PL3221333T3 - Steroidy, 6.alfa-alkilo-3,7-diony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr - Google Patents

Steroidy, 6.alfa-alkilo-3,7-diony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr

Info

Publication number
PL3221333T3
PL3221333T3 PL15800911T PL15800911T PL3221333T3 PL 3221333 T3 PL3221333 T3 PL 3221333T3 PL 15800911 T PL15800911 T PL 15800911T PL 15800911 T PL15800911 T PL 15800911T PL 3221333 T3 PL3221333 T3 PL 3221333T3
Authority
PL
Poland
Prior art keywords
intermediates
alpha
alkyl
production
fxr modulators
Prior art date
Application number
PL15800911T
Other languages
English (en)
Inventor
Alexander Weymouth-Wilson
Zofia KOMSTA
James Boydell
Laura WALLIS
Rhys BATCHELOR
Carl OTTER
Ieuan DAVIES
Original Assignee
NZP UK Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1420594.2A external-priority patent/GB201420594D0/en
Priority claimed from GBGB1420593.4A external-priority patent/GB201420593D0/en
Priority claimed from GBGB1505676.5A external-priority patent/GB201505676D0/en
Application filed by NZP UK Limited filed Critical NZP UK Limited
Publication of PL3221333T3 publication Critical patent/PL3221333T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
PL15800911T 2014-11-19 2015-11-19 Steroidy, 6.alfa-alkilo-3,7-diony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr PL3221333T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1420594.2A GB201420594D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1420593.4A GB201420593D0 (en) 2014-11-19 2014-11-19 Compounds
GBGB1505676.5A GB201505676D0 (en) 2015-04-01 2015-04-01 Compounds
PCT/GB2015/053518 WO2016079519A1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators
EP15800911.8A EP3221333B1 (en) 2014-11-19 2015-11-19 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators

Publications (1)

Publication Number Publication Date
PL3221333T3 true PL3221333T3 (pl) 2020-01-31

Family

ID=54704021

Family Applications (1)

Application Number Title Priority Date Filing Date
PL15800911T PL3221333T3 (pl) 2014-11-19 2015-11-19 Steroidy, 6.alfa-alkilo-3,7-diony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr

Country Status (14)

Country Link
US (1) US10538550B2 (pl)
EP (1) EP3221333B1 (pl)
JP (1) JP6735748B2 (pl)
KR (1) KR102546748B1 (pl)
CN (1) CN107108688B (pl)
CA (1) CA2968305A1 (pl)
DK (1) DK3221333T3 (pl)
EA (1) EA034739B1 (pl)
ES (1) ES2748692T3 (pl)
HK (1) HK1244287A1 (pl)
MX (1) MX2017006565A (pl)
PL (1) PL3221333T3 (pl)
TW (1) TWI686401B (pl)
WO (1) WO2016079519A1 (pl)

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EP3221334B1 (en) 2014-11-19 2020-02-19 Nzp Uk Limited 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators
CN107108687B (zh) 2014-11-19 2019-10-29 Nzp英国有限公司 作为制备类固醇FXR调节剂的中间体的5β-6-烷基-7-羟基-3-酮类固醇
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GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
GB201608779D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
EP3431486A1 (en) 2017-07-18 2019-01-23 Bionice, S.L.U. Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CN111138509B (zh) * 2018-11-02 2022-12-06 东莞东阳光药物研发有限公司 奥贝胆酸的制备方法
US20220016138A1 (en) * 2018-12-04 2022-01-20 President And Fellows Of Harvard College Synthetic derivatives of cholic acid 7-sulfate and uses thereof

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Also Published As

Publication number Publication date
EA201790879A1 (ru) 2017-11-30
TWI686401B (zh) 2020-03-01
WO2016079519A1 (en) 2016-05-26
US10538550B2 (en) 2020-01-21
JP2017538690A (ja) 2017-12-28
KR102546748B1 (ko) 2023-06-22
JP6735748B2 (ja) 2020-08-05
EA034739B1 (ru) 2020-03-16
CN107108688A (zh) 2017-08-29
EP3221333B1 (en) 2019-07-24
WO2016079519A9 (en) 2018-08-09
MX2017006565A (es) 2018-01-26
HK1244287A1 (zh) 2018-08-03
DK3221333T3 (da) 2019-09-30
US20180340006A1 (en) 2018-11-29
KR20170104453A (ko) 2017-09-15
CA2968305A1 (en) 2016-05-26
TW201632538A (zh) 2016-09-16
CN107108688B (zh) 2019-10-29
ES2748692T3 (es) 2020-03-17
EP3221333A1 (en) 2017-09-27

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