CO6630182A2 - Microorganismos y métodos para la biosíntesis de butadieno - Google Patents

Microorganismos y métodos para la biosíntesis de butadieno

Info

Publication number
CO6630182A2
CO6630182A2 CO12199796A CO12199796A CO6630182A2 CO 6630182 A2 CO6630182 A2 CO 6630182A2 CO 12199796 A CO12199796 A CO 12199796A CO 12199796 A CO12199796 A CO 12199796A CO 6630182 A2 CO6630182 A2 CO 6630182A2
Authority
CO
Colombia
Prior art keywords
butadiene
methods
biosynthesis
microorganisms
organisms
Prior art date
Application number
CO12199796A
Other languages
English (en)
Spanish (es)
Inventor
Mark Joseph Burk
Anthony D Burgard
Jun Sun
Robin E Osterhout
Priti Pharkya
Original Assignee
Genomatica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genomatica Inc filed Critical Genomatica Inc
Publication of CO6630182A2 publication Critical patent/CO6630182A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/02—Preparation of hydrocarbons or halogenated hydrocarbons acyclic
    • C12P5/026—Unsaturated compounds, i.e. alkenes, alkynes or allenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C11/00—Aliphatic unsaturated hydrocarbons
    • C07C11/12—Alkadienes
    • C07C11/16—Alkadienes with four carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F136/00—Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds
    • C08F136/02—Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds
    • C08F136/04—Homopolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds conjugated
    • C08F136/06—Butadiene
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/14—Fungi; Culture media therefor
    • C12N1/16—Yeasts; Culture media therefor
    • C12N1/18—Baker's yeast; Brewer's yeast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Botany (AREA)
  • Polymers & Plastics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CO12199796A 2010-05-05 2012-11-06 Microorganismos y métodos para la biosíntesis de butadieno CO6630182A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33181210P 2010-05-05 2010-05-05

Publications (1)

Publication Number Publication Date
CO6630182A2 true CO6630182A2 (es) 2013-03-01

Family

ID=45064763

Family Applications (1)

Application Number Title Priority Date Filing Date
CO12199796A CO6630182A2 (es) 2010-05-05 2012-11-06 Microorganismos y métodos para la biosíntesis de butadieno

Country Status (13)

Country Link
US (5) US8580543B2 (OSRAM)
EP (1) EP2566969B1 (OSRAM)
JP (3) JP5911847B2 (OSRAM)
KR (3) KR20180005263A (OSRAM)
CN (2) CN103080324B (OSRAM)
AU (2) AU2011248182A1 (OSRAM)
BR (1) BR112012028049A2 (OSRAM)
CA (1) CA2797409C (OSRAM)
CO (1) CO6630182A2 (OSRAM)
MX (1) MX336229B (OSRAM)
SG (2) SG10201503501TA (OSRAM)
TW (2) TWI575072B (OSRAM)
WO (1) WO2011140171A2 (OSRAM)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8129154B2 (en) 2008-06-17 2012-03-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
CN102307986A (zh) 2008-12-16 2012-01-04 基因组股份公司 用于将合成气和其他碳源转化成有用产品的微生物和方法
EP2440669A4 (en) * 2009-06-10 2013-08-28 Genomatica Inc MICROOGANISMS AND PROCEDURES FOR THE CARBON EFFECTIVE BIOSYNTHESIS MEK AND 2-BUTANOL
KR20120120493A (ko) 2009-12-10 2012-11-01 게노마티카 인코포레이티드 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체
US8445244B2 (en) 2010-02-23 2013-05-21 Genomatica, Inc. Methods for increasing product yields
JP5911847B2 (ja) * 2010-05-05 2016-04-27 ジェノマティカ， インコーポレイテッド ブタジエンの生合成のための微生物および方法
EP3312284A3 (en) 2010-07-26 2018-05-30 Genomatica, Inc. Microorganisms and methods for the biosynthesis of aromatics, 2,4-pentadienoate and 1,3-butadiene
PH12013501630A1 (en) * 2011-02-02 2014-01-06 Genomatica Inc Microorganisms and methods for the biosynthesis of butadiene
US9422578B2 (en) 2011-06-17 2016-08-23 Invista North America S.A.R.L. Methods for biosynthesizing 1,3 butadiene
CN107254492A (zh) 2011-06-17 2017-10-17 英威达技术有限责任公司 产生1,3‑丁二烯的方法
US9169486B2 (en) * 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto
EP3591056A1 (en) * 2011-08-19 2020-01-08 Genomatica, Inc. Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanedol and related alcohols
WO2013057194A1 (en) * 2011-10-19 2013-04-25 Scientist Of Fortune S.A. Process for the enzymatic production of butadiene from crotyl alcohol
CN104039974B (zh) 2011-11-09 2016-10-12 阿迈瑞斯公司 乙酰辅酶a衍生的类异戊二烯的生产
BR112014012999A2 (pt) * 2011-12-02 2017-06-13 Invista Tech Sarl método para biossíntese de butadieno
CA2859556C (en) 2011-12-16 2022-01-11 Braskem S.A. Modified microorganisms and methods of making butadiene using same
AU2012357857B2 (en) 2011-12-20 2016-01-21 Scientist Of Fortune S.A. Production of 1,3-dienes by enzymatic conversion of 3-hydroxyalk-4-enoates and/or 3-phosphonoxyalk-4-enoates
WO2013130426A1 (en) * 2012-03-02 2013-09-06 Codexis, Inc. Recombinant host cells and processes for producing 1,3-butadiene through a 5-hydroxypent-3-enoate intermediate
WO2013130481A1 (en) * 2012-03-02 2013-09-06 Codexis, Inc. Recombinant host cells and processes for producing 1,3-butadiene through a crotonol intermediate
BR112014028764A2 (pt) 2012-05-18 2017-06-27 Novozymes As mutante isolado, métodos para a obtenção do mutante isolado e de um lactobacillus transformante, e, lactobacillus transformante.
CN104769119A (zh) * 2012-06-15 2015-07-08 英威达技术有限责任公司 生物合成1,3丁二烯的方法
WO2013192183A1 (en) * 2012-06-18 2013-12-27 Braskem S/A Ap 09 Modified microorganisms and methods of co-producing butadiene with 1-propanol and/or 1,2-propanediol
US20150211024A1 (en) * 2012-08-28 2015-07-30 Braskem S.A. Methods for production of a terpene and a co-product
US20150218567A1 (en) 2012-09-27 2015-08-06 Novozymes A/S Bacterial Mutants with Improved Transformation Efficiency
BR112015007443A2 (pt) * 2012-10-02 2017-08-08 Braskem Sa método de coprodução de butadieno e succinato a partir de uma fonte de carbono fermentável, e, microrganismo.
WO2014063156A2 (en) * 2012-10-19 2014-04-24 Braskem S/A Ap 09 Modified microorganisms and methods of using same for producing butadiene and one or more of 1,3-butanediol, 1,4-butanediol, and/or 1,3-propanediol
EP2909325A4 (en) * 2012-10-22 2016-05-25 Genomatica Inc MICROORGANISMS AND METHOD FOR IMPROVING THE AVAILABILITY OF REDUCING EQUIVALENTS IN THE PRESENCE OF METHANOL AND FOR PRODUCING SUCCINATE THEREOF
WO2014076016A1 (en) * 2012-11-13 2014-05-22 Global Bioenergies Process for the enzymatic preparation of isoprene from isoprenol
WO2014081973A1 (en) * 2012-11-21 2014-05-30 The Regents Of The University Of California Nucleic acids useful for integrating into and gene expression in hyperthermophilic acidophilic archaea
US9777295B2 (en) 2012-11-28 2017-10-03 Invista North America S.A.R.L. Methods for biosynthesis of isobutene
JP6304924B2 (ja) * 2012-11-29 2018-04-04 住友ゴム工業株式会社 サイドウォール用ゴム組成物、及び空気入りタイヤ
WO2014089025A1 (en) * 2012-12-04 2014-06-12 Genomatica, Inc. Increased yields of biosynthesized products
WO2014106122A1 (en) * 2012-12-31 2014-07-03 Genomatica, Inc. Compositions and methods for bio-butadiene production screening
JP2014155455A (ja) * 2013-02-15 2014-08-28 Sekisui Chem Co Ltd 組換え細胞、並びに、クロトニルＣｏＡ又はクロチルアルコールの生産方法
JP2014161252A (ja) * 2013-02-22 2014-09-08 Sekisui Chem Co Ltd 組換え細胞
WO2014152434A2 (en) 2013-03-15 2014-09-25 Genomatica, Inc. Microorganisms and methods for producing butadiene and related compounds by formate assimilation
CA2915980A1 (en) 2013-06-21 2014-12-24 Danisco Us Inc. Compositions and methods for clostridial transformation
US10294496B2 (en) 2013-07-19 2019-05-21 Invista North America S.A.R.L. Methods for biosynthesizing 1,3 butadiene
CN105683385A (zh) 2013-08-05 2016-06-15 英威达技术有限责任公司 用于生物合成异戊二烯的方法
EP3030668A1 (en) 2013-08-05 2016-06-15 Invista Technologies S.A R.L. Methods for biosynthesis of isobutene
US10808262B2 (en) 2013-12-03 2020-10-20 Genomatica, Inc. Microorganisms and methods for improving product yields on methanol using acetyl-CoA synthesis
EP3087174B1 (en) 2013-12-27 2020-05-13 Genomatica, Inc. Methods and organisms with increased carbon flux efficiencies
US10273490B2 (en) 2014-03-27 2019-04-30 Photanol B.V. Erythritol production in cyanobacteria
US9920339B2 (en) 2014-06-16 2018-03-20 Invista North America S.A.R.L. Methods, reagents and cells for biosynthesizing compounds
US10487342B2 (en) * 2014-07-11 2019-11-26 Genomatica, Inc. Microorganisms and methods for the production of butadiene using acetyl-CoA
DK3194604T3 (da) 2014-09-18 2020-05-25 Genomatica Inc Ikke-naturlig mikrobielle organismer med forbedret energisk effektivitet
CN104298866B (zh) * 2014-09-30 2017-06-06 杭州电子科技大学 一种克劳斯硫磺回收过程中反应炉动态建模方法
JP6432774B2 (ja) * 2014-12-25 2018-12-05 江南化工株式会社 細胞賦活剤
WO2016138372A1 (en) 2015-02-27 2016-09-01 White Dog Labs, Inc. Mixotrophic fermentation method for making acetone, isopropanol, butyric acid and other bioproducts, and mixtures thereof
US10612051B2 (en) * 2015-03-31 2020-04-07 White Dog Labs, Inc. Method of producing bioproducts
WO2016164586A1 (en) 2015-04-09 2016-10-13 Genomatica, Inc. Engineered microorganisms & methods for improved crotyl alcohol production
US10941454B2 (en) 2015-05-30 2021-03-09 Genomatica, Inc. Vinylisomerase-dehydratases, alkenol dehydratases, linalool dehydratases and crotyl alcohol dehydratases and methods for making and using them
WO2017064606A1 (en) * 2015-10-12 2017-04-20 Reliance Industries Limited Process for preparation of 1,3-butadiene
SG11201803164SA (en) 2015-10-30 2018-05-30 Genomatica Inc Methanol dehydrogenase fusion proteins
GB201605354D0 (en) 2016-03-30 2016-05-11 Zuvasyntha Ltd Modified enzyme
US10919030B2 (en) 2016-09-30 2021-02-16 Regents Of The University Of Minnesota Forming dienes from cyclic ethers and diols, including tetrahydrofuran and 2-methyl-1,4-butanediol
JP6317498B2 (ja) * 2017-03-22 2018-04-25 住友ゴム工業株式会社 スタッドレスタイヤ用トレッド用ゴム組成物、及びスタッドレスタイヤ
JP6317497B2 (ja) * 2017-03-22 2018-04-25 住友ゴム工業株式会社 トレッド用ゴム組成物、及び空気入りタイヤ
WO2018183628A1 (en) * 2017-03-31 2018-10-04 Genomatica, Inc. Process and systems for obtaining 1,3-butanediol from fermentation broths
US11162115B2 (en) 2017-06-30 2021-11-02 Inv Nylon Chemicals Americas, Llc Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons
US11634733B2 (en) 2017-06-30 2023-04-25 Inv Nylon Chemicals Americas, Llc Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
US20210079334A1 (en) 2018-01-30 2021-03-18 Genomatica, Inc. Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US12234463B2 (en) 2018-06-26 2025-02-25 Genomatica, Inc. Engineered microorganisms with G3P → 3PG enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy
US20220258100A1 (en) * 2019-07-16 2022-08-18 San Diego State University (SDSU) Foundation, dba San Diego State University Research Foundation Products of manufacture and methods for methane capturing using biofiltration

Family Cites Families (158)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4076948A (en) 1968-10-10 1978-02-28 El Paso Products Company Process for treatment of adipic acid mother liquor
US3513209A (en) 1968-08-19 1970-05-19 Du Pont Method of making 1,4-cyclohexadiene
GB1230276A (OSRAM) 1968-12-09 1971-04-28
US3965182A (en) 1969-10-02 1976-06-22 Ethyl Corporation Preparation of aniline from phenol and ammonia
JPS4831084B1 (OSRAM) 1970-09-04 1973-09-26
GB1344557A (en) 1972-06-23 1974-01-23 Mitsubishi Petrochemical Co Process for preparing 1,4-butanediol
JPS5543759B2 (OSRAM) 1972-06-28 1980-11-07
DE2455617C3 (de) 1974-11-23 1982-03-18 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons
DE2501499A1 (de) 1975-01-16 1976-07-22 Hoechst Ag Verfahren zur herstellung von butandiol-(1.4)
US4190495A (en) 1976-09-27 1980-02-26 Research Corporation Modified microorganisms and method of preparing and using same
US4301077A (en) 1980-12-22 1981-11-17 Standard Oil Company Process for the manufacture of 1-4-butanediol and tetrahydrofuran
JPS60114197A (ja) 1983-11-25 1985-06-20 Agency Of Ind Science & Technol 微生物によるジカルボン酸の製造法
US4871667A (en) 1984-11-26 1989-10-03 Agency Of Industrial Science & Technology Process for preparing muconic acid
US4652685A (en) 1985-11-15 1987-03-24 General Electric Company Hydrogenation of lactones to glycols
US5143834A (en) 1986-06-11 1992-09-01 Glassner David A Process for the production and purification of succinic acid
DE3783081T2 (de) 1986-06-11 1993-04-15 Michigan Biotech Inst Verfahren zur herstellung von bernsteinsaeure durch anaerobe fermentation.
US5168055A (en) 1986-06-11 1992-12-01 Rathin Datta Fermentation and purification process for succinic acid
US5182199A (en) 1987-05-27 1993-01-26 Hartley Brian S Thermophilic ethanol production in a two-stage closed system
JPH01195596A (ja) 1988-01-30 1989-08-07 Casio Comput Co Ltd 値札システム
EP0556387B1 (en) 1988-04-27 1995-08-09 Daicel Chemical Industries, Ltd. Process for preparing optically active 1,3-butanediol
JP3043063B2 (ja) 1989-04-27 2000-05-22 バイオコントロール システムズ インコーポレイテッド 微生物のための沈澱テスト
US5192673A (en) 1990-04-30 1993-03-09 Michigan Biotechnology Institute Mutant strain of C. acetobutylicum and process for making butanol
US5079143A (en) 1990-05-02 1992-01-07 The Upjohn Company Method of indentifying compounds useful as antiparasitic drugs
DE69126298T2 (de) 1990-10-15 1997-09-04 Daicel Chem Verfahren zur Herstellung optisch aktiven (R)-1,3-Butanediols mittels eines Mikroorganismus der Gattung Rhodococcus
US5173429A (en) 1990-11-09 1992-12-22 The Board Of Trustees Of The University Of Arkansas Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism
IL100572A (en) 1991-01-03 1997-01-10 Lepetit Spa Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them
US5416020A (en) 1992-09-29 1995-05-16 Bio-Technical Resources Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid
US5807722A (en) 1992-10-30 1998-09-15 Bioengineering Resources, Inc. Biological production of acetic acid from waste gases with Clostridium ljungdahlii
US6136577A (en) 1992-10-30 2000-10-24 Bioengineering Resources, Inc. Biological production of ethanol from waste gases with Clostridium ljungdahlii
FR2702492B1 (fr) 1993-03-12 1995-05-24 Rhone Poulenc Chimie Procédé de production par fermentation d'acide itaconique.
US5487987A (en) 1993-09-16 1996-01-30 Purdue Research Foundation Synthesis of adipic acid from biomass-derived carbon sources
US5521075A (en) 1994-12-19 1996-05-28 Michigan Biotechnology Institute Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants
US5504004A (en) 1994-12-20 1996-04-02 Michigan Biotechnology Institute Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms
US5700934A (en) 1995-03-01 1997-12-23 Dsm N.V. Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors
US5478952A (en) 1995-03-03 1995-12-26 E. I. Du Pont De Nemours And Company Ru,Re/carbon catalyst for hydrogenation in aqueous solution
US5863782A (en) 1995-04-19 1999-01-26 Women's And Children's Hospital Synthetic mammalian sulphamidase and genetic sequences encoding same
US5686276A (en) 1995-05-12 1997-11-11 E. I. Du Pont De Nemours And Company Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism
US5849970A (en) * 1995-06-23 1998-12-15 The Regents Of The University Of Colorado Materials and methods for the bacterial production of isoprene
FR2736927B1 (fr) 1995-07-18 1997-10-17 Rhone Poulenc Fibres & Polymer Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes
US5573931A (en) 1995-08-28 1996-11-12 Michigan Biotechnology Institute Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants
US5869301A (en) 1995-11-02 1999-02-09 Lockhead Martin Energy Research Corporation Method for the production of dicarboxylic acids
US5770435A (en) 1995-11-02 1998-06-23 University Of Chicago Mutant E. coli strain with increased succinic acid production
JP2000506012A (ja) 1996-02-27 2000-05-23 ミシガン ステイト ユニヴァーシティー サーモアンエアロバクター・エタノリカス３９ｅの第二級アルコールデヒドロゲナーゼをコードする遺伝子のクローニング及び発現並びに酵素の生化学的特徴付け
US5958745A (en) 1996-03-13 1999-09-28 Monsanto Company Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants
DE69638265D1 (de) 1996-07-01 2010-11-11 Emmaus Foundation Inc BIOLOGISCHE HESTELLUNG VON ESSIGSäURE AUS ABGASEN
KR100459818B1 (ko) 1996-09-02 2004-12-03 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 ε-카프로락탐의 제조방법
EP0977865A1 (en) 1997-02-13 2000-02-09 James Madison University Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units
KR100516986B1 (ko) 1997-02-19 2005-09-26 코닌클리즈케 디에스엠 엔.브이. 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법
US6274790B1 (en) 1997-04-14 2001-08-14 The University Of British Columbia Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis
KR19990013007A (ko) 1997-07-31 1999-02-25 박원훈 형질전환된 대장균 ｓｓ373(ｋｃｔｃ 8818ｐ)과 이를 이용한숙신산의 생산방법
JPH11103863A (ja) 1997-10-08 1999-04-20 Nippon Shokubai Co Ltd マレイン酸異性化酵素遺伝子
US6280986B1 (en) 1997-12-01 2001-08-28 The United States Of America As Represented By The Secretary Of Agriculture Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities
US20030087381A1 (en) 1998-04-13 2003-05-08 University Of Georgia Research Foundation, Inc. Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals
WO1999053035A1 (en) 1998-04-13 1999-10-21 The University Of Georgia Research Foundation, Inc. Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells
US6159738A (en) 1998-04-28 2000-12-12 University Of Chicago Method for construction of bacterial strains with increased succinic acid production
DE19820652A1 (de) 1998-05-08 1999-11-11 Basf Ag Kationische Rutheniumkomplexe, Verfahren zu ihrer Herstellung und ihre Verwendung
US6432686B1 (en) 1998-05-12 2002-08-13 E. I. Du Pont De Nemours And Company Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport
US6444784B1 (en) 1998-05-29 2002-09-03 Exxonmobil Research & Engineering Company Wax crystal modifiers (LAW657)
AU5101599A (en) 1998-07-15 2000-02-07 E.I. Du Pont De Nemours And Company Tetrahydrofolate metabolism enzymes
DE19856136C2 (de) 1998-12-04 2002-10-24 Pasteur Institut Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension
AU3482200A (en) 1999-02-02 2000-08-25 Bernhard Palsson Methods for identifying drug targets based on genomic sequence data
US6686310B1 (en) 1999-02-09 2004-02-03 E. I. Du Pont De Nemours And Company High surface area sol-gel route prepared hydrogenation catalysts
US6365376B1 (en) 1999-02-19 2002-04-02 E. I. Du Pont De Nemours And Company Genes and enzymes for the production of adipic acid intermediates
US6448473B1 (en) 1999-03-05 2002-09-10 Monsanto Technology Llc Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways
BR0010806B1 (pt) 1999-05-21 2014-02-18 Métodos e materiais para a síntese de produtos orgânicos
US6852517B1 (en) 1999-08-30 2005-02-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US6660857B2 (en) 2000-02-03 2003-12-09 Dsm N.V. Process for the preparation of ε-caprolactam
US6878861B2 (en) 2000-07-21 2005-04-12 Washington State University Research Foundation Acyl coenzyme A thioesterases
CN1223679C (zh) 2000-07-25 2005-10-19 以马忤斯基金股份有限公司 提高微生物发酵生产乙醇的方法
BRPI0115877B1 (pt) 2000-11-20 2017-10-10 Cargill, Incorporated Transgenic collection escherichia, nucleic acid molecules and process for the manufacture of 3-hydroxypropyonic acid
JP2004521619A (ja) 2000-11-22 2004-07-22 カージル ダウ ポリマーズ エルエルシー 有機生成物の合成のための方法及び材料
CN1358841A (zh) 2000-12-11 2002-07-17 云南省微生物研究所 云南链霉菌
JP3894119B2 (ja) 2000-12-28 2007-03-14 トヨタ自動車株式会社 プレニルアルコールの製造方法
JP4776146B2 (ja) 2001-01-10 2011-09-21 ザ・ペン・ステート・リサーチ・ファンデーション 細胞代謝をモデル化する方法及びシステム
US7127379B2 (en) 2001-01-31 2006-10-24 The Regents Of The University Of California Method for the evolutionary design of biochemical reaction networks
EP1381860A4 (en) 2001-03-01 2008-10-15 Univ California MODELS AND METHOD FOR DETERMINING SYSTEMIC PROPERTIES OF REGULATED RESPONSE NETWORKS
US6743610B2 (en) 2001-03-30 2004-06-01 The University Of Chicago Method to produce succinic acid from raw hydrolysates
JP4630486B2 (ja) 2001-05-28 2011-02-09 ダイセル化学工業株式会社 新規な（ｒ）−２，３−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法
CA2356540A1 (en) 2001-08-30 2003-02-28 Emory University Expressed dna sequences involved in mitochondrial functions
WO2003040690A2 (en) 2001-11-02 2003-05-15 Rice University Recycling system for manipulation of intracellular nadh availability
US7309597B2 (en) 2002-01-18 2007-12-18 Cargill, Incorporated Alanine 2,3-Aminomutase
EP1473368A4 (en) 2002-02-06 2006-01-25 Showa Denko Kk REDUCTASE GENE OF ALPHA SUBSTITUTED ALPHA, BETA-UNSATURATED CARBONYL COMPOUND
US20030224363A1 (en) 2002-03-19 2003-12-04 Park Sung M. Compositions and methods for modeling bacillus subtilis metabolism
CA2480216A1 (en) 2002-03-29 2003-10-09 Genomatica, Inc. Human metabolic models and methods
WO2003095651A1 (fr) 2002-05-10 2003-11-20 Kyowa Hakko Kogyo Co., Ltd. Procede de production d'acide mevalonique
US7856317B2 (en) 2002-06-14 2010-12-21 Genomatica, Inc. Systems and methods for constructing genomic-based phenotypic models
US7826975B2 (en) 2002-07-10 2010-11-02 The Penn State Research Foundation Method for redesign of microbial production systems
WO2004018621A2 (en) 2002-07-10 2004-03-04 The Penn State Research Foundation Method for determining gene knockout strategies
US7413878B2 (en) 2002-07-15 2008-08-19 Kosan Biosciences, Inc. Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit
WO2004033646A2 (en) 2002-10-04 2004-04-22 E.I. Du Pont De Nemours And Company Process for the biological production of 1,3-propanediol with high yield
US7734420B2 (en) 2002-10-15 2010-06-08 The Regents Of The University Of California Methods and systems to identify operational reaction pathways
WO2004044210A2 (en) 2002-11-06 2004-05-27 University Of Florida Materials and methods for the efficient production of acetate and other products
WO2004062763A2 (en) 2003-01-13 2004-07-29 Cargill, Incorporated Method for making industrial chemicals
JP4275666B2 (ja) 2003-02-24 2009-06-10 財団法人地球環境産業技術研究機構 微生物による高効率水素製造方法
RU2268300C2 (ru) 2003-04-07 2006-01-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA
ATE462002T1 (de) 2003-07-29 2010-04-15 Res Inst Innovative Tech Earth Transformanten eines coryneformen bakteriums und deren verwendung in verfahren zur produktion von dicarbonsäure
US7927859B2 (en) 2003-08-22 2011-04-19 Rice University High molar succinate yield bacteria by increasing the intracellular NADH availability
BRPI0414300A (pt) 2003-09-17 2006-11-07 Mitsubishi Chem Corp método para produzir ácido orgánico não amino
US7244610B2 (en) 2003-11-14 2007-07-17 Rice University Aerobic succinate production in bacteria
FR2864967B1 (fr) 2004-01-12 2006-05-19 Metabolic Explorer Sa Microorganisme evolue pour la production de 1,2-propanediol
EP2194139A1 (en) 2004-01-19 2010-06-09 DSM IP Assets B.V. Biochemical synthesis of 6 amino caproic acid
US7608700B2 (en) 2004-03-08 2009-10-27 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor
DE102004031177A1 (de) 2004-06-29 2006-01-19 Henkel Kgaa Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren
WO2006020663A2 (en) 2004-08-09 2006-02-23 Rice University Aerobic succinate production in bacteria
JP2008510485A (ja) * 2004-08-26 2008-04-10 ザ ペン ステイト リサーチ ファウンデーション 微生物産生系の再設計法
EP3130676A1 (en) 2004-08-27 2017-02-15 Rice University Mutant e. coli strain with increased succinic acid production
EP2434015B1 (en) 2004-09-09 2013-11-20 Research Institute Of Innovative Technology For The Earth DNA fragment having promoter function
BRPI0515273A (pt) 2004-09-17 2008-08-05 Rice University bactérias modificadas, célula bacteriana geneticamente planejada, e método para produzir ácidos carbóxilicos em uma cultura bacteriana
WO2006041209A1 (ja) 2004-10-14 2006-04-20 Sumitomo Chemical Company, Limited ２－ヒドロキシ－４－（メチルチオ）酪酸の製造方法
US7569380B2 (en) 2004-12-22 2009-08-04 Rice University Simultaneous anaerobic production of isoamyl acetate and succinic acid
DE102005002127A1 (de) * 2005-01-17 2006-07-20 Basf Ag Verfahren zur Herstellung von Butadien aus n-Butan
JP2006204255A (ja) 2005-01-31 2006-08-10 Canon Inc アセチル−ＣｏＡアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法
EP1874334A4 (en) 2005-04-15 2011-03-30 Vascular Biogenics Ltd COMPOSITIONS WITH BETA 2-GLYCOPROTEIN I-PEPTIDES FOR THE PREVENTION AND / OR TREATMENT OF VASCULAR DISEASES
KR100679638B1 (ko) 2005-08-19 2007-02-06 한국과학기술원 포메이트 디하이드로게나제 ｄ 또는 ｅ를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법
KR100676160B1 (ko) 2005-08-19 2007-02-01 한국과학기술원 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법
CN101300356A (zh) 2005-09-09 2008-11-05 基因组股份公司 用于琥珀酸盐之生长关联性生产的方法和生物
US9297028B2 (en) 2005-09-29 2016-03-29 Butamax Advanced Biofuels Llc Fermentive production of four carbon alcohols
ZA200803755B (en) 2005-10-26 2009-12-30 Du Pont Fermentive production of four carbon alcohols
GB2433260A (en) 2005-12-16 2007-06-20 Mologic Ltd A selectable decarboxylase marker
US8206970B2 (en) 2006-05-02 2012-06-26 Butamax(Tm) Advanced Biofuels Llc Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase
DE102006025821A1 (de) 2006-06-02 2007-12-06 Degussa Gmbh Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd
US8017364B2 (en) 2006-12-12 2011-09-13 Butamax(Tm) Advanced Biofuels Llc Solvent tolerant microorganisms
AU2008206403A1 (en) 2007-01-12 2008-07-24 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
LT2821494T (lt) 2007-03-16 2017-04-25 Genomatica, Inc. 1,4-butandiolio ir jo pirmtakų biosintezės būdai ir kompozicijos
US20080293125A1 (en) 2007-04-18 2008-11-27 Gevo, Inc. Engineered microorganisms for producing isopropanol
US20080274522A1 (en) 2007-05-02 2008-11-06 Bramucci Michael G Method for the production of 2-butanone
EP2152852A2 (en) 2007-05-17 2010-02-17 Tetravitae Bioscience, Inc. Methods and compositions for producing solvents
EP2017344A1 (en) 2007-07-20 2009-01-21 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Production of itaconic acid
EP2171075A2 (en) 2007-07-23 2010-04-07 DSM IP Assets B.V. Butanol production in a eukaryotic cell
US7947483B2 (en) 2007-08-10 2011-05-24 Genomatica, Inc. Methods and organisms for the growth-coupled production of 1,4-butanediol
US20100221800A1 (en) 2007-10-12 2010-09-02 The Regents Of The University Of California Microorganism engineered to produce isopropanol
CN105368764B (zh) * 2007-12-13 2019-03-12 丹尼斯科美国公司 用于生产异戊二烯的组合物和方法
US8183028B2 (en) 2007-12-21 2012-05-22 Ls9, Inc. Methods and compositions for producing olefins
JP2011509691A (ja) 2008-01-22 2011-03-31 ジェノマティカ， インコーポレイテッド 合成ガスまたは他のガス状炭素源およびメタノールを利用するための方法および生物体
CN102015995B (zh) * 2008-03-03 2014-10-22 焦耳无限科技公司 产生碳基目的产物的二氧化碳固定工程微生物
ES2656790T3 (es) 2008-03-27 2018-02-28 Genomatica, Inc. Microorganismos para la producción de ácido adípico y otros compuestos
RU2516343C2 (ru) * 2008-04-23 2014-05-20 ДАНИСКО ЮЭс ИНК. Варианты изопренсинтазы, применяемые для улучшения продуцирования изопрена микроорганизмами
US8241877B2 (en) 2008-05-01 2012-08-14 Genomatica, Inc. Microorganisms for the production of methacrylic acid
US8129154B2 (en) 2008-06-17 2012-03-06 Genomatica, Inc. Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate
EP2307552B1 (en) * 2008-06-30 2022-10-26 The Goodyear Tire & Rubber Company Polymers of isoprene from renewable resources
US20110190513A1 (en) 2008-07-08 2011-08-04 Lynch Michael D Methods, compositions and systems for biosynthetic bio-production of 1,4-butanediol
WO2010022763A1 (en) 2008-08-25 2010-03-04 Metabolic Explorer Method for the preparation of 2-hydroxy-isobutyrate
CA2735883C (en) * 2008-09-10 2020-05-05 Genomatica, Inc. Microorganisms for the production of 1,4-butanediol
CA2737082A1 (en) 2008-09-15 2010-03-18 Danisco Us Inc. Increased isoprene production using mevalonate kinase and isoprene synthase
US8569026B2 (en) 2008-09-15 2013-10-29 Danisco Us Inc. Systems using cell culture for production of isoprene
US8357826B2 (en) 2008-10-16 2013-01-22 Karl Kharas Methods and apparatus for synthesis of alcohols from syngas
US9090898B2 (en) 2008-12-12 2015-07-28 Metabolix, Inc. Green process and compositions for producing poly(5HV) and 5 carbon chemicals
CN102307986A (zh) 2008-12-16 2012-01-04 基因组股份公司 用于将合成气和其他碳源转化成有用产品的微生物和方法
EP3135760A1 (en) * 2009-04-30 2017-03-01 Genomatica, Inc. Organisms for the production of 1,3-butanediol
VN29801A1 (OSRAM) 2009-06-04 2012-05-25
JP5787360B2 (ja) 2009-10-30 2015-09-30 株式会社ダイセル １，３−ブタンジオール生産機能を付与された遺伝子組換え微生物及びその利用
KR20120120493A (ko) 2009-12-10 2012-11-01 게노마티카 인코포레이티드 합성 가스 또는 기타 가스상 탄소원 및 메탄올을 1,3-부탄디올로 변환하는 방법 및 변환용 유기체
JP5911847B2 (ja) 2010-05-05 2016-04-27 ジェノマティカ， インコーポレイテッド ブタジエンの生合成のための微生物および方法
PH12013501630A1 (en) * 2011-02-02 2014-01-06 Genomatica Inc Microorganisms and methods for the biosynthesis of butadiene
US9169486B2 (en) * 2011-06-22 2015-10-27 Genomatica, Inc. Microorganisms for producing butadiene and methods related thereto
WO2013057194A1 (en) * 2011-10-19 2013-04-25 Scientist Of Fortune S.A. Process for the enzymatic production of butadiene from crotyl alcohol
US20150050708A1 (en) * 2013-03-15 2015-02-19 Genomatica, Inc. Microorganisms and methods for producing butadiene and related compounds by formate assimilation
WO2014152434A2 (en) * 2013-03-15 2014-09-25 Genomatica, Inc. Microorganisms and methods for producing butadiene and related compounds by formate assimilation

Also Published As

Publication number Publication date
EP2566969A2 (en) 2013-03-13
MX2012012827A (es) 2013-01-24
JP2013524853A (ja) 2013-06-20
US20180155742A1 (en) 2018-06-07
US8580543B2 (en) 2013-11-12
US20200299736A1 (en) 2020-09-24
SG10201503501TA (en) 2015-06-29
KR20190006103A (ko) 2019-01-16
SG185432A1 (en) 2012-12-28
US20110300597A1 (en) 2011-12-08
BR112012028049A2 (pt) 2015-11-24
JP2016154551A (ja) 2016-09-01
JP5911847B2 (ja) 2016-04-27
JP2018196387A (ja) 2018-12-13
KR20180005263A (ko) 2018-01-15
KR101814648B1 (ko) 2018-01-04
US20140155567A1 (en) 2014-06-05
CN103080324A (zh) 2013-05-01
EP2566969B1 (en) 2019-09-04
CA2797409A1 (en) 2011-11-10
AU2011248182A1 (en) 2012-11-15
KR20130062939A (ko) 2013-06-13
TW201139683A (en) 2011-11-16
WO2011140171A2 (en) 2011-11-10
US20220025411A1 (en) 2022-01-27
CN103080324B (zh) 2019-03-08
MX336229B (es) 2016-01-08
CA2797409C (en) 2019-12-24
TWI575072B (zh) 2017-03-21
AU2016201231A1 (en) 2016-03-17
TW201720931A (zh) 2017-06-16
EP2566969A4 (en) 2014-01-15
WO2011140171A3 (en) 2012-04-26
US9732361B2 (en) 2017-08-15
CN106047782A (zh) 2016-10-26
US10487343B2 (en) 2019-11-26

Similar Documents

Publication Publication Date Title
CO6630182A2 (es) Microorganismos y métodos para la biosíntesis de butadieno
MY179664A (en) Microorganisms and methods for the biosynthesis of butadiene
EP2563926A4 (en) MICROORGANISMS AND METHODS OF PROPYLENE BIOSYNTHESIS
PH12015502401A1 (en) Compositions and methods for enhancing microbial stability
IN2015DN01198A (OSRAM)
EP2558582A4 (en) MICROORGANISMS AND PROCESSES FOR THE PRODUCTION OF ETHYLENE GLYCOL
CO6640205A2 (es) Microorganismos y metodos para la biosintesis de p-toluato y tereftalato
BR112013032229A2 (pt) método de tratamento hidrocatalítico hidrotérmico de biomassa, e, composição
MX348495B (es) Metodos y composiciones para el control de malezas.
CL2014003217A1 (es) Métodos y composiciones de fermentación microbiana.
GB2482536B (en) Expression of antibody or a fragment thereof in lactobacillus
BR112014012543A2 (pt) métodos e materiais para síntese enzimática de compostos de mogrosídeo
MX350773B (es) Métodos y composiciones para el control de malezas.
EP2920293A4 (en) MICROBIAL STRAINS, COMPOSITIONS AND METHODS FOR EXPANDING THE PHOSPHATE AVAILABLE FOR PLANTS
CL2013001134A1 (es) Composicion de yogurt congelado que comprende microorganismos probioticos no replicantes .
AU2013225816A8 (en) Compositions and methods for treating Type III Gaucher Disease
UY33992A (es) Métodos para modificar la biosintesis de la lignina y mejorar la digestibilidad
EA201290623A1 (ru) Лактобациллы с антиоксидантным действием
CL2013001314A1 (es) Composicion de yogur de consistencia espesa que comprende microorganismos probióticos no replicantes.
UA112760C2 (uk) Теобромін у комбінації з гвайфенезином для лікування кашлю
EP2758074A4 (en) BACTERIA STRAINS FOR THE EXPRESSION OF METHYLASES AND USES THEREOF
BR112014020381A2 (pt) composições e métodos para a redução da quantidade de microrganismos patogênicos em alimentos
ZA201308256B (en) Uses, methods and biological compositions of the genus paecilomyces for the control, prevention and eradication of phytoparasites in solanaceae cultures
EP2748326A4 (en) IMPROVED COMPOSITIONS AND METHODS FOR BIOSYNTHESIS OF 1-ALKENEN IN MANIPULATED MICROORGANISMS
MY160589A (en) Microorganisms and methods for the biosynthesis of butadiene