DE602005013275D1 - Pyrrolopyridin-2-karbonsäureamide - Google Patents

Pyrrolopyridin-2-karbonsäureamide

Info

Publication number
DE602005013275D1
DE602005013275D1 DE602005013275T DE602005013275T DE602005013275D1 DE 602005013275 D1 DE602005013275 D1 DE 602005013275D1 DE 602005013275 T DE602005013275 T DE 602005013275T DE 602005013275 T DE602005013275 T DE 602005013275T DE 602005013275 D1 DE602005013275 D1 DE 602005013275D1
Authority
DE
Germany
Prior art keywords
karbonsäureamide
pyrrolopyridine
ischemia
cardioprotectants
hyperinsulinemia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005013275T
Other languages
English (en)
Inventor
Thomas Martin Krulle
Robert John Rowley
Gerard Hugh Thomas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prosidion Ltd
Original Assignee
Prosidion Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prosidion Ltd filed Critical Prosidion Ltd
Publication of DE602005013275D1 publication Critical patent/DE602005013275D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE602005013275T 2004-12-02 2005-12-02 Pyrrolopyridin-2-karbonsäureamide Active DE602005013275D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63246104P 2004-12-02 2004-12-02
PCT/GB2005/050233 WO2006059164A2 (en) 2004-12-02 2005-12-02 Pyrrolopyridine-2-carboxylic acid amides

Publications (1)

Publication Number Publication Date
DE602005013275D1 true DE602005013275D1 (de) 2009-04-23

Family

ID=36201419

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005013275T Active DE602005013275D1 (de) 2004-12-02 2005-12-02 Pyrrolopyridin-2-karbonsäureamide

Country Status (7)

Country Link
US (1) US20090099176A1 (de)
EP (1) EP1819332B1 (de)
JP (1) JP2008521873A (de)
AT (1) ATE424821T1 (de)
DE (1) DE602005013275D1 (de)
ES (1) ES2324173T3 (de)
WO (1) WO2006059164A2 (de)

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CN103497181B (zh) * 2013-09-30 2016-03-30 承德医学院 作为糖原磷酸化酶抑制剂的苯并氮杂卓酮类化合物、其制备方法及医药用途
CN104744353B (zh) * 2015-03-31 2017-11-24 山东友帮生化科技有限公司 2‑氨基‑3‑碘‑5‑氯吡啶的合成方法
CR20180413A (es) 2016-02-05 2018-12-04 Denali Therapeutics Inc Inhibidores de la proteína quinasa 1 que interactua con el receptor
EP3552017B1 (de) 2016-12-09 2022-02-23 Denali Therapeutics Inc. Verbindungen zur verwendung als ripk1-hemmer
CN113906293A (zh) * 2019-05-31 2022-01-07 株式会社新日本科学 使用色谱质谱分析装置的质谱分析方法
CN112442022B (zh) * 2019-09-02 2022-05-20 承德医学院 苯并嗪-4-酮类化合物、其制备方法及医药用途
CN114057716B (zh) * 2020-08-04 2023-06-09 承德医学院 苯并氮杂卓酮类化合物及其盐、其制备方法及医药用途
US20240025856A1 (en) 2020-09-30 2024-01-25 Katholieke Universiteit Leuven 1,2,3,4-tetrahydroquinoline derivatives as inhibitors of the yap/taz-tead activation for treating cancer
WO2022160138A1 (zh) * 2021-01-27 2022-08-04 承德医学院 苯并嗪-4-酮类化合物、其制备方法及医药用途

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US5672582A (en) 1993-04-30 1997-09-30 Merck & Co., Inc. Thrombin inhibitors
US5821241A (en) 1994-02-22 1998-10-13 Merck & Co., Inc. Fibrinogen receptor antagonists
US5885967A (en) 1994-03-04 1999-03-23 Eli Lilly And Company Antithrombotic agents
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US5618792A (en) 1994-11-21 1997-04-08 Cortech, Inc. Substituted heterocyclic compounds useful as inhibitors of (serine proteases) human neutrophil elastase
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Also Published As

Publication number Publication date
EP1819332B1 (de) 2009-03-11
JP2008521873A (ja) 2008-06-26
EP1819332A2 (de) 2007-08-22
ES2324173T3 (es) 2009-07-31
WO2006059164A3 (en) 2006-08-17
US20090099176A1 (en) 2009-04-16
WO2006059164A2 (en) 2006-06-08
ATE424821T1 (de) 2009-03-15

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Legal Events

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