CN1378548A - 分离类似的有机化合物的方法 - Google Patents
分离类似的有机化合物的方法 Download PDFInfo
- Publication number
- CN1378548A CN1378548A CN00807975A CN00807975A CN1378548A CN 1378548 A CN1378548 A CN 1378548A CN 00807975 A CN00807975 A CN 00807975A CN 00807975 A CN00807975 A CN 00807975A CN 1378548 A CN1378548 A CN 1378548A
- Authority
- CN
- China
- Prior art keywords
- molecular weight
- resin
- lactone
- acid group
- silver
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
- B01D15/1821—Simulated moving beds
- B01D15/185—Simulated moving beds characterized by the components to be separated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/04—Processes using organic exchangers
- B01J39/05—Processes using organic exchangers in the strongly acidic form
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/08—Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/16—Organic material
- B01J39/18—Macromolecular compounds
- B01J39/20—Macromolecular compounds obtained by reactions only involving unsaturated carbon-to-carbon bonds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2215/00—Separating processes involving the treatment of liquids with adsorbents
- B01D2215/02—Separating processes involving the treatment of liquids with adsorbents with moving adsorbents
- B01D2215/023—Simulated moving beds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Sustainable Development (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
Abstract
Description
原料中的纯度(%) | 洗脱部分中的纯度(%) | |
他克莫司 | 85.4 | 92.7 |
子囊霉素 | 5.45 | 0.11 |
化合物A | 1.30 | n.d. |
Claims (10)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP145103/99 | 1999-05-25 | ||
JP14510399 | 1999-05-25 | ||
JP145103/1999 | 1999-05-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1378548A true CN1378548A (zh) | 2002-11-06 |
CN1154651C CN1154651C (zh) | 2004-06-23 |
Family
ID=15377455
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB008079757A Expired - Lifetime CN1154651C (zh) | 1999-05-25 | 2000-05-19 | 分离类似的有机化合物的方法 |
Country Status (27)
Country | Link |
---|---|
US (1) | US6492513B1 (zh) |
EP (1) | EP1183261B1 (zh) |
JP (1) | JP3750527B2 (zh) |
KR (1) | KR100443048B1 (zh) |
CN (1) | CN1154651C (zh) |
AR (1) | AR024068A1 (zh) |
AT (1) | ATE275150T1 (zh) |
AU (1) | AU775075C (zh) |
BR (1) | BR0011597B1 (zh) |
CA (1) | CA2374999C (zh) |
CZ (1) | CZ300783B6 (zh) |
DE (1) | DE60013434T2 (zh) |
DK (1) | DK1183261T3 (zh) |
ES (1) | ES2223514T3 (zh) |
HK (1) | HK1050528A1 (zh) |
HU (1) | HU228268B1 (zh) |
IL (2) | IL146285A0 (zh) |
MX (1) | MXPA01011566A (zh) |
NO (1) | NO321407B1 (zh) |
NZ (1) | NZ515462A (zh) |
PL (1) | PL199512B1 (zh) |
PT (1) | PT1183261E (zh) |
RU (1) | RU2234509C2 (zh) |
TR (1) | TR200103360T2 (zh) |
TW (1) | TW500725B (zh) |
WO (1) | WO2000071546A1 (zh) |
ZA (1) | ZA200109093B (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103182198A (zh) * | 2011-12-29 | 2013-07-03 | 义守大学 | 一种以模拟移动床分离不同分子量高分子的方法 |
CN106083892A (zh) * | 2016-06-13 | 2016-11-09 | 杭州中美华东制药有限公司 | 高纯度他克莫司化合物及其制备方法 |
CN104428308B (zh) * | 2012-07-06 | 2016-11-09 | 合同酒精株式会社 | 环状大环内酯类化合物的分离方法 |
CN111909176A (zh) * | 2020-08-14 | 2020-11-10 | 卓和药业集团有限公司 | 一种从他克莫司分离废液中回收子囊霉素、他克莫司8-丙基类似物的方法 |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1474404A4 (en) | 2002-02-13 | 2006-01-11 | Biogal Gyogyszergyar | PROCESS FOR EXTRACTION OF A BIOLOGICAL MATERIAL |
US7452692B2 (en) | 2002-02-13 | 2008-11-18 | Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság | Method for extracting a macrolide from biomatter |
US7473366B2 (en) * | 2003-12-05 | 2009-01-06 | Biocon Limited | Process for the purification of macrolides |
WO2005098011A1 (en) * | 2004-04-12 | 2005-10-20 | Biocon Limited | Process for the production of macrolides using a novel strain, streptomyces sp. bicc 7522 |
US20080312447A1 (en) * | 2004-09-10 | 2008-12-18 | Ivax Pharmaceuticals S.R.O. | Process for Isolation of Crystalline Tacrolimus |
US20080269479A1 (en) * | 2004-09-10 | 2008-10-30 | Ivax Pharmaceuticals S.R.O. | Process for Isolation of Macrolide Compounds |
ITMI20042098A1 (it) * | 2004-11-03 | 2005-02-03 | Antibioticos Spa | Processo per la purificazione di tacrolimus |
EP1817315A1 (en) * | 2004-12-01 | 2007-08-15 | Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság | Processes for producing crystalline macrolides |
US20060149057A1 (en) * | 2004-12-22 | 2006-07-06 | Vilmos Keri | Method of purifying macrolides |
TW200635934A (en) * | 2005-01-05 | 2006-10-16 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | Amorphous tacrolimus and preparation thereof |
WO2007013017A1 (en) * | 2005-07-29 | 2007-02-01 | Ranbaxy Laboratories Limited | A process for purification of macrolides |
ITMI20051549A1 (it) * | 2005-08-05 | 2007-02-06 | Antibioticos Spa | Purificazione del tacrolimus su supporti dimorigine vegetale |
BRPI0620310B1 (pt) | 2005-12-16 | 2017-12-05 | Archer-Daniels-Midland Company | A method for preparing a composition enriched in compounds containing unsaturated carbon chains by simulated moving bed chromatography using an adsorbent containing silver ions |
DE602007006601D1 (de) * | 2006-03-15 | 2010-07-01 | Teva Gyogyszergyar Zartkoeruee | Verfahren zur reinigung von tacrolimus |
ATE468343T1 (de) * | 2006-03-15 | 2010-06-15 | Teva Gyogyszergyar Zartkoeruee | Verfahren zur reinigung von tacrolimus |
KR100859670B1 (ko) * | 2006-09-13 | 2008-09-23 | 동국제약 주식회사 | 타크로리무스를 고수율 및 고순도로 정제하는 방법 |
JP2010514790A (ja) * | 2006-12-28 | 2010-05-06 | リメリック バイオファーマ, インコーポレイテッド | 治療処置のための方法および組成物 |
KR20100051829A (ko) | 2007-07-31 | 2010-05-18 | 리머릭 바이오파르마 인코오포레이티드 | 인산화된 피론 유사체 및 방법 |
KR101003042B1 (ko) | 2008-03-17 | 2010-12-21 | 종근당바이오 주식회사 | 고순도 타크로리무스의 정제 방법 |
KR100910165B1 (ko) * | 2008-09-18 | 2009-07-30 | (주) 제노텍 | 은 이온 용액 추출을 이용한 불포화 알킬기를 가진 락톤 화합물 정제방법 |
WO2011163600A2 (en) | 2010-06-25 | 2011-12-29 | Apt Pharmaceuticals, Inc. | Tacrolimus compositions for aerosol administration |
US9133417B2 (en) | 2012-03-23 | 2015-09-15 | The Procter & Gamble Company | Liquid cleaning and disinfecting compositions comprising an assymetrically branched amine oxide |
US8470755B1 (en) | 2012-03-23 | 2013-06-25 | The Procter & Gamble Company | Liquid cleaning and disinfecting compositions comprising a zinc inorganic salt |
RU2694354C1 (ru) * | 2018-09-25 | 2019-07-11 | Закрытое акционерное общество "БиоХимМак СТ" | Способ сорбционно-хроматографического выделения и очистки такролимуса |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS4988801A (zh) * | 1972-12-29 | 1974-08-24 | ||
US4826603A (en) | 1986-09-09 | 1989-05-02 | United States Of America As Represented By The Secretary Of The Air Force | Hydrocarbon group-type analyzer system |
JPH06185397A (ja) * | 1992-12-15 | 1994-07-05 | Mazda Motor Corp | 燃料噴射式エンジンの燃料噴射量制御装置 |
KR970002037B1 (ko) * | 1994-12-09 | 1997-02-21 | 농촌진흥청 | 들깨유로부터 α-리놀렌산(ALA)을 분리, 정제하는 방법 |
US5616595A (en) | 1995-06-07 | 1997-04-01 | Abbott Laboratories | Process for recovering water insoluble compounds from a fermentation broth |
KR100244164B1 (ko) | 1997-07-15 | 2000-03-02 | 김용옥 | 수용성 고분자-타크로리무스 접합체 화합물 및 그의 제조 방법 |
-
2000
- 2000-05-19 AU AU46154/00A patent/AU775075C/en not_active Expired
- 2000-05-19 IL IL14628500A patent/IL146285A0/xx unknown
- 2000-05-19 US US09/926,611 patent/US6492513B1/en not_active Expired - Lifetime
- 2000-05-19 AT AT00927830T patent/ATE275150T1/de active
- 2000-05-19 PT PT00927830T patent/PT1183261E/pt unknown
- 2000-05-19 KR KR10-2001-7013989A patent/KR100443048B1/ko active IP Right Grant
- 2000-05-19 RU RU2001134894/15A patent/RU2234509C2/ru active
- 2000-05-19 PL PL357015A patent/PL199512B1/pl unknown
- 2000-05-19 CZ CZ20014209A patent/CZ300783B6/cs not_active IP Right Cessation
- 2000-05-19 HU HU0201481A patent/HU228268B1/hu unknown
- 2000-05-19 WO PCT/JP2000/003251 patent/WO2000071546A1/en active IP Right Grant
- 2000-05-19 JP JP2000619802A patent/JP3750527B2/ja not_active Expired - Lifetime
- 2000-05-19 MX MXPA01011566A patent/MXPA01011566A/es active IP Right Grant
- 2000-05-19 ES ES00927830T patent/ES2223514T3/es not_active Expired - Lifetime
- 2000-05-19 NZ NZ515462A patent/NZ515462A/en not_active IP Right Cessation
- 2000-05-19 DK DK00927830T patent/DK1183261T3/da active
- 2000-05-19 BR BRPI0011597-5A patent/BR0011597B1/pt not_active IP Right Cessation
- 2000-05-19 EP EP00927830A patent/EP1183261B1/en not_active Expired - Lifetime
- 2000-05-19 CA CA002374999A patent/CA2374999C/en not_active Expired - Lifetime
- 2000-05-19 TR TR2001/03360T patent/TR200103360T2/xx unknown
- 2000-05-19 DE DE60013434T patent/DE60013434T2/de not_active Expired - Lifetime
- 2000-05-19 CN CNB008079757A patent/CN1154651C/zh not_active Expired - Lifetime
- 2000-05-23 AR ARP000102504A patent/AR024068A1/es active IP Right Grant
- 2000-05-24 TW TW089110055A patent/TW500725B/zh not_active IP Right Cessation
-
2001
- 2001-11-01 IL IL146285A patent/IL146285A/en not_active IP Right Cessation
- 2001-11-02 ZA ZA200109093A patent/ZA200109093B/xx unknown
- 2001-11-15 NO NO20015579A patent/NO321407B1/no not_active IP Right Cessation
-
2003
- 2003-04-10 HK HK03102637A patent/HK1050528A1/xx not_active IP Right Cessation
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103182198A (zh) * | 2011-12-29 | 2013-07-03 | 义守大学 | 一种以模拟移动床分离不同分子量高分子的方法 |
CN104428308B (zh) * | 2012-07-06 | 2016-11-09 | 合同酒精株式会社 | 环状大环内酯类化合物的分离方法 |
CN106083892A (zh) * | 2016-06-13 | 2016-11-09 | 杭州中美华东制药有限公司 | 高纯度他克莫司化合物及其制备方法 |
CN106083892B (zh) * | 2016-06-13 | 2019-02-19 | 杭州中美华东制药有限公司 | 他克莫司化合物及其制备方法 |
CN111909176A (zh) * | 2020-08-14 | 2020-11-10 | 卓和药业集团有限公司 | 一种从他克莫司分离废液中回收子囊霉素、他克莫司8-丙基类似物的方法 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1154651C (zh) | 分离类似的有机化合物的方法 | |
CN1195760C (zh) | 含内酯的高分子量化合物的分离方法 | |
US6013492A (en) | Microbial process for producing calcium D-pantothenate | |
CN106928323B (zh) | 一种高纯度奥利万星关键中间体a82846b的制备方法 | |
EP1735337B2 (en) | Method of producing highly pure teicoplanin | |
CN105001309B (zh) | 一种达巴万星的分离纯化方法 | |
RO121116B1 (ro) | Procedeu pentru obţinerea inhibitorilor reductazei hmg-coa | |
US5986089A (en) | Process for the preparation of moenomycin A | |
IE913432A1 (en) | Teicoplanin recovery process | |
KR100383435B1 (ko) | 고순도 아카보스 제조방법 | |
CN101062933A (zh) | 用反相色谱法分离和纯化三氯庶糖及其合成中间体化合物 | |
CN109988226A (zh) | 一种奥利万星的纯化方法 | |
CN109666051B (zh) | 一种春雷霉素的纯化方法 | |
CN106589075B (zh) | 一种替考拉宁的提纯方法 | |
WO2018236184A2 (ko) | D-사이코스 붕산염 착물로부터 크로마토그래피를 이용한 d-사이코스의 생산 방법 및 d-사이코스를 포함하는 조성물 | |
JP2751934B2 (ja) | ビタミンb▲下1▼▲下2▼およびその誘導体の分離回収方法 | |
CN106632551A (zh) | 一种快速色谱制备非达霉素的方法 | |
KR100910165B1 (ko) | 은 이온 용액 추출을 이용한 불포화 알킬기를 가진 락톤 화합물 정제방법 | |
JP2971128B2 (ja) | マイトマイシンcの精製法 | |
CN117512037A (zh) | 一种替考拉宁的纯化方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1050528 Country of ref document: HK |
|
C56 | Change in the name or address of the patentee |
Owner name: ASTELLAS PHARMA INC. Free format text: FORMER NAME OR ADDRESS: FUJISAWA PHARMACEUTICAL CO., LTD. |
|
CP03 | Change of name, title or address |
Address after: Tokyo, Japan Patentee after: Yamanouchi Pharma Co., Ltd. Address before: Osaka City, Osaka of Japan Patentee before: Fujisawa Pharmaceutical Co., Ltd. |
|
CX01 | Expiry of patent term |
Granted publication date: 20040623 |
|
CX01 | Expiry of patent term |