CN1812973B - 可用作蛋白激酶抑制剂的吲唑化合物 - Google Patents

可用作蛋白激酶抑制剂的吲唑化合物 Download PDF

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Publication number
CN1812973B
CN1812973B CN038056127A CN03805612A CN1812973B CN 1812973 B CN1812973 B CN 1812973B CN 038056127 A CN038056127 A CN 038056127A CN 03805612 A CN03805612 A CN 03805612A CN 1812973 B CN1812973 B CN 1812973B
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independently selected
optionally substituted
nitrogen
ring
oxygen
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CN038056127A
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Chinese (zh)
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CN1812973A (zh
Inventor
H·宾奇
G·布伦奇利
J·M·C·戈利克
R·尼格特尔
M·莫蒂默尔
S·帕特尔
A·拉瑟福德
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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CN038056127A 2002-01-25 2003-01-23 可用作蛋白激酶抑制剂的吲唑化合物 Expired - Fee Related CN1812973B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35159702P 2002-01-25 2002-01-25
US60/351,597 2002-01-25
PCT/US2003/002096 WO2003064397A1 (en) 2002-01-25 2003-01-23 Indazole compounds useful as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
CN1812973A CN1812973A (zh) 2006-08-02
CN1812973B true CN1812973B (zh) 2010-12-22

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CN038056127A Expired - Fee Related CN1812973B (zh) 2002-01-25 2003-01-23 可用作蛋白激酶抑制剂的吲唑化合物

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Country Link
US (1) US7041687B2 (enExample)
EP (3) EP2295412A1 (enExample)
JP (2) JP4718118B2 (enExample)
KR (2) KR20100119902A (enExample)
CN (1) CN1812973B (enExample)
AR (1) AR038202A1 (enExample)
AU (1) AU2003212833C1 (enExample)
CA (1) CA2473986C (enExample)
IL (1) IL163117A (enExample)
MX (1) MXPA04007126A (enExample)
NO (1) NO328041B1 (enExample)
PL (1) PL371512A1 (enExample)
RU (1) RU2004125852A (enExample)
TW (1) TW200306819A (enExample)
WO (1) WO2003064397A1 (enExample)

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