ATE280757T1 - Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten - Google Patents
Indolderivate und ihre verwendung als mcp-1 rezeptor antagonistenInfo
- Publication number
- ATE280757T1 ATE280757T1 AT00901259T AT00901259T ATE280757T1 AT E280757 T1 ATE280757 T1 AT E280757T1 AT 00901259 T AT00901259 T AT 00901259T AT 00901259 T AT00901259 T AT 00901259T AT E280757 T1 ATE280757 T1 AT E280757T1
- Authority
- AT
- Austria
- Prior art keywords
- mcp
- receptor antagonists
- indole derivatives
- indole
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9902461.4A GB9902461D0 (en) | 1999-02-05 | 1999-02-05 | Chemical compounds |
PCT/GB2000/000265 WO2000046196A1 (en) | 1999-02-05 | 2000-01-31 | Indole derivatives and their use as mcp-1 antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE280757T1 true ATE280757T1 (de) | 2004-11-15 |
Family
ID=10847084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00901259T ATE280757T1 (de) | 1999-02-05 | 2000-01-31 | Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten |
Country Status (27)
Country | Link |
---|---|
US (1) | US6737435B1 (de) |
EP (1) | EP1150952B1 (de) |
JP (1) | JP2002536359A (de) |
KR (1) | KR20010094755A (de) |
CN (1) | CN1339025A (de) |
AR (1) | AR022461A1 (de) |
AT (1) | ATE280757T1 (de) |
AU (1) | AU770856B2 (de) |
BR (1) | BR0007984A (de) |
CA (1) | CA2356898A1 (de) |
CZ (1) | CZ20012807A3 (de) |
DE (1) | DE60015296T2 (de) |
EE (1) | EE200100403A (de) |
GB (1) | GB9902461D0 (de) |
HU (1) | HUP0105079A3 (de) |
ID (1) | ID30401A (de) |
IL (1) | IL144611A0 (de) |
IS (1) | IS5980A (de) |
MY (1) | MY133209A (de) |
NO (1) | NO20013809L (de) |
NZ (1) | NZ512680A (de) |
PL (1) | PL350184A1 (de) |
RU (1) | RU2235090C2 (de) |
SK (1) | SK11152001A3 (de) |
TR (1) | TR200102233T2 (de) |
WO (1) | WO2000046196A1 (de) |
ZA (1) | ZA200105311B (de) |
Families Citing this family (55)
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---|---|---|---|---|
GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB0000625D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
GB0000626D0 (en) * | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
CN1505613A (zh) | 2000-10-10 | 2004-06-16 | ʷ��˿�������ȳ�ķ����˾ | 取代的吲哚、含这类吲哚的药物组合物及它们作为PPAR-γ结合剂的用途 |
WO2002050019A2 (en) | 2000-12-20 | 2002-06-27 | Bristol-Myers Squibb Pharma Co. | Diamines as modulators of chemokine receptor activity |
HUP0303652A2 (hu) | 2000-12-20 | 2004-03-01 | Bristol-Myers Squibb Company | Ciklikus származékok, mint kemokin receptor aktivitás modulátorai és ezeket tartalmazó gyógyszerkészítmények |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
DE60328690D1 (de) | 2002-06-12 | 2009-09-17 | Chemocentryx Inc | 1-aryl-4-substituierte piperazin-derivate zur verwendung als ccr1-antagonisten zur behandlung von entzündungen und immunerkrankungen |
US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
TW200508224A (en) | 2003-02-12 | 2005-03-01 | Bristol Myers Squibb Co | Cyclic derivatives as modulators of chemokine receptor activity |
EP2385040A1 (de) | 2003-03-14 | 2011-11-09 | ONO Pharmaceutical Co., Ltd. | Stickstoffhaltige heterocyclische Derivate und Arzneimittel, die diese als Wirkstoff enthalten |
US7498323B2 (en) | 2003-04-18 | 2009-03-03 | Ono Pharmaceuticals Co., Ltd. | Spiro-piperidine compounds and medicinal use thereof |
US7230133B2 (en) | 2003-05-01 | 2007-06-12 | Bristol-Myers Squibb Company | Malonamides and malonamide derivatives as modulators of chemokine receptor activity |
US7291615B2 (en) | 2003-05-01 | 2007-11-06 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
US7732162B2 (en) | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
US7479496B2 (en) | 2004-02-19 | 2009-01-20 | Bristol-Myers Squibb Company | Substituted spiro azabicyclics as modulators of chemokine receptor activity |
US7381738B2 (en) | 2004-02-19 | 2008-06-03 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7288563B2 (en) | 2004-02-19 | 2007-10-30 | Bristol-Myers Squibb Company | Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity |
US7230022B2 (en) | 2004-02-19 | 2007-06-12 | Bristol-Myers Squibb Company | Substituted fused bicyclic amines as modulators of chemokine receptor activity |
US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
WO2005084667A1 (en) | 2004-03-03 | 2005-09-15 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
US8481035B2 (en) | 2004-04-27 | 2013-07-09 | Northwestern University | Methods for treating chronic pelvic pain syndrome with antibodies that binds MCP-1 or MIP-1A |
EP1802331A2 (de) * | 2004-09-08 | 2007-07-04 | Boys Town National Research Hospital | Behandlung von erkrankungen der glomerulären basalmembran mit beteiligung von metalloproteinase-12 |
KR101231466B1 (ko) | 2004-09-13 | 2013-02-07 | 오노 야꾸힝 고교 가부시키가이샤 | 질소 함유 복소환 유도체 및 이들을 유효 성분으로 하는약제 |
EP1889622A4 (de) | 2005-05-31 | 2009-12-23 | Ono Pharmaceutical Co | Spiropiperidinverbindung und deren medizinische verwendung |
FR2890071B1 (fr) | 2005-08-30 | 2007-11-09 | Fournier Sa Sa Lab | Nouveaux composes de l'indole |
DK1942108T3 (da) | 2005-10-28 | 2013-12-09 | Ono Pharmaceutical Co | Forbindelse indeholdende basisk gruppe samt anvendelse deraf |
EP1961744B1 (de) | 2005-11-18 | 2013-04-17 | Ono Pharmaceutical Co., Ltd. | Verbindung mit basischen gruppen und deren verwendung |
US7579351B2 (en) | 2005-12-09 | 2009-08-25 | Hoffmann-La Roche Inc. | Tricyclic amide derivatives |
CA2644809A1 (en) * | 2006-03-02 | 2007-09-07 | Astellas Pharma Inc. | 17 .beta. hsd type 5 inhibitor |
CN101443322A (zh) | 2006-03-10 | 2009-05-27 | 小野药品工业株式会社 | 含氮杂环衍生物及含有该衍生物作为活性成分的药物 |
WO2007132846A1 (ja) | 2006-05-16 | 2007-11-22 | Ono Pharmaceutical Co., Ltd. | 保護されていてもよい酸性基を含有する化合物およびその用途 |
DE102006033572A1 (de) | 2006-07-20 | 2008-01-24 | Bayer Cropscience Ag | N'-Cyano-N-halogenalkyl-imidamid Derivate |
JP5245827B2 (ja) | 2006-07-31 | 2013-07-24 | 小野薬品工業株式会社 | スピロ結合した環状基を含有する化合物およびその用途 |
US20080076120A1 (en) * | 2006-09-14 | 2008-03-27 | Millennium Pharmaceuticals, Inc. | Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders |
WO2008055945A1 (en) | 2006-11-09 | 2008-05-15 | Probiodrug Ag | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
SI2091948T1 (sl) | 2006-11-30 | 2012-07-31 | Probiodrug Ag | Novi inhibitorji glutaminil ciklaze |
ZA200905537B (en) | 2007-03-01 | 2010-10-27 | Probiodrug Ag | New use of glutaminyl cyclase inhibitors |
EP2142514B1 (de) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thioharnstoffderivate als glutaminylcyclaseinhibitoren |
MX2010007833A (es) * | 2008-01-18 | 2010-08-11 | Oxagen Ltd | Compuestos que tienen actividad antagonista de crth2. |
AU2009304293B2 (en) * | 2008-10-16 | 2012-04-26 | Addex Pharma S.A. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
ES2548913T3 (es) | 2009-09-11 | 2015-10-21 | Probiodrug Ag | Derivados heterocíclicos como inhibidores de glutaminil ciclasa |
FR2950053B1 (fr) | 2009-09-11 | 2014-08-01 | Fournier Lab Sa | Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson |
JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
JP5688745B2 (ja) | 2010-03-10 | 2015-03-25 | プロビオドルグ エージー | グルタミニルシクラーゼ(qc、ec2.3.2.5)の複素環阻害剤 |
WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
KR101350077B1 (ko) * | 2010-12-13 | 2014-01-14 | 한국화학연구원 | 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물 |
WO2012123563A1 (en) | 2011-03-16 | 2012-09-20 | Probiodrug Ag | Benz imidazole derivatives as inhibitors of glutaminyl cyclase |
AU2017370942A1 (en) | 2016-12-07 | 2019-06-13 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
EP3554541B1 (de) | 2016-12-14 | 2023-06-07 | Biora Therapeutics, Inc. | Behandlung einer erkrankung des gastrointestinaltraktes mit einem chemokin/chemokin-rezeptor-inhibitor |
EP3461819B1 (de) | 2017-09-29 | 2020-05-27 | Probiodrug AG | Hemmer der glutaminylcyclase |
KR20210095165A (ko) | 2018-11-19 | 2021-07-30 | 프로제너티, 인크. | 바이오의약품으로 질환을 치료하기 위한 방법 및 디바이스 |
EP4309722A2 (de) | 2019-12-13 | 2024-01-24 | Biora Therapeutics, Inc. | Einnehmbare vorrichtung zur abgabe eines therapeutischen mittels an den magen-darm-trakt |
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GB9716657D0 (en) | 1997-08-07 | 1997-10-15 | Zeneca Ltd | Chemical compounds |
PL195682B1 (pl) * | 1997-12-24 | 2007-10-31 | Sanofi Aventis Deutschland | Pochodne indolu, sposób ich wytwarzania, środek farmaceutyczny oraz zastosowanie pochodnych indolu |
GB9803226D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
GB9803228D0 (en) | 1998-02-17 | 1998-04-08 | Zeneca Ltd | Chemical compounds |
GB9902453D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902455D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902459D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902452D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB9902461D0 (en) | 1999-02-05 | 1999-03-24 | Zeneca Ltd | Chemical compounds |
GB0000626D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
GB0000625D0 (en) | 2000-01-13 | 2000-03-01 | Zeneca Ltd | Chemical compounds |
-
1999
- 1999-02-05 GB GBGB9902461.4A patent/GB9902461D0/en not_active Ceased
-
2000
- 2000-01-31 DE DE60015296T patent/DE60015296T2/de not_active Expired - Lifetime
- 2000-01-31 CA CA002356898A patent/CA2356898A1/en not_active Abandoned
- 2000-01-31 TR TR2001/02233T patent/TR200102233T2/xx unknown
- 2000-01-31 EE EEP200100403A patent/EE200100403A/xx unknown
- 2000-01-31 ID IDW00200101667A patent/ID30401A/id unknown
- 2000-01-31 PL PL00350184A patent/PL350184A1/xx not_active Application Discontinuation
- 2000-01-31 AT AT00901259T patent/ATE280757T1/de not_active IP Right Cessation
- 2000-01-31 AU AU21213/00A patent/AU770856B2/en not_active Ceased
- 2000-01-31 HU HU0105079A patent/HUP0105079A3/hu unknown
- 2000-01-31 KR KR1020017009862A patent/KR20010094755A/ko not_active Application Discontinuation
- 2000-01-31 IL IL14461100A patent/IL144611A0/xx unknown
- 2000-01-31 SK SK1115-2001A patent/SK11152001A3/sk unknown
- 2000-01-31 US US09/889,599 patent/US6737435B1/en not_active Expired - Fee Related
- 2000-01-31 NZ NZ512680A patent/NZ512680A/en unknown
- 2000-01-31 CN CN00803463A patent/CN1339025A/zh active Pending
- 2000-01-31 CZ CZ20012807A patent/CZ20012807A3/cs unknown
- 2000-01-31 AR ARP000100407A patent/AR022461A1/es not_active Application Discontinuation
- 2000-01-31 EP EP20000901259 patent/EP1150952B1/de not_active Expired - Lifetime
- 2000-01-31 BR BR0007984-7A patent/BR0007984A/pt not_active IP Right Cessation
- 2000-01-31 RU RU2001124567/04A patent/RU2235090C2/ru not_active IP Right Cessation
- 2000-01-31 WO PCT/GB2000/000265 patent/WO2000046196A1/en not_active Application Discontinuation
- 2000-01-31 JP JP2000597267A patent/JP2002536359A/ja active Pending
- 2000-02-04 MY MYPI20000404A patent/MY133209A/en unknown
-
2001
- 2001-06-26 IS IS5980A patent/IS5980A/is unknown
- 2001-06-27 ZA ZA200105311A patent/ZA200105311B/en unknown
- 2001-08-03 NO NO20013809A patent/NO20013809L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1150952A1 (de) | 2001-11-07 |
EE200100403A (et) | 2002-10-15 |
US6737435B1 (en) | 2004-05-18 |
KR20010094755A (ko) | 2001-11-01 |
WO2000046196A1 (en) | 2000-08-10 |
CZ20012807A3 (cs) | 2001-10-17 |
RU2235090C2 (ru) | 2004-08-27 |
GB9902461D0 (en) | 1999-03-24 |
DE60015296T2 (de) | 2006-02-02 |
HUP0105079A3 (en) | 2002-11-28 |
NO20013809D0 (no) | 2001-08-03 |
BR0007984A (pt) | 2001-11-06 |
RU2001124567A (ru) | 2004-01-10 |
DE60015296D1 (de) | 2004-12-02 |
EP1150952B1 (de) | 2004-10-27 |
HUP0105079A2 (hu) | 2002-04-29 |
ZA200105311B (en) | 2002-09-27 |
TR200102233T2 (tr) | 2001-12-21 |
ID30401A (id) | 2001-11-29 |
MY133209A (en) | 2007-10-31 |
IS5980A (is) | 2001-06-26 |
CN1339025A (zh) | 2002-03-06 |
NO20013809L (no) | 2001-10-02 |
AU2121300A (en) | 2000-08-25 |
JP2002536359A (ja) | 2002-10-29 |
NZ512680A (en) | 2003-11-28 |
AU770856B2 (en) | 2004-03-04 |
IL144611A0 (en) | 2002-05-23 |
CA2356898A1 (en) | 2000-08-10 |
SK11152001A3 (sk) | 2001-12-03 |
AR022461A1 (es) | 2002-09-04 |
PL350184A1 (en) | 2002-11-18 |
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