BRPI0407180A - Composto, composição farmacêutica, métodos para modular um receptor ativado pelo proliferador de peroxissoma, para tratar ou prevenir uma doença ou condição, para diminuir a glicose no sangue em um mamìfero, para tratar ou prevenir diabetes mellitus, doença cardiovascular e sìndrome x em um mamìfero, e, uso de um composto - Google Patents

Composto, composição farmacêutica, métodos para modular um receptor ativado pelo proliferador de peroxissoma, para tratar ou prevenir uma doença ou condição, para diminuir a glicose no sangue em um mamìfero, para tratar ou prevenir diabetes mellitus, doença cardiovascular e sìndrome x em um mamìfero, e, uso de um composto

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Publication number
BRPI0407180A
BRPI0407180A BR0407180-8A BRPI0407180A BRPI0407180A BR PI0407180 A BRPI0407180 A BR PI0407180A BR PI0407180 A BRPI0407180 A BR PI0407180A BR PI0407180 A BRPI0407180 A BR PI0407180A
Authority
BR
Brazil
Prior art keywords
treating
compound
mammal
preventing
disease
Prior art date
Application number
BR0407180-8A
Other languages
English (en)
Inventor
Scott Eugene Conner
Lynn Stacy Gossett
Jonathan Edward Green
Winton Dennis Jones
Nathan Bryan Mantlo
Donald Paul Matthews
Daniel Ray Mayhugh
Daryl Lynn Smith
Jennifer Ann Vance
Xiaodong Wang
Alan M Warshawsky
Leonard Larry Winneroski
Yanping Xu
Guoxin Zhu
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BRPI0407180A publication Critical patent/BRPI0407180A/pt

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
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Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, MéTODOS PARA MODULAR UM RECEPTOR ATIVADO PELO PROLIFERADOR DE PEROXISSOMA, PARA TRATAR OU PREVENIR UM DOENçA OU CONDIçãO, PARA DIMINUIR A GLICOSE NO SANGUE EM UM MAMìFERO, PARA TRATAR OU PREVENIR DIABETES MELLITUS, DOENçA CARDIOVASCULAR E SìNDROME X EM UM MAMìFERO, E, USO DE UM COMPOSTO". A presente invenção é direcionada a um composto da Fórmula (I); e sais, solvatos, hidratos ou estereoisómeros farmaceuticamente aceitáveis deste, que são úteis no tratamento ou na prevenção de distúrbios mediados por um receptor ativado por proliferador de peroxissomo (PPAR) tal como síndrome X, diabete do tipo II, hiperglicemia, hiperlipidemia, obesidade, coagulopatia, hipertensão, arteriosclerose e outros distúrbios relacionados a síndrome X e doenças cardiovasculares.
BR0407180-8A 2003-02-14 2004-02-10 Composto, composição farmacêutica, métodos para modular um receptor ativado pelo proliferador de peroxissoma, para tratar ou prevenir uma doença ou condição, para diminuir a glicose no sangue em um mamìfero, para tratar ou prevenir diabetes mellitus, doença cardiovascular e sìndrome x em um mamìfero, e, uso de um composto BRPI0407180A (pt)

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EP1597248A2 (en) 2005-11-23
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US20060217433A1 (en) 2006-09-28
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