CN1751037A - 作为ppar调节剂的磺酰胺衍生物 - Google Patents

作为ppar调节剂的磺酰胺衍生物 Download PDF

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CN1751037A
CN1751037A CNA2004800042507A CN200480004250A CN1751037A CN 1751037 A CN1751037 A CN 1751037A CN A2004800042507 A CNA2004800042507 A CN A2004800042507A CN 200480004250 A CN200480004250 A CN 200480004250A CN 1751037 A CN1751037 A CN 1751037A
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alkyl
aryl
hydrogen
methyl
compound
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Chinese (zh)
Inventor
S·E·康纳
L·S·戈塞特
J·E·格林
W·D·小琼斯
N·B·曼特欧
D·P·马修斯
D·R·梅休
D·L·史密斯
J·A·万斯
王晓冬
A·M·瓦沙瓦斯基
L·L·小温特罗斯基
许艳萍
朱国新
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Eli Lilly and Co
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Publication of CN1751037A publication Critical patent/CN1751037A/zh
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CNA2004800042507A 2003-02-14 2004-02-10 作为ppar调节剂的磺酰胺衍生物 Pending CN1751037A (zh)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102336689A (zh) * 2011-08-29 2012-02-01 天津市筠凯化工科技有限公司 4-氯-3-(三氟甲基)苯磺酰氯的制备及其精制方法
CN119405633A (zh) * 2024-11-25 2025-02-11 浙江大学 2,6-dmhq在抗心脏和肝脏缺血再灌注损伤中的应用

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
RU2367659C2 (ru) 2003-11-05 2009-09-20 Ф.Хоффманн-Ля Рош Аг Гетероарильные производные в качестве активаторов рецепторов, активируемых пролифераторами пероксисом (ppar)
DE602005024384D1 (de) 2004-05-05 2010-12-09 High Point Pharmaceuticals Llc Neue verbindungen, ihre herstellung und verwendung
US8053598B2 (en) 2004-05-05 2011-11-08 High Point Pharmaceuticals, Llc Compounds, their preparation and use
MX2007005205A (es) 2004-10-29 2007-05-11 Kalypsys Inc Compuestos biciclicos sulfonilo-sustituidos como moduladores de receptores activados por el proliferador de la peroxisoma.
ES2372617T3 (es) 2005-06-30 2012-01-24 High Point Pharmaceuticals, Llc Ácidos fenoxiacéticos como activadores de ppar-delta.
WO2007005455A2 (en) * 2005-06-30 2007-01-11 Bayer Cropscience Ag Improved process for preparing (disubstitutedpropenyl) phenylalkyl substituted heterocycles
US7915316B2 (en) * 2005-08-22 2011-03-29 Allergan, Inc Sulfonamides
AU2006296004B2 (en) * 2005-09-27 2011-11-17 Shionogi & Co., Ltd. Sulfonamide derivative having PGD2 receptor antagonistic activity
CN101273013B (zh) * 2005-09-27 2013-06-12 盐野义制药株式会社 具有pgd2受体拮抗活性的磺酰胺衍生物
EP1940815B1 (en) 2005-10-25 2018-08-15 Kalypsys, Inc. Salts of modulators of ppar and methods of treating metabolic disorders
CN103224477A (zh) 2005-12-22 2013-07-31 高点制药有限责任公司 作为PPAR-δ活化剂的苯氧基乙酸
US7943612B2 (en) 2006-03-09 2011-05-17 High Point Pharmaceuticals, Llc Compounds that modulate PPAR activity, their preparation and use
JP5189345B2 (ja) * 2006-11-06 2013-04-24 東ソー株式会社 トリフルオロメチル化用反応試剤
WO2008091863A1 (en) 2007-01-23 2008-07-31 Kalypsys, Inc. Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis
KR101152659B1 (ko) * 2009-10-09 2012-06-15 한국과학기술연구원 세로토닌 수용체 길항 작용과 세로토닌 트랜스포터 억제 작용을 동시에 가지는 설폰아마이드 화합물
RU2013114390A (ru) 2010-08-31 2014-10-10 СНУ Ар энд ДиБи ФАУНДЕЙШН Применение фетального репрограммирования посредством ppar-дельта-агониста
JP5767458B2 (ja) * 2010-11-09 2015-08-19 スガイ化学工業株式会社 ポリオキシエチレン付加カリックスアレーン誘導体の製造方法
BR112014016450A2 (pt) 2012-01-10 2019-09-24 Lilly Co Eli composto antagonista de leucotrieno b4
EP3756661A1 (en) 2013-09-09 2020-12-30 vTv Therapeutics LLC Use of a ppar-delta agonist for treating muscle atrophy
WO2016057322A1 (en) 2014-10-08 2016-04-14 Salk Institute For Biological Studies Ppar agonists and methods of use thereof
US10188627B2 (en) 2014-10-08 2019-01-29 Mitobridge, Inc. PPAR agonists, compounds, pharmaceutical compositions, and methods of use thereof
US10103402B2 (en) * 2015-12-01 2018-10-16 University Of Kentucky Research Foundation Liquid phenothiazine catholytes for non-aqueous redox flow batteries
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
US5089514A (en) * 1990-06-14 1992-02-18 Pfizer Inc. 3-coxazolyl [phenyl, chromanyl or benzofuranyl]-2-hydroxypropionic acid derivatives and analogs as hypoglycemic agents
JPH05125038A (ja) * 1991-03-07 1993-05-21 Tanabe Seiyaku Co Ltd フエノキシアルカン酸誘導体及びその製法
JPH05194370A (ja) * 1992-01-22 1993-08-03 Taisho Pharmaceut Co Ltd スルホンアミド誘導体
US5232945A (en) * 1992-07-20 1993-08-03 Pfizer Inc. 3-aryl-2-hydroxypropionic acid derivatives and analogs as antihypertensives
JPH0672867A (ja) * 1992-08-27 1994-03-15 Tanabe Seiyaku Co Ltd 抗脂血剤
US5902726A (en) * 1994-12-23 1999-05-11 Glaxo Wellcome Inc. Activators of the nuclear orphan receptor peroxisome proliferator-activated receptor gamma
US6062509A (en) 1994-12-23 2000-05-16 Hexcel Corporation Retrofit centerline luggage bin assemblies compatible with existing aircraft bin supports
KR19980702372A (ko) * 1995-02-21 1998-07-15 구니이 야쓰오 글루타민산 수용체 작용약
EP0888278B1 (en) 1996-02-02 2003-07-23 Merck & Co., Inc. Antidiabetic agents
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
CA2318731C (en) * 1998-01-29 2012-05-29 Tularik Inc. Ppar-gamma modulators
ATE451346T1 (de) * 1998-03-10 2009-12-15 Ono Pharmaceutical Co Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten
GB9822473D0 (en) * 1998-10-16 1998-12-09 Glaxo Group Ltd Chemical compounds
US6248781B1 (en) * 1998-10-21 2001-06-19 Novo Nordisk A/S Compounds useful in the treatment of conditions mediated by peroxisome proliferator-activated receptors (PPAR)
PL351898A1 (en) * 1999-04-06 2003-06-30 Sankyo Co O-substituted derivatives of carboxylic acids
NZ515086A (en) * 1999-04-28 2003-10-31 Aventis Pharma Gmbh Di-aryl acid derivatives as PPAR receptor ligands
TNSN00139A1 (fr) 1999-06-25 2005-11-10 Inst For Pharm Discovery Inc Acides phenoxyacetiques substitues
DE60005973T2 (de) 1999-08-27 2004-05-13 Eli Lilly And Co., Indianapolis Biaryl-oxa(thia)zolderivate und ihre verwendung als ppars modulatoren
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
AU7995300A (en) * 1999-10-05 2001-05-10 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
PE20011010A1 (es) * 1999-12-02 2001-10-18 Glaxo Group Ltd Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
JP4316787B2 (ja) 2000-01-11 2009-08-19 壽製薬株式会社 エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、
DE60129712T2 (de) 2000-08-23 2008-07-03 Eli Lilly And Co., Indianapolis Oxazolylaryloxyessigsäure derivate und ihre verwendung als ppar agonisten
EP1313717B1 (en) 2000-08-23 2007-10-17 Eli Lilly And Company Oxazolyl-arylpropionic acid derivatives and their use as ppar agonists
US7071220B2 (en) * 2000-09-18 2006-07-04 Toa Eiyo Ltd. N-substituted benzothiophenesulfonamide derivatives
WO2002060388A2 (en) * 2001-01-30 2002-08-08 Merck & Co., Inc. Acyl sulfamides for treatment of obesity, diabetes and lipid disorders
WO2002064130A1 (en) * 2001-02-15 2002-08-22 Pfizer Products Inc. Proliferative activator receptor (ppar) compounds
MXPA03011201A (es) 2001-06-07 2004-02-26 Lilly Co Eli Moduladores de receptores activados por proliferadores de persoxisomas.
ATE375350T1 (de) 2002-02-21 2007-10-15 Lilly Co Eli Modulatoren von peroxisome proliferator- aktivierten rezeptoren

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102336689A (zh) * 2011-08-29 2012-02-01 天津市筠凯化工科技有限公司 4-氯-3-(三氟甲基)苯磺酰氯的制备及其精制方法
CN119405633A (zh) * 2024-11-25 2025-02-11 浙江大学 2,6-dmhq在抗心脏和肝脏缺血再灌注损伤中的应用
CN119405633B (zh) * 2024-11-25 2025-12-02 浙江大学 2,6-dmhq在抗心脏和肝脏缺血再灌注损伤中的应用

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