CO2017003396A2 - Esteroides neuroactivos, composiciones y usos de los mismos - Google Patents

Esteroides neuroactivos, composiciones y usos de los mismos

Info

Publication number
CO2017003396A2
CO2017003396A2 CONC2017/0003396A CO2017003396A CO2017003396A2 CO 2017003396 A2 CO2017003396 A2 CO 2017003396A2 CO 2017003396 A CO2017003396 A CO 2017003396A CO 2017003396 A2 CO2017003396 A2 CO 2017003396A2
Authority
CO
Colombia
Prior art keywords
depression
tremor
compositions
neuroactive steroids
anxiety disorder
Prior art date
Application number
CONC2017/0003396A
Other languages
English (en)
Spanish (es)
Inventor
Stephen Jay Kanes
Helen Colquhoun
Original Assignee
Sage Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sage Therapeutics Inc filed Critical Sage Therapeutics Inc
Publication of CO2017003396A2 publication Critical patent/CO2017003396A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CONC2017/0003396A 2014-09-08 2017-04-07 Esteroides neuroactivos, composiciones y usos de los mismos CO2017003396A2 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462047599P 2014-09-08 2014-09-08
US201562170596P 2015-06-03 2015-06-03
US201562213015P 2015-09-01 2015-09-01
PCT/US2015/048937 WO2016040322A1 (en) 2014-09-08 2015-09-08 Neuroactive steroids, compositions, and uses thereof

Publications (1)

Publication Number Publication Date
CO2017003396A2 true CO2017003396A2 (es) 2017-08-31

Family

ID=55459478

Family Applications (1)

Application Number Title Priority Date Filing Date
CONC2017/0003396A CO2017003396A2 (es) 2014-09-08 2017-04-07 Esteroides neuroactivos, composiciones y usos de los mismos

Country Status (18)

Country Link
US (3) US20170348327A1 (cg-RX-API-DMAC7.html)
EP (1) EP3191101B1 (cg-RX-API-DMAC7.html)
JP (3) JP6837430B2 (cg-RX-API-DMAC7.html)
KR (2) KR102491549B1 (cg-RX-API-DMAC7.html)
CN (2) CN117679426A (cg-RX-API-DMAC7.html)
AU (3) AU2015315333A1 (cg-RX-API-DMAC7.html)
BR (1) BR112017004535A2 (cg-RX-API-DMAC7.html)
CA (1) CA2960611C (cg-RX-API-DMAC7.html)
CO (1) CO2017003396A2 (cg-RX-API-DMAC7.html)
IL (2) IL285703B2 (cg-RX-API-DMAC7.html)
JO (2) JOP20200195A1 (cg-RX-API-DMAC7.html)
MX (2) MX382123B (cg-RX-API-DMAC7.html)
PE (2) PE20170904A1 (cg-RX-API-DMAC7.html)
PH (1) PH12017500427A1 (cg-RX-API-DMAC7.html)
RU (2) RU2731000C2 (cg-RX-API-DMAC7.html)
SG (2) SG11201701815SA (cg-RX-API-DMAC7.html)
TW (3) TWI784261B (cg-RX-API-DMAC7.html)
WO (1) WO2016040322A1 (cg-RX-API-DMAC7.html)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014018110B1 (pt) 2012-01-23 2022-06-07 Sage Therapeutics, Inc Composições farmacêutica aquosas formuladas para administração parenteral e uso de alopregnanolona e sulfobutiléter-b-ciclodextrina
IL294306B2 (en) 2012-08-21 2024-01-01 Sage Therapeutics Inc Methods of treating epilepsy or status epilepticus
RS58297B1 (sr) 2013-04-17 2019-03-29 Sage Therapeutics Inc 19-nor c3,3-disupstituisani c21-n-pirazolil steroidi i postupci za njihovu upotrebu
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
WO2016071660A1 (en) * 2014-11-06 2016-05-12 Ieso Digital Health Limited Computer-based system for providing psychological therapy
SI3224269T1 (sl) 2014-11-27 2020-10-30 Sage Therapeutics, Inc. Sestavki in metode za zdravljenje CNS motenj
EP4059522A1 (en) * 2015-02-06 2022-09-21 Marinus Pharmaceuticals, Inc. Intravenous ganaxolone formulations and their use in treating status epilepticus and other seizure disorders
EP3280420B1 (en) * 2015-04-10 2024-03-27 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
US10780099B2 (en) 2015-10-16 2020-09-22 Marinus Pharmaceuticals, Inc. Injectable neurosteroid formulations containing nanoparticles
US20200306265A1 (en) 2016-03-08 2020-10-01 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
KR20230050474A (ko) 2016-08-11 2023-04-14 오비드 테라퓨틱스 인크. 간질 장애의 치료를 위한 방법 및 조성물
MA46042A (fr) 2016-08-23 2019-07-03 Sage Therapeutics Inc Stéroïde c21-n-pyrazolyle 3-disubstitué en 19-nor c3 cristallin
US10391105B2 (en) 2016-09-09 2019-08-27 Marinus Pharmaceuticals Inc. Methods of treating certain depressive disorders and delirium tremens
EP3579842A4 (en) 2017-02-10 2020-12-23 Asarina Pharma AB 3-BETA-HYDROXY-5-ALPHA-PRÉGNAN-20-ONE FOR USE IN THE TREATMENT OF ESSENTIAL TREMMENTS
KR102478510B1 (ko) * 2017-02-10 2022-12-16 아사리나 파마 아베 의학적 치료에서 사용하기 위한 3-베타-히드록시-5-알파-프레그난-20-온
EP4484440A3 (en) 2017-12-08 2025-03-26 Sage Therapeutics, Inc. Deuterated 21 -[4-cyano-pyrazol-1 -yl]-19-nor-pregan-3. alpha-ol-20-one derivatives for treating cns disorders
EP3781129A1 (en) * 2018-04-17 2021-02-24 M Et P Pharma AG Compositions and methods for intranasal delivery of pregnenolone
JP2021527092A (ja) * 2018-06-12 2021-10-11 セージ セラピューティクス, インコーポレイテッド 19−ノルc3,3−二置換c21−n−ピラゾリルステロイドおよびその使用方法
US10562930B1 (en) 2018-08-31 2020-02-18 Praxis Precision Medicines, Inc. Salts and crystal forms of GABAA positive allosteric modulator
EP3860595A4 (en) * 2018-11-05 2021-11-10 Ovid Therapeutics Inc. USE OF GABOXADOL, GANAXOLONE, AND ALLOPREGNANOLONE TO TREAT MOTION DISORDERS
CN111281877A (zh) * 2018-11-22 2020-06-16 南京诺瑞特医药科技有限公司 神经活性类固醇的新制剂
US11266662B2 (en) 2018-12-07 2022-03-08 Marinus Pharmaceuticals, Inc. Ganaxolone for use in prophylaxis and treatment of postpartum depression
KR20210149028A (ko) * 2018-12-14 2021-12-08 프락시스 프리시젼 메디신즈, 인크. 우울증의 치료 방법
SG11202112111WA (en) 2019-05-10 2021-11-29 Brii Biosciences Inc Pharmaceutical composition containing brexanolone, ganaxolone, or zuranolone, and use thereof
WO2020252384A1 (en) * 2019-06-14 2020-12-17 Vorsanger Gary Treatment methods utilizing oxytocin receptor agonists
MX2022001553A (es) 2019-08-05 2022-04-18 Marinus Pharmaceuticals Inc Ganaxolona para su uso en el tratamiento del estado epileptico.
CN112341511A (zh) * 2019-08-09 2021-02-09 南京诺瑞特医药科技有限公司 3-羟基-5-孕烷-20-酮衍生物及其用途
US10857163B1 (en) 2019-09-30 2020-12-08 Athenen Therapeutics, Inc. Compositions that preferentially potentiate subtypes of GABAA receptors and methods of use thereof
IL293525A (en) 2019-12-06 2022-08-01 Marinus Pharmaceuticals Inc Ganaxolone for use in the treatment of multiple sclerosis complex
WO2021163253A1 (en) * 2020-02-12 2021-08-19 Glia, Llc Progesterone combinations
US20230414636A1 (en) 2020-03-25 2023-12-28 Sage Therapeutics, Inc. Use of gabaa modulators for treatment of respiratory conditions
TW202227092A (zh) * 2020-08-17 2022-07-16 美商布里生物科學股份有限公司 含有神經活性類固醇之醫藥組合物及其用途
US11969434B1 (en) 2022-08-29 2024-04-30 Lipocine Inc. Oral allopregnanolone compositions and methods of use
US11337987B1 (en) 2021-05-07 2022-05-24 Lipocine Inc. Compositions and methods for treating central nervous system disorders
US12208103B1 (en) 2021-05-07 2025-01-28 Lipocine Inc. Compositions and methods for treating CNS disorders
CN115487138A (zh) * 2021-06-18 2022-12-20 北京万全德众医药生物技术有限公司 别孕烯醇酮注射剂及其制备方法
US12186327B2 (en) 2022-08-29 2025-01-07 Lipocine Inc. Oral allopregnanolone compositions and methods of use
EP4583902A2 (en) * 2022-09-07 2025-07-16 Oxeia Biopharmaceuticals, Inc. Treatment of mild traumatic brain injury
WO2025109453A1 (en) * 2023-11-22 2025-05-30 Emcure Pharmaceuticals Limited Deuterated dydrogesterone
WO2025178616A1 (en) * 2024-02-21 2025-08-28 Lipocine, Inc. Oral allopregnanolone compositions and methods of use

Family Cites Families (186)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3117142A (en) 1961-03-01 1964-01-07 Roussel Uclaf Novel preparation of estradiol and estrone
US3169134A (en) 1963-03-21 1965-02-09 Searle & Co 2, 3-oxygenated-17alpha-methyl-5alpha-androstan-17beta-ols
BE754111A (fr) 1969-07-29 1971-01-29 Upjohn Co Nouveaux 7alpha- et 7beta-methyl-3alpha,5alpha- cycloandrostanes et composes analogues 19-nor et leur procede de preparation
US3943124A (en) 1970-12-17 1976-03-09 Gordon Hanley Phillipps Chemical compounds
US3983111A (en) 1972-05-05 1976-09-28 Glaxo Laboratories Limited Steroidal anaesthetics of the pregnane and 19-norpregnane series
GB1430942A (en) 1972-05-05 1976-04-07 Glaxo Lab Ltd 21-substituted 3alpha-hydroxy pregnanes
US3865939A (en) 1973-02-23 1975-02-11 Procter & Gamble Edible oils having hypocholesterolemic properties
US4071625A (en) 1974-05-13 1978-01-31 Richardson-Merrell Inc. 19-Oxygenated-5α-androstanes for the enhancement of libido
GB1570394A (en) 1976-01-06 1980-07-02 Glaxo Lab Ltd 11-acyloxy-3-hydroxy steroids
US4192871A (en) 1976-01-06 1980-03-11 Glaxo Laboratories Limited Chemical compounds
GB1581234A (en) 1976-04-05 1980-12-10 Glaxo Operations Ltd 11a - amino - 3a - hydroxysteroids
SE8600632D0 (sv) 1986-02-13 1986-02-13 Kabivitrum Ab Novel pharmaceutical composition
US5120723A (en) 1987-08-25 1992-06-09 University Of Southern California Method, compositions, and compounds for modulating brain excitability
US5232917A (en) 1987-08-25 1993-08-03 University Of Southern California Methods, compositions, and compounds for allosteric modulation of the GABA receptor by members of the androstane and pregnane series
US5319115A (en) 1987-08-25 1994-06-07 Cocensys Inc. Method for making 3α-hydroxy, 3β-substituted-pregnanes
US5719197A (en) 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
EP0603312A4 (en) 1991-09-13 1995-06-07 Cocensys Inc NEW GABA A RECEPTOR WITH STEROID BINDING POINTS.
JP4008024B2 (ja) 1993-05-24 2007-11-14 パーデュー、ファーマ、リミテッド、パートナーシップ Gabaaレセプター複合体と相互作用させるための化合物
EP0656365B1 (en) 1993-12-02 1997-04-09 Akzo Nobel N.V. Substituted 2beta-morpholinoandrostane derivatives
DK1038880T3 (da) 1994-02-14 2008-03-03 Euro Celtique Sa Androstaner og pregnaner til allosterisk modulering af GABA-receptor
US5939545A (en) 1994-02-14 1999-08-17 Cocensys, Inc. Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series
BR9507200A (pt) 1994-03-25 1997-09-16 Isotechnika Inc Melhora da eficácia de drogas por deuteração
WO1996003421A1 (en) 1994-07-21 1996-02-08 Pharmacia & Upjohn Company Neurologically active aminosteroids
PT808325E (pt) * 1994-11-23 2001-06-29 Cocensys Inc Series de androstanos e pregnanos para modulacao alosterica do receptor de gaba
US6780853B1 (en) 1995-06-06 2004-08-24 Euro-Celtique S.A. Neuroactive steroids of the androstane and pregnane series
KR19990022323A (ko) 1995-06-06 1999-03-25 씨. 랜 낸시 안드로스탄 및 프레그난 시리즈의 신경활성 스테로이드
JP4313435B2 (ja) 1995-07-24 2009-08-12 トラスティーズ オブ ボストン ユニバーシティー プレグネノロンサルフェート誘導体によるnmdaレセプター活性の抑制
WO1998005337A1 (en) 1996-08-01 1998-02-12 Cocensys, Inc. Use of gaba and nmda receptor ligands for the treatment of migraine headache
US7630757B2 (en) 1997-01-06 2009-12-08 Flint Hills Scientific Llc System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject
US5874418A (en) 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
US6046177A (en) 1997-05-05 2000-04-04 Cydex, Inc. Sulfoalkyl ether cyclodextrin based controlled release solid pharmaceutical formulations
US6316613B1 (en) 1997-07-25 2001-11-13 Beckman Coulter, Inc. Chiral separation of pharmaceutical compounds with charged cyclodextrins using capillary electrophoresis
US6245757B1 (en) 1997-10-03 2001-06-12 Research Corporation Technologies, Inc. Use of progestins to treat ischemic event
AU756001B2 (en) 1998-03-11 2003-01-02 Umecrine Mood Ab Epiallopregnanolone in the treatment of CNS disorders
US20020198174A1 (en) 2001-05-07 2002-12-26 Allergan Sales, Inc. Disinfecting and solubilizing steroid compositions
US6376531B1 (en) 1998-11-13 2002-04-23 Rupert Charles Bell Method of treatment using deuterium compounds
US20030236236A1 (en) 1999-06-30 2003-12-25 Feng-Jing Chen Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs
AU775102B2 (en) * 1999-09-13 2004-07-15 David M. Swope Composition and method for decreasing neurologic symptomatology
EP1104760B1 (en) 1999-12-03 2003-03-12 Pfizer Products Inc. Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents
US6613308B2 (en) 2000-09-19 2003-09-02 Advanced Inhalation Research, Inc. Pulmonary delivery in treating disorders of the central nervous system
US20020072509A1 (en) 2000-10-11 2002-06-13 Stein Donald Gerald Methods for the treatment of a traumatic central nervous system injury
EP1216713A1 (en) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions of estrogen-cyclodextrin complexes
GR1003861B (el) 2000-12-29 2002-04-11 Νεα νευροστεροειδη που αλληλεπιδρουν με τον υποδοχεα gabaa.
CA2443266A1 (en) 2001-02-13 2002-08-22 University Of Florida A bi-directional dual promoter complex with enhanced promoter activity for transgene expression in eukaryotes
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US7090830B2 (en) 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
CA2641760A1 (en) 2001-05-24 2002-11-28 Alexza Pharmaceuticals, Inc. Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
US20030032638A1 (en) 2001-05-24 2003-02-13 Kim John J. Delivery of benzodiazepines through an inhalation route
JP2003063965A (ja) 2001-06-13 2003-03-05 Otsuka Pharmaceut Factory Inc 注射用シロスタゾール水性製剤
SE0104423D0 (sv) * 2001-12-27 2001-12-27 Umecrine Ab Pregnane steroids and their use in the treatment of CNS disorders
WO2003076476A2 (en) 2002-01-14 2003-09-18 Ansell Healthcare Products, Inc. Magnetically detectable latex articles
CA2496867A1 (en) 2002-08-28 2004-03-11 Hollis-Eden Pharmaceuticals, Inc. Therapeutic treatment methods
US20040132826A1 (en) * 2002-10-25 2004-07-08 Collegium Pharmaceutical, Inc. Modified release compositions of milnacipran
US9339508B2 (en) 2003-01-17 2016-05-17 Mapreg Use of 3-methoxy-pregnenolone for the preparation of a drug for treating a traumatic brain injury
EP1626980A4 (en) 2003-05-29 2007-07-04 Univ Washington NEUROACTIVE 13,24-CYCLO-18,21-DINORCHOLANES AND STRUCTURELY RELATED PENTACYCLIC STEROIDS
US7816074B2 (en) 2003-07-31 2010-10-19 The Research Foundation Of State University Of New York α4 β2 δGABA-A receptors as a strategy for PMS and alcoholism
GB0321607D0 (en) 2003-09-15 2003-10-15 Vectura Ltd Manufacture of pharmaceutical compositions
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US7892483B2 (en) 2004-03-12 2011-02-22 Cipla Limited Sterilization process
WO2005105822A2 (en) 2004-04-23 2005-11-10 Euro-Celtique S.A. 3-alpha-hydroxy 21-n- heteroaryl-pregnane derivatives for modulation of brain excitability and a process for the production thereof
EP1591455A1 (en) * 2004-04-29 2005-11-02 Institut National De La Sante Et De La Recherche Medicale (Inserm) Essential tremor diagnostic and treatment
ITMI20041763A1 (it) 2004-09-16 2004-12-16 Altergon Sa Nuove formulazioni iniettabili contenenti progesterone
US20060063707A1 (en) 2004-09-17 2006-03-23 Lifelike Biomatic, Inc. Compositions for enhancing memory and methods therefor
US8604011B2 (en) * 2004-09-27 2013-12-10 The Regents Of The University Of California Therapy for treatment of chronic degenerative brain diseases and nervous system injury
AU2005330504B2 (en) 2004-09-29 2010-10-28 Harbor Biosciences, Inc. Steroid analogs and characterization and treatment methods
BRPI0608087A2 (pt) 2005-02-15 2009-11-10 Elan Pharma Int Ltd formulações injetáveis e em aerossol de benzodiazepina em nanopartìculas
RS52471B (sr) 2005-03-24 2013-02-28 Emory University Režimi doziranja za lečenje traumatske povrede mozga progesteronom
EP1868593A2 (en) 2005-04-07 2007-12-26 Hythiam, Inc. Improved methods of and compositions for the prevention of anxiety, substance abuse, and dependence
US20110319386A1 (en) 2005-08-26 2011-12-29 Braincells Inc. Neurogenesis by muscarinic receptor modulation
EA017290B1 (ru) 2005-11-28 2012-11-30 Домейн Раша Инвестментс Лимитед Композиции на основе ганаксолона
US20070287931A1 (en) 2006-02-14 2007-12-13 Dilorenzo Daniel J Methods and systems for administering an appropriate pharmacological treatment to a patient for managing epilepsy and other neurological disorders
BRPI0716604A2 (pt) 2006-09-08 2013-04-09 Braincells Inc combinaÇÕes contendo um derivado de 4-acilaminopiridina
US20090239942A1 (en) 2006-09-15 2009-09-24 Cloyd James C Topiramate Compositions and Methods of Making and Using the Same
US20090203658A1 (en) 2007-01-08 2009-08-13 Duke University Neuroactive steroid compositions and methods of use therefor
US20090074677A1 (en) * 2007-01-08 2009-03-19 Duke University Neuroactive steroid compositions and methods of use therefor
US7813811B2 (en) 2007-02-08 2010-10-12 Neuropace, Inc. Refillable reservoir lead systems
LT2545939T (lt) 2007-04-11 2021-03-10 Biomarin Pharmaceutical Inc. Tetrahidrobiopterinas, skirtas gydyti ligas, susijusias supadidėjusiu fenilalanino kiekiu
US8530463B2 (en) 2007-05-07 2013-09-10 Hale Biopharma Ventures Llc Multimodal particulate formulations
WO2008154579A1 (en) 2007-06-11 2008-12-18 University Of Southern California Allopregnanolone in a method for enhancing neurological function (alzheimer disease)
AU2008265898B2 (en) 2007-06-15 2013-11-28 Research Triangle Institute Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
GB0711948D0 (en) 2007-06-20 2007-08-01 Bionature E A Ltd Neurosteriod compounds
WO2009000038A1 (en) 2007-06-28 2008-12-31 Cnsbio Pty Ltd Combination methods and compositions for treatment of neuropathic pain
US20100297181A1 (en) 2007-12-26 2010-11-25 Eisai R&D Management Co., Ltd. AMPA Receptor Antagonists for Epilepsy, Mental Disorders or Deficits in Sensory Organ
JP2011508775A (ja) 2008-01-03 2011-03-17 ビオマリン プハルマセウトイカル インコーポレイテッド Bh4応答性状態を治療するためのプテリン類似体
US20090198145A1 (en) 2008-02-06 2009-08-06 Chow Harrison Compositions, methods, and systems for rapid induction and maintenance of continuous rem sleep
US8729070B2 (en) 2008-02-20 2014-05-20 Targia Pharmaceuticals CNS pharmaceutical compositions and methods of use
WO2010063030A2 (en) 2008-11-30 2010-06-03 Feigelson, Daniel Dermal application of vasoconstrictors
CZ2008434A3 (cs) 2008-07-10 2009-12-09 Ústav organické chemie a biochemie Akademie ved CR, v. v. i. Pregnanové anionické slouceniny, zpusob jejich výroby a jejich použití
SMT202000257T1 (it) 2008-10-10 2020-07-08 Vm Discovery Inc Composizioni e metodi per il trattamento dei disturbi da uso di alcol, dolore e altre malattie
WO2010088409A2 (en) 2009-01-30 2010-08-05 Emory University Methods of neuroprotection using neuroprotective steroids and a vitamin d
WO2010107922A1 (en) * 2009-03-17 2010-09-23 Duke University Neuroactive steroid compositions and methods of use for lowering cholesterol
WO2011079047A1 (en) 2009-12-23 2011-06-30 Drugtech Corporation Methods for reducing the occurrence of preterm delivery and other pregnancy-related conditions
KR101747476B1 (ko) 2010-01-21 2017-06-14 드로브리지 파마슈티컬스 피티와이 엘티디 마취 제제
US8747365B2 (en) 2010-11-03 2014-06-10 Sanofi-Aventis Deutschland Gmbh Needle cannula containing medicament
WO2012075286A2 (en) 2010-12-01 2012-06-07 The Regents Of The University Of California Intrapulmonary benzodiazepine for the treatment and prevention of seizures
CZ303443B6 (cs) 2011-02-15 2012-09-12 Ústav organické chemie a biochemie Akademie ved CR, v.v.i. Deriváty pregnanolonu substituované v poloze 3alfa kationickou skupinou, zpusob jejich výroby, jejich použití a prostredek je obsahující
WO2012116290A2 (en) 2011-02-25 2012-08-30 Washington University Neuroactive 17(20)-z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
FR2973031B1 (fr) 2011-03-23 2013-11-29 Univ Strasbourg Derives de l'allopregnanolone et de l'epiallopregnanolone et leurs utilisations pour traiter un etat neuropathologique
US9084797B2 (en) 2011-05-23 2015-07-21 Besins Healthcare Luxembourg Sarl Progesterone treatment for improving sleep quality
EP2727473A4 (en) 2011-06-28 2015-05-06 Vivozon Inc COMBINATION OF EFFICIENT SUBSTANCES WITH SYNERGISTIC EFFECTS OF MULTIPLE TARGETING AND USE THEREOF
JP2014521662A (ja) 2011-07-29 2014-08-28 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア GABAA受容体のモジュレーターとしての新規な17β−ヘテロアリール置換ステロイド
SMT202300232T1 (it) 2011-09-08 2023-09-06 Sage Therapeutics Inc Steroidi neuroattivi, composizioni e relativi usi
US10478505B2 (en) 2011-09-23 2019-11-19 The Regents Of The University Of California Edible oils to enhance delivery of orally administered steroids
JP2014528485A (ja) 2011-10-14 2014-10-27 セージ セラピューティクス, インコーポレイテッド 3,3−二置換19−ノルプレグナン化合物およびその使用
WO2013079624A1 (en) 2011-11-29 2013-06-06 Amino Up Chemical Co., Ltd. Composition comprising vicenin-2 having a beneficial effect on neurological and/or cognitive function
BR112014018110B1 (pt) 2012-01-23 2022-06-07 Sage Therapeutics, Inc Composições farmacêutica aquosas formuladas para administração parenteral e uso de alopregnanolona e sulfobutiléter-b-ciclodextrina
US20150175651A1 (en) 2012-06-15 2015-06-25 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
US20140050789A1 (en) 2012-08-13 2014-02-20 The Regents Of The University Of California Mitigation of epileptic seizures by combination therapy using benzodiazepines and neurosteroids
IL294306B2 (en) * 2012-08-21 2024-01-01 Sage Therapeutics Inc Methods of treating epilepsy or status epilepticus
WO2014058736A1 (en) 2012-10-08 2014-04-17 Washington University Neuroactive 19-alkoxy-17(20)-z-vinylcyano-substituted steroids, prodrugs thereof, and methods of treatment using same
US9757391B2 (en) 2012-11-09 2017-09-12 Goodchild Investments Pty Ltd Neuroactive steroids and their use to facilitate neuroprotection
US20150313915A1 (en) 2012-11-30 2015-11-05 The Regents Of The University Of California Anticonvulsant activity of steroids
JP6542127B2 (ja) 2012-12-18 2019-07-10 ワシントン・ユニバーシティWashington University 向神経活性19−アルコキシ−17−置換ステロイド、そのプロドラッグおよびそれを使用する処置方法
WO2014108808A2 (en) 2013-01-09 2014-07-17 Henry James Lorne Pharmaceutical formulations for the treatment and prevention of trauma-induced neuropathology and neurodegeneration
WO2014169831A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor c3,3-disubstituted c21-c-bound heteroaryl steroids and methods of use thereof
AU2014256228C1 (en) 2013-04-17 2017-09-14 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
RS58297B1 (sr) 2013-04-17 2019-03-29 Sage Therapeutics Inc 19-nor c3,3-disupstituisani c21-n-pirazolil steroidi i postupci za njihovu upotrebu
WO2014169836A1 (en) 2013-04-17 2014-10-23 Sage Therapeutics, Inc. 19-nor neuroactive steroids and methods of use thereof
BR112016000975B1 (pt) 2013-07-19 2020-10-06 Sage Therapeutics, Inc. Compostos esteróides neuroativos e composições compreendendo os mesmos
RS61370B1 (sr) 2013-08-23 2021-02-26 Sage Therapeutics Inc Neuroaktivni steroidi, njihove kompozicije i upotreba
TW201625661A (zh) 2014-05-29 2016-07-16 賽吉醫療公司 神經活性類固醇,其組合物及其用途
US10246482B2 (en) 2014-06-18 2019-04-02 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
JOP20200195A1 (ar) 2014-09-08 2017-06-16 Sage Therapeutics Inc سترويدات وتركيبات نشطة عصبياً، واستخداماتها
CN118344424A (zh) 2014-10-16 2024-07-16 萨奇治疗股份有限公司 靶向cns障碍的组合物和方法
DK3206493T3 (da) 2014-10-16 2020-08-10 Sage Therapeutics Inc Sammensætninger og fremgangsmåder til behandling af cns-forstyrrelser
SI3224269T1 (sl) 2014-11-27 2020-10-30 Sage Therapeutics, Inc. Sestavki in metode za zdravljenje CNS motenj
ES2857082T3 (es) 2015-01-26 2021-09-28 Sage Therapeutics Inc Composiciones y métodos para el tratamiento de trastornos del SNC
EP4059522A1 (en) 2015-02-06 2022-09-21 Marinus Pharmaceuticals, Inc. Intravenous ganaxolone formulations and their use in treating status epilepticus and other seizure disorders
ES2935476T3 (es) 2015-02-20 2023-03-07 Sage Therapeutics Inc Esteroides neuroactivos, composiciones y usos de los mismos
EP3280420B1 (en) 2015-04-10 2024-03-27 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
MA45276A (fr) 2015-06-18 2018-04-25 Sage Therapeutics Inc Solutions de stéroïdes neuroactifs et leurs méthodes d'utilisation
GB2541015A (en) 2015-08-06 2017-02-08 Ge Oil & Gas Uk Ltd Subsea flying lead
AU2016338916B2 (en) 2015-10-14 2021-12-23 The Regents Of The University Of California Enhancing beta cell replication and/or survival
EP3377070A4 (en) 2015-11-20 2019-07-10 Sage Therapeutics, Inc. COMPOUNDS AND METHOD FOR THEIR USE
US20200306265A1 (en) 2016-03-08 2020-10-01 Sage Therapeutics, Inc. Neuroactive steroids, compositions, and uses thereof
AU2017297375B2 (en) 2016-07-11 2022-09-15 Sage Therapeutics, Inc. C17, C20, and C21 substituted neuroactive steroids and their methods of use
WO2018013615A1 (en) 2016-07-11 2018-01-18 Sage Therapeutics, Inc. C7, c12, and c16 substituted neuroactive steroids and their methods of use
KR20230050474A (ko) 2016-08-11 2023-04-14 오비드 테라퓨틱스 인크. 간질 장애의 치료를 위한 방법 및 조성물
US20180050107A1 (en) 2016-08-16 2018-02-22 Janssen Pharmaceutica Nv Neurosteroid compositions and methods of use thereof
US20180050005A1 (en) 2016-08-16 2018-02-22 Janssen Pharmaceutica Nv Concentrated Solution of 17-Hydroxydocosahexaenoic Acid
MA46042A (fr) 2016-08-23 2019-07-03 Sage Therapeutics Inc Stéroïde c21-n-pyrazolyle 3-disubstitué en 19-nor c3 cristallin
KR102630701B1 (ko) 2016-09-07 2024-01-29 글리아, 엘엘씨 두개 신경의 약리학적 피부 활성화에 의한 신경변성 질환과 관련된 증상의 치료
US10391105B2 (en) 2016-09-09 2019-08-27 Marinus Pharmaceuticals Inc. Methods of treating certain depressive disorders and delirium tremens
WO2018169798A1 (en) 2017-03-11 2018-09-20 The Regents Of The University Of California Mitigation of cns disorders by combination therapy using neurosteroids, and ampa blockers
CN110520131A (zh) 2017-04-18 2019-11-29 马瑞纳斯制药公司 缓释可注射的神经类固醇制剂
US20180338959A1 (en) 2017-05-24 2018-11-29 Ovid Therapeutics Inc. Treatment of depressive disorders
US11752115B2 (en) 2017-06-21 2023-09-12 The Board Of Trustees Of The University Of Illinois PPAR-alpha agonist treatment of neuropsychiatric disorders
EP3642206A4 (en) 2017-06-23 2021-04-07 The Regents of The University of California INCREASED GABA ABILITY TO MODULATE IMMUNE REACTIONS
WO2018237282A1 (en) 2017-06-23 2018-12-27 The Board Of Trustees Of The University Of Illinois Treatment of neuropsychiatric disorders with neurosteroids and analogues thereof
AU2018327357B2 (en) 2017-09-07 2024-08-22 Sage Therapeutics, Inc. Neuroactive steroids and their methods of use
US20200276209A1 (en) 2017-09-11 2020-09-03 Sage Therapeutics, Inc. Methods of treating epilepsy or status epilepticus
JP2020534270A (ja) 2017-09-14 2020-11-26 セージ セラピューティクス, インコーポレイテッド 19−ノルc3,3−二置換c21−n−ピラゾリルステロイドおよびその使用方法
KR20200085837A (ko) 2017-11-10 2020-07-15 마리누스 파마슈티컬스 인코포레이티드 유전적 간질 질환 치료에 사용하기 위한 가낙솔론의 용도
EP4484440A3 (en) 2017-12-08 2025-03-26 Sage Therapeutics, Inc. Deuterated 21 -[4-cyano-pyrazol-1 -yl]-19-nor-pregan-3. alpha-ol-20-one derivatives for treating cns disorders
CA3086299A1 (en) 2017-12-22 2019-06-27 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
AU2018392093B2 (en) 2017-12-22 2024-02-01 Sage Therapeutics, Inc. Compositions and methods for treating CNS disorders
MA51568A (fr) 2018-01-12 2021-04-21 Sage Therapeutics Inc Composés aza-, oxa et thia-pregnan-20-one-3.alpha.-ol s'utilisant dans le traitement de troubles du système nerveux central
CA3099089A1 (en) 2018-05-04 2019-11-07 Acerus Pharmaceuticals Corporation Neurosteroid derivatives and uses thereof
JP2021527092A (ja) 2018-06-12 2021-10-11 セージ セラピューティクス, インコーポレイテッド 19−ノルc3,3−二置換c21−n−ピラゾリルステロイドおよびその使用方法
DK3864022T3 (da) 2018-10-12 2023-12-18 Sage Therapeutics Inc Neuroaktive steroider substitueret i Position 10 med en cyklisk gruppe til anvendelse til behandlingen af CNS-lidelser
CA3116892A1 (en) 2018-10-19 2020-04-23 Sage Therapeutics, Inc. 9(11)-unsaturated neuroactive steroids and their methods of use
EP3876935A4 (en) 2018-11-08 2022-08-17 Varsona Therapeutics, Inc. TOPICAL FORMULATIONS OF 5-A REDUCTASE INHIBITORS AND THEIR USES
AU2019384157A1 (en) 2018-11-21 2021-06-17 Certego Therapeutics Inc. Gaboxadol for reducing risk of suicide and rapid relief of depression
IL312610A (en) 2018-12-05 2024-07-01 Sage Therapeutics Inc Neuroactive steroids and methods of using them
US11266662B2 (en) 2018-12-07 2022-03-08 Marinus Pharmaceuticals, Inc. Ganaxolone for use in prophylaxis and treatment of postpartum depression
PH12021551396A1 (en) 2018-12-14 2022-05-11 Acerus Biopharma Inc Active ester derivatives of testosterone, compositions and uses thereof
WO2020132504A1 (en) 2018-12-21 2020-06-25 Sage Therapeutics, Inc. 3.alpha.-hydroxy-17.beta.-amide neuroactive steroids and compositions thereof
TW202523658A (zh) 2019-05-24 2025-06-16 美商賽吉醫療公司 化合物、組合物及使用方法
BR112021024033A2 (pt) 2019-05-31 2022-02-08 Sage Therapeutics Inc Esteroides neuroativos e suas composições
CA3144701A1 (en) 2019-06-27 2020-12-30 Sage Therapeutics, Inc. Compositions and methods for treating cns disorders
CA3143545A1 (en) 2019-06-27 2020-12-30 Sage Therapeutics, Inc. Compounds for treating cns disorders
KR20220038680A (ko) 2019-06-27 2022-03-29 세이지 테라퓨틱스, 인크. Cns 장애를 치료하기 위한 조성물 및 방법
EP4069250A1 (en) 2019-12-05 2022-10-12 Sage Therapeutics, Inc. A 19-nor c3,3-disubstituted c21-n-pyrazolyl steroid and methods of use thereof
EP4121438A2 (en) 2020-03-18 2023-01-25 Sage Therapeutics, Inc. Neuroactive steroids and their methods of use
US20230414636A1 (en) 2020-03-25 2023-12-28 Sage Therapeutics, Inc. Use of gabaa modulators for treatment of respiratory conditions
WO2021262836A1 (en) 2020-06-24 2021-12-30 Sage Therapeutics, Inc. 3.alpha.-hydroxy, 17.beta.-c(o)-n-aryl substituted neuroactive steroids and compositions thereof
CN116367827A (zh) 2020-07-20 2023-06-30 萨奇治疗股份有限公司 19-去甲-c3,3-二取代-c21-n-吡唑基类固醇的制剂及其使用方法
WO2022115381A1 (en) 2020-11-25 2022-06-02 Sage Therapeutics, Onc. Compositions and methods for treating cns disorders cross reference to related application
KR20230136599A (ko) 2021-01-28 2023-09-26 세이지 테라퓨틱스, 인크. 성 기능장애의 치료를 위한 신경활성 스테로이드의용도
US20240148756A1 (en) 2021-02-18 2024-05-09 Sage Therapeutics, Inc. Use of neuroactive steroid for treatment of sexual dysfunction
KR20230158033A (ko) 2021-03-17 2023-11-17 세이지 테라퓨틱스, 인크. 주요 우울 장애의 치료를 위한 19-노르 c3,3-이치환된 c21-n-피라졸릴 스테로이드
JP2024513581A (ja) 2021-04-12 2024-03-26 セージ セラピューティクス, インコーポレイテッド 本態性振戦の治療
CN117580580A (zh) 2021-04-29 2024-02-20 萨奇治疗股份有限公司 用于在哺乳期女性中治疗重度抑郁障碍和产后抑郁症的神经活性类固醇
TW202308654A (zh) 2021-04-29 2023-03-01 美商賽吉醫療公司 19-nor-c3,3-二取代c21-n-吡唑基類固醇及其使用方法

Also Published As

Publication number Publication date
PH12017500427A1 (en) 2017-07-31
KR20230015518A (ko) 2023-01-31
TW201625266A (zh) 2016-07-16
IL285703B1 (en) 2023-11-01
CA2960611C (en) 2024-09-10
EP3191101A1 (en) 2017-07-19
IL250942B (en) 2021-09-30
JOP20200195A1 (ar) 2017-06-16
SG10202107866YA (en) 2021-08-30
KR102491549B1 (ko) 2023-01-20
JP6837430B2 (ja) 2021-03-03
IL285703B2 (en) 2024-03-01
JO3667B1 (ar) 2020-08-27
CA2960611A1 (en) 2016-03-17
TW202329978A (zh) 2023-08-01
EP3191101A4 (en) 2018-04-11
AU2021202433A1 (en) 2021-05-13
BR112017004535A2 (pt) 2018-07-03
TWI688389B (zh) 2020-03-21
MX2017003037A (es) 2017-06-14
TWI784261B (zh) 2022-11-21
JP2017526703A (ja) 2017-09-14
US12083131B2 (en) 2024-09-10
CN117679426A (zh) 2024-03-12
RU2020127610A (ru) 2021-09-30
MX2020011537A (es) 2020-11-24
AU2021202433C1 (en) 2024-01-25
JP2020059760A (ja) 2020-04-16
AU2021202433B2 (en) 2023-07-13
IL250942A0 (en) 2017-04-30
WO2016040322A1 (en) 2016-03-17
IL285703A (en) 2021-09-30
PE20221050A1 (es) 2022-06-30
MX382123B (es) 2025-03-13
KR20170048567A (ko) 2017-05-08
AU2015315333A1 (en) 2017-03-23
CN107106574A (zh) 2017-08-29
AU2023248120A1 (en) 2023-11-02
US20200253985A1 (en) 2020-08-13
TW202106306A (zh) 2021-02-16
NZ729758A (en) 2024-09-27
US20170348327A1 (en) 2017-12-07
RU2017111816A3 (cg-RX-API-DMAC7.html) 2019-05-08
PE20170904A1 (es) 2017-07-12
JP2022113879A (ja) 2022-08-04
EP3191101B1 (en) 2024-11-27
US20250213591A1 (en) 2025-07-03
RU2731000C2 (ru) 2020-08-26
SG11201701815SA (en) 2017-04-27
RU2017111816A (ru) 2018-10-10

Similar Documents

Publication Publication Date Title
CO2017003396A2 (es) Esteroides neuroactivos, composiciones y usos de los mismos
MX2018010902A (es) Esteroides neuroactivos, composiciones y usos de los mismos.
CL2019001259A1 (es) Esteroides y conjugados de proteínas de los mismos.
CO2018001149A2 (es) Anticuerpos monoclonales contra bcma
BR112018070199A2 (pt) composição farmacêutica de hormônio esteroide
CR20150664A (es) Moduladores de los receptores de estrógeno y sus usos
CL2018002874A1 (es) Anticuerpos de hemaglutinina contra el virus de la influenza b y métodos de uso (divisional de solicitud n° 2413-2016).
CA3279953A1 (en) C7, c12, and c16 substituted neuroactive steroids and their methods of use
SI2986624T1 (sl) 19-nor nevroaktivni steroidi za metode zdravljenja
MX2015012437A (es) Esteroides neuroactivos, composiciones, y usos de los mismos.
CO2017002472A2 (es) Formulación de acetato de abiraterona
EA201691808A8 (ru) Кортикостероидные композиции для местного применения
EA201790884A1 (ru) 6-алкил-7-гидрокси-4-ен-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
BR112015030356A2 (pt) métodos de tratamento de uma taupatia
EA201790881A1 (ru) 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
EA201790885A1 (ru) 6α-АЛКИЛ-6,7-ДИОНОВЫЕ СТЕРОИДЫ В КАЧЕСТВЕ ПРОМЕЖУТОЧНЫХ СОЕДИНЕНИЙ ДЛЯ ПОЛУЧЕНИЯ СТЕРОИДНЫХ МОДУЛЯТОРОВ FXR
EA201790879A1 (ru) 6-альфа-алкил-3,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
BR112016029917A2 (pt) composições e métodos para estimular o sistema enteroendócrino intestinal
HUE054337T2 (hu) C-3 és C-17 módosított triterpenoidok HIV-1 inhibitorokként
UY36173A (es) Metodo de tratamiento de enfermedades relacionadas con el factor inducible por hipoxia
BR112016008288A2 (pt) receptor fc gama solúvel para tratamento de doenças autoimunes bolhosas
EP3710011C0 (fr) Triterpènes pentacycliques dans le traitement d'une pathologie bucco-dentaire
HK1235002A1 (en) Neuroactive steroids, compositions, and uses thereof
AR107833A1 (es) Esteroides neuroactivos, composiciones y usos de los mismos
UY35622A (es) Moduladores de los receptores de estrógeno y sus usos