CN1495182A - 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺 - Google Patents

用于抑制细胞增殖的取代的双吲哚基马来酰亚胺 Download PDF

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Publication number
CN1495182A
CN1495182A CNA031275400A CN03127540A CN1495182A CN 1495182 A CN1495182 A CN 1495182A CN A031275400 A CNA031275400 A CN A031275400A CN 03127540 A CN03127540 A CN 03127540A CN 1495182 A CN1495182 A CN 1495182A
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CN
China
Prior art keywords
alkyl
methyl
hydrogen
compound
indol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA031275400A
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English (en)
Chinese (zh)
Inventor
M
唐娜·M·赫因
D
丹尼斯·D·基思
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN1495182A publication Critical patent/CN1495182A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNA031275400A 1996-07-29 1997-07-19 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺 Pending CN1495182A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2207996P 1996-07-29 1996-07-29
US60/022,079 1996-07-29

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CNB971967768A Division CN1151149C (zh) 1996-07-29 1997-07-19 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺

Publications (1)

Publication Number Publication Date
CN1495182A true CN1495182A (zh) 2004-05-12

Family

ID=21807711

Family Applications (2)

Application Number Title Priority Date Filing Date
CNA031275400A Pending CN1495182A (zh) 1996-07-29 1997-07-19 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺
CNB971967768A Expired - Fee Related CN1151149C (zh) 1996-07-29 1997-07-19 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB971967768A Expired - Fee Related CN1151149C (zh) 1996-07-29 1997-07-19 用于抑制细胞增殖的取代的双吲哚基马来酰亚胺

Country Status (23)

Country Link
US (2) US5856517A (cg-RX-API-DMAC7.html)
EP (1) EP0915872B1 (cg-RX-API-DMAC7.html)
JP (1) JP2000516589A (cg-RX-API-DMAC7.html)
KR (1) KR20000029637A (cg-RX-API-DMAC7.html)
CN (2) CN1495182A (cg-RX-API-DMAC7.html)
AR (1) AR008267A1 (cg-RX-API-DMAC7.html)
AT (1) ATE240318T1 (cg-RX-API-DMAC7.html)
AU (1) AU739742B2 (cg-RX-API-DMAC7.html)
BR (1) BR9711605A (cg-RX-API-DMAC7.html)
CA (1) CA2262092A1 (cg-RX-API-DMAC7.html)
CO (1) CO4900055A1 (cg-RX-API-DMAC7.html)
CY (1) CY2483B1 (cg-RX-API-DMAC7.html)
DE (1) DE69722003T2 (cg-RX-API-DMAC7.html)
DK (1) DK0915872T3 (cg-RX-API-DMAC7.html)
ES (1) ES2198001T3 (cg-RX-API-DMAC7.html)
HR (1) HRP970414A2 (cg-RX-API-DMAC7.html)
MA (1) MA24287A1 (cg-RX-API-DMAC7.html)
PE (1) PE91698A1 (cg-RX-API-DMAC7.html)
PT (1) PT915872E (cg-RX-API-DMAC7.html)
SA (1) SA97180473A (cg-RX-API-DMAC7.html)
TR (1) TR199900157T2 (cg-RX-API-DMAC7.html)
WO (1) WO1998004552A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA976492B (cg-RX-API-DMAC7.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1064279E (pt) * 1998-03-17 2003-10-31 Hoffmann La Roche Bisindolilmaleimidas substituidas para a inibicao da proliferacao celular
US6313143B1 (en) * 1999-12-16 2001-11-06 Hoffmann-La Roche Inc. Substituted pyrroles
WO2001044247A2 (en) * 1999-12-16 2001-06-21 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
US6743785B2 (en) * 1999-12-16 2004-06-01 Eli Lilly And Company Agents and methods for the treatment of proliferative diseases
EP1250334B1 (en) * 1999-12-16 2004-05-19 Eli Lilly And Company Medicaments useful for the treatment of proliferative diseases
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
TW201041580A (en) 2001-09-27 2010-12-01 Alcon Inc Inhibitors of glycogen synthase kinase-3 (GSK-3) for treating glaucoma
US20030139373A1 (en) * 2001-11-20 2003-07-24 Breimer Lars Holger Method for cancer therapy
MY142390A (en) * 2002-05-22 2010-11-30 Glaxosmithkline Llc 3' - [(2z)-[1-(3,4-dimethylphenyl)-1,5- dihydro-3- methyl-5-0xo-4h-pyrazol-4- ylidene]hydrazino]-2' -hydroxy -[1,1' -biphenyl]-3-carboxylic acid bis-(monoethanolamine)
US7012100B1 (en) 2002-06-04 2006-03-14 Avolix Pharmaceuticals, Inc. Cell migration inhibiting compositions and methods and compositions for treating cancer
RS51826B (sr) 2005-02-09 2012-02-29 Arqule Inc. Maleimid derivati, farmaceutske kompozicije i postupak lečenja kancera
JP2010513386A (ja) * 2006-12-19 2010-04-30 ノバルティス アーゲー キナーゼ阻害剤としてのインドリルマレイミド誘導体
CA2690782C (en) 2007-06-22 2016-02-02 Arqule, Inc. Compositions and methods for treatment of cancer
CA2690799C (en) 2007-06-22 2015-06-16 Arqule, Inc. Pyrrolidinone, pyrrolidine-2,5-dione, pyrrolidine and thiosuccinimide derivatives, compositions and methods for treatment of cancer
CN101801937A (zh) 2007-06-22 2010-08-11 艾科尔公司 喹唑啉酮化合物及其使用方法
JP2009035537A (ja) * 2007-07-10 2009-02-19 Nippon Synthetic Chem Ind Co Ltd:The Ｎ−置換アニリン誘導体及び１−置換インドール誘導体の製造方法
FR2927075A1 (fr) * 2008-02-04 2009-08-07 Centre Nat Rech Scient Molecules comprenant un squelette bis-(heteroaryl)maleimide, et leur utilisation dans l'inhibition d'enzymes
GB201111427D0 (en) * 2011-07-05 2011-08-17 Amakem Nv Novel bisindolylmaleimides, pan-pkc inhibitors
ES2919024T3 (es) 2014-02-11 2022-07-21 Mitokinin Inc Composiciones y procedimientos que utilizan las mismas para el tratamiento de enfermedades neurodegenerativas y mitocondriales
JP2017524739A (ja) 2014-07-17 2017-08-31 アンセルムＩｎｓｅｒｍ 神経筋接合部関連疾患の処置方法
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
WO2018237145A1 (en) * 2017-06-21 2018-12-27 Mitokinin, Inc. Compositions and methods using the same for treatment of neurodegenerative and mitochondrial disease

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ280738B6 (cs) * 1988-02-10 1996-04-17 F. Hoffmann - La Roche And Co., Aktiengesellschaft Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5380746A (en) * 1989-05-05 1995-01-10 Goedecke Aktiengesellschaft Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the preparation thereof and pharmaceutical compositions containing them
DE4005969A1 (de) * 1990-02-26 1991-08-29 Boehringer Mannheim Gmbh Neue trisubstituierte pyrrole, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
JPH0539289A (ja) * 1991-02-15 1993-02-19 Masahiro Irie 無水マレイン酸誘導体およびその製造方法
AU3761393A (en) * 1992-03-20 1993-10-21 Wellcome Foundation Limited, The Indole derivatives with antiviral activity
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung

Also Published As

Publication number Publication date
AU739742B2 (en) 2001-10-18
AU3769097A (en) 1998-02-20
US6030994A (en) 2000-02-29
MA24287A1 (fr) 1998-04-01
EP0915872A1 (en) 1999-05-19
DK0915872T3 (da) 2003-09-08
CY2483B1 (en) 2005-06-03
CO4900055A1 (es) 2000-03-27
DE69722003T2 (de) 2004-04-01
CN1226247A (zh) 1999-08-18
DE69722003D1 (de) 2003-06-18
EP0915872B1 (en) 2003-05-14
TR199900157T2 (xx) 1999-04-21
ATE240318T1 (de) 2003-05-15
HRP970414A2 (en) 1998-06-30
CN1151149C (zh) 2004-05-26
ES2198001T3 (es) 2004-01-16
CA2262092A1 (en) 1998-02-05
WO1998004552A1 (en) 1998-02-05
BR9711605A (pt) 1999-08-24
JP2000516589A (ja) 2000-12-12
PT915872E (pt) 2003-09-30
SA97180473A (ar) 2005-12-03
PE91698A1 (es) 1998-12-24
ZA976492B (en) 1998-01-29
AR008267A1 (es) 1999-12-29
US5856517A (en) 1999-01-05
KR20000029637A (ko) 2000-05-25

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