CN1807463A - 银耳杂多糖及其提取物、制备方法和用途 - Google Patents
银耳杂多糖及其提取物、制备方法和用途 Download PDFInfo
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- CN1807463A CN1807463A CNA2005100234274A CN200510023427A CN1807463A CN 1807463 A CN1807463 A CN 1807463A CN A2005100234274 A CNA2005100234274 A CN A2005100234274A CN 200510023427 A CN200510023427 A CN 200510023427A CN 1807463 A CN1807463 A CN 1807463A
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- white fungus
- fungus heteropolysaccharideand
- extract
- heteropolysaccharideand
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Abstract
Description
检测项目和检测方法简述 | 结果 |
粘度(配制0.5%银耳杂多糖水溶液,恒温25℃,用旋转粘度机检测,仪器型号:NDJ-1) | 0.7-2pa.s |
透光率(以水为对照,在400nm处测0.5%水溶液的透光度,恒温25℃,用752紫外光栅分光光度计检测) | 90%-99% |
亲水能力(配制不同浓度的银耳杂多糖水溶液,恒温25℃,用旋转粘度机检测粘度,仪器型号:NDJ-1) | 当水溶液中的银耳杂多糖的含量达到2%,溶液成凝胶状态(粘度大于20pa.s) |
1%银耳杂多糖水溶液pH值 | 5.6-6.9 |
外观 | 白色或浅灰白色粉剂或颗粒 |
检测项目和检测方法简述 | 结果 |
粘度(配制0.5%银耳杂多糖提取物水溶液,恒温25℃,用旋转粘度机检测,仪器型号:NDJ-1) | 0.6-1.8pa.s |
透光率(以水为对照,在400nm处测0.5%水溶液的透光度,恒温25℃,用752紫外光栅分光光度计检测) | 80%-97% |
亲水能力(配制不同浓度的银耳杂多糖提取物水溶液,恒温25℃,用旋转粘度机检测粘度,仪器型号:NDJ-1) | 当水溶液中的银耳杂多糖提取物的含量达到2%,溶液成凝胶状态(粘度大于20pa.s) |
1%银耳杂多糖提取物水溶液pH值 | 5.5-7.0 |
外观 | 白色或浅灰白色粉剂或颗粒 |
实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 | |
银耳杂多糖含量(%) | 93.2 | 98.0 | 84.7 | 91.5 | 87.4 | 90.1 | 80.0 | 87.3 | 84.4 | 89.2 | 93.6 |
实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 | |
实施例12中各纯化的银耳杂多糖中的中性糖含量(%) | 75 | 93 | 86 | 80 | 76 | 74 | 91 | 83 | 83 | 77 | 70 |
下列实施例经纯化后得到的实施例12 | |||||||||||
实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | 实施例6 | 实施例7 | 实施例8 | 实施例9 | 实施例10 | 实施例11 | |
甘露糖(%) | 40 | 52.8 | 40.1 | 49.2 | 35 | 42.2 | 39 | 35.5 | 60 | 53 | 39.7 |
岩藻糖(%) | 17.5 | 18.4 | 21 | 15.1 | 14 | 19.1 | 25 | 21.8 | 10 | 10.2 | 13.8 |
木糖(%) | 10.3 | 13.2 | 14 | 10.1 | 12.5 | 8 | 14.4 | 18 | 8 | 8.3 | 9 |
葡萄糖(%) | 8.5 | 8.3 | 11.2 | 5.3 | 15 | 5 | 12.5 | 7.6 | 5.1 | 5.2 | 7.9 |
实施例1 | 实施例2 | 实施例3 | 实施例4 | 实施例5 | 实施例6 | 实施例7 | 实施例8 | 实施例9 | 实施例10 | 实施例11 | |
实施例12中各纯化的银耳杂多糖中葡萄糖醛酸含量(%) | 23.0 | 6.4 | 12.8 | 18.0 | 21.5 | 22.5 | 7.2 | 14.0 | 15.2 | 20.5 | 28.0 |
银耳杂多糖提取物中葡萄糖醛酸含量(%) | 21.4 | 6.3 | 10.8 | 16.5 | 18.8 | 20.3 | 5.8 | 12.2 | 12.8 | 18.3 | 26.2 |
实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 | |
实施例12中各纯化的银耳杂多糖中蛋白含量(%) | 0.1 | 0.2 | 0.7 | 1.5 | 1.8 | 3.0 | 1.7 | 2.4 | 1.4 | 2.5 | 0.9 |
实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 |
0.20% | 0.80% | 3.90% | 1.80% | 2.60% | 3.00% | 2.26% | 2.50% | 4.00% | 2.70% | 1.42% |
实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 |
0.1% | 0.6% | 3.3% | 0.4% | 1.0% | 0.3% | 0.9% | 0.4% | 2.8% | 0.5% | 0.6% |
实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 | |
实施例12中各纯化的银耳杂多糖平均分子量(万道尔顿) | 135 | 145 | 85 | 95 | 112 | 160 | 95 | 93 | 102 | 115 | 110 |
银耳杂多糖提取物平均分子量(万道尔顿) | 125 | 140 | 75 | 99 | 100 | 115 | 82 | 85 | 90 | 105 | 127 |
下列实施例经纯化后得到的实施例12 | |||||||||||
实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 | |
分子量6000以上 | 99.80% | 100% | 90% | 95.20% | 98% | 99.10% | 94.70% | 92.90% | 97.50% | 99.20% | 98% |
分子量6000以下 | 0.2% | 0% | 10% | 4.8% | 2% | 0.9% | 5.3% | 7.1% | 2.5% | 0.8% | 2% |
实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 | |
分子量6000以上 | 93.5% | 98.1% | 76.5% | 87.9% | 86.0% | 89.7% | 75.0% | 81.4% | 82.5% | 88.8% | 92.0% |
分子量6000以下 | 6.5% | 1.9% | 23.5% | 12.1% | 14% | 10.3% | 25% | 18.6% | 17.5% | 11.2% | 8% |
实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 | |
灰分% | 5.60 | 0.50 | 6.90 | 3.70 | 8.00 | 5.70 | 7.90 | 6.20 | 7.60 | 7.10 | 3.50 |
实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 | |
实施例12中各纯化的银耳杂多糖pH值 | 5.6 | 6.2 | 6.1 | 5.8 | 6.9 | 5.6 | 6.0 | 6.2 | 6.5 | 6.2 | 6.0 |
银耳杂多糖提取物pH值 | 5.8 | 6.1 | 6.5 | 6.2 | 7.0 | 5.5 | 6.0 | 5.9 | 6.3 | 6.2 | 6.4 |
项目 | 实例 | 实例 | 实 | 实例 | 实例 | 实 | 实例 | 实 | 实 | 实例 | 实例 |
1 | 2 | 例3 | 4 | 5 | 例6 | 7 | 例8 | 例9 | 10 | 11 | |
实施例12中各纯化的银耳杂多糖粘度(pa.s) | 1.45 | 1.82 | 0.70 | 1.01 | 1.25 | 2 | 0.98 | 0.85 | 0.99 | 1.17 | 1.22 |
银耳杂多糖提取物粘度(pa.s) | 1.46 | 1.80 | 0.6 | 1.18 | 1.25 | 1.29 | 0.66 | 0.76 | 0.98 | 1.22 | 1.52 |
下列实施例经纯化后得到的实施例12 | |||||||||||
项目 | 实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 |
粘度pa.s | >20 | >20 | >20 | >20 | >20 | >20 | >20 | >20 | >20 | >20 | >20 |
观察 | 均呈凝胶状态 |
项目 | 实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 |
粘度pa.s | >20 | >20 | >20 | >20 | >20 | >20 | >20 | >20 | >20 | >20 | >20 |
观察 | 均呈凝胶状态 |
实例1 | 实例2 | 实例3 | 实例4 | 实例5 | 实例6 | 实例7 | 实例8 | 实例9 | 实例10 | 实例11 | |
实施例12中各纯化的银耳杂多糖透光率% | 99 | 99 | 92 | 93 | 93 | 94 | 95 | 98 | 90 | 93 | 97 |
银耳杂多糖提取物透光率% | 97 | 96 | 80 | 95 | 85 | 96 | 87 | 92 | 84 | 92 | 91 |
项目 | 溶解性 |
水 | 溶解,无分层或沉淀现象 |
30%以下乙醇水溶液 | 溶解,无分层或沉淀现象 |
30%以下丙二醇水溶液 | 溶解,无分层或沉淀现象 |
30%以下丁二醇水溶液 | 溶解,无分层或沉淀现象 |
30%以下甘油水溶液 | 溶解,无分层或沉淀现象 |
含可溶性蛋白质水溶液 | 溶解,无分层或沉淀现象 |
含乳制品水溶液 | 溶解,无分层或沉淀现象 |
乳化液中(软磷脂、油脂等) | 溶解或可以很好分散,无分层或沉淀现象 |
银耳杂多糖剂量分组(%) | 活性氧浓度(mmol/L) |
0(对照组)0.10.51.0 | 91.4±4.755.9±0.6**40.5±0.6**19.6±0.5** |
SOD活性(NU/ml) | ||
银耳杂多糖剂量分组(%) | 角质形成细胞 | 成纤维细胞 |
0(对照组)0.050.10.5 | 22.8±1.124.4±1.426.7±1.0**27.9±1.6** | 13.9±3.820.3±1.0*22.8±1.8*26.0±1.4** |
MDA(nmol/ml) | ||
银耳杂多糖剂量分组(%) | 角质形成细胞 | 成纤维细胞 |
0(对照组)0.050.10.5 | 1.94±0.161.80±0.271.52±0.06*1.35±0.24* | 2.85±0.182.95±0.092.51±0.132.06±0.16** |
失水率(%) | |||
时间(小时)2481218 | 1.0%银耳杂多糖6.7±0.113.9±0.228.1±0.537.2±2.660.9±1.1 | 1.0%透明质酸8.4±0.2**16.7±0.4**32.2±0.7**45.5±1.0**69.9±1.2** | 1.0%甘油6.1±0.113.2±0.229.7±0.5*41.0±0.5*63.9±1.3* |
饮用者编号 | 银耳杂多糖 | 蜂蜜 | 麦芽糊精 | |||||||||
0.1% | 0.3% | 0.5% | 1% | 0.1% | 0.3% | 0.5% | 1% | 0.1% | 0.3% | 0.5% | 1% | |
男1 | 1 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
男2 | 1 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
男3 | 2 | 2 | 3 | 3 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
男4 | 1 | 1 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
男5 | 1 | 2 | 3 | 3 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 0 |
男6 | 1 | 2 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
男7 | 2 | 3 | 3 | 3 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 |
男8 | 1 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
男9 | 2 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
男10 | 1 | 2 | 3 | 3 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 |
男11 | 0 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
男12 | 1 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
男13 | 2 | 3 | 3 | 3 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 3 |
男14 | 1 | 1 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
男15 | 1 | 1 | 3 | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
男16 | 1 | 1 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
男17 | 1 | 2 | 3 | 3 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
男18 | 1 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
男19 | 1 | 2 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 |
男20 | 1 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
女1 | 0 | 1 | 3 | 3 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
女2 | 1 | 2 | 3 | 3 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 |
女3 | 2 | 3 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
女4 | 1 | 2 | 3 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 2 |
女5 | 1 | 2 | 3 | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
女6 | 2 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
女7 | 2 | 2 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
女8 | 2 | 2 | 3 | 3 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
女9 | 1 | 1 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 2 |
女10 | 1 | 1 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
女11 | 0 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
女12 | 1 | 3 | 3 | 3 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 |
女13 | 1 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 2 |
女14 | 1 | 2 | 3 | 3 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 |
女15 | 2 | 3 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
女16 | 2 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
女17 | 1 | 3 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
女18 | 2 | 2 | 3 | 3 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 2 |
女19 | 1 | 3 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
女20 | 1 | 1 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
合计 | 48 | 81 | 120 | 120 | 6 | 11 | 15 | 26 | 2 | 5 | 18 | 28 |
饮用者编号 | 银耳杂多糖 | 甘油 | 硅油配成乳化液 | |||||||||
0.1% | 0.3% | 0.5% | 1% | 0.1% | 0.3% | 0.5% | 1% | 0.1% | 0.3% | 0.5% | 1% | |
男1 | 0 | 2 | 3 | 3 | 0 | 1 | 1 | 2 | 0 | 0 | 0 | 1 |
男2 | 1 | 3 | 3 | 3 | 1 | 1 | 2 | 2 | 0 | 1 | 2 | 2 |
男3 | 2 | 2 | 3 | 3 | 1 | 2 | 2 | 2 | 1 | 2 | 2 | 3 |
男4 | 0 | 1 | 3 | 3 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 |
男5 | 1 | 2 | 3 | 3 | 1 | 1 | 1 | 2 | 1 | 1 | 1 | 1 |
男6 | 1 | 3 | 3 | 3 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 0 |
男7 | 2 | 3 | 3 | 3 | 0 | 1 | 1 | 3 | 0 | 1 | 2 | 2 |
男8 | 1 | 3 | 3 | 3 | 1 | 2 | 3 | 3 | 1 | 2 | 2 | 3 |
男9 | 0 | 2 | 3 | 3 | 0 | 0 | 0 | 2 | 1 | 1 | 1 | 1 |
男10 | 1 | 3 | 3 | 3 | 1 | 1 | 2 | 3 | 1 | 1 | 1 | 2 |
男11 | 0 | 3 | 3 | 3 | 0 | 0 | 0 | 0 | 1 | 2 | 3 | 3 |
男12 | 1 | 2 | 3 | 3 | 1 | 1 | 2 | 3 | 1 | 1 | 2 | 2 |
男13 | 2 | 3 | 3 | 3 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
男14 | 0 | 1 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
男15 | 1 | 2 | 3 | 3 | 1 | 1 | 3 | 3 | 1 | 1 | 1 | 1 |
男16 | 1 | 3 | 3 | 3 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 1 |
男17 | 1 | 2 | 3 | 3 | 1 | 1 | 2 | 3 | 0 | 0 | 1 | 1 |
男18 | 0 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
男19 | 1 | 2 | 3 | 3 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 2 |
男20 | 1 | 2 | 3 | 3 | 1 | 2 | 2 | 2 | 1 | 2 | 3 | 3 |
女1 | 0 | 1 | 3 | 3 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 2 |
女2 | 1 | 2 | 3 | 3 | 1 | 1 | 2 | 2 | 1 | 1 | 2 | 3 |
女3 | 0 | 2 | 3 | 3 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
女4 | 1 | 2 | 3 | 3 | 1 | 1 | 1 | 2 | 0 | 0 | 0 | 1 |
女5 | 1 | 2 | 3 | 3 | 1 | 1 | 3 | 3 | 1 | 1 | 1 | 1 |
女6 | 0 | 2 | 3 | 3 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 2 |
女7 | 2 | 2 | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
女8 | 2 | 2 | 3 | 3 | 0 | 0 | 0 | 1 | 1 | 1 | 2 | 2 |
女9 | 0 | 2 | 3 | 3 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 1 |
女10 | 1 | 3 | 3 | 3 | 1 | 2 | 2 | 2 | 0 | 0 | 0 | 0 |
女11 | 0 | 2 | 3 | 3 | 1 | 1 | 1 | 3 | 1 | 1 | 2 | 3 |
女12 | 1 | 3 | 3 | 3 | 0 | 1 | 2 | 3 | 2 | 2 | 2 | 2 |
女13 | 0 | 1 | 3 | 3 | 1 | 2 | 2 | 2 | 1 | 1 | 1 | 2 |
女14 | 1 | 2 | 3 | 3 | 1 | 1 | 1 | 2 | 0 | 1 | 2 | 2 |
女15 | 2 | 3 | 3 | 3 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 1 |
女16 | 2 | 2 | 3 | 3 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 2 |
女17 | 1 | 2 | 3 | 3 | 1 | 2 | 3 | 3 | 2 | 2 | 2 | 3 |
女18 | 2 | 2 | 3 | 3 | 1 | 1 | 1 | 2 | 0 | 0 | 1 | 1 |
女19 | 0 | 2 | 3 | 3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
女20 | 1 | 2 | 3 | 3 | 0 | 1 | 1 | 2 | 1 | 1 | 1 | 2 |
合计 | 35 | 87 | 120 | 120 | 21 | 33 | 45 | 74 | 24 | 32 | 47 | 63 |
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