MX2017006565A - Esteroides 6.alfa.-alquil-3,7-diona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr). - Google Patents
Esteroides 6.alfa.-alquil-3,7-diona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr).Info
- Publication number
- MX2017006565A MX2017006565A MX2017006565A MX2017006565A MX2017006565A MX 2017006565 A MX2017006565 A MX 2017006565A MX 2017006565 A MX2017006565 A MX 2017006565A MX 2017006565 A MX2017006565 A MX 2017006565A MX 2017006565 A MX2017006565 A MX 2017006565A
- Authority
- MX
- Mexico
- Prior art keywords
- intermediates
- alpha
- alkyl
- production
- fxr modulators
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Abstract
La invención se refiere a compuestos de la fórmula (I) en donde R1, R2, Y1, R4 y R5 son como se definen aquí; los compuestos son intermedios en la síntesis de ácidos biliares sintéticos.(ver Fórmula).
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1420593.4A GB201420593D0 (en) | 2014-11-19 | 2014-11-19 | Compounds |
GBGB1420594.2A GB201420594D0 (en) | 2014-11-19 | 2014-11-19 | Compounds |
GBGB1505676.5A GB201505676D0 (en) | 2015-04-01 | 2015-04-01 | Compounds |
PCT/GB2015/053518 WO2016079519A1 (en) | 2014-11-19 | 2015-11-19 | 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017006565A true MX2017006565A (es) | 2018-01-26 |
Family
ID=54704021
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017006565A MX2017006565A (es) | 2014-11-19 | 2015-11-19 | Esteroides 6.alfa.-alquil-3,7-diona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr). |
Country Status (14)
Country | Link |
---|---|
US (1) | US10538550B2 (es) |
EP (1) | EP3221333B1 (es) |
JP (1) | JP6735748B2 (es) |
KR (1) | KR102546748B1 (es) |
CN (1) | CN107108688B (es) |
CA (1) | CA2968305A1 (es) |
DK (1) | DK3221333T3 (es) |
EA (1) | EA034739B1 (es) |
ES (1) | ES2748692T3 (es) |
HK (1) | HK1244287A1 (es) |
MX (1) | MX2017006565A (es) |
PL (1) | PL3221333T3 (es) |
TW (1) | TWI686401B (es) |
WO (1) | WO2016079519A1 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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EA033445B1 (ru) | 2014-11-19 | 2019-10-31 | Nzp Uk Ltd | 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr |
CA2968310A1 (en) | 2014-11-19 | 2016-05-26 | NZP UK Limited | 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators |
MX2017006563A (es) | 2014-11-19 | 2018-01-26 | Nzp Uk Ltd | Esteroides de 6-alquil-7-hidroxi-4-en-3-ona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr). |
EA201891491A1 (ru) * | 2015-12-22 | 2018-11-30 | Интерсепт Фармасьютикалз, Инк. | Полиморфные кристаллические формы обетихолевой кислоты |
GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
GB201608779D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
EP3431486A1 (en) | 2017-07-18 | 2019-01-23 | Bionice, S.L.U. | Process and intermediates for the synthesis of obeticholic acid and derivatives thereof |
GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
CN111138509B (zh) * | 2018-11-02 | 2022-12-06 | 东莞东阳光药物研发有限公司 | 奥贝胆酸的制备方法 |
EP3890745A4 (en) * | 2018-12-04 | 2022-09-14 | President and Fellows of Harvard College | SYNTHETIC CHOLIC ACID 7-SULPHATE DERIVATIVES AND USES THEREOF |
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AU2002308295B2 (en) | 2001-03-12 | 2007-08-23 | Intercept Pharmaceuticals, Inc. | Steroids as agonists for FXR |
US20090062256A1 (en) | 2001-06-01 | 2009-03-05 | Bristol-Myers Squibb Pharma Company | LACTAMS SUBSTITUTED BY CYCLIC SUCCINATES AS INHIBITORS OF Abeta PROTEIN PRODUCTION |
AU2002352524B2 (en) | 2001-11-07 | 2007-10-04 | Nektar Therapeutics | Branched polymers and their conjugates |
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ITMI20050912A1 (it) | 2005-05-19 | 2006-11-20 | Erregierre Spa | Processo di preparazione di acidi 3-a-ya(b)-diidrossi-6-a(b)-alchil-5b-colanici |
JP2007210888A (ja) | 2006-01-12 | 2007-08-23 | Mitsubishi Chemicals Corp | ステロイド化合物の製造方法 |
CN101395170A (zh) | 2006-02-14 | 2009-03-25 | 英特塞普特药品公司 | 用于预防或治疗fxr介导的疾病或状态的作为fxr配体的胆汁酸衍生物 |
CA2656320C (en) | 2006-06-27 | 2015-04-28 | Intercept Pharmaceuticals, Inc. | Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated diseases or conditions |
EA017714B1 (ru) | 2007-01-19 | 2013-02-28 | Интерсепт Фармасьютикалз, Инк. | Модуляторы tgr5 и способы их применения |
BRPI0916735B8 (pt) | 2008-07-30 | 2021-05-25 | Intercept Pharmaceuticals Inc | compostos moduladores de tgr5, composições farmacêuticas compreendendo os mesmos e seus usos |
SI2698375T1 (sl) | 2008-11-19 | 2018-10-30 | Intercept Pharmaceuticals, Inc. | Modulatorji TGR5 in njihova uporaba |
WO2010059859A1 (en) * | 2008-11-19 | 2010-05-27 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
WO2011014661A2 (en) | 2009-07-29 | 2011-02-03 | The University Of Chicago | Liver x receptor agonists |
EP3789394A1 (en) * | 2012-06-19 | 2021-03-10 | Intercept Pharmaceuticals, Inc. | Crystalline forms c of obeticholic acid |
WO2014066819A1 (en) | 2012-10-26 | 2014-05-01 | Intercept Pharmaceuticals, Inc. | Process for preparing bile acid derivatives |
MY170802A (en) | 2012-11-28 | 2019-08-28 | Intercept Pharmaceuticals Inc | Treatment of pulmonary disease |
US20140206657A1 (en) * | 2013-01-18 | 2014-07-24 | City Of Hope | Bile acid analog tgr5 agonists |
DK3848038T3 (da) | 2013-05-14 | 2023-02-06 | Intercept Pharmaceuticals Inc | 11-Hydroxyl-6substituerede-derivater af galdesyrer og aminosyrerkonjugater heraf som farnesoid X receptor modulerer. |
KR20160013163A (ko) | 2013-05-24 | 2016-02-03 | 네스텍 소시에테아노님 | 과민성 대장 증후군 진단을 예측하기 위한 경로 특이적 검정법 |
WO2015183794A1 (en) | 2014-05-27 | 2015-12-03 | City Of Hope | Tgr5 agonist complexes for treating diabetes and cancer |
SG11201609403UA (en) | 2014-05-29 | 2016-12-29 | Bar Pharmaceuticals S R L | Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases |
EP3215179A4 (en) | 2014-11-06 | 2018-07-25 | Enanta Pharmaceuticals, Inc. | Bile acid analogs an fxr/tgr5 agonists and methods of use thereof |
MX2017006563A (es) | 2014-11-19 | 2018-01-26 | Nzp Uk Ltd | Esteroides de 6-alquil-7-hidroxi-4-en-3-ona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr). |
CA2968310A1 (en) | 2014-11-19 | 2016-05-26 | NZP UK Limited | 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators |
EA033445B1 (ru) | 2014-11-19 | 2019-10-31 | Nzp Uk Ltd | 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr |
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CN106397522A (zh) | 2015-07-31 | 2017-02-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 3,7‑二(叔丁基二甲基硅基氧基)‑6‑烯‑5β‑胆烷‑24‑酸甲酯 |
CN106478759A (zh) | 2015-08-31 | 2017-03-08 | 陕西合成药业股份有限公司 | 奥贝胆酸衍生物及其制备方法和用途 |
CN106478756A (zh) | 2015-09-02 | 2017-03-08 | 中美华世通生物医药科技(武汉)有限公司 | Oca-e单晶及其制备方法和用途 |
CN106518946A (zh) | 2015-09-10 | 2017-03-22 | 上海迪诺医药科技有限公司 | 磺酰脲衍生物、其药物组合物及应用 |
-
2015
- 2015-11-19 EP EP15800911.8A patent/EP3221333B1/en active Active
- 2015-11-19 MX MX2017006565A patent/MX2017006565A/es active IP Right Grant
- 2015-11-19 ES ES15800911T patent/ES2748692T3/es active Active
- 2015-11-19 US US15/528,331 patent/US10538550B2/en active Active
- 2015-11-19 JP JP2017527790A patent/JP6735748B2/ja active Active
- 2015-11-19 CA CA2968305A patent/CA2968305A1/en not_active Abandoned
- 2015-11-19 EA EA201790879A patent/EA034739B1/ru unknown
- 2015-11-19 KR KR1020177016857A patent/KR102546748B1/ko active IP Right Grant
- 2015-11-19 PL PL15800911T patent/PL3221333T3/pl unknown
- 2015-11-19 WO PCT/GB2015/053518 patent/WO2016079519A1/en active Application Filing
- 2015-11-19 CN CN201580062897.3A patent/CN107108688B/zh active Active
- 2015-11-19 TW TW104138185A patent/TWI686401B/zh active
- 2015-11-19 DK DK15800911.8T patent/DK3221333T3/da active
-
2018
- 2018-03-19 HK HK18103794.2A patent/HK1244287A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
TW201632538A (zh) | 2016-09-16 |
JP2017538690A (ja) | 2017-12-28 |
WO2016079519A9 (en) | 2018-08-09 |
EP3221333A1 (en) | 2017-09-27 |
PL3221333T3 (pl) | 2020-01-31 |
TWI686401B (zh) | 2020-03-01 |
CN107108688B (zh) | 2019-10-29 |
EA034739B1 (ru) | 2020-03-16 |
JP6735748B2 (ja) | 2020-08-05 |
ES2748692T3 (es) | 2020-03-17 |
HK1244287A1 (zh) | 2018-08-03 |
WO2016079519A1 (en) | 2016-05-26 |
CA2968305A1 (en) | 2016-05-26 |
US20180340006A1 (en) | 2018-11-29 |
DK3221333T3 (da) | 2019-09-30 |
EP3221333B1 (en) | 2019-07-24 |
KR20170104453A (ko) | 2017-09-15 |
EA201790879A1 (ru) | 2017-11-30 |
US10538550B2 (en) | 2020-01-21 |
KR102546748B1 (ko) | 2023-06-22 |
CN107108688A (zh) | 2017-08-29 |
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