EA201790879A1 - 6-альфа-алкил-3,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr - Google Patents

6-альфа-алкил-3,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr

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Publication number
EA201790879A1
EA201790879A1 EA201790879A EA201790879A EA201790879A1 EA 201790879 A1 EA201790879 A1 EA 201790879A1 EA 201790879 A EA201790879 A EA 201790879A EA 201790879 A EA201790879 A EA 201790879A EA 201790879 A1 EA201790879 A1 EA 201790879A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fxr
alpha
alkyl
obtaining
intermediate connections
Prior art date
Application number
EA201790879A
Other languages
English (en)
Other versions
EA034739B1 (ru
Inventor
Александер Уэймаут-Уилсон
Зофиа Комста
Джеймс Бойдэлл
Лаура Уоллис
Риз Батчелор
Карл Оттер
Юань Дэвис
Original Assignee
ЭнЗиПи Юкей ЛИМИТЕД
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505676.5A external-priority patent/GB201505676D0/en
Application filed by ЭнЗиПи Юкей ЛИМИТЕД filed Critical ЭнЗиПи Юкей ЛИМИТЕД
Publication of EA201790879A1 publication Critical patent/EA201790879A1/ru
Publication of EA034739B1 publication Critical patent/EA034739B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Изобретение относится к соединениям формулы (I)где R, R, Y, Rи Rтакие, как определено в описании изобретения. Эти соединения представляют собой промежуточные соединения в синтезе синтетических желчных кислот.
EA201790879A 2014-11-19 2015-11-19 6-альфа-алкил-3,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr EA034739B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505676.5A GB201505676D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053518 WO2016079519A1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators

Publications (2)

Publication Number Publication Date
EA201790879A1 true EA201790879A1 (ru) 2017-11-30
EA034739B1 EA034739B1 (ru) 2020-03-16

Family

ID=54704021

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201790879A EA034739B1 (ru) 2014-11-19 2015-11-19 6-альфа-алкил-3,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr

Country Status (14)

Country Link
US (1) US10538550B2 (ru)
EP (1) EP3221333B1 (ru)
JP (1) JP6735748B2 (ru)
KR (1) KR102546748B1 (ru)
CN (1) CN107108688B (ru)
CA (1) CA2968305A1 (ru)
DK (1) DK3221333T3 (ru)
EA (1) EA034739B1 (ru)
ES (1) ES2748692T3 (ru)
HK (1) HK1244287A1 (ru)
MX (1) MX2017006565A (ru)
PL (1) PL3221333T3 (ru)
TW (1) TWI686401B (ru)
WO (1) WO2016079519A1 (ru)

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Also Published As

Publication number Publication date
HK1244287A1 (zh) 2018-08-03
TWI686401B (zh) 2020-03-01
KR102546748B1 (ko) 2023-06-22
JP6735748B2 (ja) 2020-08-05
TW201632538A (zh) 2016-09-16
ES2748692T3 (es) 2020-03-17
WO2016079519A1 (en) 2016-05-26
CN107108688B (zh) 2019-10-29
JP2017538690A (ja) 2017-12-28
CA2968305A1 (en) 2016-05-26
DK3221333T3 (da) 2019-09-30
PL3221333T3 (pl) 2020-01-31
CN107108688A (zh) 2017-08-29
WO2016079519A9 (en) 2018-08-09
EP3221333B1 (en) 2019-07-24
EA034739B1 (ru) 2020-03-16
US20180340006A1 (en) 2018-11-29
US10538550B2 (en) 2020-01-21
EP3221333A1 (en) 2017-09-27
MX2017006565A (es) 2018-01-26
KR20170104453A (ko) 2017-09-15

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