RU2001124567A - Производные индола и их применение в качестве антагонистов мср-1 - Google Patents
Производные индола и их применение в качестве антагонистов мср-1Info
- Publication number
- RU2001124567A RU2001124567A RU2001124567/04A RU2001124567A RU2001124567A RU 2001124567 A RU2001124567 A RU 2001124567A RU 2001124567/04 A RU2001124567/04 A RU 2001124567/04A RU 2001124567 A RU2001124567 A RU 2001124567A RU 2001124567 A RU2001124567 A RU 2001124567A
- Authority
- RU
- Russia
- Prior art keywords
- compound according
- chlorophenyl
- compound
- formula
- ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Claims (10)
1. Соединение формулы (I)
в которой R1 представляет водород, галоген или метокси;
R2 представляет водород, галоген, метил, этил или метокси;
R3 представляет карбокси, тетразолил или -CONHSO2R4,
где R4 представляет метил, этил, фенил, 2,5-диметилизоксазолил или трифторметил;
Т представляет -СН2- или -SO2;
кольцо А представляет 3-хлорфенил, 4-хлорфенил, 3-трифторметилфенил, 3,4-дихлорфенил, 3,4-дифторфенил, 3-фтор-4-хлорфенил, 3-хлор-4-фторфенил или 2,3-дихлорпирид-5-ил;
или его фармацевтически приемлемая соль или пролекарство.
2. Соединение по п.1, в котором кольцо А представляет 3-хлорфенил, 4-хлорфенил, 3-трифторметилфенил, 3,4-дихлорфенил, 3,4-дифторфенил, 3-фтор-4-хлорфенил или 3-хлор-4-фторфенил.
3. Соединение по п.2, в котором кольцо А представляет 3,4-дихлорфенил, 3-фтор-4-хлорфенил или 3-хлор-4-фторфенил.
4. Соединение по п.1, в котором кольцо А представляет 3,4-дихлорфенил, 2,3-дихлорпирид-5-ил или 3-хлор-4-фторфенил.
5. Соединение по любому из предшествующих пунктов, в котором Т представляет -СН2-.
6. Соединение по любому из предшествующих пунктов, в котором R3 представляет карбоксигруппу.
7. Соединение по п.1, в котором в соединении формулы (I),
R1 представляет водород;
R2 представляет водород;
R3 представляет карбоксигруппу;
Т представляет -СН2-;
кольцо А представляет 3,4-дихлорфенил или 3-хлор-4-фторфенил;
или его фармацевтически приемлемая соль или пролекарство.
8. Способ получения соединения по п.1, причем включает:
а) реакцию соединений формулы (II)
в которой Ra представляет R3, определенную в п.1, или защищенную форму группы R3, Rb представляет водород или подходящую гидроксизащитную группу, а R1 и R2 представляют группы, определенные в п.1, с соединением формулы (III)
в которой Т и кольцо А имеют значения, определенные в п.1, a L представляет удаляемую группу;
и после этого при необходимости:
i) превращение соединения формулы (I) в другое соединение формулы (I),
ii) удаление любой защитной группы, или
iii) образование его фармацевтически приемлемой соли или пролекарства.
9. Фармацевтическая композиция, включающая соединение по любому из пп.1-7 в сочетании с фармацевтически приемлемым носителем.
10. Соединение по любому из пп.1-7 для применения при получении лекарственного средства для лечения заболевания, опосредованного моноцитарным хемоаттрактантным белком-1 или RANTES (регулируемый при активации, экспрессируемый и секретируемый нормальными Т-клетками), такого как воспалительное заболевание.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9902461.4 | 1999-02-05 | ||
| GBGB9902461.4A GB9902461D0 (en) | 1999-02-05 | 1999-02-05 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2001124567A true RU2001124567A (ru) | 2004-01-10 |
| RU2235090C2 RU2235090C2 (ru) | 2004-08-27 |
Family
ID=10847084
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001124567/04A RU2235090C2 (ru) | 1999-02-05 | 2000-01-31 | Производные индола и их применение в качестве антагонистов мср-1 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US6737435B1 (ru) |
| EP (1) | EP1150952B1 (ru) |
| JP (1) | JP2002536359A (ru) |
| KR (1) | KR20010094755A (ru) |
| CN (1) | CN1339025A (ru) |
| AR (1) | AR022461A1 (ru) |
| AT (1) | ATE280757T1 (ru) |
| AU (1) | AU770856B2 (ru) |
| BR (1) | BR0007984A (ru) |
| CA (1) | CA2356898A1 (ru) |
| CZ (1) | CZ20012807A3 (ru) |
| DE (1) | DE60015296T2 (ru) |
| EE (1) | EE200100403A (ru) |
| GB (1) | GB9902461D0 (ru) |
| HU (1) | HUP0105079A3 (ru) |
| ID (1) | ID30401A (ru) |
| IL (1) | IL144611A0 (ru) |
| IS (1) | IS5980A (ru) |
| MY (1) | MY133209A (ru) |
| NO (1) | NO20013809L (ru) |
| NZ (1) | NZ512680A (ru) |
| PL (1) | PL350184A1 (ru) |
| RU (1) | RU2235090C2 (ru) |
| SK (1) | SK11152001A3 (ru) |
| TR (1) | TR200102233T2 (ru) |
| WO (1) | WO2000046196A1 (ru) |
| ZA (1) | ZA200105311B (ru) |
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| GB9803226D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
| GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902455D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
| GB0000625D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
| GB0000626D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
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1999
- 1999-02-05 GB GBGB9902461.4A patent/GB9902461D0/en not_active Ceased
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2000
- 2000-01-31 PL PL00350184A patent/PL350184A1/xx not_active Application Discontinuation
- 2000-01-31 CN CN00803463A patent/CN1339025A/zh active Pending
- 2000-01-31 SK SK1115-2001A patent/SK11152001A3/sk unknown
- 2000-01-31 BR BR0007984-7A patent/BR0007984A/pt not_active IP Right Cessation
- 2000-01-31 DE DE60015296T patent/DE60015296T2/de not_active Expired - Lifetime
- 2000-01-31 HU HU0105079A patent/HUP0105079A3/hu unknown
- 2000-01-31 US US09/889,599 patent/US6737435B1/en not_active Expired - Fee Related
- 2000-01-31 TR TR2001/02233T patent/TR200102233T2/xx unknown
- 2000-01-31 JP JP2000597267A patent/JP2002536359A/ja active Pending
- 2000-01-31 AU AU21213/00A patent/AU770856B2/en not_active Ceased
- 2000-01-31 ID IDW00200101667A patent/ID30401A/id unknown
- 2000-01-31 AT AT00901259T patent/ATE280757T1/de not_active IP Right Cessation
- 2000-01-31 KR KR1020017009862A patent/KR20010094755A/ko not_active Application Discontinuation
- 2000-01-31 RU RU2001124567/04A patent/RU2235090C2/ru not_active IP Right Cessation
- 2000-01-31 NZ NZ512680A patent/NZ512680A/en unknown
- 2000-01-31 CZ CZ20012807A patent/CZ20012807A3/cs unknown
- 2000-01-31 WO PCT/GB2000/000265 patent/WO2000046196A1/en not_active Application Discontinuation
- 2000-01-31 EP EP20000901259 patent/EP1150952B1/en not_active Expired - Lifetime
- 2000-01-31 CA CA002356898A patent/CA2356898A1/en not_active Abandoned
- 2000-01-31 AR ARP000100407A patent/AR022461A1/es not_active Application Discontinuation
- 2000-01-31 IL IL14461100A patent/IL144611A0/xx unknown
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2001
- 2001-06-26 IS IS5980A patent/IS5980A/is unknown
- 2001-06-27 ZA ZA200105311A patent/ZA200105311B/en unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2000046196A1 (en) | 2000-08-10 |
| ID30401A (id) | 2001-11-29 |
| DE60015296T2 (de) | 2006-02-02 |
| ZA200105311B (en) | 2002-09-27 |
| HUP0105079A3 (en) | 2002-11-28 |
| NO20013809L (no) | 2001-10-02 |
| SK11152001A3 (sk) | 2001-12-03 |
| NO20013809D0 (no) | 2001-08-03 |
| US6737435B1 (en) | 2004-05-18 |
| BR0007984A (pt) | 2001-11-06 |
| PL350184A1 (en) | 2002-11-18 |
| CZ20012807A3 (cs) | 2001-10-17 |
| CA2356898A1 (en) | 2000-08-10 |
| AU2121300A (en) | 2000-08-25 |
| EP1150952A1 (en) | 2001-11-07 |
| EP1150952B1 (en) | 2004-10-27 |
| KR20010094755A (ko) | 2001-11-01 |
| DE60015296D1 (de) | 2004-12-02 |
| IS5980A (is) | 2001-06-26 |
| EE200100403A (et) | 2002-10-15 |
| AU770856B2 (en) | 2004-03-04 |
| NZ512680A (en) | 2003-11-28 |
| IL144611A0 (en) | 2002-05-23 |
| JP2002536359A (ja) | 2002-10-29 |
| RU2235090C2 (ru) | 2004-08-27 |
| TR200102233T2 (tr) | 2001-12-21 |
| ATE280757T1 (de) | 2004-11-15 |
| CN1339025A (zh) | 2002-03-06 |
| HUP0105079A2 (hu) | 2002-04-29 |
| GB9902461D0 (en) | 1999-03-24 |
| MY133209A (en) | 2007-10-31 |
| AR022461A1 (es) | 2002-09-04 |
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