CN1886400A - 9,10－α,α－OH紫杉烷类似物及其制备方法 - Google Patents

9,10－α,α－OH紫杉烷类似物及其制备方法 Download PDF

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Publication number
CN1886400A
CN1886400A CNA2004800346381A CN200480034638A CN1886400A CN 1886400 A CN1886400 A CN 1886400A CN A2004800346381 A CNA2004800346381 A CN A2004800346381A CN 200480034638 A CN200480034638 A CN 200480034638A CN 1886400 A CN1886400 A CN 1886400A
Authority
CN
China
Prior art keywords
chemical formula
deacetyltaxol
compound
thiazolinyl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2004800346381A
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English (en)
Chinese (zh)
Inventor
詹姆斯·D·麦克切斯尼
詹姆斯·费拉拉
扬·齐格穆特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tapestry Pharmaceuticals Inc
Original Assignee
Tapestry Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tapestry Pharmaceuticals Inc filed Critical Tapestry Pharmaceuticals Inc
Publication of CN1886400A publication Critical patent/CN1886400A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
CNA2004800346381A 2003-09-25 2004-09-27 9,10－α,α－OH紫杉烷类似物及其制备方法 Pending CN1886400A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50668003P 2003-09-25 2003-09-25
US60/506,680 2003-09-25

Publications (1)

Publication Number Publication Date
CN1886400A true CN1886400A (zh) 2006-12-27

Family

ID=34393186

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2004800346381A Pending CN1886400A (zh) 2003-09-25 2004-09-27 9,10－α,α－OH紫杉烷类似物及其制备方法

Country Status (14)

Country Link
US (8) US7745650B2 (enExample)
EP (2) EP1664033B1 (enExample)
JP (5) JP4874102B2 (enExample)
CN (1) CN1886400A (enExample)
AT (1) ATE377593T1 (enExample)
AU (1) AU2004275881A1 (enExample)
CA (1) CA2539975C (enExample)
DE (1) DE602004009943T2 (enExample)
DK (1) DK1664033T3 (enExample)
ES (1) ES2295937T3 (enExample)
HR (1) HRP20080057T3 (enExample)
PL (1) PL1664033T3 (enExample)
PT (1) PT1664033E (enExample)
WO (1) WO2005030150A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103764138A (zh) * 2011-04-07 2014-04-30 阿伯疗法责任有限公司 紫杉烷和Abeo-紫杉烷类似物

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AU2004275881A1 (en) 2003-09-25 2005-04-07 Tapestry Pharmaceuticals, Inc. 9,10-alpha,alpha-OH-taxane analogs and methods for production thereof
EP2634252B1 (en) 2005-02-11 2018-12-19 University of Southern California Method of expressing proteins with disulfide bridges
CA2634746A1 (en) * 2005-12-21 2007-07-05 Tapestry Pharmaceuticals, Inc. Processes for taxane derivatives and intermediates useful therein
US20090156828A1 (en) * 2005-12-21 2009-06-18 Tapestry Pharmaceuticals, Inc. Novel Compounds and Methods for Forming Taxanes and Using the Same
US20090306400A1 (en) * 2006-03-27 2009-12-10 Henri John T Convergent process for the synthesis of taxane derivatives.
US8008256B2 (en) * 2006-05-01 2011-08-30 University Of Southern California Combination therapy for treatment of cancer
WO2007143839A1 (en) * 2006-06-12 2007-12-21 6570763 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel and 10-deacetylbaccatin iii from 9-dihydro-13-acetylbaccatin iii
US7847111B2 (en) 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en) * 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
WO2008109360A1 (en) * 2007-02-28 2008-09-12 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
US8802394B2 (en) 2008-11-13 2014-08-12 Radu O. Minea Method of expressing proteins with disulfide bridges with enhanced yields and activity
US9227983B2 (en) 2011-04-07 2016-01-05 Arbor Therapeutics, LLC Taxane and abeo-taxane analogs
KR101444693B1 (ko) * 2011-06-06 2014-09-26 아버 테라퓨틱스 엘엘씨 암 화학요법제의 산에 불안정한 친유성 전구약물
CA3174050A1 (en) 2020-03-04 2021-09-10 Aquedeon Medical, Inc. Vascular and aortic connectors with telescoping sheath and deployment methods thereof
US12622797B2 (en) 2021-03-04 2026-05-12 Aquedeon Medical, Inc. Vascular and aortic connectors with robotic delivery and deployment methods thereof

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MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US6794523B2 (en) * 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
WO1993021173A1 (en) * 1992-04-17 1993-10-28 Abbott Laboratories Taxol derivatives
FR2697019B1 (fr) 1992-10-15 1994-11-25 Rhone Poulenc Rorer Sa Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent.
CA2147984C (en) 1992-11-13 2006-03-14 Robert A. Holton Butenyl-substituted taxanes and composition
EP0688212B1 (en) * 1993-03-05 2002-06-12 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
DE69432140T2 (de) * 1993-03-05 2003-07-31 Florida State University, Tallahassee Verfahren zur Herstellung von 9-Desoxotaxanen
US6710191B2 (en) * 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
DK1227093T3 (da) 1993-03-22 2005-08-29 Univ Florida State Beta-lactamer, der kan anvendes til fremstilling af taxaner med en furyl- eller thienylsubstitueret sidekæde
FR2707293A1 (fr) * 1993-07-08 1995-01-13 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur préparation et les compositions pharmaceutiques qui les contiennent.
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IT1275936B1 (it) 1995-03-17 1997-10-24 Indena Spa Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
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US6048990A (en) * 1998-05-01 2000-04-11 Napro Biotherapeutics, Inc. Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position
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AU2004275881A1 (en) 2003-09-25 2005-04-07 Tapestry Pharmaceuticals, Inc. 9,10-alpha,alpha-OH-taxane analogs and methods for production thereof
SI1664033T1 (sl) 2003-09-25 2008-04-30 Tapestry Pharmaceuticals Inc Analogi 9,10-alfa,alfa-oh-taksana in postopki za proizvodnjo le-teh
CA2616906A1 (en) 2005-05-12 2006-11-23 Tapestry Pharmaceuticals, Inc. Molecular constructs suitable for targeted conjugates
US20090156828A1 (en) 2005-12-21 2009-06-18 Tapestry Pharmaceuticals, Inc. Novel Compounds and Methods for Forming Taxanes and Using the Same
CA2634746A1 (en) 2005-12-21 2007-07-05 Tapestry Pharmaceuticals, Inc. Processes for taxane derivatives and intermediates useful therein
US20090306400A1 (en) 2006-03-27 2009-12-10 Henri John T Convergent process for the synthesis of taxane derivatives.
WO2008121476A1 (en) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US20080207743A1 (en) 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
WO2008109360A1 (en) 2007-02-28 2008-09-12 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103764138A (zh) * 2011-04-07 2014-04-30 阿伯疗法责任有限公司 紫杉烷和Abeo-紫杉烷类似物

Also Published As

Publication number Publication date
EP1664033B1 (en) 2007-11-07
DE602004009943T2 (de) 2008-08-28
US7745650B2 (en) 2010-06-29
JP2011137045A (ja) 2011-07-14
JP2007506792A (ja) 2007-03-22
EP1664033A4 (en) 2006-09-13
JP5525394B2 (ja) 2014-06-18
CA2539975A1 (en) 2005-04-07
AU2004275881A1 (en) 2005-04-07
JP6216417B2 (ja) 2017-10-18
US10639293B2 (en) 2020-05-05
US10238621B2 (en) 2019-03-26
JP2014196345A (ja) 2014-10-16
EP1785416A3 (en) 2007-05-30
WO2005030150A3 (en) 2005-07-14
US20100324128A1 (en) 2010-12-23
WO2005030150A2 (en) 2005-04-07
JP2011012070A (ja) 2011-01-20
US20050148657A1 (en) 2005-07-07
PT1664033E (pt) 2008-01-17
ES2295937T3 (es) 2008-04-16
US20150133536A1 (en) 2015-05-14
DK1664033T3 (da) 2008-03-25
EP1664033A2 (en) 2006-06-07
US7879904B2 (en) 2011-02-01
US20190142784A1 (en) 2019-05-16
CA2539975C (en) 2012-11-20
EP1785416A2 (en) 2007-05-16
JP2016180006A (ja) 2016-10-13
US20200237708A1 (en) 2020-07-30
US20120077871A1 (en) 2012-03-29
US8962870B2 (en) 2015-02-24
JP6106634B2 (ja) 2017-04-05
US9402824B2 (en) 2016-08-02
DE602004009943D1 (de) 2007-12-20
PL1664033T3 (pl) 2008-04-30
US20180125811A1 (en) 2018-05-10
JP4874102B2 (ja) 2012-02-15
US9820962B2 (en) 2017-11-21
HRP20080057T3 (en) 2008-02-29
JP5629632B2 (ja) 2014-11-26
ATE377593T1 (de) 2007-11-15
US20160331718A1 (en) 2016-11-17

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