CO6491119A2 - Método de producción de un polipéptido o virus de interés en un cultivo celular contínuo - Google Patents
Método de producción de un polipéptido o virus de interés en un cultivo celular contínuoInfo
- Publication number
- CO6491119A2 CO6491119A2 CO12020130A CO12020130A CO6491119A2 CO 6491119 A2 CO6491119 A2 CO 6491119A2 CO 12020130 A CO12020130 A CO 12020130A CO 12020130 A CO12020130 A CO 12020130A CO 6491119 A2 CO6491119 A2 CO 6491119A2
- Authority
- CO
- Colombia
- Prior art keywords
- cell culture
- cell
- culture system
- polypeptide
- interest
- Prior art date
Links
- 238000004113 cell culture Methods 0.000 title abstract 8
- 241000700605 Viruses Species 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 210000004027 cell Anatomy 0.000 abstract 7
- 210000004962 mammalian cell Anatomy 0.000 abstract 3
- 238000012258 culturing Methods 0.000 abstract 2
- 238000010790 dilution Methods 0.000 abstract 2
- 239000012895 dilution Substances 0.000 abstract 2
- 230000014759 maintenance of location Effects 0.000 abstract 2
- 230000010412 perfusion Effects 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
- 210000002966 serum Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M3/00—Tissue, human, animal or plant cell, or virus culture apparatus
- C12M3/006—Cell injection or fusion devices
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0056—Xeno-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/98—Xeno-free medium and culture conditions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/00051—Methods of production or purification of viral material
- C12N2710/00052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/24—Metalloendopeptidases (3.4.24)
- C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23031309P | 2009-07-31 | 2009-07-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6491119A2 true CO6491119A2 (es) | 2012-07-31 |
Family
ID=42668436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO12020130A CO6491119A2 (es) | 2009-07-31 | 2012-02-06 | Método de producción de un polipéptido o virus de interés en un cultivo celular contínuo |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US8580554B2 (enExample) |
| EP (2) | EP3480292A1 (enExample) |
| JP (2) | JP5808742B2 (enExample) |
| KR (2) | KR101752789B1 (enExample) |
| CN (1) | CN102549142B (enExample) |
| AU (1) | AU2010277490B2 (enExample) |
| BR (1) | BR112012002137B8 (enExample) |
| CA (1) | CA2769354A1 (enExample) |
| CO (1) | CO6491119A2 (enExample) |
| DK (1) | DK2459697T3 (enExample) |
| EA (1) | EA022219B1 (enExample) |
| ES (1) | ES2705206T3 (enExample) |
| HR (1) | HRP20182165T1 (enExample) |
| IN (1) | IN2012DN00899A (enExample) |
| MX (2) | MX2012001274A (enExample) |
| NZ (1) | NZ597742A (enExample) |
| PL (1) | PL2459697T3 (enExample) |
| PT (1) | PT2459697T (enExample) |
| SG (1) | SG178176A1 (enExample) |
| SI (1) | SI2459697T1 (enExample) |
| TR (1) | TR201900213T4 (enExample) |
| WO (1) | WO2011012725A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3626736T (pt) | 2010-07-08 | 2025-08-11 | Takeda Pharmaceuticals Co | Método de produção de fvw recombinante de elevado peso molecular na cultura celular |
| SG191745A1 (en) * | 2011-01-17 | 2013-08-30 | Hoffmann La Roche | Separation apparatus and use thereof |
| CA2835053C (en) | 2011-05-13 | 2020-07-07 | Octapharma Ag | A method of increasing the productivity of eucaryotic cells in the production of recombinant fviii |
| KR101662412B1 (ko) * | 2011-07-01 | 2016-10-04 | 암젠 인크 | 포유동물 세포 배양 |
| CN203129697U (zh) | 2013-02-05 | 2013-08-14 | 客贝利(厦门)休闲用品有限公司 | 一种帐篷架杆 |
| CN104136605B (zh) | 2011-11-24 | 2018-08-14 | 吉尼松公司 | 与工业制药应用相容的可放大的慢病毒载体生产系统 |
| US9574167B2 (en) | 2013-02-15 | 2017-02-21 | Pharyx, Inc. | Methods and apparatus for independent control of product and reactant concentrations |
| CN118388581A (zh) | 2013-03-08 | 2024-07-26 | 建新公司 | 治疗性蛋白药物物质的整合连续制造 |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| ES2842350T3 (es) | 2013-03-19 | 2021-07-13 | Cmc Biologics As | Un procedimiento para la producción de un producto (por ejemplo, polipéptido) en un proceso de fermentación de cultivo celular continuo |
| CA2920934C (en) * | 2013-08-30 | 2022-12-06 | Glaxosmithkline Biologicals S.A. | Large scale production of viruses in cell culture |
| US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| TWI671312B (zh) | 2014-01-17 | 2019-09-11 | 美商健臻公司 | 無菌層析法及製法 |
| TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
| KR20160146763A (ko) | 2014-04-01 | 2016-12-21 | 어드밴텍 바이오사이언스 파마큐티카 엘티디에이 | 부형제로서 칼슘이 첨가되지 않은 factor viii의 안정화 |
| JP2017509659A (ja) | 2014-04-01 | 2017-04-06 | アドヴァンテック・バイオサイエンス・ファルマスーティカ・リミターダ | 低糖−低グリシンの安定な第ｖｉｉｉ因子製剤 |
| CN106414719B (zh) * | 2014-06-13 | 2020-02-14 | 杰特有限公司 | 生物反应器中重组von Willebrand因子的改进生产 |
| KR20240173213A (ko) * | 2016-01-26 | 2024-12-10 | 베링거 인겔하임 인터내셔날 게엠베하 | 연결된 관류 대 연속-유동식 교반-탱크 반응기 세포 배양 시스템 |
| EP3443064A1 (en) * | 2016-04-15 | 2019-02-20 | Boehringer Ingelheim International GmbH | Cell retention device and method |
| US20200063086A1 (en) * | 2016-12-21 | 2020-02-27 | Hoffmann-La Roche Inc. | Growth control of eukaryotic cells |
| IL321253A (en) | 2018-05-01 | 2025-08-01 | Amgen Inc | Antibodies with a modulated glycan profile |
| WO2019239780A1 (ja) * | 2018-06-15 | 2019-12-19 | 富士フイルム株式会社 | 細胞培養方法、細胞培養装置、及び生産物の製造方法 |
| BR112021003420A2 (pt) | 2018-08-31 | 2021-05-18 | Genzyme Corporation | resina cromatográfica estéril e uso da mesma em processos de manufatura |
| CN113355297A (zh) * | 2021-06-23 | 2021-09-07 | 吉林冠界生物技术有限公司 | 一种灌流式培养全悬浮mdck细胞生产重组禽流感病毒的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5019512A (en) | 1989-03-17 | 1991-05-28 | Baxter International Inc. | Spin filter for removing substantially cell-free culture medium from suspension cell culture system |
| US5626734A (en) | 1995-08-18 | 1997-05-06 | University Technologies International, Inc. | Filter for perfusion cultures of animal cells and the like |
| EP1325127B1 (en) | 2000-10-02 | 2009-03-11 | Novo Nordisk Health Care AG | Method for the production of vitamin k-dependent proteins |
| AU2002342922A1 (en) * | 2001-11-28 | 2003-06-10 | Sandoz Ag | Cell culture process |
| TWI384069B (zh) | 2004-08-27 | 2013-02-01 | Pfizer Ireland Pharmaceuticals | 多胜肽之製法 |
| AU2006257073B2 (en) | 2005-06-17 | 2011-08-04 | Children's Medical Center Corporation | ADAMTS13-comprising compositions having thrombolytic activity |
| SI2522717T1 (sl) * | 2006-01-04 | 2014-05-30 | Baxter International Inc. | Mediji celične kulture brez oligopeptidov |
| CA2709890A1 (en) * | 2007-12-27 | 2009-07-09 | Andre Giovagnoli | Cell culture processes |
-
2010
- 2010-07-30 US US12/847,921 patent/US8580554B2/en active Active
- 2010-08-02 SG SG2012006599A patent/SG178176A1/en unknown
- 2010-08-02 CN CN201080036754.2A patent/CN102549142B/zh active Active
- 2010-08-02 ES ES10737916T patent/ES2705206T3/es active Active
- 2010-08-02 KR KR1020127004996A patent/KR101752789B1/ko active Active
- 2010-08-02 SI SI201031835T patent/SI2459697T1/sl unknown
- 2010-08-02 PT PT10737916T patent/PT2459697T/pt unknown
- 2010-08-02 CA CA2769354A patent/CA2769354A1/en not_active Abandoned
- 2010-08-02 KR KR1020177017512A patent/KR101885046B1/ko active Active
- 2010-08-02 IN IN899DEN2012 patent/IN2012DN00899A/en unknown
- 2010-08-02 BR BR112012002137A patent/BR112012002137B8/pt active IP Right Grant
- 2010-08-02 PL PL10737916T patent/PL2459697T3/pl unknown
- 2010-08-02 HR HRP20182165TT patent/HRP20182165T1/hr unknown
- 2010-08-02 MX MX2012001274A patent/MX2012001274A/es active IP Right Grant
- 2010-08-02 WO PCT/EP2010/061191 patent/WO2011012725A1/en not_active Ceased
- 2010-08-02 EA EA201270213A patent/EA022219B1/ru not_active IP Right Cessation
- 2010-08-02 NZ NZ597742A patent/NZ597742A/en unknown
- 2010-08-02 EP EP18199855.0A patent/EP3480292A1/en not_active Withdrawn
- 2010-08-02 EP EP10737916.6A patent/EP2459697B1/en active Active
- 2010-08-02 TR TR2019/00213T patent/TR201900213T4/tr unknown
- 2010-08-02 AU AU2010277490A patent/AU2010277490B2/en active Active
- 2010-08-02 JP JP2012522190A patent/JP5808742B2/ja active Active
- 2010-08-02 DK DK10737916.6T patent/DK2459697T3/en active
-
2012
- 2012-01-27 MX MX2014008515A patent/MX353610B/es unknown
- 2012-02-06 CO CO12020130A patent/CO6491119A2/es unknown
-
2013
- 2013-10-10 US US14/050,710 patent/US9650612B2/en active Active
-
2015
- 2015-01-14 JP JP2015004718A patent/JP6177260B2/ja active Active
-
2017
- 2017-04-12 US US15/486,181 patent/US10221400B2/en active Active
-
2019
- 2019-01-18 US US16/252,216 patent/US10745672B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112012002137B8 (pt) | método para produzir um polipeptídeo e/ou vírus de interesse em uma cultura de célula contínua isenta de soro | |
| ES2527173T3 (es) | Células de fucosilación deficiente | |
| AR132549A2 (es) | Medio de cultivo para células cho libre de suero que comprende ornitina y putrescina, método para cultivar células cho y método in vitro para producir una proteína | |
| AR111785A2 (es) | Método in vitro de producción de eritrocitos | |
| AR124871A2 (es) | Métodos de fabricación para el control del contenido de lisina c-terminal, galactosa y ácido siálico en proteínas recombinantes | |
| NZ593235A (en) | Method for the production of recombinant adenovirus serotype 35 | |
| NZ601424A (en) | Method for the production of ad26 adenoviral vectors | |
| AR069956A1 (es) | Procesos para cultivar celulas mamiferas secretoras de proteinas sanguineas heterologas | |
| JP2016105737A5 (enExample) | ||
| BR112013025086A2 (pt) | sistema e métodos de biorreator multifuncional para classificação e cultura de células | |
| CO6680636A2 (es) | Método para producir adamts13 recombinante en cultivo celular | |
| JP2015532096A5 (enExample) | ||
| MX340242B (es) | Proceso mejorado para el cultivo de celulas. | |
| AR074963A1 (es) | Sistema y metodo para recuperar informacion relevante. | |
| BR112016027290A2 (pt) | métodos para a produção de ramnolipídeos". | |
| JP2015521848A5 (enExample) | ||
| MX2020013633A (es) | Metodos para producir proteinas recombinantes. | |
| BR112015007319A2 (pt) | composições e métodos para produzir glicoproteínas | |
| BR112013028006A2 (pt) | método para aumentar a produtividade de células eucarióticas na produção do recombinante fviii | |
| Cai et al. | Differential homeostasis of sessile and pendant epithelium reconstituted in a 3D‐printed “GeminiChip” | |
| Peirce et al. | Immobilization of carbonic anhydrase for biomimetic CO2 capture in a slurry absorber as cross-linked enzyme aggregates (CLEA) | |
| CL2013002723A1 (es) | Metodo de produccion de una particula semejante a virus (vlp) de alfavirus salmonido (sav) en celulas de insecto. | |
| AR085271A1 (es) | Procedimiento para la produccion a escala comercial de prrsv | |
| BRPI0914805B8 (pt) | método para replicar vírus em uma cultura de células scldk, processo para adaptar células cldk dependentes do substrato para desenvolvimento em suspensão, método para propagar continuamente células scldk em suspensão, e, composição | |
| BR112017017303B8 (pt) | Método para obtenção de clones de células de alta produtividade |