ATE280757T1 - Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten - Google Patents

Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten

Info

Publication number
ATE280757T1
ATE280757T1 AT00901259T AT00901259T ATE280757T1 AT E280757 T1 ATE280757 T1 AT E280757T1 AT 00901259 T AT00901259 T AT 00901259T AT 00901259 T AT00901259 T AT 00901259T AT E280757 T1 ATE280757 T1 AT E280757T1
Authority
AT
Austria
Prior art keywords
mcp
receptor antagonists
indole derivatives
indole
derivatives
Prior art date
Application number
AT00901259T
Other languages
English (en)
Inventor
Alan Wellington Faull
Jason Grant Kettle
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE280757T1 publication Critical patent/ATE280757T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT00901259T 1999-02-05 2000-01-31 Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten ATE280757T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9902461.4A GB9902461D0 (en) 1999-02-05 1999-02-05 Chemical compounds
PCT/GB2000/000265 WO2000046196A1 (en) 1999-02-05 2000-01-31 Indole derivatives and their use as mcp-1 antagonists

Publications (1)

Publication Number Publication Date
ATE280757T1 true ATE280757T1 (de) 2004-11-15

Family

ID=10847084

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00901259T ATE280757T1 (de) 1999-02-05 2000-01-31 Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten

Country Status (27)

Country Link
US (1) US6737435B1 (de)
EP (1) EP1150952B1 (de)
JP (1) JP2002536359A (de)
KR (1) KR20010094755A (de)
CN (1) CN1339025A (de)
AR (1) AR022461A1 (de)
AT (1) ATE280757T1 (de)
AU (1) AU770856B2 (de)
BR (1) BR0007984A (de)
CA (1) CA2356898A1 (de)
CZ (1) CZ20012807A3 (de)
DE (1) DE60015296T2 (de)
EE (1) EE200100403A (de)
GB (1) GB9902461D0 (de)
HU (1) HUP0105079A3 (de)
ID (1) ID30401A (de)
IL (1) IL144611A0 (de)
IS (1) IS5980A (de)
MY (1) MY133209A (de)
NO (1) NO20013809L (de)
NZ (1) NZ512680A (de)
PL (1) PL350184A1 (de)
RU (1) RU2235090C2 (de)
SK (1) SK11152001A3 (de)
TR (1) TR200102233T2 (de)
WO (1) WO2000046196A1 (de)
ZA (1) ZA200105311B (de)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB0000625D0 (en) * 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
GB0000626D0 (en) * 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
CN1505613A (zh) 2000-10-10 2004-06-16 ʷ��˿�������ȳ�ķ���޹�˾ 取代的吲哚、含这类吲哚的药物组合物及它们作为PPAR-γ结合剂的用途
WO2002050019A2 (en) 2000-12-20 2002-06-27 Bristol-Myers Squibb Pharma Co. Diamines as modulators of chemokine receptor activity
HUP0303652A2 (hu) 2000-12-20 2004-03-01 Bristol-Myers Squibb Company Ciklikus származékok, mint kemokin receptor aktivitás modulátorai és ezeket tartalmazó gyógyszerkészítmények
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
DE60328690D1 (de) 2002-06-12 2009-09-17 Chemocentryx Inc 1-aryl-4-substituierte piperazin-derivate zur verwendung als ccr1-antagonisten zur behandlung von entzündungen und immunerkrankungen
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
TW200508224A (en) 2003-02-12 2005-03-01 Bristol Myers Squibb Co Cyclic derivatives as modulators of chemokine receptor activity
EP2385040A1 (de) 2003-03-14 2011-11-09 ONO Pharmaceutical Co., Ltd. Stickstoffhaltige heterocyclische Derivate und Arzneimittel, die diese als Wirkstoff enthalten
US7498323B2 (en) 2003-04-18 2009-03-03 Ono Pharmaceuticals Co., Ltd. Spiro-piperidine compounds and medicinal use thereof
US7230133B2 (en) 2003-05-01 2007-06-12 Bristol-Myers Squibb Company Malonamides and malonamide derivatives as modulators of chemokine receptor activity
US7291615B2 (en) 2003-05-01 2007-11-06 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US7479496B2 (en) 2004-02-19 2009-01-20 Bristol-Myers Squibb Company Substituted spiro azabicyclics as modulators of chemokine receptor activity
US7381738B2 (en) 2004-02-19 2008-06-03 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7288563B2 (en) 2004-02-19 2007-10-30 Bristol-Myers Squibb Company Substituted bicycloalkylamine derivatives as modulators of chemokine receptor activity
US7230022B2 (en) 2004-02-19 2007-06-12 Bristol-Myers Squibb Company Substituted fused bicyclic amines as modulators of chemokine receptor activity
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
WO2005084667A1 (en) 2004-03-03 2005-09-15 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US8481035B2 (en) 2004-04-27 2013-07-09 Northwestern University Methods for treating chronic pelvic pain syndrome with antibodies that binds MCP-1 or MIP-1A
EP1802331A2 (de) * 2004-09-08 2007-07-04 Boys Town National Research Hospital Behandlung von erkrankungen der glomerulären basalmembran mit beteiligung von metalloproteinase-12
KR101231466B1 (ko) 2004-09-13 2013-02-07 오노 야꾸힝 고교 가부시키가이샤 질소 함유 복소환 유도체 및 이들을 유효 성분으로 하는약제
EP1889622A4 (de) 2005-05-31 2009-12-23 Ono Pharmaceutical Co Spiropiperidinverbindung und deren medizinische verwendung
FR2890071B1 (fr) 2005-08-30 2007-11-09 Fournier Sa Sa Lab Nouveaux composes de l'indole
DK1942108T3 (da) 2005-10-28 2013-12-09 Ono Pharmaceutical Co Forbindelse indeholdende basisk gruppe samt anvendelse deraf
EP1961744B1 (de) 2005-11-18 2013-04-17 Ono Pharmaceutical Co., Ltd. Verbindung mit basischen gruppen und deren verwendung
US7579351B2 (en) 2005-12-09 2009-08-25 Hoffmann-La Roche Inc. Tricyclic amide derivatives
CA2644809A1 (en) * 2006-03-02 2007-09-07 Astellas Pharma Inc. 17 .beta. hsd type 5 inhibitor
CN101443322A (zh) 2006-03-10 2009-05-27 小野药品工业株式会社 含氮杂环衍生物及含有该衍生物作为活性成分的药物
WO2007132846A1 (ja) 2006-05-16 2007-11-22 Ono Pharmaceutical Co., Ltd. 保護されていてもよい酸性基を含有する化合物およびその用途
DE102006033572A1 (de) 2006-07-20 2008-01-24 Bayer Cropscience Ag N'-Cyano-N-halogenalkyl-imidamid Derivate
JP5245827B2 (ja) 2006-07-31 2013-07-24 小野薬品工業株式会社 スピロ結合した環状基を含有する化合物およびその用途
US20080076120A1 (en) * 2006-09-14 2008-03-27 Millennium Pharmaceuticals, Inc. Methods for the identification, evaluation and treatment of patients having CC-Chemokine receptor 2 (CCR-2) mediated disorders
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
SI2091948T1 (sl) 2006-11-30 2012-07-31 Probiodrug Ag Novi inhibitorji glutaminil ciklaze
ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
EP2142514B1 (de) 2007-04-18 2014-12-24 Probiodrug AG Thioharnstoffderivate als glutaminylcyclaseinhibitoren
MX2010007833A (es) * 2008-01-18 2010-08-11 Oxagen Ltd Compuestos que tienen actividad antagonista de crth2.
AU2009304293B2 (en) * 2008-10-16 2012-04-26 Addex Pharma S.A. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
ES2548913T3 (es) 2009-09-11 2015-10-21 Probiodrug Ag Derivados heterocíclicos como inhibidores de glutaminil ciclasa
FR2950053B1 (fr) 2009-09-11 2014-08-01 Fournier Lab Sa Utilisation de derives d'indole benzoique comme activateurs de nurr-1, pour le traitement de la maladie de parkinson
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
KR101350077B1 (ko) * 2010-12-13 2014-01-14 한국화학연구원 신규한 3-인돌리논 유도체 및 이를 포함하는 조성물
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
AU2017370942A1 (en) 2016-12-07 2019-06-13 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
EP3554541B1 (de) 2016-12-14 2023-06-07 Biora Therapeutics, Inc. Behandlung einer erkrankung des gastrointestinaltraktes mit einem chemokin/chemokin-rezeptor-inhibitor
EP3461819B1 (de) 2017-09-29 2020-05-27 Probiodrug AG Hemmer der glutaminylcyclase
KR20210095165A (ko) 2018-11-19 2021-07-30 프로제너티, 인크. 바이오의약품으로 질환을 치료하기 위한 방법 및 디바이스
EP4309722A2 (de) 2019-12-13 2024-01-24 Biora Therapeutics, Inc. Einnehmbare vorrichtung zur abgabe eines therapeutischen mittels an den magen-darm-trakt

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3196162A (en) * 1961-03-13 1965-07-20 Merck & Co Inc Indolyl aliphatic acids
US3557142A (en) 1968-02-20 1971-01-19 Sterling Drug Inc 4,5,6,7-tetrahydro-indole-lower-alkanoic acids and esters
US3776923A (en) 1970-01-06 1973-12-04 American Cyanamid Co 2-nitro-4-oxo-4,5,6,7-tetrahydroindole
US3997557A (en) 1974-04-23 1976-12-14 American Hoechst Corporation Substituted N-aminoalkylpyrroles
US4496742A (en) 1981-10-13 1985-01-29 The Upjohn Company Analogs of 5,6-dihydro PGI2
FR2537974A1 (fr) 1982-12-16 1984-06-22 Adir Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant
US4529724A (en) 1983-10-11 1985-07-16 Mcneilab, Inc. 6H-indolo[2,1-c][1,4]benzodiazepines and 12-oxo derivatives useful as antihypertensives
FR2565981B1 (fr) 1984-06-15 1986-09-19 Adir Nouveaux derives de thieno (2,3-b) pyrrole, leur procede de preparation et les compositions pharmaceutiques les renfermant
CA1241660A (en) * 1984-06-25 1988-09-06 Yvan Guindon Indole-2-alkanoic acids
EP0190224A1 (de) 1984-07-30 1986-08-13 Schering Corporation VERFAHREN ZUR HERSTELLUNG VON CIS, ENDO-OCTAHYDROCYCLOPENTA[b]PYRROL-2-CARBOXYLATEN
US4675332A (en) 1984-12-10 1987-06-23 Warner-Lambert Company Acidic tetrazolyl substituted indole compounds and their use as antiallergy agents
DE3568431D1 (en) 1984-12-12 1989-04-06 Merck & Co Inc Substituted aromatic sulfonamides, their preparation and ophthalmic compositions containing them
US4721725A (en) 1986-01-27 1988-01-26 E. R. Squibb & Sons, Inc. Aryl-cycloalkyl[b]pyrrole derivatives
IL84796A (en) 1986-12-17 1992-03-29 Merck Frosst Canada Inc Substituted n-benzyl-indoles and pharmaceutical compositions containing them
US4751231A (en) 1987-09-16 1988-06-14 Merck & Co., Inc. Substituted thieno[2,3-b]pyrrole-5-sulfonamides as antiglaucoma agents
DE3907388A1 (de) 1989-03-08 1990-09-13 Kali Chemie Pharma Gmbh Verfahren zur herstellung von indolcarbonsaeurederivaten
US5272145A (en) 1989-08-22 1993-12-21 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
NZ234883A (en) 1989-08-22 1995-01-27 Merck Frosst Canada Inc Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof
DD298913A5 (de) 1989-11-17 1992-03-19 Arzneimittelwerk Dresden Gmbh,De Verfahren zur herstellung von n-substituierten 3-aminopyrrolen
DE3943225A1 (de) 1989-12-23 1991-06-27 Schering Ag Neue ss-carboline, verfahren zu deren herstellung und deren verwendung in arzneimitteln
US5081145A (en) * 1990-02-01 1992-01-14 Merck Frosst Canada, Inc. Indole-2-alkanoic acids compositions of and anti allergic use thereof
US5260322A (en) 1990-10-08 1993-11-09 Merck & Co., Inc. Angiotension II antagonists in the treatment of hyperuricemia
US5190968A (en) 1991-09-30 1993-03-02 Merck Frosst Canada, Inc. (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5389650A (en) 1991-09-30 1995-02-14 Merck Frosst Canada, Inc. (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5308850A (en) 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5290798A (en) 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5273980A (en) 1991-09-30 1993-12-28 Merck Frosst Canada Inc. Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis
CA2079374C (en) 1991-09-30 2003-08-05 Merck Frosst Canada Incorporated (bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5318985A (en) * 1991-12-20 1994-06-07 Merrell Dow Pharmaceuticals Inc. Potentiation of NMDA antagonists
AU3488693A (en) 1992-02-13 1993-09-03 Merck Frosst Canada Inc. (Azaaromaticalkoxy)indoles as inhibitors of leukotriene biosynthesis
CA2130937A1 (en) 1992-04-03 1993-10-14 Gordon L. Bundy Pharmaceutically active bicyclic-heterocyclic amines
US5334719A (en) 1992-06-17 1994-08-02 Merck Frosst Canada, Inc. Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis
US5288743A (en) 1992-11-20 1994-02-22 Abbott Laboratories Indole carboxylate derivatives which inhibit leukotriene biosynthesis
ZA939516B (en) 1992-12-22 1994-06-06 Smithkline Beecham Corp Endothelin receptor antagonists
US5852046A (en) 1993-08-03 1998-12-22 Hoechst Aktiengesellschaft Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
EP0639573A1 (de) 1993-08-03 1995-02-22 Hoechst Aktiengesellschaft Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament
US5399699A (en) 1994-01-24 1995-03-21 Abbott Laboratories Indole iminooxy derivatives which inhibit leukotriene biosynthesis
CN1166169A (zh) 1994-07-27 1997-11-26 三共株式会社 用作毒蕈碱性受体别构效应物的杂环化合物
US5482960A (en) 1994-11-14 1996-01-09 Warner-Lambert Company Nonpeptide endothelin antagonists
JPH10510538A (ja) * 1994-12-13 1998-10-13 スミスクライン・ビーチャム・コーポレイション 新規化合物
US5684032A (en) 1994-12-13 1997-11-04 Smithkline Beecham Corporation Compounds
CZ299246B6 (cs) 1995-04-04 2008-05-28 Encysive Pharmaceuticals Inc. Sulfonamid, farmaceutická kompozice s jeho obsahem a jeho použití pro výrobu léciva
IT1282797B1 (it) 1995-04-21 1998-03-31 Colla Paolo Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids
US5604253A (en) * 1995-05-22 1997-02-18 Merck Frosst Canada, Inc. N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors
US5639780A (en) * 1995-05-22 1997-06-17 Merck Frosst Canada, Inc. N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors
AU6966696A (en) 1995-10-05 1997-04-28 Warner-Lambert Company Method for treating and preventing inflammation and atherosclerosis
EP0954305B9 (de) 1996-02-26 2010-08-04 Advanced Research & Technology Institute Verwendung von carbonanhydrase-hemmern zur behandlung von makulär-ödemen
US5955492A (en) 1996-03-28 1999-09-21 Smithkline Beecham Corporation Carboxylic acid indole inhibitors of chemokines
US5859044A (en) 1996-07-31 1999-01-12 Pfizer Inc. β-adrenergic agonists
WO1998006703A1 (en) 1996-08-14 1998-02-19 Warner-Lambert Company 2-phenyl benzimidazole derivatives as mcp-1 antagonists
GB9716656D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
PL195682B1 (pl) * 1997-12-24 2007-10-31 Sanofi Aventis Deutschland Pochodne indolu, sposób ich wytwarzania, środek farmaceutyczny oraz zastosowanie pochodnych indolu
GB9803226D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9803228D0 (en) 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
GB9902453D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902455D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902459D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902452D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB0000626D0 (en) 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
GB0000625D0 (en) 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds

Also Published As

Publication number Publication date
EP1150952A1 (de) 2001-11-07
EE200100403A (et) 2002-10-15
US6737435B1 (en) 2004-05-18
KR20010094755A (ko) 2001-11-01
WO2000046196A1 (en) 2000-08-10
CZ20012807A3 (cs) 2001-10-17
RU2235090C2 (ru) 2004-08-27
GB9902461D0 (en) 1999-03-24
DE60015296T2 (de) 2006-02-02
HUP0105079A3 (en) 2002-11-28
NO20013809D0 (no) 2001-08-03
BR0007984A (pt) 2001-11-06
RU2001124567A (ru) 2004-01-10
DE60015296D1 (de) 2004-12-02
EP1150952B1 (de) 2004-10-27
HUP0105079A2 (hu) 2002-04-29
ZA200105311B (en) 2002-09-27
TR200102233T2 (tr) 2001-12-21
ID30401A (id) 2001-11-29
MY133209A (en) 2007-10-31
IS5980A (is) 2001-06-26
CN1339025A (zh) 2002-03-06
NO20013809L (no) 2001-10-02
AU2121300A (en) 2000-08-25
JP2002536359A (ja) 2002-10-29
NZ512680A (en) 2003-11-28
AU770856B2 (en) 2004-03-04
IL144611A0 (en) 2002-05-23
CA2356898A1 (en) 2000-08-10
SK11152001A3 (sk) 2001-12-03
AR022461A1 (es) 2002-09-04
PL350184A1 (en) 2002-11-18

Similar Documents

Publication Publication Date Title
ATE280757T1 (de) Indolderivate und ihre verwendung als mcp-1 rezeptor antagonisten
ATE261945T1 (de) Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
ATE250039T1 (de) Benzodiazepinderivate und deren verwendung als metabotrope glutamatrezeptor antagonisten
DE69925730D1 (de) 4-benzyl-piperidin-alkylsulfoxid-heterozyklen und ihre verwendung als subtyp-selektive nmda rezeptor antagonisten
ATE403647T1 (de) Indolinderivate und deren verwendung als 5-ht2 rezeptor liganden
DE60106607D1 (de) Substituierte 1-aminoalkyl-lactame und ihre verwendung als muscarinrezeptor antagonisten
DE60045564D1 (de) 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten
DE60036803D1 (de) Arylmethyl-carbonylamino-thiazolderivate und ihre verwendung als antitumormittel
ATE280158T1 (de) 3-phenylpyridinderivative und deren verwendung als nk-1 rezeptorantagonisten
ATE369368T1 (de) Indolderivate und deren verwendung als 5-ht2b- und 5-ht2c-rezeptorliganden
ATE301638T1 (de) 3-arylindolderivate und deren verwendung als cb2- rezeptoragonisten
DE60112322D1 (de) Aminothiazole und deren verwendung als adenosinrezeptorantagonisten
DE60001840D1 (de) Chinuclidin-derivate und deren verwendung als muscarin-m3-rezeptoren-liganden
ATE263151T1 (de) Indolderivate verwendbar als endothelinrezeptorantagonisten
ATE299865T1 (de) Piperazinderivate verwendbar als ccr5 antagonisten
DE50015651D1 (de) Cycloalkylsubstituierte benzimidazole und ihre verwendung als parp inhibitoren
ATE282593T1 (de) Indolin-2-on derivate und deren verwendung als liganden der ocytocin rezeptoren
DE60114413D1 (de) Substituierte 1-aminoalkyl-lactame und deren verwendung als muscarinrezeptor-antagonisten
ATE357443T1 (de) Dihydrobenzodioxincarbonsäureamid- und ketonderivate als 5-ht4-rezeptorantagonisten
DE602004022458D1 (de) Pyrazolderivate und ihre verwendung als orexin-rezeptor-antagonisten
DE69816290D1 (de) Chinolin-4-carboxamidderivate als nk-2 und nk-3 rezeptor antagonisten
ATE254621T1 (de) Thienoisoxazolyl- und thienylpyrazolyl-phenoxy substituierte propyl derivate als d4 antagonisten
ATE196766T1 (de) Indolin-derivate verwendbar als 5-ht-2c rezeptor- antagonisten
EE200200394A (et) Indooli derivaadid kui MCP-1 retseptori antagonistid
DE60317632D1 (de) 2-oxazolamine und ihre verwendung als 5-ht2b-rezeptor-antagonisten

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties