement des pathologies cutanees inflammatoires
BR112018016671A2 (pt) 2016-02-16 2018-12-26 The University Of Queensland sulfonilureias e compostos relacionados e uso do mesmo
EP3445749B1 (en) 2016-04-18 2022-12-21 Novartis AG Compounds and compositions for treating conditions associated with nlrp activity
US11597706B2 (en) 2016-04-18 2023-03-07 Novartis Ag Compounds and compositions for treating conditions associated with NLRP activity
CN110366549A (zh) 2017-01-23 2019-10-22 基因泰克公司 作为白介素-1活性抑制剂的化合物
CA3059458A1 (en) 2017-05-24 2018-11-29 The University Of Queensland Novel compounds and uses
US11370776B2 (en) 2017-07-07 2022-06-28 Inflazome Limited Sulfonylureas and sulfonylthioureas as NLRP3 inhibitors
MA56075A (fr) 2017-07-07 2022-04-06 Inflazome Ltd Nouveaux composés de sulfonamide carboxamide
WO2019034686A1 (en) 2017-08-15 2019-02-21 Inflazome Limited NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS
WO2019034693A1 (en) 2017-08-15 2019-02-21 Inflazome Limited SULFONYLURATES AND SULFONYLTHIOURES AS INHIBITORS OF NLRP3
MA49903A (fr) 2017-08-15 2020-06-24 Inflazome Ltd Sulfonylureés et sulfonylthioureés en tant qu'inhibiteurs de nlrp3
UY37848A (es) 2017-08-15 2019-03-29 Inflazome Ltd Sulfonilureas y sulfoniltioureas útiles como inhibidores de nlrp3
WO2019034688A1 (en) 2017-08-15 2019-02-21 Inflazome Limited NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS
EP3668601A1 (en) 2017-08-15 2020-06-24 Inflazome Limited Novel sulfonamide carboxamide compounds
WO2019034697A1 (en) 2017-08-15 2019-02-21 Inflazome Limited NOVEL CARBOXAMIDE SULFONAMIDE COMPOUNDS
WO2019043610A1 (en) * 2017-08-31 2019-03-07 Cadila Healthcare Limited NEW SUBSTITUTED SULFONYLUREA DERIVATIVES
SG11202003984UA (en) 2017-11-09 2020-05-28 Inflazome Ltd Novel sulfonamide carboxamide compounds
US12221434B2 (en) 2017-11-09 2025-02-11 Inflazome Limited Sulfonamide carboxamide compounds
WO2019092172A1 (en) 2017-11-09 2019-05-16 Inflazome Limited Novel sulfonamide carboxamide compounds
GB201721185D0 (en) 2017-12-18 2018-01-31 Nodthera Ltd Sulphonyl urea derivatives
WO2019166619A1 (en) 2018-03-02 2019-09-06 Inflazome Limited Novel compounds
GB201803394D0 (en) 2018-03-02 2018-04-18 Inflazome Ltd Novel compounds
GB201803393D0 (en) 2018-03-02 2018-04-18 Inflazome Ltd Novel compounds
GB201806578D0 (en) 2018-04-23 2018-06-06 Inflazome Ltd Novel compound
US20220267276A1 (en) 2018-07-03 2022-08-25 Novartis Ag Nlrp modulators
WO2020018970A1 (en) 2018-07-20 2020-01-23 Genentech, Inc. Sulfonylurea compounds as inhibitors of interleukin-1 activity
KR20210034596A (ko) 2018-07-20 2021-03-30 에프. 호프만-라 로슈 아게 인터류킨-1 활성의 저해제로서 술폰이미드아미드 화합물
BR112021002770A2 (pt) 2018-08-15 2021-05-04 Inflazome Limited compostos inovadores de sulfonamidaurea
GB201902327D0 (en) 2019-02-20 2019-04-03 Inflazome Ltd Novel compounds
GB201817038D0 (en) 2018-10-19 2018-12-05 Inflazome Ltd Novel processes
JP2022505525A (ja) 2018-10-24 2022-01-14 ノバルティス アーゲー Nlrp活性に関連する状態を治療するための化合物及び組成物
GB201819083D0 (en) 2018-11-23 2019-01-09 Inflazome Ltd Novel compounds

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI789401B (zh) * 2017-07-07 2023-01-11 愛爾蘭商英弗雷佐姆有限公司 新穎化合物
US11981667B2 (en) 2017-07-07 2024-05-14 Inflazome Limited Sulfonamide carboxamide compounds

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