CN1339025A - 吲哚衍生物及其作为mcp－1拮抗剂的用途 - Google Patents

吲哚衍生物及其作为mcp－1拮抗剂的用途 Download PDF

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Publication number
CN1339025A
CN1339025A CN00803463A CN00803463A CN1339025A CN 1339025 A CN1339025 A CN 1339025A CN 00803463 A CN00803463 A CN 00803463A CN 00803463 A CN00803463 A CN 00803463A CN 1339025 A CN1339025 A CN 1339025A
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CN
China
Prior art keywords
compound
chloro
phenyl
formula
ethyl
Prior art date
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Pending
Application number
CN00803463A
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English (en)
Chinese (zh)
Inventor
A·W·福尔
J·G·凯特勒
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AstraZeneca AB
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AstraZeneca AB
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Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of CN1339025A publication Critical patent/CN1339025A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN00803463A 1999-02-05 2000-01-31 吲哚衍生物及其作为mcp－1拮抗剂的用途 Pending CN1339025A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9902461.4 1999-02-05
GBGB9902461.4A GB9902461D0 (en) 1999-02-05 1999-02-05 Chemical compounds

Publications (1)

Publication Number Publication Date
CN1339025A true CN1339025A (zh) 2002-03-06

Family

ID=10847084

Family Applications (1)

Application Number Title Priority Date Filing Date
CN00803463A Pending CN1339025A (zh) 1999-02-05 2000-01-31 吲哚衍生物及其作为mcp－1拮抗剂的用途

Country Status (27)

Country Link
US (1) US6737435B1 (https=)
EP (1) EP1150952B1 (https=)
JP (1) JP2002536359A (https=)
KR (1) KR20010094755A (https=)
CN (1) CN1339025A (https=)
AR (1) AR022461A1 (https=)
AT (1) ATE280757T1 (https=)
AU (1) AU770856B2 (https=)
BR (1) BR0007984A (https=)
CA (1) CA2356898A1 (https=)
CZ (1) CZ20012807A3 (https=)
DE (1) DE60015296T2 (https=)
EE (1) EE200100403A (https=)
GB (1) GB9902461D0 (https=)
HU (1) HUP0105079A3 (https=)
ID (1) ID30401A (https=)
IL (1) IL144611A0 (https=)
IS (1) IS5980A (https=)
MY (1) MY133209A (https=)
NO (1) NO20013809L (https=)
NZ (1) NZ512680A (https=)
PL (1) PL350184A1 (https=)
RU (1) RU2235090C2 (https=)
SK (1) SK11152001A3 (https=)
TR (1) TR200102233T2 (https=)
WO (1) WO2000046196A1 (https=)
ZA (1) ZA200105311B (https=)

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Also Published As

Publication number Publication date
CZ20012807A3 (cs) 2001-10-17
DE60015296T2 (de) 2006-02-02
MY133209A (en) 2007-10-31
BR0007984A (pt) 2001-11-06
GB9902461D0 (en) 1999-03-24
CA2356898A1 (en) 2000-08-10
HUP0105079A2 (hu) 2002-04-29
DE60015296D1 (de) 2004-12-02
NZ512680A (en) 2003-11-28
RU2235090C2 (ru) 2004-08-27
NO20013809L (no) 2001-10-02
SK11152001A3 (sk) 2001-12-03
EE200100403A (et) 2002-10-15
US6737435B1 (en) 2004-05-18
AU770856B2 (en) 2004-03-04
NO20013809D0 (no) 2001-08-03
IS5980A (is) 2001-06-26
RU2001124567A (ru) 2004-01-10
PL350184A1 (en) 2002-11-18
KR20010094755A (ko) 2001-11-01
AR022461A1 (es) 2002-09-04
EP1150952A1 (en) 2001-11-07
JP2002536359A (ja) 2002-10-29
TR200102233T2 (tr) 2001-12-21
WO2000046196A1 (en) 2000-08-10
EP1150952B1 (en) 2004-10-27
ID30401A (id) 2001-11-29
AU2121300A (en) 2000-08-25
ATE280757T1 (de) 2004-11-15
IL144611A0 (en) 2002-05-23
HUP0105079A3 (en) 2002-11-28
ZA200105311B (en) 2002-09-27

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