CN1512996A - 头孢地尼结晶酸盐及用其制备头孢地尼的方法 - Google Patents
头孢地尼结晶酸盐及用其制备头孢地尼的方法 Download PDFInfo
- Publication number
- CN1512996A CN1512996A CNA028113349A CN02811334A CN1512996A CN 1512996 A CN1512996 A CN 1512996A CN A028113349 A CNA028113349 A CN A028113349A CN 02811334 A CN02811334 A CN 02811334A CN 1512996 A CN1512996 A CN 1512996A
- Authority
- CN
- China
- Prior art keywords
- cefdinir
- formula
- acid
- solvent
- mixture
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/22—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with radicals containing only hydrogen and carbon atoms, attached in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Description
2θ | d | I/Io | 2θ | d | I/Io |
8.4 | 10.5 | 100 | 20.3 | 4.4 | 73 |
9.4 | 9.4 | 21 | 21.2 | 4.2 | 39 |
11.8 | 7.5 | 28 | 23.0 | 3.9 | 38 |
14.1 | 6.3 | 61 | 23.8 | 3.7 | 80 |
17.0 | 5.2 | 30 | 25.2 | 3.5 | 48 |
18.6 | 4.8 | 95 | 27.4 | 3.3 | 38 |
19.0 | 4.7 | 55 | 28.7 | 3.1 | 36 |
19.6 | 4.5 | 32 | 30.0 | 3.0 | 30 |
2θ | d | I/Io | 2θ | d | I/Io |
6.1 | 14.4 | 44 | 21.8 | 4.1 | 100 |
11.8 | 7.5 | 38 | 22.0 | 4.0 | 90 |
13.3 | 6.7 | 28 | 22.6 | 3.9 | 30 |
16.5 | 5.4 | 30 | 23.7 | 3.8 | 27 |
17.0 | 5.2 | 21 | 24.3 | 3.7 | 22 |
19.0 | 4.7 | 26 | 24.9 | 3.6 | 52 |
19.7 | 4.5 | 38 | 25.5 | 3.5 | 17 |
20.6 | 4.3 | 17 | 31.1 | 2.9 | 17 |
Claims (11)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2001-0031339A KR100451672B1 (ko) | 2001-06-05 | 2001-06-05 | 결정성 세프디니르 산부가염, 이의 제조방법 및 이를이용한 세프디니르의 제조방법 |
KR31339/2001 | 2001-06-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1512996A true CN1512996A (zh) | 2004-07-14 |
CN1235902C CN1235902C (zh) | 2006-01-11 |
Family
ID=19710401
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB028113349A Expired - Fee Related CN1235902C (zh) | 2001-06-05 | 2002-06-05 | 头孢地尼结晶酸盐及用其制备头孢地尼的方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US7157576B2 (zh) |
EP (1) | EP1392703B1 (zh) |
JP (2) | JP4152879B2 (zh) |
KR (1) | KR100451672B1 (zh) |
CN (1) | CN1235902C (zh) |
WO (1) | WO2002098884A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010075765A1 (zh) | 2008-12-31 | 2010-07-08 | 浙江奥默生物医药有限公司 | 头孢地尼酸式复盐化合物及制备方法 |
CN102643293A (zh) * | 2012-03-30 | 2012-08-22 | 石药集团中诺药业(石家庄)有限公司 | 头孢地尼三元复合物及其用于制备头孢地尼的方法 |
CN103012433A (zh) * | 2012-12-13 | 2013-04-03 | 珠海保税区丽珠合成制药有限公司 | 头孢地尼晶型b的制备方法 |
CN106397456A (zh) * | 2016-08-31 | 2017-02-15 | 成都倍特药业有限公司 | 一种含高纯度头孢地尼的组合物及其精制方法 |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2003014056A1 (ja) * | 2001-08-08 | 2004-11-25 | 鐘淵化学工業株式会社 | 光学活性2−置換カルボン酸の製造法 |
EP1458728A1 (en) * | 2001-12-13 | 2004-09-22 | Ranbaxy Laboratories Limited | Crystalline cefdinir potassium dihydrate |
MXPA04010627A (es) * | 2002-04-26 | 2005-02-14 | Ranbaxy Lab Ltd | Proceso para la preparacion de cefdinir. |
ITMI20020913A0 (it) * | 2002-04-29 | 2002-04-29 | Acs Dobfar Spa | Nuova forma cristallina del cefdinir |
EP1842852A1 (en) * | 2002-08-13 | 2007-10-10 | Sandoz AG | A cefdinir intermediate |
ITMI20022076A1 (it) * | 2002-10-01 | 2004-04-02 | Antibioticos Spa | Sali di intermedi del cefdinir. |
US7244842B2 (en) * | 2002-11-15 | 2007-07-17 | Orchid Chemicals & Pharmaceuticals Ltd. | Amorphous hydrate of a cephalosporin antibiotic |
ITMI20022724A1 (it) * | 2002-12-20 | 2004-06-21 | Antibioticos Spa | Sali cristallini del cefdinir. |
ZA200507748B (en) * | 2003-03-24 | 2007-03-28 | Acs Dobfar Spa | Novel crystal of 7-[2-(2-aminothiazole-4-yl)-2-hydroxyimino-acetamido-3-vinyl-3-cephem-4-carboxylic acid (syn isomer) and method for preparation thereof |
WO2004104010A1 (en) * | 2003-05-20 | 2004-12-02 | Ranbaxy Laboratories Limited | Crystalline form of cefdinir |
US20050137182A1 (en) * | 2003-06-02 | 2005-06-23 | Ramesh Dandala | Novel crystalline form of cefdinir |
US7105659B2 (en) * | 2003-06-02 | 2006-09-12 | Aurobind - Pharma Ltd. | Process for preparing cefdinir |
US20040242556A1 (en) * | 2003-06-02 | 2004-12-02 | Ramesh Dandala | Novel crystalline form of cefdinir |
US20050059818A1 (en) * | 2003-09-12 | 2005-03-17 | Duerst Richard W. | Polymorph of a pharmaceutical |
US20050209211A1 (en) * | 2004-03-16 | 2005-09-22 | Devalina Law | Trihemihydrate, anhydrate and novel hydrate forms of Cefdinir |
US20060069079A1 (en) * | 2004-09-27 | 2006-03-30 | Sever Nancy E | Stable amorphous cefdinir |
US20050245738A1 (en) * | 2004-05-03 | 2005-11-03 | Lupin Ltd | Stable bioavailable crystalline form or cefdinir and a process for the preparation thereof |
WO2006059753A1 (en) * | 2004-11-30 | 2006-06-08 | Astellas Pharma Inc. | Novel oral pharmaceutical suspension of cefdinir crystal |
KR20080064990A (ko) * | 2005-10-31 | 2008-07-10 | 테바 파마슈티컬 인더스트리즈 리미티드 | 세프디니르의 제조방법 |
JP2008525531A (ja) * | 2005-10-31 | 2008-07-17 | テバ ファーマシューティカル インダストリーズ リミティド | セフジニルカリウム塩の結晶形 |
KR100912214B1 (ko) * | 2005-10-31 | 2009-08-14 | 테바 파마슈티컬 인더스트리즈 리미티드 | 세프디니르 세슘 염의 결정형 |
US20070128268A1 (en) * | 2005-12-07 | 2007-06-07 | Herwig Jennewein | Pharmaceutical compositions comprising an antibiotic |
CN101565427B (zh) * | 2009-06-11 | 2011-04-27 | 浙江昂利康制药有限公司 | 头孢地尼的制备方法 |
Family Cites Families (20)
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US4260543A (en) * | 1978-07-03 | 1981-04-07 | Merck & Co., Inc. | Crystalline N-formimidoyl thienamycin |
DK162718C (da) * | 1982-09-30 | 1992-05-11 | Fujisawa Pharmaceutical Co | Analogifremgangsmaade til fremstilling af 7-substitueret-3-vinyl-3-cephemforbindelser |
ZA836918B (en) * | 1982-09-30 | 1984-05-30 | Fujisawa Pharmaceutical Co | 7-substituted-3-vinyl-3-cephem compounds and processes for the production of the same |
US4748238A (en) * | 1984-03-14 | 1988-05-31 | Merck & Co., Inc. | Crystalline 1R,5S,6S,8R-1-methyl-2-(N,N-dimethylcarbamimidoylmethylthio)-6-(1-hydroxyethyl)-1-carbapen-2-em-3-carboxylic acid |
US4713451A (en) * | 1984-04-09 | 1987-12-15 | Merck & Co., Inc. | Crystalline dimethyliminothienamycin |
IE60588B1 (en) * | 1986-07-30 | 1994-07-27 | Sumitomo Pharma | Carbapenem compound in crystalline form, and its production and use |
US4866171A (en) * | 1987-04-11 | 1989-09-12 | Lederle (Japan), Ltd. | (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate |
JPH0674276B2 (ja) * | 1987-08-19 | 1994-09-21 | 藤沢薬品工業株式会社 | 7−[2−(2−アミノチアゾール−4−イル)−2−ヒドロキシイミノアセトアミド−3−ビニル−3−セフェム−4−カルボン酸(シン異性体)の新規結晶 |
ZA885709B (en) * | 1987-08-19 | 1989-04-26 | Fujisawa Pharmaceutical Co | Novel crystalline 7-(2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4-carboxylic acid(syn isomer) |
GB8800295D0 (en) * | 1988-01-07 | 1988-02-10 | Fujisawa Pharmaceutical Co | Process for preparation of 7-(2-amino-thiazol-4-y)-2-hydroxyimino-acetanidol-3-cephem compounds |
DE69324106T2 (de) * | 1992-11-17 | 1999-12-09 | Sankyo Co | Krystallines Carbapenemderivat |
JPH09110869A (ja) * | 1995-10-23 | 1997-04-28 | Lederle Japan Ltd | カルバペネム化合物 |
ATE218572T1 (de) * | 1995-12-27 | 2002-06-15 | Hanmi Pharmaceutical Co Ltd | Verfahren zur herstellung von cefdinir |
TW538045B (en) * | 1997-01-16 | 2003-06-21 | Biochemie Gmbh | Process for purifying cefixime |
AT405283B (de) * | 1997-04-04 | 1999-06-25 | Biochemie Gmbh | Neues kristallines 7-(z)-(2-(2-aminothiazol-4-yl) -2-hydroxyiminoacetamido)-3-vinyl-3-cephem-4- carbonsäure dicyclohexylammoniumsalz und verfahren zu dessen herstellung |
TWI250160B (en) * | 1999-07-06 | 2006-03-01 | Sankyo Co | Crystalline 1-methylcarbapenem compound |
CN1666365A (zh) * | 2002-07-01 | 2005-09-07 | 纳幕尔杜邦公司 | 汽相沉积催化剂及其在燃料电池中的用途 |
EP1842852A1 (en) * | 2002-08-13 | 2007-10-10 | Sandoz AG | A cefdinir intermediate |
ITMI20022724A1 (it) * | 2002-12-20 | 2004-06-21 | Antibioticos Spa | Sali cristallini del cefdinir. |
US20040242556A1 (en) * | 2003-06-02 | 2004-12-02 | Ramesh Dandala | Novel crystalline form of cefdinir |
-
2001
- 2001-06-05 KR KR10-2001-0031339A patent/KR100451672B1/ko active IP Right Grant
-
2002
- 2002-06-05 WO PCT/KR2002/001064 patent/WO2002098884A1/en active Application Filing
- 2002-06-05 CN CNB028113349A patent/CN1235902C/zh not_active Expired - Fee Related
- 2002-06-05 US US10/479,291 patent/US7157576B2/en not_active Expired - Fee Related
- 2002-06-05 EP EP02730990.5A patent/EP1392703B1/en not_active Expired - Fee Related
- 2002-06-05 JP JP2003502005A patent/JP4152879B2/ja not_active Expired - Lifetime
-
2008
- 2008-04-07 JP JP2008099293A patent/JP5027042B2/ja not_active Expired - Lifetime
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010075765A1 (zh) | 2008-12-31 | 2010-07-08 | 浙江奥默生物医药有限公司 | 头孢地尼酸式复盐化合物及制备方法 |
CN102643293A (zh) * | 2012-03-30 | 2012-08-22 | 石药集团中诺药业(石家庄)有限公司 | 头孢地尼三元复合物及其用于制备头孢地尼的方法 |
CN103012433A (zh) * | 2012-12-13 | 2013-04-03 | 珠海保税区丽珠合成制药有限公司 | 头孢地尼晶型b的制备方法 |
CN103012433B (zh) * | 2012-12-13 | 2015-06-24 | 珠海保税区丽珠合成制药有限公司 | 头孢地尼晶型b的制备方法 |
CN106397456A (zh) * | 2016-08-31 | 2017-02-15 | 成都倍特药业有限公司 | 一种含高纯度头孢地尼的组合物及其精制方法 |
CN106397456B (zh) * | 2016-08-31 | 2019-05-07 | 成都倍特药业有限公司 | 一种含高纯度头孢地尼的组合物及其精制方法 |
Also Published As
Publication number | Publication date |
---|---|
EP1392703A4 (en) | 2004-10-27 |
JP2004534053A (ja) | 2004-11-11 |
KR20020092612A (ko) | 2002-12-12 |
JP5027042B2 (ja) | 2012-09-19 |
EP1392703A1 (en) | 2004-03-03 |
WO2002098884A1 (en) | 2002-12-12 |
US20040210049A1 (en) | 2004-10-21 |
KR100451672B1 (ko) | 2004-10-08 |
US7157576B2 (en) | 2007-01-02 |
JP2008189688A (ja) | 2008-08-21 |
EP1392703B1 (en) | 2014-09-03 |
CN1235902C (zh) | 2006-01-11 |
JP4152879B2 (ja) | 2008-09-17 |
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