CN1777577B - 抗菌剂 - Google Patents
抗菌剂 Download PDFInfo
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- CN1777577B CN1777577B CN2004800059353A CN200480005935A CN1777577B CN 1777577 B CN1777577 B CN 1777577B CN 2004800059353 A CN2004800059353 A CN 2004800059353A CN 200480005935 A CN200480005935 A CN 200480005935A CN 1777577 B CN1777577 B CN 1777577B
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- 0 C*=C(C)*1CCOCC1 Chemical compound C*=C(C)*1CCOCC1 0.000 description 15
- QARVLSVVCXYDNA-UHFFFAOYSA-N Brc1ccccc1 Chemical compound Brc1ccccc1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 description 1
- UAEPNZWRGJTJPN-UHFFFAOYSA-N CC1CCCCC1 Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 description 1
- KWQBGHKHQVQYRV-BQBZGAKWSA-N C[C@@H]([C@@H](C(OC)=O)NCC=C)O Chemical compound C[C@@H]([C@@H](C(OC)=O)NCC=C)O KWQBGHKHQVQYRV-BQBZGAKWSA-N 0.000 description 1
- TYJHIHJOPMCGTI-ABAIWWIYSA-N C[C@H]([C@@H](C(NO)=O)NC(c(cc1)ccc1C(c1ccccc1)=O)=O)O Chemical compound C[C@H]([C@@H](C(NO)=O)NC(c(cc1)ccc1C(c1ccccc1)=O)=O)O TYJHIHJOPMCGTI-ABAIWWIYSA-N 0.000 description 1
- NIEBHDXUIJSHSL-UHFFFAOYSA-N O=Cc(cc1)ccc1I Chemical compound O=Cc(cc1)ccc1I NIEBHDXUIJSHSL-UHFFFAOYSA-N 0.000 description 1
- INYFYSNGHZBBOI-TZHYSIJRSA-N O[C@H](CC1)C(C(NOCc2ccccc2)=O)N1C(c(cc1)ccc1OC(F)(F)F)=O Chemical compound O[C@H](CC1)C(C(NOCc2ccccc2)=O)N1C(c(cc1)ccc1OC(F)(F)F)=O INYFYSNGHZBBOI-TZHYSIJRSA-N 0.000 description 1
- KARBXAHAPUFNDM-YHMJZVADSA-N O[C@H](CC1)C(C(O)=O)N1C(c(cc1)ccc1OC(F)(F)F)=O Chemical compound O[C@H](CC1)C(C(O)=O)N1C(c(cc1)ccc1OC(F)(F)F)=O KARBXAHAPUFNDM-YHMJZVADSA-N 0.000 description 1
- RMVRSNDYEFQCLF-UHFFFAOYSA-N Sc1ccccc1 Chemical compound Sc1ccccc1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 description 1
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- C07C233/00—Carboxylic acid amides
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
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- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
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- C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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| US60/466,974 | 2003-04-30 | ||
| US52021103P | 2003-11-13 | 2003-11-13 | |
| US60/520,211 | 2003-11-13 | ||
| PCT/US2004/000433 WO2004062601A2 (en) | 2003-01-08 | 2004-01-08 | Antibacterial agents |
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