EA201101085A1 - Феноксиуксусные кислоты в качестве активаторов ppar дельта - Google Patents

Феноксиуксусные кислоты в качестве активаторов ppar дельта

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Publication number
EA201101085A1
EA201101085A1 EA201101085A EA201101085A EA201101085A1 EA 201101085 A1 EA201101085 A1 EA 201101085A1 EA 201101085 A EA201101085 A EA 201101085A EA 201101085 A EA201101085 A EA 201101085A EA 201101085 A1 EA201101085 A1 EA 201101085A1
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EA
Eurasian Patent Office
Prior art keywords
phenoxyacic
acids
ppar delta
compounds
delta activators
Prior art date
Application number
EA201101085A
Other languages
English (en)
Inventor
Пер Сауерберг
Павел Пигера
Зденек Поливка
Мирослав Гавранек
Ингрид Петтерссон
Йохн Патрик Могенсен
Original Assignee
ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
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Application filed by ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи filed Critical ХАЙ ПОЙНТ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи
Publication of EA201101085A1 publication Critical patent/EA201101085A1/ru

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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C07C69/736—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
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Abstract

Новые соединения общей формулы (I), применение этих соединений в виде фармацевтических композиций, фармацевтические композиции, включающие такие соединения, и способы лечения с применением таких соединений и композиций. Настоящие соединения являются активаторами PPARδ и должны быть пригодными для лечения состояний, опосредуемых PPARδ.
EA201101085A 2005-12-22 2006-12-21 Феноксиуксусные кислоты в качестве активаторов ppar дельта EA201101085A1 (ru)

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Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8053598B2 (en) * 2004-05-05 2011-11-08 High Point Pharmaceuticals, Llc Compounds, their preparation and use
DE602005022585D1 (de) * 2004-05-05 2010-09-09 High Point Pharmaceuticals Llc Phenoxyessigsäurederivate als ppar-agonisten
BRPI0620468A2 (pt) * 2005-12-22 2011-11-08 Transtech Pharma Inc ácidos fenóxi acéticos como ativadores de ppar delta
ITMI20071261A1 (it) * 2007-06-22 2008-12-23 Dipharma Francis Srl Procedimento per la preparazione di cinacalcet
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
JP2013006769A (ja) * 2009-10-08 2013-01-10 Nippon Chemiphar Co Ltd ペルオキシソーム増殖剤活性化受容体の活性化剤
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8933024B2 (en) 2010-06-18 2015-01-13 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120053A1 (de) 2011-03-08 2012-09-13 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8901114B2 (en) 2011-03-08 2014-12-02 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120055A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
JP5929109B2 (ja) * 2011-11-11 2016-06-01 デクセリアルズ株式会社 新規なエチニルベンゾフェノン化合物類又はその類縁体
DE112013006600T5 (de) * 2013-09-05 2016-04-21 Hitachi, Ltd. Speichersystem und Speichersteuerverfahren
WO2015035171A1 (en) 2013-09-09 2015-03-12 High Point Pharmaceuticals, Llc Use of a ppar-delta agonist for treating muscle atrophy
GB201318886D0 (en) * 2013-10-25 2013-12-11 Givaudan Sa Improvements i or relating to organic compounds
MA55040A (fr) * 2019-02-20 2021-12-29 Reneo Pharmaceuticals Inc Utilisation d'agonistes de ppar-delta dans le traitement de la myopathie mitochondriale
CN114727976A (zh) * 2019-09-20 2022-07-08 雷内奥制药公司 PPAR-δ激动剂在肾脏疾病治疗中的用途
KR20230054373A (ko) 2020-07-22 2023-04-24 르네오 파마슈티컬스, 인크. 결정질 ppar-델타 작용제
CN116761596A (zh) * 2020-11-25 2023-09-15 雷内奥制药公司 制造PPAR-δ激动剂的方法
WO2023147309A1 (en) 2022-01-25 2023-08-03 Reneo Pharmaceuticals, Inc. Use of ppar-delta agonists in the treatment of disease

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2331336A1 (fr) * 1975-11-14 1977-06-10 Rolland Sa A Acides oxy-4,4' bis(phenoxy-2 alcanocarboxyliques), leurs derives et leur application comme medicament
US4920132A (en) * 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US5324743A (en) * 1992-12-10 1994-06-28 Eli Lilly And Company Leukotriene B4 antagonists
IL109451A0 (en) * 1993-04-29 1994-07-31 Zeneca Ltd Heterocyclic derivatives
HUP9902056A3 (en) 1996-01-17 2002-02-28 Novo Nordisk As Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use
JP2002503202A (ja) 1996-02-02 2002-01-29 メルク エンド カンパニー インコーポレーテッド 抗糖尿病薬
AU719146B2 (en) 1996-02-02 2000-05-04 Merck & Co., Inc. Antidiabetic agents
AU712607B2 (en) 1996-02-02 1999-11-11 Merck & Co., Inc. Method of treating diabetes and related disease states
WO1997028137A1 (en) 1996-02-02 1997-08-07 Merck & Co., Inc. Heterocyclic derivatives as antidiabetic and antiobesity agents
WO1997028149A1 (en) 1996-02-02 1997-08-07 Merck & Co., Inc. Method for raising hdl cholesterol levels
AU2652397A (en) 1996-05-13 1997-12-05 Nippon Shinyaku Co. Ltd. Substituted ethylene compounds and drugs
US5773469A (en) 1996-06-18 1998-06-30 Ortho Pharmaceutical Corporation Diaryl antimicrobial agents
WO1997048876A1 (en) 1996-06-21 1997-12-24 Smith International, Inc. Rolling cone bit having gage and nestled gage cutter elements having enhancements in materials and geometry to optimize borehole corner cutting duty
PL192359B1 (pl) 1996-08-30 2006-10-31 Novo Nordisk As Pochodna GLP-1(7-37) lub analogu GLP-1(7-37), środek farmaceutyczny oraz zastosowanie pochodnej GLP-1(7-37) lub analogu GLP-1(7-37)
EP0948327B1 (en) 1996-12-23 2006-03-08 Merck & Co., Inc. Antidiabetic agents
JP2003514508A (ja) 1997-07-01 2003-04-15 ノボ ノルディスク アクティーゼルスカブ グルカゴン拮抗剤／逆作用剤
EP1000066A1 (en) 1997-07-16 2000-05-17 Novo Nordisk A/S Fused 1,2,4-thiadiazine derivatives, their preparation and use
DE69840510D1 (de) 1997-07-24 2009-03-12 Astellas Pharma Inc Medizinische zusammensetzungen mit cholesterin erniedrigender wirkung
CN1302206A (zh) 1997-10-17 2001-07-04 阿温蒂斯药物制品公司 喹啉衍生物的治疗用途
BR0009864A (pt) 1999-04-20 2002-01-08 Novo Nordisk As Composto, composição farmacêutica, métodos para o tratamento de doenças, para o tratamento e/ou prevenção de condições mediadas pelos receptores nucleares e para o tratamento e/ou prevenção de diabete e/ou obesidade, e, uso de um composto
US6972294B1 (en) * 1999-04-20 2005-12-06 Novo Nordisk, A/S Compounds, their preparation and use
US6525094B1 (en) * 1999-06-01 2003-02-25 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylether derivatives
GB9914977D0 (en) 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
US6368155B1 (en) 1999-07-16 2002-04-09 Molex Incorporated Intelligent sensing connectors
TWI262185B (en) 1999-10-01 2006-09-21 Eisai Co Ltd Carboxylic acid derivatives having anti-hyperglycemia and anti-hyperlipemia action, and pharmaceutical composition containing the derivatives
US6369098B1 (en) 1999-10-05 2002-04-09 Bethesda Pharmaceuticals, Inc. Dithiolane derivatives
PL356745A1 (en) 1999-11-10 2004-06-28 Takeda Chemical Industries, Ltd Body weight gain inhibitors
MXPA02004733A (es) 1999-11-11 2002-08-30 Lilly Co Eli Combinaciones oncoliticas para el tratamiento del cancer.
US6569901B2 (en) * 2000-01-28 2003-05-27 Novo Nordisk A/S Alkynyl-substituted propionic acid derivatives, their preparation and use
CA2395298A1 (en) 2000-01-28 2001-08-02 Novo Nordisk A/S Propionic acid derivatives and their use in the treatment of diabetes and obesity
JP2003520839A (ja) 2000-01-28 2003-07-08 ノボ ノルディスク アクティーゼルスカブ 新規化合物、それらの製造及び使用
US6555577B1 (en) * 2000-01-28 2003-04-29 Novo Nordisk A/S Compounds, their preparation and use
JP2003523336A (ja) 2000-02-18 2003-08-05 メルク エンド カムパニー インコーポレーテッド 糖尿病及び脂質障害のためのアリールオキシ酢酸
BR0109107A (pt) 2000-03-09 2002-12-03 Aventis Pharma Gmbh Usos terapêuticos de mediadores ppar
US6448293B1 (en) * 2000-03-31 2002-09-10 Pfizer Inc. Diphenyl ether compounds useful in therapy
JP2001354671A (ja) 2000-04-14 2001-12-25 Nippon Chemiphar Co Ltd ペルオキシソーム増殖剤応答性受容体δの活性化剤
JP2004501076A (ja) 2000-04-17 2004-01-15 ノボ　ノルディスク　アクティーゼルスカブ 新規化合物、それらの製造及び使用
JP2003533222A (ja) 2000-05-18 2003-11-11 シエーリング アクチエンゲゼルシャフト 経年卵母細胞の受精
CN1338310A (zh) 2000-08-10 2002-03-06 清华大学 一种猪瘟病毒表位疫苗及其制备方法
JP4790969B2 (ja) 2000-08-11 2011-10-12 日本ケミファ株式会社 ペルオキシソーム増殖剤応答性受容体δの活性化剤
EP1313715B1 (en) * 2000-08-23 2007-08-01 Eli Lilly And Company Oxazolyl-aryloxyacetic acid derivatives and their use as ppar agonists
US6630504B2 (en) * 2000-08-31 2003-10-07 Pfizer Inc. Phenoxyphenylheterocyclyl derivatives as SSRIs
GB0024361D0 (en) 2000-10-05 2000-11-22 Glaxo Group Ltd Medicaments
AU2002224138A1 (en) 2000-12-05 2002-06-18 Nippon Chemiphar Co. Ltd. Peroxisome proliferator activated receptor d activators
GB0031107D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
GB0031103D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
GB0031109D0 (en) 2000-12-20 2001-01-31 Glaxo Group Ltd Chemical compounds
US7238716B2 (en) 2000-12-28 2007-07-03 Takeda Pharmaceuticals Company Limited Alkanoic acid derivatives process for their production and use thereof
WO2002070011A2 (en) 2001-02-02 2002-09-12 Smithkline Beecham Corporation Treatment of ppar mediated diseases
US7078422B2 (en) 2001-03-23 2006-07-18 Nippon Chemiphar Co., Ltd. Activator for peroxisome proliferator-activated receptor
EP1375484A4 (en) 2001-03-28 2009-08-05 Eisai R&D Man Co Ltd CARBOXYLIC ACIDS
JPWO2002080899A1 (ja) 2001-03-30 2005-01-06 エーザイ株式会社 消化器疾患治療剤
TWI311133B (en) 2001-04-20 2009-06-21 Eisai R&D Man Co Ltd Carboxylic acid derivativeand the salt thereof
WO2002098840A1 (fr) 2001-06-04 2002-12-12 Eisai Co., Ltd. Derive de l'acide carboxylique et medicament comprenant un sel ou un ester dudit derive
NL1018283C2 (nl) 2001-06-13 2002-12-19 Dsm Nv Werkwijze voor het in contact brengen van gesmolten ureum met een gasstroom.
FR2826574B1 (fr) 2001-06-29 2005-08-26 Oreal Compositions contenant un derive d'hydroxydiphenyl ether inhibant le developpement des odeurs corporelles
US6869967B2 (en) * 2001-07-30 2005-03-22 Novo Nordisk A/S Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
US7067530B2 (en) * 2001-07-30 2006-06-27 Novo Nordisk A/S Compounds, their preparation and use
JP2004536152A (ja) 2001-07-30 2004-12-02 ノボ　ノルディスク　アクティーゼルスカブ 新規ビニルｎ−（２−ベンゾイルフェニル）−ｌ−チロシン誘導体及び抗糖尿病剤等へのそれらの使用
CN1537093A (zh) * 2001-07-30 2004-10-13 ŵ��Ų�ڿ˹�˾ 新乙烯基羧酸衍生物以及它们作为抗糖尿病等药物的用途
BRPI0211844B8 (pt) 2001-08-10 2021-05-25 Nippon Chemiphar Co composto de ácido fenóxi-acético ou um de seus sais farmaceuticamente aceitáveis, e, composição farmacêutica
EP1452521A4 (en) 2001-08-17 2007-03-14 Eisai R&D Man Co Ltd CYCLIC COMPOUND AND AGONIST OF PPAR RECEPTOR
JP4269052B2 (ja) * 2001-09-14 2009-05-27 アムジエン・インコーポレーテツド 連結ビアリール化合物
WO2003033493A1 (fr) 2001-10-12 2003-04-24 Nippon Chemiphar Co.,Ltd. Activateur du recepteur $g(d) active par le proliferateur de peroxisome
EP1438283A1 (en) 2001-10-17 2004-07-21 Novo Nordisk A/S Dicarboxylic acid derivatives, their preparation and therapeutic use
US7220877B2 (en) * 2001-10-17 2007-05-22 Novo Nordisk A/S Compounds, their preparation and use
DE10151390A1 (de) 2001-10-18 2003-05-08 Bayer Ag Essigsäurederivate
JP2003171275A (ja) 2001-12-11 2003-06-17 Sumitomo Pharmaceut Co Ltd ＰＰＡＲδアゴニスト
AU2003217274A1 (en) 2002-02-25 2003-09-09 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
EP1480957A1 (en) 2002-03-01 2004-12-01 Smithkline Beecham Corporation Hppars activators
US20030207924A1 (en) 2002-03-07 2003-11-06 Xue-Min Cheng Compounds that modulate PPAR activity and methods of preparation
US6867224B2 (en) 2002-03-07 2005-03-15 Warner-Lambert Company Compounds that modulate PPAR activity and methods of preparation
US6833380B2 (en) 2002-03-07 2004-12-21 Warner-Lambert Company, Llc Compounds that modulate PPAR activity and methods of preparation
US6875780B2 (en) 2002-04-05 2005-04-05 Warner-Lambert Company Compounds that modulate PPAR activity and methods for their preparation
DE10222034A1 (de) 2002-05-17 2003-11-27 Bayer Ag Tetrahydroisochinolin-Derivate
GB0214149D0 (en) 2002-06-19 2002-07-31 Glaxo Group Ltd Chemical compounds
GB0214254D0 (en) 2002-06-20 2002-07-31 Glaxo Group Ltd Chemical compounds
JP2005535644A (ja) 2002-06-26 2005-11-24 ファルマシア コーポレイション 安定な非経口パレコキシブ液体製剤
DE10229777A1 (de) 2002-07-03 2004-01-29 Bayer Ag Indolin-Phenylsulfonamid-Derivate
WO2004007439A1 (ja) 2002-07-10 2004-01-22 Sumitomo Pharmaceuticals Co., Ltd. ビアリール誘導体
BR0314335A (pt) 2002-09-05 2005-07-26 Novo Nordisk As Composto, uso do mesmo, composição farmacêutica, e métodos para o tratamento e/ou prevenção de condições mediadas por receptores nucleares, e de diabetes de tipo i, diabetes de tipo ii, tolerância prejudicada à glicose, resistência à insulina ou obesidade
WO2004037778A1 (en) 2002-10-21 2004-05-06 Janssen Pharmaceutica, N.V. Substituted tetralins and indanes
CA2503280A1 (en) * 2002-10-28 2004-05-06 Novo Nordisk A/S Allyloxy and allylsulfanyl compounds and use thereof as ppar modulators
US20050080115A1 (en) * 2002-10-28 2005-04-14 Lone Jeppesen Novel compounds, their preparation and use
MXPA05004405A (es) * 2002-10-28 2005-07-05 Novo Nordisk As Compuestos novedosos utiles en el tratamiento de enfermedades mediadas por ppar.
US7129268B2 (en) * 2002-10-28 2006-10-31 Novo Nordisk A/S Peroxisome proliferator activated receptor-active arylene acetic acid derivatives
WO2004063166A1 (en) 2003-01-06 2004-07-29 Eli Lilly And Company Heterocyclic ppar modulators
DE10300099A1 (de) 2003-01-07 2004-07-15 Bayer Healthcare Ag Indol-Phenylsulfonamid-Derivate
CN1751037A (zh) 2003-02-14 2006-03-22 伊莱利利公司 作为ppar调节剂的磺酰胺衍生物
EP1604971A4 (en) 2003-03-11 2006-08-16 Ono Pharmaceutical Co PROCESS FOR ADDING ACTIVE CHARCOAL IN WATER PURIFICATION AND WATER PURIFICATION METHOD
JPWO2004080947A1 (ja) 2003-03-13 2006-06-08 小野薬品工業株式会社 イミノエーテル誘導体化合物およびその化合物を有効成分として含有する薬剤
CA2521175A1 (en) 2003-04-07 2004-10-28 Kalypsys, Inc. Para-sulfonyl substituted phenyl compounds as modulators of ppars
US7244763B2 (en) 2003-04-17 2007-07-17 Warner Lambert Company Llc Compounds that modulate PPAR activity and methods of preparation
US20050070532A1 (en) 2003-04-17 2005-03-31 Liu Kevin Aryl compounds as modulators of PPARS and methods of treating metabolic disorders
EA200501713A1 (ru) 2003-04-30 2006-06-30 ДЗЕ ИНСТИТЬЮТС ФОР ФАРМАСЬЮТИКАЛ ДИСКАВЕРИ, ЭлЭлСи Фенилзамещённые карбоновые кислоты
EP1697304B1 (en) 2003-11-25 2008-02-20 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
WO2005097096A1 (en) 2004-03-31 2005-10-20 Pharmacia & Upjohn Company Llc A phenyl acetic acid cyclooxygenase-2 inhibitor for the treatment of ocular disorders
AU2005230837A1 (en) 2004-04-01 2005-10-20 Aventis Pharmaceuticals Inc. 1,3,4-oxadiazol-2-ones as PPAR delta modulators
NZ549823A (en) 2004-04-01 2009-12-24 Aventis Pharma Inc 1,3,4-oxadiazol-2-ones as PPAR delta modulators
SG138623A1 (en) 2004-04-01 2008-01-28 Aventis Pharmaceuticals Inc Us Use of ppr delta agonists for treating demyelinating diseases
WO2005097782A1 (ja) 2004-04-07 2005-10-20 Kyowa Hakko Kogyo Co., Ltd. ピペリジン誘導体
ATE486838T1 (de) 2004-05-05 2010-11-15 High Point Pharmaceuticals Llc Neue verbindungen, ihre herstellung und verwendung
DE602005022585D1 (de) * 2004-05-05 2010-09-09 High Point Pharmaceuticals Llc Phenoxyessigsäurederivate als ppar-agonisten
US8053598B2 (en) * 2004-05-05 2011-11-08 High Point Pharmaceuticals, Llc Compounds, their preparation and use
EP2298742B1 (en) 2005-06-30 2014-01-08 High Point Pharmaceuticals, LLC phenoxy acetic acids as PPAR delta activators
BRPI0620468A2 (pt) * 2005-12-22 2011-11-08 Transtech Pharma Inc ácidos fenóxi acéticos como ativadores de ppar delta
FR2898271B1 (fr) 2006-03-09 2009-01-16 Pierre Fabre Medicament Sa Nouvelle utilisation d'agents antihistaminiques pour le traitement preventif ou procede de syndromes inflammatoires, en particulier ceux declenches par les toga virus.
CA2645719A1 (en) * 2006-03-09 2007-09-13 High Point Pharmaceuticals, Llc Compounds that modulate ppar activity, their preparation and use
WO2007141295A1 (en) 2006-06-08 2007-12-13 High Point Pharmaceuticals, Llc Process for preparing phenoxy acetic acid derivatives
WO2015035171A1 (en) * 2013-09-09 2015-03-12 High Point Pharmaceuticals, Llc Use of a ppar-delta agonist for treating muscle atrophy

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