JP4874102B2 - ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 - Google Patents

９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 Download PDF

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JP4874102B2
JP4874102B2 JP2006528316A JP2006528316A JP4874102B2 JP 4874102 B2 JP4874102 B2 JP 4874102B2 JP 2006528316 A JP2006528316 A JP 2006528316A JP 2006528316 A JP2006528316 A JP 2006528316A JP 4874102 B2 JP4874102 B2 JP 4874102B2
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formula
reaction
scheme
mmol
group
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JP2007506792A5 (enExample
JP2007506792A (ja
Inventor
ジェームズ ディー． マッチェスニー，
ジェームズ フェラーラ，
ジャン ジグムント，
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タペストリー ファーマシューティカルズ インコーポレーテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
JP2006528316A 2003-09-25 2004-09-27 ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 Expired - Lifetime JP4874102B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50668003P 2003-09-25 2003-09-25
US60/506,680 2003-09-25
PCT/US2004/031816 WO2005030150A2 (en) 2003-09-25 2004-09-27 9,10-α,α-OH-TAXANE ANALOGS AND METHODS FOR PRODUCTION THEREOF

Related Child Applications (2)

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JP2010200399A Division JP5525394B2 (ja) 2003-09-25 2010-09-07 ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法
JP2011086840A Division JP5629632B2 (ja) 2003-09-25 2011-04-08 ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法

Publications (3)

Publication Number Publication Date
JP2007506792A JP2007506792A (ja) 2007-03-22
JP2007506792A5 JP2007506792A5 (enExample) 2010-10-28
JP4874102B2 true JP4874102B2 (ja) 2012-02-15

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JP2006528316A Expired - Lifetime JP4874102B2 (ja) 2003-09-25 2004-09-27 ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法
JP2010200399A Expired - Lifetime JP5525394B2 (ja) 2003-09-25 2010-09-07 ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法
JP2011086840A Expired - Lifetime JP5629632B2 (ja) 2003-09-25 2011-04-08 ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法
JP2014141964A Expired - Lifetime JP6106634B2 (ja) 2003-09-25 2014-07-10 ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法
JP2016137271A Expired - Lifetime JP6216417B2 (ja) 2003-09-25 2016-07-12 ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法

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JP2010200399A Expired - Lifetime JP5525394B2 (ja) 2003-09-25 2010-09-07 ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法
JP2011086840A Expired - Lifetime JP5629632B2 (ja) 2003-09-25 2011-04-08 ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法
JP2014141964A Expired - Lifetime JP6106634B2 (ja) 2003-09-25 2014-07-10 ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法
JP2016137271A Expired - Lifetime JP6216417B2 (ja) 2003-09-25 2016-07-12 ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法

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Country Link
US (8) US7745650B2 (enExample)
EP (2) EP1664033B1 (enExample)
JP (5) JP4874102B2 (enExample)
CN (1) CN1886400A (enExample)
AT (1) ATE377593T1 (enExample)
AU (1) AU2004275881A1 (enExample)
CA (1) CA2539975C (enExample)
DE (1) DE602004009943T2 (enExample)
DK (1) DK1664033T3 (enExample)
ES (1) ES2295937T3 (enExample)
HR (1) HRP20080057T3 (enExample)
PL (1) PL1664033T3 (enExample)
PT (1) PT1664033E (enExample)
WO (1) WO2005030150A2 (enExample)

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US7745650B2 (en) 2003-09-25 2010-06-29 Tapestry Pharmaceuticals, Inc 9,10-α,α-OH-taxane analogs and methods for production thereof
US7754850B2 (en) 2005-02-11 2010-07-13 University Of Southern California Chimeric disintegrin domain
US20100069643A1 (en) * 2005-12-21 2010-03-18 Mcchesney James D Convergent Process for the Synthesis of Taxane Derivatives
CN101370798A (zh) * 2005-12-21 2009-02-18 挂毯药品公司 用于形成紫杉烷的新化合物和方法及其应用
CA2647766A1 (en) * 2006-03-27 2007-11-08 Tapestry Pharmaceuticals, Inc. A convergent process for the synthesis of taxane derivatives
US8008256B2 (en) * 2006-05-01 2011-08-30 University Of Southern California Combination therapy for treatment of cancer
EP2029563A4 (en) * 2006-06-12 2009-12-02 Canada Inc 6570763 HALF-SYNTHETIC ROUTE FOR THE PREPARATION OF PACLITAXEL, DOCETAXEL AND 10-DEACETYLBACCATIN III FROM 9-DIHYDRO-13-ACETYLBACCATIN III
US7847111B2 (en) 2006-06-19 2010-12-07 Canada Inc. Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III
WO2008106621A1 (en) 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
US11786504B2 (en) 2006-09-28 2023-10-17 Tapestry Pharmaceuticals, Inc. Taxane analogs for the treatment of brain cancer
US11873308B2 (en) 2006-11-06 2024-01-16 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
WO2008121476A1 (en) * 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US20080207743A1 (en) * 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment
WO2010056901A2 (en) 2008-11-13 2010-05-20 University Of Southern California Method of expressing proteins with disulfide bridges with enhanced yields and activity
KR20140048113A (ko) * 2011-04-07 2014-04-23 아버 테라퓨틱스 엘엘씨 탁산 및 아베오-탁산 유사체
US9227983B2 (en) 2011-04-07 2016-01-05 Arbor Therapeutics, LLC Taxane and abeo-taxane analogs
CA2836914C (en) * 2011-06-06 2016-01-26 Arbor Therapeutics, LLC Acid-labile lipophilic prodrugs of cancer chemotherapeutic agents
MX2022010898A (es) 2020-03-04 2022-09-29 Aquedeon Medical Inc Injertos vasculares y aorticos con cubierta telescopica y metodos de implementacion de los mismos.

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US6794523B2 (en) * 1991-09-23 2004-09-21 Florida State University Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
JPH07505887A (ja) * 1992-04-17 1995-06-29 アボツト・ラボラトリーズ タキソール誘導体
FR2697019B1 (fr) 1992-10-15 1994-11-25 Rhone Poulenc Rorer Sa Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent.
ATE249826T1 (de) 1992-11-13 2003-10-15 Univ Florida State Isobutenyl-substituierte taxane und deren pharmazeutische zusammensetzungen
EP1148055A1 (en) * 1993-03-05 2001-10-24 Florida State University C9 taxane derivatives and pharmaceutical compositions containing them
JP3892481B2 (ja) * 1993-03-05 2007-03-14 フロリダ・ステート・ユニバーシティー ９−デスオキソタキサンの製法
US6710191B2 (en) * 1993-03-05 2004-03-23 Florida State University 9β-hydroxytetracyclic taxanes
EP1398028A3 (en) * 1993-03-22 2004-03-24 Florida State University Taxanes having alkoxy, alkenoxy or aryloxy substituted side-chain and pharmaceutical compositions containing same
FR2707293A1 (fr) * 1993-07-08 1995-01-13 Rhone Poulenc Rorer Sa Nouveaux taxoides, leur préparation et les compositions pharmaceutiques qui les contiennent.
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US7745650B2 (en) * 2003-09-25 2010-06-29 Tapestry Pharmaceuticals, Inc 9,10-α,α-OH-taxane analogs and methods for production thereof
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US20100069643A1 (en) 2005-12-21 2010-03-18 Mcchesney James D Convergent Process for the Synthesis of Taxane Derivatives
CN101370798A (zh) 2005-12-21 2009-02-18 挂毯药品公司 用于形成紫杉烷的新化合物和方法及其应用
CA2647766A1 (en) 2006-03-27 2007-11-08 Tapestry Pharmaceuticals, Inc. A convergent process for the synthesis of taxane derivatives
WO2008106621A1 (en) 2007-02-28 2008-09-04 Tapestry Pharmaceuticals, Inc Taxane analogs for the treatment of brain cancer
WO2008121476A1 (en) 2007-03-28 2008-10-09 Tapestry Pharmaceuticals, Inc. Biologically active taxane analogs and methods of treatment by oral administration
US20080207743A1 (en) 2007-02-28 2008-08-28 Rodger Lamb Biologically Active Taxane Analogs and Methods of Treatment

Also Published As

Publication number Publication date
US7879904B2 (en) 2011-02-01
EP1664033A4 (en) 2006-09-13
DE602004009943T2 (de) 2008-08-28
JP2011137045A (ja) 2011-07-14
US20120077871A1 (en) 2012-03-29
US20190142784A1 (en) 2019-05-16
JP5525394B2 (ja) 2014-06-18
PT1664033E (pt) 2008-01-17
PL1664033T3 (pl) 2008-04-30
CA2539975A1 (en) 2005-04-07
ATE377593T1 (de) 2007-11-15
JP5629632B2 (ja) 2014-11-26
JP2016180006A (ja) 2016-10-13
HRP20080057T3 (en) 2008-02-29
WO2005030150A3 (en) 2005-07-14
US9402824B2 (en) 2016-08-02
US9820962B2 (en) 2017-11-21
JP2011012070A (ja) 2011-01-20
US20050148657A1 (en) 2005-07-07
US10639293B2 (en) 2020-05-05
JP6216417B2 (ja) 2017-10-18
EP1785416A2 (en) 2007-05-16
US20100324128A1 (en) 2010-12-23
US20200237708A1 (en) 2020-07-30
ES2295937T3 (es) 2008-04-16
JP2014196345A (ja) 2014-10-16
EP1664033B1 (en) 2007-11-07
US10238621B2 (en) 2019-03-26
US7745650B2 (en) 2010-06-29
US20160331718A1 (en) 2016-11-17
JP2007506792A (ja) 2007-03-22
CN1886400A (zh) 2006-12-27
DK1664033T3 (da) 2008-03-25
WO2005030150A2 (en) 2005-04-07
US8962870B2 (en) 2015-02-24
US20180125811A1 (en) 2018-05-10
CA2539975C (en) 2012-11-20
US20150133536A1 (en) 2015-05-14
EP1785416A3 (en) 2007-05-30
EP1664033A2 (en) 2006-06-07
DE602004009943D1 (de) 2007-12-20
AU2004275881A1 (en) 2005-04-07
JP6106634B2 (ja) 2017-04-05

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