JP2007506792A5 - - Google Patents
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- Publication number
- JP2007506792A5 JP2007506792A5 JP2006528316A JP2006528316A JP2007506792A5 JP 2007506792 A5 JP2007506792 A5 JP 2007506792A5 JP 2006528316 A JP2006528316 A JP 2006528316A JP 2006528316 A JP2006528316 A JP 2006528316A JP 2007506792 A5 JP2007506792 A5 JP 2007506792A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- groups
- acid
- olefin
- aromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 4
- 150000001336 alkenes Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 2
- MIOPJNTWMNEORI-GMSGAONNSA-N (S)-camphorsulfonic acid Chemical compound C1C[C@@]2(CS(O)(=O)=O)C(=O)C[C@@H]1C2(C)C MIOPJNTWMNEORI-GMSGAONNSA-N 0.000 claims 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hcl hcl Chemical compound Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 0 CCC(*)CC1OC[C@@]1(C)[C@](C[C@@](*)[C@@](*C(*)=O)C(C1(C)C)=C(C)[C@](C2)OC(C[C@](*)NC(*)=O)=O)[C@@](C)C12O Chemical compound CCC(*)CC1OC[C@@]1(C)[C@](C[C@@](*)[C@@](*C(*)=O)C(C1(C)C)=C(C)[C@](C2)OC(C[C@](*)NC(*)=O)=O)[C@@](C)C12O 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50668003P | 2003-09-25 | 2003-09-25 | |
| US60/506,680 | 2003-09-25 | ||
| PCT/US2004/031816 WO2005030150A2 (en) | 2003-09-25 | 2004-09-27 | 9,10-α,α-OH-TAXANE ANALOGS AND METHODS FOR PRODUCTION THEREOF |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010200399A Division JP5525394B2 (ja) | 2003-09-25 | 2010-09-07 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2011086840A Division JP5629632B2 (ja) | 2003-09-25 | 2011-04-08 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007506792A JP2007506792A (ja) | 2007-03-22 |
| JP2007506792A5 true JP2007506792A5 (enExample) | 2010-10-28 |
| JP4874102B2 JP4874102B2 (ja) | 2012-02-15 |
Family
ID=34393186
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006528316A Expired - Lifetime JP4874102B2 (ja) | 2003-09-25 | 2004-09-27 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2010200399A Expired - Lifetime JP5525394B2 (ja) | 2003-09-25 | 2010-09-07 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2011086840A Expired - Lifetime JP5629632B2 (ja) | 2003-09-25 | 2011-04-08 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2014141964A Expired - Lifetime JP6106634B2 (ja) | 2003-09-25 | 2014-07-10 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2016137271A Expired - Lifetime JP6216417B2 (ja) | 2003-09-25 | 2016-07-12 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010200399A Expired - Lifetime JP5525394B2 (ja) | 2003-09-25 | 2010-09-07 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2011086840A Expired - Lifetime JP5629632B2 (ja) | 2003-09-25 | 2011-04-08 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2014141964A Expired - Lifetime JP6106634B2 (ja) | 2003-09-25 | 2014-07-10 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
| JP2016137271A Expired - Lifetime JP6216417B2 (ja) | 2003-09-25 | 2016-07-12 | ９，１０−α，α−ＯＨ−タキサンアナログおよびその生成のための方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US7745650B2 (enExample) |
| EP (2) | EP1664033B1 (enExample) |
| JP (5) | JP4874102B2 (enExample) |
| CN (1) | CN1886400A (enExample) |
| AT (1) | ATE377593T1 (enExample) |
| AU (1) | AU2004275881A1 (enExample) |
| CA (1) | CA2539975C (enExample) |
| DE (1) | DE602004009943T2 (enExample) |
| DK (1) | DK1664033T3 (enExample) |
| ES (1) | ES2295937T3 (enExample) |
| HR (1) | HRP20080057T3 (enExample) |
| PL (1) | PL1664033T3 (enExample) |
| PT (1) | PT1664033E (enExample) |
| WO (1) | WO2005030150A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1664033B1 (en) | 2003-09-25 | 2007-11-07 | Tapestry Pharmaceuticals, Inc. | 9,10-alpha,alpha-oh-taxane analogs and methods for production the reof |
| US7754850B2 (en) | 2005-02-11 | 2010-07-13 | University Of Southern California | Chimeric disintegrin domain |
| WO2007073383A1 (en) * | 2005-12-21 | 2007-06-28 | Tapestry Pharmaceuticals, Inc. | Novel compounds and methods for forming taxanes and using the same |
| JP2009521463A (ja) * | 2005-12-21 | 2009-06-04 | タペストリー ファーマシューティカルズ インコーポレーテッド | タキサン誘導体のための方法およびそれに有用な中間体 |
| JP2009531446A (ja) * | 2006-03-27 | 2009-09-03 | タペストリー ファーマシューティカルズ インコーポレーテッド | タキサン誘導体の合成のためのコンバージェントプロセス |
| US8008256B2 (en) * | 2006-05-01 | 2011-08-30 | University Of Southern California | Combination therapy for treatment of cancer |
| US7847111B2 (en) | 2006-06-19 | 2010-12-07 | Canada Inc. | Semi-synthetic route for the preparation of paclitaxel, docetaxel, and 10-deacetylbaccatin III from 9-dihydro-13-acetylbaccatin III |
| EP2029563A4 (en) * | 2006-06-12 | 2009-12-02 | Canada Inc 6570763 | HALF-SYNTHETIC ROUTE FOR THE PREPARATION OF PACLITAXEL, DOCETAXEL AND 10-DEACETYLBACCATIN III FROM 9-DIHYDRO-13-ACETYLBACCATIN III |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008109360A1 (en) | 2007-02-28 | 2008-09-12 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| US20080207743A1 (en) * | 2007-02-28 | 2008-08-28 | Rodger Lamb | Biologically Active Taxane Analogs and Methods of Treatment |
| WO2010056901A2 (en) | 2008-11-13 | 2010-05-20 | University Of Southern California | Method of expressing proteins with disulfide bridges with enhanced yields and activity |
| US9227983B2 (en) | 2011-04-07 | 2016-01-05 | Arbor Therapeutics, LLC | Taxane and abeo-taxane analogs |
| KR20140048113A (ko) * | 2011-04-07 | 2014-04-23 | 아버 테라퓨틱스 엘엘씨 | 탁산 및 아베오-탁산 유사체 |
| AU2012275953B2 (en) * | 2011-06-06 | 2015-01-22 | Arbor Therapeutics, LLC | Acid-labile lipophilic prodrugs of cancer chemotherapeutic agents |
| DK4096588T3 (da) | 2020-03-04 | 2024-10-21 | Aquedeon Medical Inc | Instrument til anlæggelse af en vaskulær og aortatransplantat konnektor med teleskopskede |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX9102128A (es) * | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| US6794523B2 (en) * | 1991-09-23 | 2004-09-21 | Florida State University | Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them |
| DK0639186T3 (da) * | 1992-04-17 | 1999-12-13 | Abbott Lab | Taxolderivater |
| FR2697019B1 (fr) * | 1992-10-15 | 1994-11-25 | Rhone Poulenc Rorer Sa | Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| JPH08503218A (ja) * | 1992-11-13 | 1996-04-09 | フロリダ・ステート・ユニバーシティー | ブテニル置換タキサンおよび組成物 |
| US6066747A (en) * | 1993-03-05 | 2000-05-23 | Florida State University | Process for the preparation of 9-desoxotaxanes |
| US6710191B2 (en) * | 1993-03-05 | 2004-03-23 | Florida State University | 9β-hydroxytetracyclic taxanes |
| DE69430797T2 (de) | 1993-03-05 | 2003-02-27 | Florida State University, Tallahassee | C9 taxanderivate und diese enthaltende pharmazeutische zusammensetzungen |
| ATE295164T1 (de) * | 1993-03-22 | 2005-05-15 | Univ Florida State | Taxane mit furyl oder thienyl enthaltender substituierter seitenkette |
| FR2707293A1 (fr) | 1993-07-08 | 1995-01-13 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2715846A1 (fr) * | 1994-02-07 | 1995-08-11 | Rhone Poulenc Rorer Sa | Nouvelle composition pharmceutique à base de taxoïdes. |
| IT1275936B1 (it) | 1995-03-17 | 1997-10-24 | Indena Spa | Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni |
| US5635531A (en) * | 1996-07-08 | 1997-06-03 | Bristol-Myers Squibb Company | 3'-aminocarbonyloxy paclitaxels |
| US5739359A (en) | 1997-01-24 | 1998-04-14 | Virginia Tech Intellectual Properties, Inc. | Methods for preparing 1-deoxy paclitaxels |
| US6048990A (en) * | 1998-05-01 | 2000-04-11 | Napro Biotherapeutics, Inc. | Method for selective acylation of C-2'-O-protected-10-hydroxy-taxol at the C-10 position |
| CO5280224A1 (es) * | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| HK1047896A1 (zh) | 2000-02-02 | 2003-03-14 | 佛罗里达州立大学研究基金有限公司 | C10杂取代的乙酸基紫衫烷抗肿瘤剂 |
| JP2004528309A (ja) | 2001-03-23 | 2004-09-16 | ナプロ バイオセラピューティクス，インコーポレイテッド | 癌治療用分子複合体 |
| CA2354471A1 (en) | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 ester substituted taxanes |
| AU2002361701A1 (en) | 2001-12-20 | 2003-07-09 | Bristol-Myers Squibb Company | Pharmaceutical compositons of orally active taxane derivatives having enhanced bioavailability |
| US6898834B1 (en) * | 2003-03-03 | 2005-05-31 | Westbridge Pty Ltd | Barrel stave reclaim |
| EP1894921A3 (en) | 2003-09-25 | 2008-03-12 | Tapestry Pharmaceuticals, Inc. | 9, 10-Alpha, Alpha-Oh-Taxane analogs and methods for production thereof |
| EP1664033B1 (en) * | 2003-09-25 | 2007-11-07 | Tapestry Pharmaceuticals, Inc. | 9,10-alpha,alpha-oh-taxane analogs and methods for production the reof |
| AU2006247471A1 (en) | 2005-05-12 | 2006-11-23 | Tapestry Pharmaceuticals, Inc. | Molecular constructs suitable for targeted conjugates |
| WO2007073383A1 (en) | 2005-12-21 | 2007-06-28 | Tapestry Pharmaceuticals, Inc. | Novel compounds and methods for forming taxanes and using the same |
| JP2009521463A (ja) | 2005-12-21 | 2009-06-04 | タペストリー ファーマシューティカルズ インコーポレーテッド | タキサン誘導体のための方法およびそれに有用な中間体 |
| JP2009531446A (ja) | 2006-03-27 | 2009-09-03 | タペストリー ファーマシューティカルズ インコーポレーテッド | タキサン誘導体の合成のためのコンバージェントプロセス |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| WO2008109360A1 (en) | 2007-02-28 | 2008-09-12 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| US20080207743A1 (en) | 2007-02-28 | 2008-08-28 | Rodger Lamb | Biologically Active Taxane Analogs and Methods of Treatment |
-
2004
- 2004-09-27 EP EP04789167A patent/EP1664033B1/en not_active Expired - Lifetime
- 2004-09-27 HR HR20080057T patent/HRP20080057T3/xx unknown
- 2004-09-27 US US10/951,555 patent/US7745650B2/en not_active Expired - Lifetime
- 2004-09-27 DE DE602004009943T patent/DE602004009943T2/de not_active Expired - Fee Related
- 2004-09-27 DK DK04789167T patent/DK1664033T3/da active
- 2004-09-27 PT PT04789167T patent/PT1664033E/pt unknown
- 2004-09-27 CN CNA2004800346381A patent/CN1886400A/zh active Pending
- 2004-09-27 ES ES04789167T patent/ES2295937T3/es not_active Expired - Lifetime
- 2004-09-27 AU AU2004275881A patent/AU2004275881A1/en not_active Abandoned
- 2004-09-27 WO PCT/US2004/031816 patent/WO2005030150A2/en not_active Ceased
- 2004-09-27 JP JP2006528316A patent/JP4874102B2/ja not_active Expired - Lifetime
- 2004-09-27 EP EP06026009A patent/EP1785416A3/en not_active Withdrawn
- 2004-09-27 PL PL04789167T patent/PL1664033T3/pl unknown
- 2004-09-27 AT AT04789167T patent/ATE377593T1/de not_active IP Right Cessation
- 2004-09-27 CA CA2539975A patent/CA2539975C/en not_active Expired - Lifetime
-
2010
- 2010-06-02 US US12/792,427 patent/US7879904B2/en not_active Expired - Lifetime
- 2010-09-07 JP JP2010200399A patent/JP5525394B2/ja not_active Expired - Lifetime
- 2010-11-24 US US12/954,253 patent/US8962870B2/en active Active
-
2011
- 2011-04-08 JP JP2011086840A patent/JP5629632B2/ja not_active Expired - Lifetime
-
2014
- 2014-07-10 JP JP2014141964A patent/JP6106634B2/ja not_active Expired - Lifetime
-
2015
- 2015-01-23 US US14/604,147 patent/US9402824B2/en not_active Expired - Lifetime
-
2016
- 2016-07-12 JP JP2016137271A patent/JP6216417B2/ja not_active Expired - Lifetime
- 2016-07-27 US US15/220,975 patent/US9820962B2/en not_active Expired - Lifetime
-
2017
- 2017-10-09 US US15/728,049 patent/US10238621B2/en not_active Expired - Lifetime
-
2019
- 2019-01-14 US US16/247,425 patent/US10639293B2/en not_active Expired - Lifetime
-
2020
- 2020-04-15 US US16/849,879 patent/US20200237708A1/en not_active Abandoned
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