CN1839133A - 作为巨噬细胞移动抑制因子的抑制剂的取代的二氮杂萘衍生物及其在治疗人类疾病中的应用 - Google Patents
作为巨噬细胞移动抑制因子的抑制剂的取代的二氮杂萘衍生物及其在治疗人类疾病中的应用 Download PDFInfo
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- CN1839133A CN1839133A CNA2004800241375A CN200480024137A CN1839133A CN 1839133 A CN1839133 A CN 1839133A CN A2004800241375 A CNA2004800241375 A CN A2004800241375A CN 200480024137 A CN200480024137 A CN 200480024137A CN 1839133 A CN1839133 A CN 1839133A
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Psychiatry (AREA)
- Virology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Child & Adolescent Psychology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49744303P | 2003-08-22 | 2003-08-22 | |
| US60/497,443 | 2003-08-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1839133A true CN1839133A (zh) | 2006-09-27 |
Family
ID=34272569
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNA2004800241375A Pending CN1839133A (zh) | 2003-08-22 | 2004-08-09 | 作为巨噬细胞移动抑制因子的抑制剂的取代的二氮杂萘衍生物及其在治疗人类疾病中的应用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20050124604A1 (https=) |
| EP (1) | EP1656376A1 (https=) |
| JP (1) | JP2007503388A (https=) |
| CN (1) | CN1839133A (https=) |
| AR (1) | AR045471A1 (https=) |
| AU (1) | AU2004268941A1 (https=) |
| BR (1) | BRPI0413695A (https=) |
| CA (1) | CA2531506A1 (https=) |
| MX (1) | MXJL06000006A (https=) |
| PE (1) | PE20051112A1 (https=) |
| TW (1) | TW200524928A (https=) |
| UY (1) | UY28483A1 (https=) |
| WO (1) | WO2005021546A1 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103360388A (zh) * | 2012-04-10 | 2013-10-23 | 江苏先声药物研究有限公司 | 5-氨基-1,4-二氢-1,8-萘啶衍生物及其药物组合物和用途 |
| CN111658653A (zh) * | 2019-03-08 | 2020-09-15 | 南京药捷安康生物科技有限公司 | 磷酸二酯酶抑制剂的用途 |
| CN112654621A (zh) * | 2018-06-27 | 2021-04-13 | 百时美施贵宝公司 | 可作为t细胞活化剂的经取代萘啶酮化合物 |
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| MY140679A (en) * | 2001-05-24 | 2010-01-15 | Avanir Pharmaceuticals | Inhibitors of macrohage migration inhibitory factor and methods for identifying the same |
| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| EP1861407A1 (en) * | 2005-03-24 | 2007-12-05 | Avanir Pharmaceuticals | Thienopyridinone derivatives as macrophage migration inhibitory factor inhibitors |
| GB0605689D0 (en) * | 2006-03-21 | 2006-05-03 | Novartis Ag | Organic compounds |
| US8048892B2 (en) | 2006-12-18 | 2011-11-01 | Amgen Inc. | Azaquinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| EP2111399A2 (en) | 2006-12-18 | 2009-10-28 | Amgen Inc. | Naphthalenone compounds exhibiting prolyl hydroxylase inhibitory activity, compositions, and uses thereof |
| EP2155680B1 (en) | 2007-04-18 | 2013-12-04 | Amgen, Inc | Indanone derivatives that inhibit prolyl hydroxylase |
| EP2142509B1 (en) | 2007-04-18 | 2013-12-04 | Amgen, Inc | Quinolones and azaquinolones that inhibit prolyl hydroxylase |
| US8097620B2 (en) | 2007-05-04 | 2012-01-17 | Amgen Inc. | Diazaquinolones that inhibit prolyl hydroxylase activity |
| ES2389063T3 (es) | 2007-05-04 | 2012-10-22 | Amgen, Inc | Derivados de tienopiridina y tiazolopiridina que inhiben la actividad prolil hidroxilasa |
| US9643922B2 (en) | 2008-08-18 | 2017-05-09 | Yale University | MIF modulators |
| US9540322B2 (en) | 2008-08-18 | 2017-01-10 | Yale University | MIF modulators |
| TW201120037A (en) * | 2009-10-26 | 2011-06-16 | Sunesis Pharmaceuticals Inc | Compounds and methods for treatment of cancer |
| EP2592933B1 (en) * | 2010-07-16 | 2017-04-05 | Anderson Gaweco | Mif inhibitors and their uses |
| GB2497476B (en) * | 2010-09-06 | 2018-01-10 | Guangzhou Inst Biomed & Health | Amide Compounds |
| US9133164B2 (en) * | 2011-04-13 | 2015-09-15 | Innov88 Llc | MIF inhibitors and their uses |
| US9617212B2 (en) | 2013-12-17 | 2017-04-11 | Controlled Chemicals, Inc. | Isoindolin-1-ones as macrophage migration inhibitory factor (MIF) inhibitors |
| US20230322804A1 (en) * | 2016-07-13 | 2023-10-12 | bioMérieux | Reagents for reversibly protecting biological molecules |
| WO2018119183A2 (en) | 2016-12-22 | 2018-06-28 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| EA201992781A1 (ru) | 2017-05-22 | 2020-04-01 | Эмджен Инк. | Ингибиторы g12c kras и способы их применения |
| MA50077A (fr) | 2017-09-08 | 2020-07-15 | Amgen Inc | Inhibiteurs de kras g12c et leurs procédés d'utilisation |
| CN107556309B (zh) * | 2017-09-11 | 2020-12-01 | 浙江永宁药业股份有限公司 | 多取代四氢萘啶类化合物的药物用途及其制备方法 |
| WO2019213516A1 (en) | 2018-05-04 | 2019-11-07 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| ES2995514T3 (en) | 2018-05-04 | 2025-02-10 | Amgen Inc | Kras g12c inhibitors and methods of using the same |
| EP3790886B1 (en) | 2018-05-10 | 2024-06-26 | Amgen Inc. | Kras g12c inhibitors for the treatment of cancer |
| ES2938987T3 (es) | 2018-06-01 | 2023-04-18 | Amgen Inc | Inhibidores de KRAS G12c y métodos de uso de los mismos |
| US20190375749A1 (en) * | 2018-06-11 | 2019-12-12 | Amgen Inc. | Kras g12c inhibitors and methods of using the same |
| ES3060664T3 (en) | 2018-06-12 | 2026-03-27 | Amgen Inc | Kras g12c inhibitors encompassing a piperazine ring and use thereof in the treatment of cancer |
| PT3814347T (pt) * | 2018-06-27 | 2023-07-18 | Bristol Myers Squibb Co | Compostos de naftiridinona úteis como ativadores de células t |
| JP7516029B2 (ja) | 2018-11-16 | 2024-07-16 | アムジエン・インコーポレーテツド | Kras g12c阻害剤化合物の重要な中間体の改良合成法 |
| JP7377679B2 (ja) | 2018-11-19 | 2023-11-10 | アムジエン・インコーポレーテツド | がん治療のためのkrasg12c阻害剤及び1種以上の薬学的に活性な追加の薬剤を含む併用療法 |
| US11053226B2 (en) | 2018-11-19 | 2021-07-06 | Amgen Inc. | KRAS G12C inhibitors and methods of using the same |
| CN111471059B (zh) * | 2019-01-23 | 2022-12-02 | 药捷安康(南京)科技股份有限公司 | Pde9抑制剂及其用途 |
| EP3738593A1 (en) | 2019-05-14 | 2020-11-18 | Amgen, Inc | Dosing of kras inhibitor for treatment of cancers |
| NZ782284A (en) | 2019-05-21 | 2024-11-29 | Amgen Inc | Solid state forms |
| AR119821A1 (es) | 2019-08-28 | 2022-01-12 | Bristol Myers Squibb Co | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t |
| EP4081522A1 (en) | 2019-12-23 | 2022-11-02 | Bristol-Myers Squibb Company | Substituted piperazine derivatives useful as t cell activators |
| AR120823A1 (es) | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos útiles como activadores de células t |
| CN114846007B (zh) | 2019-12-23 | 2024-11-22 | 百时美施贵宝公司 | 可用作t细胞激活剂的经取代的喹唑啉基化合物 |
| AU2021358123A1 (en) | 2020-10-05 | 2023-06-08 | Enliven Inc. | 5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases |
| WO2022093817A1 (en) * | 2020-10-26 | 2022-05-05 | Yale University | Macrophage migration inhibitory factor inhibitors, and methods of making and using same |
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| TW200418829A (en) * | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
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2004
- 2004-08-09 EP EP04780510A patent/EP1656376A1/en not_active Ceased
- 2004-08-09 CN CNA2004800241375A patent/CN1839133A/zh active Pending
- 2004-08-09 MX MXJL06000006A patent/MXJL06000006A/es unknown
- 2004-08-09 CA CA002531506A patent/CA2531506A1/en not_active Abandoned
- 2004-08-09 WO PCT/US2004/025683 patent/WO2005021546A1/en not_active Ceased
- 2004-08-09 BR BRPI0413695-0A patent/BRPI0413695A/pt not_active IP Right Cessation
- 2004-08-09 JP JP2006523903A patent/JP2007503388A/ja active Pending
- 2004-08-09 AU AU2004268941A patent/AU2004268941A1/en not_active Abandoned
- 2004-08-17 US US10/920,031 patent/US20050124604A1/en not_active Abandoned
- 2004-08-18 TW TW093124762A patent/TW200524928A/zh unknown
- 2004-08-20 AR ARP040102991A patent/AR045471A1/es not_active Application Discontinuation
- 2004-08-20 UY UY28483A patent/UY28483A1/es not_active Application Discontinuation
- 2004-08-21 PE PE2004000808A patent/PE20051112A1/es not_active Application Discontinuation
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2007
- 2007-03-16 US US11/687,601 patent/US7361760B2/en not_active Expired - Fee Related
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103360388A (zh) * | 2012-04-10 | 2013-10-23 | 江苏先声药物研究有限公司 | 5-氨基-1,4-二氢-1,8-萘啶衍生物及其药物组合物和用途 |
| CN103360388B (zh) * | 2012-04-10 | 2017-11-14 | 江苏先声药业有限公司 | 5‑氨基‑1,4‑二氢‑1,8‑萘啶衍生物及其药物组合物和用途 |
| CN112654621A (zh) * | 2018-06-27 | 2021-04-13 | 百时美施贵宝公司 | 可作为t细胞活化剂的经取代萘啶酮化合物 |
| CN112654621B (zh) * | 2018-06-27 | 2024-05-14 | 百时美施贵宝公司 | 可作为t细胞活化剂的经取代萘啶酮化合物 |
| CN111658653A (zh) * | 2019-03-08 | 2020-09-15 | 南京药捷安康生物科技有限公司 | 磷酸二酯酶抑制剂的用途 |
| WO2020182076A1 (zh) * | 2019-03-08 | 2020-09-17 | 南京药捷安康生物科技有限公司 | 磷酸二酯酶抑制剂的用途 |
| CN111658653B (zh) * | 2019-03-08 | 2022-09-09 | 药捷安康(南京)科技股份有限公司 | 磷酸二酯酶抑制剂的用途 |
| AU2020235187B2 (en) * | 2019-03-08 | 2023-09-07 | Transthera Sciences (Nanjing), Inc. | Uses of phosphodiesterase inhibitors |
| TWI816026B (zh) * | 2019-03-08 | 2023-09-21 | 大陸商藥捷安康(南京)科技股份有限公司 | 磷酸二酯酶抑制劑的用途和藥盒 |
| AU2020235187B8 (en) * | 2019-03-08 | 2024-02-08 | Transthera Sciences (Nanjing), Inc. | Uses of phosphodiesterase inhibitors |
| AU2020235187A8 (en) * | 2019-03-08 | 2024-02-08 | Transthera Sciences (Nanjing), Inc. | Uses of phosphodiesterase inhibitors |
| US12465601B2 (en) | 2019-03-08 | 2025-11-11 | Transthera Sciences (Nanjing), Inc. | Uses of phosphodiesterase inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007503388A (ja) | 2007-02-22 |
| EP1656376A1 (en) | 2006-05-17 |
| MXJL06000006A (es) | 2006-05-04 |
| AR045471A1 (es) | 2005-10-26 |
| BRPI0413695A (pt) | 2006-10-24 |
| WO2005021546A1 (en) | 2005-03-10 |
| CA2531506A1 (en) | 2005-03-10 |
| US7361760B2 (en) | 2008-04-22 |
| AU2004268941A1 (en) | 2005-03-10 |
| US20050124604A1 (en) | 2005-06-09 |
| US20070191388A1 (en) | 2007-08-16 |
| TW200524928A (en) | 2005-08-01 |
| UY28483A1 (es) | 2005-03-31 |
| PE20051112A1 (es) | 2006-02-03 |
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