EA201790884A1 - 6-алкил-7-гидрокси-4-ен-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr - Google Patents
6-алкил-7-гидрокси-4-ен-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxrInfo
- Publication number
- EA201790884A1 EA201790884A1 EA201790884A EA201790884A EA201790884A1 EA 201790884 A1 EA201790884 A1 EA 201790884A1 EA 201790884 A EA201790884 A EA 201790884A EA 201790884 A EA201790884 A EA 201790884A EA 201790884 A1 EA201790884 A1 EA 201790884A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- fxr
- steroids
- hydroxy
- alkyl
- obtaining
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Данное изобретение относится к соединениям формулы (I)где R, R, Y, Rи Rявляются такими, как описано в описании изобретения. Эти соединения являются промежуточными соединениями в синтезе синтетических желчных кислот.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1420593.4A GB201420593D0 (en) | 2014-11-19 | 2014-11-19 | Compounds |
GBGB1420594.2A GB201420594D0 (en) | 2014-11-19 | 2014-11-19 | Compounds |
GBGB1505670.8A GB201505670D0 (en) | 2015-04-01 | 2015-04-01 | Compounds |
PCT/GB2015/053516 WO2016079517A1 (en) | 2014-11-19 | 2015-11-19 | 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators |
Publications (3)
Publication Number | Publication Date |
---|---|
EA201790884A1 true EA201790884A1 (ru) | 2017-11-30 |
EA201790884A8 EA201790884A8 (ru) | 2019-07-31 |
EA033427B1 EA033427B1 (ru) | 2019-10-31 |
Family
ID=54704019
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201790884A EA033427B1 (ru) | 2014-11-19 | 2015-11-19 | 6-алкил-7-гидрокси-4-ен-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr |
Country Status (16)
Country | Link |
---|---|
US (1) | US10301350B2 (ru) |
EP (1) | EP3221331B1 (ru) |
JP (1) | JP6700274B2 (ru) |
KR (1) | KR102526631B1 (ru) |
CN (1) | CN107207559B (ru) |
BR (1) | BR112017010319B1 (ru) |
CA (1) | CA2968309A1 (ru) |
DK (1) | DK3221331T3 (ru) |
EA (1) | EA033427B1 (ru) |
ES (1) | ES2759725T3 (ru) |
HK (1) | HK1246801A1 (ru) |
MX (1) | MX2017006563A (ru) |
PL (1) | PL3221331T3 (ru) |
PT (1) | PT3221331T (ru) |
TW (1) | TWI690536B (ru) |
WO (1) | WO2016079517A1 (ru) |
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MX2017006567A (es) | 2014-11-19 | 2018-01-26 | Nzp Uk Ltd | Esteroides 6.alfa.-alquil-6,7-diona como intermedios para la produccion de moduladores esteroides del receptor x farnesoide (fxr). |
DK3221333T3 (da) | 2014-11-19 | 2019-09-30 | Nzp Uk Ltd | 6-alfa-alkyl-3,7-dionsteroider som mellemprodukter til fremstilling af steroide FXR-modulatorer |
PL3221332T3 (pl) | 2014-11-19 | 2019-10-31 | Nzp Uk Ltd | Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr |
CZ2015504A3 (cs) * | 2015-07-16 | 2017-01-25 | Zentiva, K.S. | Krystalické formy obeticholové kyseliny |
EP3394081A1 (en) * | 2015-12-22 | 2018-10-31 | Intercept Pharmaceuticals, Inc. | Polymorphic crystalline forms of obeticholic acid |
GB201608776D0 (en) * | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
GB201608779D0 (en) * | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
GB201608777D0 (en) * | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
KR102499441B1 (ko) * | 2016-11-29 | 2023-02-13 | 이난타 파마슈티칼스, 인코포레이티드 | 술포닐우레아 담즙산 유도체의 제조 방법 |
EP3431486A1 (en) | 2017-07-18 | 2019-01-23 | Bionice, S.L.U. | Process and intermediates for the synthesis of obeticholic acid and derivatives thereof |
CN111138509B (zh) * | 2018-11-02 | 2022-12-06 | 东莞东阳光药物研发有限公司 | 奥贝胆酸的制备方法 |
CN112521438B (zh) * | 2020-12-08 | 2021-11-23 | 苏利制药科技江阴有限公司 | 一种β-谷甾醇的合成工艺 |
WO2023288123A1 (en) * | 2021-07-16 | 2023-01-19 | Interecept Pharmaceuticals, Inc. | Methods and intermediates for the preparation of 3.alpha.,7.alpha.,11.beta.-trihydroxy-6.alpha.-ethyl-5.beta.-cholan-24-oic acid |
CN113912661B (zh) * | 2021-11-11 | 2023-04-21 | 湖南科瑞生物制药股份有限公司 | 一种7-羟基甾体化合物的合成方法 |
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-
2015
- 2015-11-19 CN CN201580062904.XA patent/CN107207559B/zh active Active
- 2015-11-19 EP EP15800909.2A patent/EP3221331B1/en active Active
- 2015-11-19 CA CA2968309A patent/CA2968309A1/en not_active Abandoned
- 2015-11-19 EA EA201790884A patent/EA033427B1/ru not_active IP Right Cessation
- 2015-11-19 TW TW104138183A patent/TWI690536B/zh active
- 2015-11-19 BR BR112017010319-2A patent/BR112017010319B1/pt active IP Right Grant
- 2015-11-19 ES ES15800909T patent/ES2759725T3/es active Active
- 2015-11-19 JP JP2017527817A patent/JP6700274B2/ja active Active
- 2015-11-19 PL PL15800909T patent/PL3221331T3/pl unknown
- 2015-11-19 KR KR1020177016855A patent/KR102526631B1/ko active IP Right Grant
- 2015-11-19 MX MX2017006563A patent/MX2017006563A/es active IP Right Grant
- 2015-11-19 PT PT158009092T patent/PT3221331T/pt unknown
- 2015-11-19 DK DK15800909T patent/DK3221331T3/da active
- 2015-11-19 US US15/528,214 patent/US10301350B2/en active Active
- 2015-11-19 WO PCT/GB2015/053516 patent/WO2016079517A1/en active Application Filing
-
2018
- 2018-03-19 HK HK18103792.4A patent/HK1246801A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US10301350B2 (en) | 2019-05-28 |
EP3221331A1 (en) | 2017-09-27 |
HK1246801A1 (zh) | 2018-09-14 |
PL3221331T3 (pl) | 2020-03-31 |
EA201790884A8 (ru) | 2019-07-31 |
NZ731924A (en) | 2020-12-18 |
BR112017010319A2 (pt) | 2017-12-26 |
CA2968309A1 (en) | 2016-05-26 |
CN107207559A (zh) | 2017-09-26 |
JP2017534670A (ja) | 2017-11-24 |
ES2759725T3 (es) | 2020-05-12 |
BR112017010319B1 (pt) | 2023-04-11 |
TW201632537A (zh) | 2016-09-16 |
US20170327528A1 (en) | 2017-11-16 |
EP3221331B1 (en) | 2019-09-18 |
KR102526631B1 (ko) | 2023-04-27 |
MX2017006563A (es) | 2018-01-26 |
EA033427B1 (ru) | 2019-10-31 |
WO2016079517A1 (en) | 2016-05-26 |
KR20170086604A (ko) | 2017-07-26 |
JP6700274B2 (ja) | 2020-05-27 |
TWI690536B (zh) | 2020-04-11 |
CN107207559B (zh) | 2019-10-25 |
DK3221331T3 (da) | 2019-12-02 |
PT3221331T (pt) | 2019-12-23 |
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