KR101800140B1 - 벤조티아졸론 화합물 - Google Patents

벤조티아졸론 화합물 Download PDF

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Publication number
KR101800140B1
KR101800140B1 KR1020167007782A KR20167007782A KR101800140B1 KR 101800140 B1 KR101800140 B1 KR 101800140B1 KR 1020167007782 A KR1020167007782 A KR 1020167007782A KR 20167007782 A KR20167007782 A KR 20167007782A KR 101800140 B1 KR101800140 B1 KR 101800140B1
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KR
South Korea
Prior art keywords
compound
formula
ylamino
butoxyphenyl
thiazol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020167007782A
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English (en)
Korean (ko)
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KR20160038079A (ko
Inventor
준 카오
베른하르트 에르브
로빈 알렉 페어허스트
아르노 그항듀히
신지 하다키야마
막달레나 코지크자크-홀브로
신종 라이
필리프 루스텐베르거
베른트 리베젤
니콜라 투필리
토마스 울리치
시앙 우
지안구앙 주
Original Assignee
노파르티스 아게
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Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20160038079A publication Critical patent/KR20160038079A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
    • C07C53/08—Acetic acid
    • C07C53/10—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Emergency Medicine (AREA)
  • Cosmetics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Macromonomer-Based Addition Polymer (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020167007782A 2011-09-06 2012-09-05 벤조티아졸론 화합물 Expired - Fee Related KR101800140B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2011079379 2011-09-06
CNPCT/CN2011/079379 2011-09-06
PCT/IB2012/054580 WO2013035047A1 (en) 2011-09-06 2012-09-05 Benzothiazolone compound

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020147008777A Division KR101628585B1 (ko) 2011-09-06 2012-09-05 벤조티아졸론 화합물

Publications (2)

Publication Number Publication Date
KR20160038079A KR20160038079A (ko) 2016-04-06
KR101800140B1 true KR101800140B1 (ko) 2017-11-21

Family

ID=47010668

Family Applications (2)

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KR1020167007782A Expired - Fee Related KR101800140B1 (ko) 2011-09-06 2012-09-05 벤조티아졸론 화합물
KR1020147008777A Expired - Fee Related KR101628585B1 (ko) 2011-09-06 2012-09-05 벤조티아졸론 화합물

Family Applications After (1)

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KR1020147008777A Expired - Fee Related KR101628585B1 (ko) 2011-09-06 2012-09-05 벤조티아졸론 화합물

Country Status (39)

Country Link
US (6) US8933108B2 (enExample)
EP (1) EP2753609B1 (enExample)
JP (2) JP6130835B2 (enExample)
KR (2) KR101800140B1 (enExample)
CN (2) CN103781771B (enExample)
AP (1) AP3830A (enExample)
AR (1) AR087787A1 (enExample)
AU (1) AU2013200422C1 (enExample)
BR (1) BR112014004732A2 (enExample)
CA (1) CA2845766A1 (enExample)
CL (1) CL2014000493A1 (enExample)
CO (1) CO6900147A2 (enExample)
CR (1) CR20140114A (enExample)
CU (1) CU24303B1 (enExample)
CY (1) CY1118585T1 (enExample)
DK (1) DK2753609T3 (enExample)
EA (1) EA022909B1 (enExample)
ES (1) ES2615052T3 (enExample)
GT (1) GT201400042A (enExample)
HR (1) HRP20170075T1 (enExample)
HU (1) HUE030530T2 (enExample)
IL (1) IL231235A (enExample)
JO (1) JO3192B1 (enExample)
LT (1) LT2753609T (enExample)
MX (1) MX345405B (enExample)
MY (1) MY163301A (enExample)
PE (1) PE20141993A1 (enExample)
PH (1) PH12014500399A1 (enExample)
PL (1) PL2753609T3 (enExample)
PT (1) PT2753609T (enExample)
RS (1) RS55468B1 (enExample)
SG (1) SG2014013114A (enExample)
SI (1) SI2753609T1 (enExample)
TN (1) TN2014000060A1 (enExample)
TW (1) TWI555738B (enExample)
UA (1) UA114295C2 (enExample)
UY (1) UY34312A (enExample)
WO (1) WO2013035047A1 (enExample)
ZA (2) ZA201401112B (enExample)

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Publication number Priority date Publication date Assignee Title
UA117092C2 (uk) 2011-09-06 2018-06-25 Байєр Інтеллектуал Проперті Гмбх Амінозаміщені імідазопіридазини
JO3192B1 (ar) 2011-09-06 2018-03-08 Novartis Ag مركب بنزوثيازولون
HUE033655T2 (en) * 2012-08-30 2017-12-28 Novartis Ag Benzothiazolone Compounds with Beta-2-Adrenoceptor Effects
EP2920176B1 (en) 2012-11-19 2017-09-13 Bayer Pharma Aktiengesellschaft Aminoimidazopyridazines as mknk1 kinase inhibitors
SI2961391T1 (sl) * 2013-02-28 2017-08-31 Novartis Ag Formulacija,ki obsega benzotiazolonsko spojino
US10967119B1 (en) 2019-04-01 2021-04-06 Azizi Bilal Wearable medication injecting device

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Publication number Publication date
ZA201401112B (en) 2016-01-27
AP2014007462A0 (en) 2014-02-28
KR20160038079A (ko) 2016-04-06
RS55468B1 (sr) 2017-04-28
US10251868B2 (en) 2019-04-09
US8933108B2 (en) 2015-01-13
MX2014002688A (es) 2014-04-14
DK2753609T3 (en) 2017-02-06
KR101628585B1 (ko) 2016-06-08
CR20140114A (es) 2014-05-06
AU2013200422A1 (en) 2013-03-21
CL2014000493A1 (es) 2014-10-03
AU2013200422B2 (en) 2014-08-07
US20130245080A1 (en) 2013-09-19
LT2753609T (lt) 2017-01-10
PT2753609T (pt) 2017-02-08
TW201317221A (zh) 2013-05-01
CU24303B1 (es) 2018-01-10
ES2615052T3 (es) 2017-06-05
CN103781771A (zh) 2014-05-07
CN103781771B (zh) 2016-08-24
BR112014004732A2 (pt) 2017-03-28
KR20140057382A (ko) 2014-05-12
MX345405B (es) 2017-01-30
PL2753609T3 (pl) 2017-05-31
IL231235A (en) 2017-09-28
GT201400042A (es) 2015-02-19
AP3830A (en) 2016-09-30
CN106187942B (zh) 2020-06-26
US20180140582A1 (en) 2018-05-24
TN2014000060A1 (en) 2015-07-01
EA022909B1 (ru) 2016-03-31
HUE030530T2 (en) 2017-05-29
ZA201500790B (en) 2017-04-26
TWI555738B (zh) 2016-11-01
JP2014525472A (ja) 2014-09-29
PE20141993A1 (es) 2014-12-17
NZ621089A (en) 2015-07-31
CY1118585T1 (el) 2017-07-12
PH12014500399A1 (en) 2021-06-02
WO2013035047A1 (en) 2013-03-14
EP2753609B1 (en) 2016-11-09
IL231235A0 (en) 2014-04-30
US20150094346A1 (en) 2015-04-02
UY34312A (es) 2013-04-30
JP2017132781A (ja) 2017-08-03
CN106187942A (zh) 2016-12-07
US9913828B2 (en) 2018-03-13
CU20140028A7 (es) 2014-05-27
EP2753609A1 (en) 2014-07-16
SG2014013114A (en) 2014-07-30
AU2013200422C1 (en) 2015-01-15
JO3192B1 (ar) 2018-03-08
JP6340103B2 (ja) 2018-06-06
HRP20170075T1 (hr) 2017-03-24
US20150336914A1 (en) 2015-11-26
JP6130835B2 (ja) 2017-05-17
MY163301A (en) 2017-09-15
UA114295C2 (uk) 2017-05-25
CO6900147A2 (es) 2014-03-20
EA201490573A1 (ru) 2014-06-30
AR087787A1 (es) 2014-04-16
US20160075670A1 (en) 2016-03-17
CA2845766A1 (en) 2013-03-14
SI2753609T1 (sl) 2017-03-31
US20160279107A1 (en) 2016-09-29

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