CR20130267A - Inhibidores de nampt y rock - Google Patents
Inhibidores de nampt y rockInfo
- Publication number
- CR20130267A CR20130267A CR20130267A CR20130267A CR20130267A CR 20130267 A CR20130267 A CR 20130267A CR 20130267 A CR20130267 A CR 20130267A CR 20130267 A CR20130267 A CR 20130267A CR 20130267 A CR20130267 A CR 20130267A
- Authority
- CR
- Costa Rica
- Prior art keywords
- nampt
- rock inhibitors
- compounds
- rock
- inhibit
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/4035—Isoindoles, e.g. phthalimide
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
LA PRESENTE INVENCIÓN TIENE COMPUESTOS QUE INHIBEN LA ACTIVIDAD DE LA NAMPT, COMPOSICIONES QUE CONTIENEN LOS COMPUESTOS Y MÉTODOS PARA TRATAR ENFERMEDADES EN LAS CUALES SE EXPRESA LA NAMPT. COMPUETOS QUE INHIBEN LA ACTIVIDAD DE LA ROCK, COMPOSICIONES QUE CONTIENEN LOS COMPUESTOS Y MÉTODOS PARA TRATAR ENFERMEDADES EN LAS CUALES SE EXPRESA LA ROCK.
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-
2011
- 2011-11-11 SG SG10201602857UA patent/SG10201602857UA/en unknown
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- 2011-11-11 JP JP2013538943A patent/JP6117104B2/ja active Active
- 2011-11-11 CN CN2011800647158A patent/CN103313968A/zh active Pending
- 2011-11-11 SG SG2013037643A patent/SG190819A1/en unknown
- 2011-11-11 MX MX2013005454A patent/MX2013005454A/es unknown
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- 2011-11-11 RU RU2013126657/04A patent/RU2013126657A/ru not_active Application Discontinuation
- 2011-11-11 BR BR112013012078A patent/BR112013012078A2/pt not_active IP Right Cessation
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- 2011-11-11 WO PCT/US2011/060425 patent/WO2012067965A1/en active Application Filing
- 2011-11-11 KR KR1020137015348A patent/KR20140009251A/ko not_active Application Discontinuation
- 2011-11-11 SG SG10202010119TA patent/SG10202010119TA/en unknown
- 2011-11-11 UY UY0001033726A patent/UY33726A/es not_active Application Discontinuation
- 2011-11-11 TW TW100141323A patent/TW201238950A/zh unknown
- 2011-11-11 CA CA2816594A patent/CA2816594A1/en not_active Abandoned
- 2011-11-11 US US13/294,303 patent/US9302989B2/en active Active
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UY33726A (es) | 2012-06-29 |
US20160031880A1 (en) | 2016-02-04 |
CN103313968A (zh) | 2013-09-18 |
CO6761389A2 (es) | 2013-09-30 |
EP2640698A1 (en) | 2013-09-25 |
MX2013005454A (es) | 2013-06-24 |
PE20140913A1 (es) | 2014-08-22 |
JP2017132792A (ja) | 2017-08-03 |
KR20140009251A (ko) | 2014-01-22 |
SG10201602857UA (en) | 2016-05-30 |
GT201300124A (es) | 2014-12-12 |
IL225862A0 (en) | 2013-06-27 |
AR083855A1 (es) | 2013-03-27 |
SG10202010119TA (en) | 2020-11-27 |
AU2011329233A1 (en) | 2013-05-23 |
JP6117104B2 (ja) | 2017-04-19 |
RU2013126657A (ru) | 2014-12-27 |
US10093624B2 (en) | 2018-10-09 |
DOP2013000106A (es) | 2013-10-15 |
ECSP13012993A (es) | 2014-01-31 |
CL2013001340A1 (es) | 2013-09-06 |
JP2013542265A (ja) | 2013-11-21 |
US20120122842A1 (en) | 2012-05-17 |
CA2816594A1 (en) | 2012-05-24 |
TW201238950A (en) | 2012-10-01 |
AU2017200079A1 (en) | 2017-02-02 |
US9302989B2 (en) | 2016-04-05 |
BR112013012078A2 (pt) | 2019-09-24 |
SG190819A1 (en) | 2013-07-31 |
WO2012067965A1 (en) | 2012-05-24 |
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