CN1681788A - 抑制cox－2的吡啶衍生物 - Google Patents

抑制cox－2的吡啶衍生物 Download PDF

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Publication number
CN1681788A
CN1681788A CNA038218496A CN03821849A CN1681788A CN 1681788 A CN1681788 A CN 1681788A CN A038218496 A CNA038218496 A CN A038218496A CN 03821849 A CN03821849 A CN 03821849A CN 1681788 A CN1681788 A CN 1681788A
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alkyl
methyl
phenyl
methylsulfonyl
compound
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Chinese (zh)
Inventor
保罗·贝斯威克
桑迪普·莫迪
尼尔·佩格
约翰·斯基德莫尔
马丁·斯沃布里克
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Glaxo Group Ltd
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Glaxo Group Ltd
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Publication of CN1681788A publication Critical patent/CN1681788A/zh
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    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
CNA038218496A 2002-09-16 2003-09-12 抑制cox－2的吡啶衍生物 Pending CN1681788A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0221443.5A GB0221443D0 (en) 2002-09-16 2002-09-16 Pyridine derivates
GB0221443.5 2002-09-16

Publications (1)

Publication Number Publication Date
CN1681788A true CN1681788A (zh) 2005-10-12

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ID=9944138

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA038218496A Pending CN1681788A (zh) 2002-09-16 2003-09-12 抑制cox－2的吡啶衍生物

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US (1) US7446117B2 (enExample)
EP (1) EP1546107B1 (enExample)
JP (1) JP4630063B2 (enExample)
KR (1) KR20050046782A (enExample)
CN (1) CN1681788A (enExample)
AR (1) AR041246A1 (enExample)
AT (1) ATE462694T1 (enExample)
AU (1) AU2003276063A1 (enExample)
BR (1) BR0313718A (enExample)
CA (1) CA2493497A1 (enExample)
DE (1) DE60331931D1 (enExample)
ES (1) ES2343316T3 (enExample)
GB (1) GB0221443D0 (enExample)
IL (1) IL166460A0 (enExample)
IS (1) IS7659A (enExample)
MA (1) MA27436A1 (enExample)
MX (1) MXPA05002886A (enExample)
NO (1) NO20050662L (enExample)
NZ (1) NZ538201A (enExample)
PL (1) PL376023A1 (enExample)
RU (1) RU2005103618A (enExample)
TW (1) TW200404541A (enExample)
WO (1) WO2004024691A1 (enExample)
ZA (1) ZA200501174B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101889010B (zh) * 2007-12-04 2012-12-05 弗·哈夫曼-拉罗切有限公司 异*唑-吡啶衍生物
CN105916846A (zh) * 2013-11-07 2016-08-31 麦迪韦逊科技有限公司 用于合成经保护的n-烷基三唑甲醛的三唑中间体

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60305053T2 (de) 2002-08-19 2006-08-31 Glaxo Group Ltd., Greenford Pyrimidinderivate als selektive cox-2-inhibitoren
GB0221443D0 (en) 2002-09-16 2002-10-23 Glaxo Group Ltd Pyridine derivates
WO2005007627A1 (ja) * 2003-07-18 2005-01-27 Nihon Nohyaku Co., Ltd. フェニルピリジン誘導体、その中間体及びこれを有効成分とする除草剤
EP2395002B1 (en) 2005-11-08 2014-06-18 Vertex Pharmaceuticals Inc. Pharmaceutical composition containing a heterocyclic modulator of atp-binding cassette transporters.
NZ581259A (en) 2007-05-09 2012-07-27 Vertex Pharma Modulators of cystic fibrosis transmembrane conductance regulator
LT2639223T (lt) * 2007-12-07 2017-06-26 Vertex Pharmaceuticals Incorporated Cikloalkilkarboksiamido-piridino benzenkarboksirūgščių gamybos būdas
UA102534C2 (xx) 2007-12-07 2013-07-25 Вертекс Фармасьютикалз Инкорпорейтед ТВЕРДА ФОРМА 3-(6-(1-(2,2-ДИФТОРБЕНЗО$d]$1,3]-ДІОКСОЛ-5-ІЛ)-ЦИКЛОПРОПАНКАРБОКСАМІДО)-3-МЕТИЛПІРИДИН-2-ІЛ)БЕНЗОЙНОЇ КИСЛОТИ (ВАРІАНТИ)$ТВЕРДАЯ ФОРМА 3-(6-(1-(2,2-ДИФТОРБЕНЗО$d]$1,3]-ДИОКСОЛ-5-ИЛ)-ЦИКЛОПРОПАНКАРБОКСАМИДО)-3-МЕТИЛПИРИДИН-2-ИЛ)БЕНЗОЙНОЙ КИСЛОТЫ (ВАРИАНТЫ)
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