JP2017132781A5 - - Google Patents
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- Publication number
- JP2017132781A5 JP2017132781A5 JP2017038701A JP2017038701A JP2017132781A5 JP 2017132781 A5 JP2017132781 A5 JP 2017132781A5 JP 2017038701 A JP2017038701 A JP 2017038701A JP 2017038701 A JP2017038701 A JP 2017038701A JP 2017132781 A5 JP2017132781 A5 JP 2017132781A5
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- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- formula
- free form
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 17
- 150000003839 salts Chemical class 0.000 claims 10
- 125000006239 protecting group Chemical group 0.000 claims 5
- -1 2- (1- (4-butoxyphenyl) -2-methylpropan-2-ylamino) -1-hydroxyethyl Chemical group 0.000 claims 3
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- FAIIOPGOQIHOGV-UHFFFAOYSA-N 1-(4-butoxyphenyl)-2-methylpropan-2-amine Chemical compound CCCCOC1=CC=C(CC(C)(C)N)C=C1 FAIIOPGOQIHOGV-UHFFFAOYSA-N 0.000 claims 1
- SCOJKGRNQDKFRP-UHFFFAOYSA-N 2-chloro-n-methoxy-n-methylacetamide Chemical compound CON(C)C(=O)CCl SCOJKGRNQDKFRP-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003444 phase transfer catalyst Substances 0.000 claims 1
- 238000011916 stereoselective reduction Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011079379 | 2011-09-06 | ||
| CNPCT/CN2011/079379 | 2011-09-06 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529113A Division JP6130835B2 (ja) | 2011-09-06 | 2012-09-05 | ベンゾチアゾロン化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017132781A JP2017132781A (ja) | 2017-08-03 |
| JP2017132781A5 true JP2017132781A5 (enExample) | 2017-10-19 |
| JP6340103B2 JP6340103B2 (ja) | 2018-06-06 |
Family
ID=47010668
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529113A Expired - Fee Related JP6130835B2 (ja) | 2011-09-06 | 2012-09-05 | ベンゾチアゾロン化合物 |
| JP2017038701A Expired - Fee Related JP6340103B2 (ja) | 2011-09-06 | 2017-03-01 | ベンゾチアゾロン化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014529113A Expired - Fee Related JP6130835B2 (ja) | 2011-09-06 | 2012-09-05 | ベンゾチアゾロン化合物 |
Country Status (39)
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3192B1 (ar) | 2011-09-06 | 2018-03-08 | Novartis Ag | مركب بنزوثيازولون |
| UA117092C2 (uk) | 2011-09-06 | 2018-06-25 | Байєр Інтеллектуал Проперті Гмбх | Амінозаміщені імідазопіридазини |
| HRP20171362T1 (hr) * | 2012-08-30 | 2017-11-03 | Novartis Ag | Soli benzotiazolonskog spoja koje služe kao agonist beta-2-adrenoceptora |
| HK1208025A1 (en) | 2012-11-19 | 2016-02-19 | 拜耳医药股份公司 | Aminoimidazopyridazines |
| MA38354B1 (fr) | 2013-02-28 | 2016-09-30 | Novartis Ag | Préparation contenant un composé de benzothiazolone |
| US10967119B1 (en) | 2019-04-01 | 2021-04-06 | Azizi Bilal | Wearable medication injecting device |
Family Cites Families (46)
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|---|---|---|---|---|
| ATE149089T1 (de) * | 1987-09-15 | 1997-03-15 | Rowett Research Inst | Anwendungsgebiete von beta-adrenergenen agonisten |
| US20070082918A1 (en) * | 1993-11-02 | 2007-04-12 | Naftchi N E | Neurologically active compounds and compounds with multiple activities |
| GB9405019D0 (en) | 1994-03-15 | 1994-04-27 | Smithkline Beecham Plc | Novel compounds |
| ZA967892B (en) | 1995-09-21 | 1998-03-18 | Lilly Co Eli | Selective β3 adrenergic agonists. |
| WO1999009018A1 (en) | 1997-08-14 | 1999-02-25 | Kirin Beer Kabushiki Kaisha | BENZOTHIAZOLONE DERIVATIVES HAVING SELECTIVE β2 RECEPTOR AGONIST ACTIVITY |
| AU760250B2 (en) | 1998-12-04 | 2003-05-08 | Neurosearch A/S | New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents |
| US6566372B1 (en) | 1999-08-27 | 2003-05-20 | Ligand Pharmaceuticals Incorporated | Bicyclic androgen and progesterone receptor modulator compounds and methods |
| US6872723B2 (en) * | 2002-01-28 | 2005-03-29 | Wyeth | Stabilized difloxacin injectable solution |
| US6743797B2 (en) * | 2002-02-22 | 2004-06-01 | Chantest, Inc. | Methods for treating cardiac arrhythmia |
| GB0217225D0 (en) | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicinal compounds |
| PE20050130A1 (es) * | 2002-08-09 | 2005-03-29 | Novartis Ag | Compuestos organicos |
| GB0225540D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Medicinal compounds |
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| BRPI0408680A (pt) * | 2003-03-26 | 2006-03-28 | Pharmacia & Upjohn Co Llc | processo para produzir álcoois e aminas enantiomericamente enriquecidos |
| AU2004226824B2 (en) * | 2003-04-04 | 2008-05-01 | Novartis Ag | Quinoline-2-one-derivatives for the treatment of airways diseases |
| EP1635800A2 (en) | 2003-06-10 | 2006-03-22 | Kalypsys, Inc. | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease |
| JP2007503472A (ja) * | 2003-06-10 | 2007-02-22 | カリプシス・インコーポレーテッド | 病気治療用のヒストン脱アセチル化酵素阻害剤としてのカルボニル化合物 |
| WO2005004852A1 (en) | 2003-07-11 | 2005-01-20 | Glaxo Group Limited | Pharmaceutical formulations |
| JP2009513531A (ja) | 2003-07-11 | 2009-04-02 | グラクソ グループ リミテッド | 糖エステルを含む吸入可能医薬製剤 |
| ES2329586T3 (es) | 2003-11-21 | 2009-11-27 | Theravance, Inc. | Compuestos que tienen actividad agonista del receptor beta2 adrenergico y antagonista del receptor muscarino. |
| GB0328490D0 (en) | 2003-12-09 | 2004-01-14 | Glaxo Group Ltd | Medicinal compounds |
| JP2005187357A (ja) | 2003-12-25 | 2005-07-14 | Nippon Suisan Kaisha Ltd | 選択的なβ２受容体アゴニスト活性を有するベンゾチアゾロン誘導体の製造方法 |
| GB0402797D0 (en) * | 2004-02-09 | 2004-03-10 | Novartis Ag | Organic compounds |
| EP1595873A1 (de) | 2004-05-13 | 2005-11-16 | Boehringer Ingelheim Pharma GmbH & Co.KG | Substituierte Cycloalkylderivate zur Behandlung von Atemswegerkrankungen |
| EP1789394A1 (de) | 2004-05-13 | 2007-05-30 | Boehringer Ingelheim International Gmbh | Hydroxy-substituierte benzkondensierte heterozyklen als betaagonisten zur behandlung von atemwegserkrankungen |
| US7317023B2 (en) | 2004-07-21 | 2008-01-08 | Theravance, Inc. | Diaryl ether β2 adrenergic receptor agonists |
| DE102004045648A1 (de) | 2004-09-21 | 2006-03-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Betamimetika zur Behandlung von Atemwegserkrankungen |
| GB0426164D0 (en) * | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
| DE102005007654A1 (de) | 2005-02-19 | 2006-08-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue langwirksame Betamimetika zur Behandlung von Atemwegserkrankungen |
| TW200738659A (en) | 2005-08-29 | 2007-10-16 | Astrazeneca Ab | Novel compounds |
| TW200740781A (en) | 2005-08-29 | 2007-11-01 | Astrazeneca Ab | Novel compounds |
| WO2007086078A2 (en) | 2006-01-30 | 2007-08-02 | Panacea Biotec Ltd. | Novel pharmaceutical compositions and process of preparation thereof |
| US8518980B2 (en) | 2006-02-10 | 2013-08-27 | Summit Corporation Plc | Treatment of Duchenne muscular dystrophy |
| TW200745084A (en) | 2006-03-08 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| GB0613154D0 (en) | 2006-06-30 | 2006-08-09 | Novartis Ag | Organic Compounds |
| EP2064174B1 (en) * | 2006-08-10 | 2016-10-26 | The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services | Preparation of (r,r)- or (r,s)-fenoterol analogues and their use in treating congestive heart failure |
| TW200833670A (en) * | 2006-12-20 | 2008-08-16 | Astrazeneca Ab | Novel compounds 569 |
| TW200911237A (en) | 2007-08-03 | 2009-03-16 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
| WO2010015792A1 (en) | 2008-08-06 | 2010-02-11 | Argenta Discovery Limited | Nitrogen containing heterocyclic compounds useful as bifunctional modulators of m3 receptors and beta-2 receptors |
| GB0814728D0 (en) | 2008-08-12 | 2008-09-17 | Argenta Discovery Ltd | New combination |
| GB0823140D0 (en) | 2008-12-18 | 2009-01-28 | Astrazeneca Ab | New combination |
| GB201009801D0 (en) | 2010-06-11 | 2010-07-21 | Astrazeneca Ab | Compounds 950 |
| GB201107985D0 (en) | 2011-05-13 | 2011-06-29 | Astrazeneca Ab | Process |
| JO3192B1 (ar) | 2011-09-06 | 2018-03-08 | Novartis Ag | مركب بنزوثيازولون |
| HRP20171362T1 (hr) * | 2012-08-30 | 2017-11-03 | Novartis Ag | Soli benzotiazolonskog spoja koje služe kao agonist beta-2-adrenoceptora |
| MA38354B1 (fr) | 2013-02-28 | 2016-09-30 | Novartis Ag | Préparation contenant un composé de benzothiazolone |
-
2012
- 2012-09-04 JO JOP/2012/0250A patent/JO3192B1/ar active
- 2012-09-05 AP AP2014007462A patent/AP3830A/en active
- 2012-09-05 CN CN201610536836.2A patent/CN106187942B/zh not_active Expired - Fee Related
- 2012-09-05 MY MYPI2014000358A patent/MY163301A/en unknown
- 2012-09-05 EA EA201490573A patent/EA022909B1/ru not_active IP Right Cessation
- 2012-09-05 WO PCT/IB2012/054580 patent/WO2013035047A1/en not_active Ceased
- 2012-09-05 PE PE2014000312A patent/PE20141993A1/es not_active Application Discontinuation
- 2012-09-05 US US13/603,990 patent/US8933108B2/en not_active Expired - Fee Related
- 2012-09-05 MX MX2014002688A patent/MX345405B/es active IP Right Grant
- 2012-09-05 PL PL12770249T patent/PL2753609T3/pl unknown
- 2012-09-05 DK DK12770249.6T patent/DK2753609T3/en active
- 2012-09-05 AU AU2013200422A patent/AU2013200422C1/en not_active Ceased
- 2012-09-05 ES ES12770249.6T patent/ES2615052T3/es active Active
- 2012-09-05 RS RS20161145A patent/RS55468B1/sr unknown
- 2012-09-05 SG SG2014013114A patent/SG2014013114A/en unknown
- 2012-09-05 CU CUP2014000028A patent/CU24303B1/xx unknown
- 2012-09-05 TW TW101132414A patent/TWI555738B/zh not_active IP Right Cessation
- 2012-09-05 CN CN201280043386.3A patent/CN103781771B/zh not_active Expired - Fee Related
- 2012-09-05 BR BR112014004732A patent/BR112014004732A2/pt not_active Application Discontinuation
- 2012-09-05 EP EP12770249.6A patent/EP2753609B1/en active Active
- 2012-09-05 KR KR1020147008777A patent/KR101628585B1/ko not_active Expired - Fee Related
- 2012-09-05 SI SI201230841A patent/SI2753609T1/sl unknown
- 2012-09-05 HU HUE12770249A patent/HUE030530T2/en unknown
- 2012-09-05 JP JP2014529113A patent/JP6130835B2/ja not_active Expired - Fee Related
- 2012-09-05 UA UAA201401193A patent/UA114295C2/uk unknown
- 2012-09-05 LT LTEP12770249.6T patent/LT2753609T/lt unknown
- 2012-09-05 HR HRP20170075TT patent/HRP20170075T1/hr unknown
- 2012-09-05 PH PH1/2014/500399A patent/PH12014500399A1/en unknown
- 2012-09-05 KR KR1020167007782A patent/KR101800140B1/ko not_active Expired - Fee Related
- 2012-09-05 PT PT127702496T patent/PT2753609T/pt unknown
- 2012-09-05 UY UY0001034312A patent/UY34312A/es not_active Application Discontinuation
- 2012-09-05 CA CA2845766A patent/CA2845766A1/en not_active Abandoned
- 2012-09-06 AR ARP120103276A patent/AR087787A1/es unknown
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2014
- 2014-02-10 TN TNP2014000060A patent/TN2014000060A1/en unknown
- 2014-02-13 ZA ZA2014/01112A patent/ZA201401112B/en unknown
- 2014-02-27 IL IL231235A patent/IL231235A/en active IP Right Grant
- 2014-02-27 CL CL2014000493A patent/CL2014000493A1/es unknown
- 2014-03-04 GT GT201400042A patent/GT201400042A/es unknown
- 2014-03-06 CO CO14048375A patent/CO6900147A2/es not_active Application Discontinuation
- 2014-03-06 CR CR20140114A patent/CR20140114A/es unknown
- 2014-12-10 US US14/566,021 patent/US20150094346A1/en not_active Abandoned
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2015
- 2015-02-03 ZA ZA2015/00790A patent/ZA201500790B/en unknown
- 2015-08-03 US US14/817,175 patent/US20150336914A1/en not_active Abandoned
- 2015-11-20 US US14/947,458 patent/US20160075670A1/en not_active Abandoned
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2016
- 2016-06-10 US US15/178,579 patent/US9913828B2/en not_active Expired - Fee Related
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2017
- 2017-02-02 CY CY20171100153T patent/CY1118585T1/el unknown
- 2017-03-01 JP JP2017038701A patent/JP6340103B2/ja not_active Expired - Fee Related
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2018
- 2018-01-22 US US15/876,619 patent/US10251868B2/en not_active Expired - Fee Related