CO6220960A2 - Compuesto de piperazina novedoso y uso del mismo como inhibidor de polimerasa del virus de la hepatitis c - Google Patents

Compuesto de piperazina novedoso y uso del mismo como inhibidor de polimerasa del virus de la hepatitis c

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Publication number
CO6220960A2
CO6220960A2 CO08116130A CO08116130A CO6220960A2 CO 6220960 A2 CO6220960 A2 CO 6220960A2 CO 08116130 A CO08116130 A CO 08116130A CO 08116130 A CO08116130 A CO 08116130A CO 6220960 A2 CO6220960 A2 CO 6220960A2
Authority
CO
Colombia
Prior art keywords
group
optionally substituted
substituents selected
ring
same
Prior art date
Application number
CO08116130A
Other languages
English (en)
Inventor
Hiroyuki Abe
Masahiro Tanaka
Kazuyuki Sugimoto
Akira Suma
Masahiro Yokota
Makoto Shiozaki
Kiyose Iio
Kazuhito Ueyama
Dai Motoda
Toru Noguchi
Tsuyoshi Adachi
Junichiro Tsuruha
Satoki Doi
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of CO6220960A2 publication Critical patent/CO6220960A2/es

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    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1.- Un agente anti-VHC que comprende como ingrediente activo un compuesto representado por la siguiente fórmula [I], o una sal farmacéuticamente aceptable del mismo, o un solvato del mismo:en donde: el anillo A es un anillo de carbono de C3-12 sustituido opcionalmente con 1 a 5 sustituyentes seleccionados del grupo A que se define más abajo, o un grupo heterocíclico sustituido opcionalmente con 1 a 5 sustituyentes seleccionados del grupo A (en donde el grupo heterocíclico tiene, además de los átomos de carbono, de 1 a 6 heteroátomos seleccionados de nitrógeno, oxígeno y azufre); n es un entero de 1 a 6; el anillo B es un anillo de carbono de C3-12 sustituido opcionalmente con 1 a 5 sustituyentes seleccionados del grupo A, o un grupo heterocíclico sustituido opcionalmente con 1 a 5 sustituyentes seleccionados del grupo A (en donde el grupo heterocíclico tiene, además de los átomos de carbono, de 1 a 6 heteroátomos seleccionados de nitrógeno, oxígeno y azufre); y R es un átomo de hidrógeno, -COR1, -COOR2, -CONR3R4, -SO2R5, -CO-COOR6, -CO-CH=CH-COOR11, -CO(CH2)aNHR7, -CO(CH2)b-NHCOR8, -CO-(CH2)-NHCOOR9 (en donde R1 a y R9 a R11 son iguales o diferentes, y cada uno es un átomo de hidrógeno o un grupo alquilo de C1-10 sustituido opcionalmente con 1 a 5 sustituyentes seleccionados del grupo B que se define más abajo, y a, b y c son iguales o diferentes y cada uno es un entero de 1 a 4), -CO-CONH2, -C(=NH)NH2, -C(=S)NH2, un grupo alquilo de C1-10 sustituido opcionalmente con 1 a 5 sustituyentes seleccionados del grupo B, o en donde X es un enlace, alquileno de C1-4, -CO-(CH2)p-, CONR10-(CH2)q-, -CO(CH2)r-O-(CH2)s-, -CO-(CH2)t-NH-(CH2)u-, -CO-(CH2)v-CONH-(CH2)w-, o -CO-NH-SO2-; el anillo C es un anillo de carbono de C3-12 sustituido opcionalmente con 1 a 5 sustituyentes seleccionados del grupo A, ...
CO08116130A 2006-04-18 2008-10-30 Compuesto de piperazina novedoso y uso del mismo como inhibidor de polimerasa del virus de la hepatitis c CO6220960A2 (es)

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JP2006115008 2006-04-18
US79656506P 2006-05-01 2006-05-01

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US (2) US8017612B2 (es)
EP (1) EP2009004A4 (es)
JP (2) JP4447044B2 (es)
KR (1) KR101077806B1 (es)
CN (1) CN101472902A (es)
AU (1) AU2007239285B2 (es)
BR (1) BRPI0711262A2 (es)
CA (1) CA2649521C (es)
CO (1) CO6220960A2 (es)
IL (1) IL194738A0 (es)
MX (1) MX2008013545A (es)
MY (1) MY146923A (es)
NZ (1) NZ572660A (es)
RU (1) RU2412171C2 (es)
WO (1) WO2007119889A1 (es)
ZA (1) ZA200809355B (es)

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KR102527786B1 (ko) 2016-04-07 2023-04-28 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 단백질 조정제로서 유용한 헤테로시클릭 아미드
JOP20190024A1 (ar) 2016-08-26 2019-02-19 Gilead Sciences Inc مركبات بيروليزين بها استبدال واستخداماتها
EP3541375B1 (en) * 2016-11-18 2023-08-23 Merck Sharp & Dohme LLC Factor xiia inhibitors
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CN114057666B (zh) * 2020-08-04 2023-02-07 沈阳药科大学 一种4,5-二取代-2-氨基噻唑类化合物的合成方法
JP2023542205A (ja) * 2020-09-24 2023-10-05 ヤンセン ファーマシューティカ エヌ．ベー． 新規化合物
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JPWO2007119889A1 (ja) 2009-08-27
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AU2007239285A1 (en) 2007-10-25
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