MX2023005520A - Combinaciones de inhibidores de cinasa para tratamiento de cancer. - Google Patents
Combinaciones de inhibidores de cinasa para tratamiento de cancer.Info
- Publication number
- MX2023005520A MX2023005520A MX2023005520A MX2023005520A MX2023005520A MX 2023005520 A MX2023005520 A MX 2023005520A MX 2023005520 A MX2023005520 A MX 2023005520A MX 2023005520 A MX2023005520 A MX 2023005520A MX 2023005520 A MX2023005520 A MX 2023005520A
- Authority
- MX
- Mexico
- Prior art keywords
- combinations
- inhibitor
- kinase inhibitor
- cancer treatment
- inhibitor combinations
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 abstract 4
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 abstract 2
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 abstract 2
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 102000001291 MAP Kinase Kinase Kinase Human genes 0.000 abstract 1
- 108060006687 MAP kinase kinase kinase Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La invención se refiere a combinaciones de amida de ácido 4-[(S)-2-azetidin-1-il-1-(4-cloro-3-trifluorometil-fenil)-etilami no]-quinazolin-8-carboxílico y/o sus sales y solvatos fisiológicamente aceptables, y un inhibidor de MEK cinasa, y como un tercer inhibidor opcional, con un inhibidor de EGFR, y al uso de estas combinaciones para el tratamiento de cáncer, y a combinaciones de amida de ácido 4-[(S)-2-azetidin-1-il-1-(4-cloro- 3-trifluorometil-fenil)-etilamino]-quinazolin-8-carboxílico y/o sus sales y solvatos fisiológicamente aceptables, y un inhibidor de EGFR.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063114144P | 2020-11-16 | 2020-11-16 | |
US202163162649P | 2021-03-18 | 2021-03-18 | |
PCT/EP2021/081612 WO2022101459A1 (en) | 2020-11-16 | 2021-11-15 | Kinase inhibitor combinations for cancer treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2023005520A true MX2023005520A (es) | 2023-05-23 |
Family
ID=78819455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2023005520A MX2023005520A (es) | 2020-11-16 | 2021-11-15 | Combinaciones de inhibidores de cinasa para tratamiento de cancer. |
Country Status (9)
Country | Link |
---|---|
US (1) | US20240024324A1 (es) |
EP (1) | EP4243819A1 (es) |
JP (1) | JP2023551408A (es) |
KR (1) | KR20230110296A (es) |
AU (1) | AU2021376892A1 (es) |
CA (1) | CA3201799A1 (es) |
IL (1) | IL302951A (es) |
MX (1) | MX2023005520A (es) |
WO (1) | WO2022101459A1 (es) |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200306819A (en) | 2002-01-25 | 2003-12-01 | Vertex Pharma | Indazole compounds useful as protein kinase inhibitors |
EP1615906A1 (en) | 2003-04-03 | 2006-01-18 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of protein kinases |
MXPA06003557A (es) | 2003-09-30 | 2006-06-20 | Irm Llc | Compuestos y composiciones como inhibidores de cinasa de proteina. |
AU2004283751B2 (en) | 2003-10-24 | 2011-05-19 | Exelixis, Inc. | p70S6 kinase modulators and method of use |
EP1687305B1 (en) | 2003-11-21 | 2008-07-09 | Novartis AG | 1h-imidazoquinoline derivatives as protein kinase inhibitors |
BRPI0417498A (pt) | 2003-12-09 | 2007-05-29 | Us Gov Health & Human Serv | método para suprimir uma resposta imune em um indivìduo; método de inibição da proliferação de um célula; método de tratamento de um distúrbio proliferativo em um indivìduo; método para selecionar um agente imunossupressor ou anti-proliferativo; composição farmacêutica e estente vascular |
CA2563699C (en) | 2004-04-23 | 2014-03-25 | Exelixis, Inc. | Kinase modulators and method of use |
JP5214971B2 (ja) | 2004-10-20 | 2013-06-19 | メルク セローノ ソシエテ アノニム | 3−アリルアミノピペリジン誘導体 |
US7994172B2 (en) | 2004-12-28 | 2011-08-09 | Exelixis, Inc. | [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases |
GB0501999D0 (en) | 2005-02-01 | 2005-03-09 | Sentinel Oncology Ltd | Pharmaceutical compounds |
US8343953B2 (en) | 2005-06-22 | 2013-01-01 | Astex Therapeutics Limited | Pharmaceutical compounds |
UA99284C2 (ru) | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
WO2010093419A1 (en) | 2009-02-11 | 2010-08-19 | Merck Patent Gmbh | Novel amino azaheterocyclic carboxamides |
UA110113C2 (xx) | 2010-07-29 | 2015-11-25 | Біциклічні азагетероциклічні карбоксаміди | |
PE20140966A1 (es) | 2010-11-24 | 2014-08-06 | Merck Patent Gmbh | Quinazolincarboxamida azetidinas |
NZ725361A (en) * | 2014-04-03 | 2022-09-30 | Merck Patent Gmbh | Combinations of cancer therapeutics |
KR20170090498A (ko) * | 2014-12-11 | 2017-08-07 | 메르크 파텐트 게엠베하 | 항암 활성을 갖는 6-옥소-1,6-디히드로-피리다진 유도체와 퀴나졸린 유도체의 조합 |
-
2021
- 2021-11-15 AU AU2021376892A patent/AU2021376892A1/en active Pending
- 2021-11-15 KR KR1020237019989A patent/KR20230110296A/ko unknown
- 2021-11-15 MX MX2023005520A patent/MX2023005520A/es unknown
- 2021-11-15 US US18/252,897 patent/US20240024324A1/en active Pending
- 2021-11-15 EP EP21815924.2A patent/EP4243819A1/en active Pending
- 2021-11-15 WO PCT/EP2021/081612 patent/WO2022101459A1/en active Application Filing
- 2021-11-15 CA CA3201799A patent/CA3201799A1/en active Pending
- 2021-11-15 JP JP2023529009A patent/JP2023551408A/ja active Pending
- 2021-11-15 IL IL302951A patent/IL302951A/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL302951A (en) | 2023-07-01 |
KR20230110296A (ko) | 2023-07-21 |
US20240024324A1 (en) | 2024-01-25 |
EP4243819A1 (en) | 2023-09-20 |
CA3201799A1 (en) | 2022-05-19 |
JP2023551408A (ja) | 2023-12-08 |
WO2022101459A1 (en) | 2022-05-19 |
AU2021376892A1 (en) | 2023-06-29 |
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